Membrane Receptors And Enzymes As Targets Of Insecticidal Action
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Membrane Receptors And Enzymes As Targets Of Insecticidal Action
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Author : J. Marshall Clark
language : en
Publisher: Springer
Release Date : 2012-03-14
Membrane Receptors And Enzymes As Targets Of Insecticidal Action written by J. Marshall Clark and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-14 with Science categories.
One of the fundamental concepts of toxicology is that chemicals act at selective receptors and that such interactions result in phar macologic responses which, depending on dose, mayor may not result in toxicity. For us to understand how insecticides produce their toxic effects, we must first understand their molecular interactions with their target receptors. With this in mind, we organized a symposium which was given in conjunction with the XVII International Congress of Entomology in Hamburg on August 21, 1984. The goal of this symposium was to bring together researchers with a wide range of expertise who shared a common interest in the action of insecticides on the insect nervous system. It was decided to restrict the scope of the symposium so that selected topics could be discussed in greater depth. The volume which resulted from this symposium, -Membranes Receptors and Enzymes as Targets of Insecticidal Action-, details a number of bio chemical modes of action of insecticides on the insect nervous system. The volume is divided into two sections; the first dealing with the action of insecticides on the GABA-ch1oride channel complex. This section evolves from a discussion of the symptoms of cyclodiene toxicity presented by Dr. D. E. Woolley, to the structure-activity relationships and pharmacology of the channel complex and is concluded with the extremely interesting work of Dr. C. C. Wang on the action(s) of avermectin at this receptor.
Membrane Receptors And Enzymes As Targets Of Insecticidal Action
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Author : J. Marshall Clark
language : en
Publisher: Springer
Release Date : 1986-06-14
Membrane Receptors And Enzymes As Targets Of Insecticidal Action written by J. Marshall Clark and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986-06-14 with Science categories.
One of the fundamental concepts of toxicology is that chemicals act at selective receptors and that such interactions result in phar macologic responses which, depending on dose, mayor may not result in toxicity. For us to understand how insecticides produce their toxic effects, we must first understand their molecular interactions with their target receptors. With this in mind, we organized a symposium which was given in conjunction with the XVII International Congress of Entomology in Hamburg on August 21, 1984. The goal of this symposium was to bring together researchers with a wide range of expertise who shared a common interest in the action of insecticides on the insect nervous system. It was decided to restrict the scope of the symposium so that selected topics could be discussed in greater depth. The volume which resulted from this symposium, -Membranes Receptors and Enzymes as Targets of Insecticidal Action-, details a number of bio chemical modes of action of insecticides on the insect nervous system. The volume is divided into two sections; the first dealing with the action of insecticides on the GABA-ch1oride channel complex. This section evolves from a discussion of the symptoms of cyclodiene toxicity presented by Dr. D. E. Woolley, to the structure-activity relationships and pharmacology of the channel complex and is concluded with the extremely interesting work of Dr. C. C. Wang on the action(s) of avermectin at this receptor.
Membrane Receptors And Enzymes As Targets Of Insecticidal Action
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Author : J. Marshall Clark
language : en
Publisher: Springer
Release Date : 1986-05-31
Membrane Receptors And Enzymes As Targets Of Insecticidal Action written by J. Marshall Clark and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986-05-31 with Science categories.
One of the fundamental concepts of toxicology is that chemicals act at selective receptors and that such interactions result in phar macologic responses which, depending on dose, mayor may not result in toxicity. For us to understand how insecticides produce their toxic effects, we must first understand their molecular interactions with their target receptors. With this in mind, we organized a symposium which was given in conjunction with the XVII International Congress of Entomology in Hamburg on August 21, 1984. The goal of this symposium was to bring together researchers with a wide range of expertise who shared a common interest in the action of insecticides on the insect nervous system. It was decided to restrict the scope of the symposium so that selected topics could be discussed in greater depth. The volume which resulted from this symposium, -Membranes Receptors and Enzymes as Targets of Insecticidal Action-, details a number of bio chemical modes of action of insecticides on the insect nervous system. The volume is divided into two sections; the first dealing with the action of insecticides on the GABA-ch1oride channel complex. This section evolves from a discussion of the symptoms of cyclodiene toxicity presented by Dr. D. E. Woolley, to the structure-activity relationships and pharmacology of the channel complex and is concluded with the extremely interesting work of Dr. C. C. Wang on the action(s) of avermectin at this receptor.
Biochemical Sites Of Insecticide Action And Resistance
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Author : Isaac Ishaaya
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Biochemical Sites Of Insecticide Action And Resistance written by Isaac Ishaaya and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
In recent years many of the conventional methods of insect control by broad spectrum synthetic chemicals have come under scrutiny because of their unde sirable effects on human health and the environment. In addition, some classes of pesticide chemistry, which generated resistance problems and severely affected the environment, are no longer used. It is against this background that the authors of this book present up-to-date findings-relating to biochemical sites that can serve as targets for developing insecticides with selective prop erties, and as the basis for the elucidation of resistance mechanisms and countermeasures. The book consists of eight chapters relating to biochemical targets for insec ticide action and seven chapters relating to biochemical modes of resistance and countermeasures. The authors of the chapters are world leaders in pesti cide chemistry, biochemical modes of action and mechanisms of resistance. Biochemical sites such as chitin formation, juvenile hormone and ecdysone receptors, acetylcholine and GABA receptors, ion channels, and neuropeptides are potential targets for insecticide action. The progress made in recent years in molecular biology (presented in depth in this volume) has led to the iden tification of genes that confer mechanisms of resistance, such as increased detoxification, decreased penetration and insensitive target sites. A combina tion of factors can lead to potentiation of the resistance level. Classifications of these mechanisms are termed gene amplification, changes in structural genes, and modification of gene expression.
Insecticide Action
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Author : J.E. Chambers
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Insecticide Action written by J.E. Chambers and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Intoxication of humans and animals has become increasingly important in recent years as has contamination of the environment by a variety of chemicals. In order to develop effective means by which such intoxication and contamination can be properly handled, it is imperative to know how these environmental agents act in humans and animals. Despite studies conducted by various investigators, the mechanisms of action of these environmental agents have not been fully elucidated. Insecticides are by no means an exception in terms of the seriousness of the problem and of the urgency of the need for such information. In order to complete a picture of the effects of any particular insecticide, it is of utmost importance that its actions at various levels ranging from those of molecules to whole animals be analyzed and synthesized. To understand the toxicological action on animals or humans, it is not sufficient to know the action at each level only. The actions at various levels must be integrated to construct a picture of the toxic effect on the intact organism. However, in spite of the large body of information that has been accumulated during the past few decades, little or no attempt has been made to integrate experimental data obtained at the molecular, cellular, organ, and animal levels together in order to define the whole picture of insecticidal action.
Controlled Release Biochemical Effects Of Pesticides Inhibition Of Plant Pathogenic Fungi
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Author :
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Controlled Release Biochemical Effects Of Pesticides Inhibition Of Plant Pathogenic Fungi written by and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Technology & Engineering categories.
Since the middle of the Sixties, new types of formulation for biologically active com pounds have been developed, which have been introduced into the literature under the term Controlled Release Formulations (CRF). Stimulated by results from former and successful pharmaceutical research, which was engaged in the production of prepa rations with protracted effects (introduction onto the market in the year 1952 of D amphetamine in the form of pellets, coated to varying degrees with fats and waxes) 1), experiments were carried out to transfer the prolongation of effectiveness to pesticidal substances also, by means of a depot formulation. Initial work was concerned with the production of protective coatings for sonar systems in marine ecosystems. By means of antifouling paints or rubber coatings containing tri-n-butyl-tin oxide (TBTO), the growth of marine organisms on sonar domes, buoys and hulls in the water could be effectively prevented 2. 3). Controlled release formUlations of pesticides are defined as depot systems which continuously release their toxic constituents into the environment over a specified period of time (usually months to years) 4). According to this definition, such formu lations can be successfully employed where a chronic exposure to biologically active compounds is required over a longer period. The following hypothetical example is intended to illustrate this 5). In Fig. 1, the duration of activity of a non-persistent pesticide with a loss rate under environmental conditions of t1/2 = 15 days, is graphically illustrated.
Cockroaches As Models For Neurobiology
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Author : Ivan Huber
language : en
Publisher: CRC Press
Release Date : 1990-02-28
Cockroaches As Models For Neurobiology written by Ivan Huber and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-02-28 with Science categories.
Cockroaches offer a useful and inexpensive alternative to traditional laboratory animals, yet most researchers are unfamiliar with their biology. This unique and comprehensive cockroach handbook is written for everyone from novice to expert. It addresses every aspect of cockroach biology, with a particular emphasis on the neuroendocrine system. Liberally illustrated chapters include such topics as cockroach culture, anatomy, behavior, and various experimental techniques. One of the few available books to provide broad coverage of the neurobiology of a single organism, this second volume is a must for all researchers in biomedical or veterinary fields, as well as for entomologists.
Rational Approaches To Structure Activity And Ecotoxicology Of Agrochemicals
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Author : Wilfried Draber
language : en
Publisher: CRC Press
Release Date : 1992-07-14
Rational Approaches To Structure Activity And Ecotoxicology Of Agrochemicals written by Wilfried Draber and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-07-14 with Technology & Engineering categories.
This book presents discussions of the most important aspects in the development of agrochemicals. The book covers such broad areas as structure activity and ecotoxicological analyses in comprehensive reviews for general methods and chronicles for individual examples. Topics in structure-activity relationships include how to combine submolecular structures of pharmacological interests and modify them according to chemorational models with computer-aided procedures such as the traditional Hansch-type QSAR, the sequential, simplex optimization, and molecular modeling. Topics in the ecotoxicology of organo phosphorus compounds are discussed in terms of the quantitative structure-toxicity relationship (QSTR). Chronicles of molecular orbital methodology in predicting environmental fates of agrochemicals are also provided. This volume will be invaluable for researchers in the agrochemical and pharmaceutical industries.
Cockroaches As Models For Neurobiology Applications In Biomedical Research
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Author : Ivan Huber
language : en
Publisher: CRC Press
Release Date : 2019-07-23
Cockroaches As Models For Neurobiology Applications In Biomedical Research written by Ivan Huber and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-23 with Science categories.
Cockroaches offer a useful and inexpensive alternative to traditional laboratory animals, yet most researchers are unfamiliar with their biology. This unique and comprehensive cockroach handbook is written for everyone from novice to expert. It addresses every aspect of cockroach biology, with a particular emphasis on the neuroendocrine system. Liberally illustrated chapters include such topics as cockroach culture, anatomy, behavior, and various experimental techniques. One of the few available books to provide broad coverage of the neurobiology of a single organism, this second volume is a must for all researchers in biomedical or veterinary fields, as well as for entomologists.
Mode Of Action And Metabolism Of Insecticidal Bicycloorthobenzoates
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Author : Yanli Deng
language : en
Publisher:
Release Date : 1991
Mode Of Action And Metabolism Of Insecticidal Bicycloorthobenzoates written by Yanli Deng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with categories.