Menthol Gel For The Management Of Neuropathic Pain After Hand Surgery
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Menthol Gel For The Management Of Neuropathic Pain After Hand Surgery
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Author :
language : en
Publisher:
Release Date : 2017
Menthol Gel For The Management Of Neuropathic Pain After Hand Surgery written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Menthol gel for the management of neuropathic pain after hand surgery u2013 a case reportKokki Hannu, Kokki MerjaSchool of Medicine, University of Eastern Finland, Kuopio, Finland; Department of Anaesthesia and Operative Services, Kuopio University Hospital, Kuopio, FinlandBackgroundThe prevalence of neuropathic pain varies between 1.3% and 18% depending of the definition. It affects significantly the quality of life and has important social and economic consequences (1). Complex regional pain syndrome (CRPS) is one of the most severe neuropathic pain conditions. Up to 26% of patients with surgical treatment of traumatic hand injuries may develop CRPS (2).Menthol has been used for analgesia since the ancient times. Recent interest on menthol in pain management has risen since 2002 when the menthol sensing channel transient receptor potential melastatin 8 (TRPM8) was identified (3,4). Since then menthol has been shown to be effective on the management of several acute nociceptive, inflammatory and neuropathic pain conditions.Here we present a case report where menthol was used in the treatment of refractory CRPS after traumatic hand injury and surgery.CaseA 39 years old non-smoking healthy male had a traumatic complete tear of the distal biceps tendon on 18th of June 2017. Two days later a surgery was performed to reattach the tendon to the bone. After surgery he developed a severe lancinating neuropathic pain at the elbow area. Pain was worse on night-time, NRS 7-8/10 and he could sleep only 3-4 h a night. Paracetamol-codeine and titzanidine were uneffective, gabapentin had some effect, but he was so somnolent at daytima that he could not return to work. Four weeks after the primary injury he was prescribed menthol-gel (Ice Poweru00ae, Fysioline Ltd., Tampere, Finland) for day-time used and menthol patches for nights on the elbow area. Since the first night, he was able to sleep 6-7 h a night and pain rating decreased to 3-5/10. After 4 weeks of treatment, he returned to work and was able to stop the menthol-use. Six months after the injury the muscle function has restored, he may have some muscle aches in few nights a week, which are relieved with menthol gel. At daytimes, he has no pain nor other symptoms.Discussion and conclusionsMenthol is a counter-irritant compound. Initially it stimulates nociceptors and then desensitize them. TRPM8 channels are expressed widely in pain system. In periphery 15% of sensory neurons are TRPM8 activated by menthol. Topically applied menthol activates higher central analgesic pathways also. TRPM8 receptors are expressed in the dorsal root ganglia and the trigeminal ganglia, and in spinal cord in the dorsal and ventral root, i.e. in the ascending and descending pain system (5).CRPS is a relatively common outcome after surgery and trauma and often treatment-resistant. This case report shows that topical menthol could be highly potent component in multimodal pain management in persistent post-operative/post-traumatic pain.References1. Inoue S, Taguchi T, Yamashita T, Nakamura M, Ushida T. The prevalence and impact of chronic neuropathic pain on daily and social life: A nationwide study in a Japanese population. Eur J Pain. 2017;21:727-37.2. Savau015f S, u0130nal EE, Yavuz DD, Uslusoy F, Altuntau015f SH, Aydu0131n MA. Risk factors for complex regional pain syndrome in patients with surgically treated traumatic injuries attending hand therapy. J Hand Ther. 2018;31:250-254.3. McKemy DD, Neuhausser WM, Julius D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature. 2002;416:52-8.4. Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson DA, Story GM, Earley TJ, Dragoni I, McIntyre P, Bevan S, Patapoutian A. A TRP channel that senses cold stimuli and menthol. Cell. 2002;108:705-15.5. Facer P, Casula MA, Smith GD, Benham CD, Chessell IP, Bountra C, Sinisi M, Birch R, Anand P. Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy. BMC Neurol. 2007 May 23;7:11.
Menthol Gel For The Management Of Chemotherapy Induced Neuropathic Pain A Case Report
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Author : Hannu Kokki
language : en
Publisher:
Release Date : 2017
Menthol Gel For The Management Of Chemotherapy Induced Neuropathic Pain A Case Report written by Hannu Kokki and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
MENTHOL GEL FOR THE MANAGEMENT OF CHEMOTHERAPY-INDUCED NEUROPATHIC PAIN u2013 A CASE REPORTKokki Hannu1, Kokki Merja21 School of Medicine, University of Eastern Finland, Kuopio, Finland2 Department of Anaesthesia and Intensive Care, Kuopio University Hospital, Kuopio, FinlandBackground and aims: Several drugs used in oncology may cause chemotherapy-induced peripheral neuropathy (CIPN). CIPN occurs in 58-78% of patients who receive eg. carboplatin and paclitaxel, and 1/3 of patients have symptoms 6 months after chemotherapy. 1Recent interest on menthol in pain management has risen since 2002 when the menthol sensing channel transient receptor potential melastatin 8 (TRPM8) was identified. 2Here we present a case report where menthol-cream was used in the treatment of refractory CIPN pain.Methods:A 49 years old women underwent debulking surgery for ovarian cancer and peritoneal carcinosis on 7/2017. After surgery, she had chemotherapy with carboplatin and paclitaxel. On 8/2018 she had no sings of recurrence of the cancer, but severe pain in the hands and feet. Ibuprofen, oxycodone-naloxone and venlafaxine provide only 30% pain relief. Her pain on NRS was on average 4/10, least 2/10 and most 6/10. Her pain interfere with several daily functions, mood and normal daily activities most severely affected.She was prescribed menthol-cream (Ice Poweru00ae, Fysioline Ltd., Tampere, Finland) to be used 2-4-times a day.Results:After 4 weeks use of menthol-cream she was able to stop other analgesics. On 12/2018, after 4 months use of menthol-cream, she had neither pain nor any other symptoms of neuropathy. Her life satisfaction (LS) on the 4-item LS-scale (4-20) 3 had improved, score before menthol-cream was 8/20 and after it 6/20.Conclusions:In consistent with other reports 4, in this case topical menthol was highly effective on CIPN.References1. Seretny M et al. Pain 20142. McKemy DD, et al. Nature 20023. Allardt E. Research Reports No. 1. University of Helsinki, 1973.4. Fallon MT, et al. Support Care Cancer. 2015.
Compounded Topical Pain Creams
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2020-07-21
Compounded Topical Pain Creams written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-21 with Medical categories.
Pain is both a symptom and a disease. It manifests in multiple forms and its treatment is complex. Physical, social, economic, and emotional consequences of pain can impair an individual's overall health, well-being, productivity, and relationships in myriad ways. The impact of pain at a population level is vast and, while estimates differ, the Centers for Disease Control and Prevention reported that 50 million U.S. adults are living in pain. In terms of pain's global impact, estimates suggest the problem affects approximately 1 in 5 adults across the world, with nearly 1 in 10 adults newly diagnosed with chronic pain each year. In recent years, the issues surrounding the complexity of pain management have contributed to increased demand for alternative strategies for treating pain. One such strategy is to expand use of topical pain medicationsâ€"medications applied to intact skin. This nonoral route of administration for pain medication has the potential benefit, in theory, of local activity and fewer systemic side effects. Compounding is an age-old pharmaceutical practice of combining, mixing, or adjusting ingredients to create a tailored medication to meet the needs of a patient. The aim of compounding, historically, has been to provide patients with access to therapeutic alternatives that are safe and effective, especially for people with clinical needs that cannot otherwise be met by commercially available FDA-approved drugs. Compounded Topical Pain Creams explores issues regarding the safety and effectiveness of the ingredients in these pain creams. This report analyzes the available scientific data relating to the ingredients used in compounded topical pain creams and offers recommendations regarding the treatment of patients.
Magnesium In The Central Nervous System
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Author : Robert Vink
language : en
Publisher: University of Adelaide Press
Release Date : 2011
Magnesium In The Central Nervous System written by Robert Vink and has been published by University of Adelaide Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
The Neurobiology Physiology And Psychology Of Pain
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Author : Rajkumar Rajendram
language : en
Publisher: Academic Press
Release Date : 2021-11-09
The Neurobiology Physiology And Psychology Of Pain written by Rajkumar Rajendram and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-09 with Medical categories.
The Neurobiology, Physiology and Psychology of Pain focuses on bettering readers’ understanding of acute and chronic pain. Featuring chapters on neurotransmitters, pharmacology, and brain imaging, this volume discusses, in detail, the mechanisms of pain and experimental studies undertaken to better understand the pathways involved. The translational work in this area has applicability for neurologists, anesthesiologists, pharmacologists, and anyone working in the intersection of these areas. This volume is integral for anyone interested in the molecular underpinnings of pain at every level. Provides comprehensive coverage on a broad range of topics related to the neuroscience of pain Contains an abstract, key facts, a mini dictionary of terms, and summary points to aid in understanding in each chapter Features chapters on molecular pathways, imaging and a deep look at behavior associated with the experience of pain Contains unique topics that will help readers navigate key areas for research and further clinical recommendations
The Neuroscience Of Pain Anesthetics And Analgesics
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Author : Rajkumar Rajendram
language : en
Publisher: Academic Press
Release Date : 2021-11-30
The Neuroscience Of Pain Anesthetics And Analgesics written by Rajkumar Rajendram and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-30 with Medical categories.
The Neuroscience of Pain, Anesthetics and Analgesics examines the syndromes of pain and how they interlink with anesthesia and analgesics. The book covers assessments, screening and resources, and provides applications to related areas of medicine. It explores how the perception of pain results from a multifaceted interaction between illness beliefs, age, gender, time of onset, stress, socioeconomic status, and other factors. In addition, it scrutinizes how the neuroscience of pain in one condition may be relevant to understanding pain observed in other conditions. Sections address the onset of pain, the cause of pain, and the administration of analgesia or anesthesia. The book works to clarify all of the subjects pertinent to anesthesia and the brain. Featuring chapters on neurotransmitters, pharmacology and brain imaging, this volume discusses the mechanisms of pain and experimental studies undertaken to better understand the pathways involved. Includes content on the features and assessments of pain, anesthesia and analgesia Provides a mini-dictionary of terms and summary points that succinctly encapsulate each chapter Covers a broad range of topics related to the neuroscience of analgesics and anesthetics Helps readers navigate key areas for research and further clinical recommendations Features chapters on molecular pathways, imaging and a deep look at behavior associated with the experience of pain
Chemotherapy Induced Neuropathic Pain
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Author : Robert B. Raffa
language : en
Publisher: CRC Press
Release Date : 2012-07-24
Chemotherapy Induced Neuropathic Pain written by Robert B. Raffa and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-24 with Health & Fitness categories.
There have been tremendous recent advances in the pharmacotherapy, dose regimens, and combinations used to treat cancer and for the treatment or prevention of the spread of disease. As a direct result of these advances, there are an increasing number of cancer survivors, although research dealing with chemotherapy-induced pain is still in its early
Case Studies In Pain Management
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Author : Alan David Kaye
language : en
Publisher: Cambridge University Press
Release Date : 2014-10-16
Case Studies In Pain Management written by Alan David Kaye and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-16 with Medical categories.
Edited by internationally recognized pain experts, this book offers 73 clinically relevant cases, accompanied by discussion in a question-and-answer format.
Spasmodic Torticollis Handbook
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Author : Karen Frei, MD
language : en
Publisher: Springer Publishing Company
Release Date : 2003-07-01
Spasmodic Torticollis Handbook written by Karen Frei, MD and has been published by Springer Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-07-01 with Medical categories.
Spasmodic torticollis, also known as cervical dystonia, affects about three people in 10,000, or an estimated 85,000 individuals in the United States alone. Despite this, there has been until now a lack of information outside of the professional medical literature for use by individuals with this disorder and their families. This book provides comprehensive information on the disorder for people with spasmodic torticollis and those close to them. Medical terms and concepts are introduced sequentially and then used as building blocks for the later discussion. Beginning with a clear definition of the disorder, opening chapters categorize this neurologic disease as one of the broader category of movement disorders, and differentiate it from other conditions with which it is often confused. The authors then present a stepwise introduction to the relevant anatomy and physiology of the nervous system and neck. They draw on the experiences of their patients to build a progressive depiction of the experiences an individual might have as he or she goes through the initial onset of symptoms, progression of the disorder, seeking medical care, diagnosis, treatment, and subsequent outcome. Personal vignettes from the experiences of selected patients are provided where they illustrate particular points in the discussion. Subsequent chapters discuss various modes of treatment for spasmodic torticollis. Prior to the mid-1980?s, there were no specific treatments for this disorder. Nearly all treatment consisted of using oral medications that were primarily intended for other medical conditions. Since most of these medications are still in use, and a few new ones have been added, a chapter is devoted to detailing them and discussing the general principles of medication therapy. During the past decade, chemodenervation using botulinum toxin has become the primary and most effective treatment for spasmodic torticollis. For those few patients who require surgery, a description is provided of the neurosurgical techniques developed during the last twenty years specifically for its treatment. The final chapter is a manual of therapeutic rehabilitation exercises designed to alleviate the symptoms of spasmodic torticollis. These exercises can be performed by most patients with no assistance and a bare minimum of equipment. Since each person?s case of spasmodic torticollis is different, only certain of the exercises may be appropriate for any given individual. They should be undertaken only after discussion with your physician. These exercises are accompanied by detailed illustrations that emphasize the particular muscles relevant to each posture or movement. About the Authors: Dr. Pathak is a neurologist with a special interest in the neurologic rehabilitation of movement disorders, especially spasmodic torticollis. Dr. Frei is a neurologist specialized in the field of neurogenetics, and has conducted clinical trials on a number of movement disorders, including spasmodic torticollis. Dr. Truong is a neurologist and movement disorders specialist. He has conducted active research in the management of movement disorders, including spasmodic torticollus. He was one of the pioneers in the use of botulinum toxin to manage this condition, and has lectured worldwide on the management of movement disorders.
The Pharmacology Of Pain
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Author : A. Dickenson
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Pharmacology Of Pain written by A. Dickenson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Pain is a symptom of many clinical disorders, afflicts a large proportion of the population and is largely treated by pharmacological means. However, the two main classes of drugs used are the opioids and the non-steroidal anti inflammatory drugs, drugs that have a long history. The last decade has seen remarkable advances in our understanding of some of the pharmacological bases of pain and analgesia and this book aims to reflect these rapid changes in our understanding of pain mechanisms. One impetus to these scientific advances has been dialogue and interactions between scientists and clinicians; as a result we now has a number of animal models of clinical pain states, to mimic certain aspects of clinical pathophysiological pain states. Molecular aspects of receptors and the synthesis of tools for probing receptor function have also been rapid growth areas. A number of controlled clinical studies using novel licensed drugs have also resulted from recent research, offering hope to certain patients with severe intractable pain. However, we desperately need the pharmaceutical industry to develop new drugs based on these novel targets for analgesic therapy. This book attempts to provide an overview of the important areas of the pharmacology of pain. This book, although providing an account of the pharmacology of pain transmission and its control based on the underlying anatomical organization and physiological responses, does not attempt to cover these latter two areas.