Metabolism And Chromatin Modification In Cancer

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Metabolism And Chromatin Modification In Cancer

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Author : Guillermo Barreto
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-13

Metabolism And Chromatin Modification In Cancer written by Guillermo Barreto and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-13 with Science categories.

Metabolism And Epigenetic Regulation Implications In Cancer

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Author : Tapas Kumar Kundu
language : en
Publisher: Springer Nature
Release Date : 2022-10-27

Metabolism And Epigenetic Regulation Implications In Cancer written by Tapas Kumar Kundu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-27 with Science categories.

Metabolic programs of individuals are key determinants for disease susceptibility and immune response. This book, edited by experts in the field, summarizes epigenetic signaling pathways that regulate metabolic programs associated with cancer and cancer-related secondary diseases. The first part of the book highlights key metabolic pathways that are implicated in cancer and provides a comprehensive overview on the carbohydrate, protein, lipid, amino- and nucleic acid metabolic pathways that are deregulated in cancer. Special attention is paid to the altered tumor micro-environment that is influenced by the metabolic milieu. Furthermore, the fundamental relationship between the cellular metabolic environment and cell death-mediated autophagy is discussed. The second part of the book covers our understanding of the fundamental epigenetic regulations that are implicated in controlling the metabolic programs in cancer cells. Many aspects of epigenetic regulation of non-coding RNAs as well as DNA/RNA methylation, which influencing metabolic homeostasis in cancer, are discussed in detail. Special emphasis is placed on the epigenetic regulation of the amino acid, glucose/carbohydrate metabolism and epigenetic regulation during hypoxia and its connection to cancer. Last but not least, the third part of the book covers small molecule modulators of histone modifying enzymes, which can be used as therapeutic tools. The readers learn about the cross-talk between epigenetics and immunometabolims, as well as the epigenetic regulation of oncometabolites to combat cancer. Given its scope, the book will appeal to a broad readership interested in epigenetic, cancer and metabolic research.

Cancer Epigenetics

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Author : Trygve Tollefsbol
language : en
Publisher: CRC Press
Release Date : 2008-09-19

Cancer Epigenetics written by Trygve Tollefsbol and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-19 with Medical categories.

During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being de

New Anti Cancer Strategies Targeting Epigenetic Modifications And Associated Metabolism Reprogramming

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Author : Lixiang Xue
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-05

New Anti Cancer Strategies Targeting Epigenetic Modifications And Associated Metabolism Reprogramming written by Lixiang Xue and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-05 with Science categories.

Influence Of Acetyl Coa Metabolism In Histone Acetylation And Cancer

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Author : Joyce V. Lee
language : en
Publisher:
Release Date : 2017

Influence Of Acetyl Coa Metabolism In Histone Acetylation And Cancer written by Joyce V. Lee and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.

Cancer cells increase nutrient uptake to support viability and proliferation. The influx of nutrients alters intermediary metabolite levels, and compelling evidence shows that metabolite availability impacts cell functions through altering chromatin modifications and downstream gene expression. One such metabolic intermediate is acetyl-CoA, as the concentration of acetyl-CoA is positively correlated with histone and non-histone protein acetylation. Histone acetylation is emerging as a nutrient-sensitive process, conferring gene expression changes in response to nutrient availability. In this thesis, we examined the impact of acetyl-CoA metabolism on the epigenome. We established that histone acetylation is sensitive to acetyl-CoA concentrations, which are dynamically regulated by glucose availability. This dynamic increase in histone acetylation induces the expression of cancer-promoting genes. We hypothesized that oncogene activation could lead to increased histone acetylation through reprogrammed metabolism. In two mouse models of cancer, histone acetylation increased upon oncogene activation. Additionally, histone acetylation was positively correlated with phosphorylated AKT in human prostate tumors and glioma. To test whether AKT regulates histone acetylation through metabolic changes, we utilized glioblastoma cell lines expressing constitutively active AKT and found that AKT promotes histone acetylation in nutrient-limited conditions. Mechanistically, this occurs partly through AKT-mediated phosphorylation of ACLY at serine 455, increasing ACLY activity. These studies reveal a novel role for AKT-driven metabolic changes on global histone acetylation in cancer cells. To better understand how concentrations of acetyl-CoA could lead to differential gene expression, we investigated a subset of acetyl-CoA regulated genes. Under conditions in which intracellular acetyl-CoA is abundant, glioma cells upregulate expression of adhesion and migration genes, increase transwell migration, adhere better to ECM, and are efficient in wound healing. Genetic deletion or biochemical inhibition of acetyl-CoA generating enzyme, ACLY, abrogates nutrient-dependent adhesion and migration. We postulated that specificity for regulation of migration related gene expression would be achieved through regulation of transcription factors. Using computational analysis of our acetyl-CoA gene set, NFAT1 was predicted as the top transcription factor in promoting these genes. Through fluorescent single cell analyses, we find that acetyl-CoA triggers calcium oscillations that allow for NFAT1 nuclear localization. These findings suggest that that acetyl-CoA availability is differentially regulated in cancer cells and contributes to malignant phenotypes.

Introduction To Epigenetics

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Author : Renato Paro
language : en
Publisher: Springer Nature
Release Date : 2021-03-23

Introduction To Epigenetics written by Renato Paro and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-23 with Science categories.

This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease

The Role Of High Glucose In Tumorigenesis Using Genome Wide Analysis

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Author : Selene Bobadilla
language : en
Publisher:
Release Date : 2017

The Role Of High Glucose In Tumorigenesis Using Genome Wide Analysis written by Selene Bobadilla and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Carcinogenesis categories.

Altered cellular metabolism is considered a crucial hallmark of cancer, and has been an area of accelerated research. Interestingly, metabolic alterations in cancer can lead to changes in metabolite concentration, and these may play a role in tumorigenesis through functions that are not overtly metabolic. Tumor suppressor p53 plays a prominent role in cancer and much of human biology. Many functions have been attributed to p53, including roles in DNA repair and recombination through association with proteins involved in genome stability and chromatin modification. However, its broadest cellular effect is through its function as a transcription factor (TF). p53 is regulated through multiple post-translational modifications (PTMs) in response to a variety of cellular stresses including DNA damage. One important PTM is phosphorylation on the Thr55 residue, which is mediated by TBP Associated Factor 1 (TAF1) on the p21 promoter and leads to p53 promoter dissociation and termination of p21 transcription. TAF1 is the largest subunit of transcription factor TFIID and a cell cycle regulatory protein important for G1 phase progression. Interestingly, TAF1 phosphorylates p53 in a cellular ATP level-dependent manner. Because high glucose (HG) conditions lead to increased cellular ATP levels, we tested its effect on p53 function and found that global p53 binding to target promoters is reduced under HG conditions even in the presence of DNA damage. Functional analysis of cell growth inhibition as well as cell apoptosis suggests HG is a potent inhibitor of these p53-dependent cellular responses. Further, we examined the overall HG effect on the DNA damage-dependent gene expression changes and found that HG alters the DNA damage transcriptome. Importantly, HG affected the expression of genes that have already been shown to play a role in cancer. These studies suggest that cancer cells use the dynamic nature of cell metabolism to promote transformation via metabolite concentration. Altogether, this work establishes a molecular mechanism by which hyperglycemia may indirectly contribute to malignant transformation, providing an explanation for the association between diabetes and cancer.

Chromatin And Genomic Instability In Cancer

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Author :
language : en
Publisher: Academic Press
Release Date : 2021-09-08

Chromatin And Genomic Instability In Cancer written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-08 with Science categories.

Chromatin and DNA Repair in Cancer, Volume 364 in the International Review of Cell and Molecular Biology series reviews and details current advances in cell and molecular biology. Chapters in this new release cover Genomic Instability and metabolism in cancer, Histones variants and Histones modifications in cancer and Aging, DNA Double-stranded breaks Repair in Cancer, Reactive oxygen species and DNA damage response in cancer, Transcription-Associated DNA Breaks and Cancer: A Matter of DNA Topology, Mechanisms of Base Excision Repair: Its Significance to Human Health, and more. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. This great resource ranks high amongst scientific journals dealing with cell biology. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists, drawn from international sources Offers a wide range of perspectives on specific subjects

Metabolism In Cancer

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Author : Thorsten Cramer
language : en
Publisher: Springer
Release Date : 2016-08-24

Metabolism In Cancer written by Thorsten Cramer and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-24 with Medical categories.

This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.

Epigenetics And Metabolomics

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Author : Paban K. Agrawala
language : en
Publisher: Elsevier
Release Date : 2021-08-25

Epigenetics And Metabolomics written by Paban K. Agrawala and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-25 with Medical categories.

Epigenetics and Metabolomics, a new volume in the Translational Epigenetics series, offers a synthesized discussion of epigenetic control of metabolic activity, and systems-based approaches for better understanding these mechanisms. Over a dozen chapter authors provide an overview of epigenetics in translational medicine and metabolomics techniques, followed by analyses of epigenetic and metabolomic linkage mechanisms likely to result in effective identification of disease biomarkers, as well as new therapies targeting the removal of the inappropriate epigenetic alterations. Epigenetic interventions in cancer, brain damage, and neuroendocrine disease, among other disorders, are discussed in-depth, with an emphasis on exploring next steps for clinical translation and personalized healthcare. Offers a synthesized discussion of epigenetic regulation of metabolic activity and systems-based approaches to power new research Discusses epigenetic control of metabolic pathways and possible therapeutic targets for cancer, neurodegenerative, and neuroendocrine diseases, among others Provides guidance in epigenomics and metabolomic research methodology