Metallointercalators

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Metallointercalators

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Author : Janice Aldrich-Wright
language : en
Publisher: Springer
Release Date : 2011-04-06

Metallointercalators written by Janice Aldrich-Wright and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-06 with Science categories.

A comprehensive treatment of the characterisation techniques used in investigating inorganic and organic molecules that interact with biomolecules is presented to the reader in a clear fashion. The work consists of two parts: (i) synthetic aspects of metallointercalators along with targeting and improving transport and (ii) the various techniques that are used for probing their interactions, such as; DNA-NMR, PGSE-NMR, DNA ESI-MS, Linear and Circular Dichroism, Fluorescence Spectroscopy, Confocal Microscopy, Viscosity, TGA and dialysis, Microarrays, biological analysis. Chapters are devoted to the synthesis and the techniques used to study the interactions of inorganic complexes with biomolecules. Considerably detailed examples are used to help illustrate the application of these techniques. This book is a useful resource for an array of inorganic and organic advanced undergraduate and graduate courses and for researchers in drug discovery.

Metallointercalators

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Author :
language : en
Publisher: Springer
Release Date : 2011-07-11

Metallointercalators written by and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-11 with categories.

The Application Of Metallointercalators In Recognition Of And Charge Trasnport In Nucleic Acids

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Author : Duncan T. Odom
language : en
Publisher:
Release Date : 2001

The Application Of Metallointercalators In Recognition Of And Charge Trasnport In Nucleic Acids written by Duncan T. Odom and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with DNA. categories.

Metal complexes that utilize the 9,10-phenanthrene quinone diimine (phi) moiety bind to DNA through the major groove. These metallointercalators can recognize DNA sites and perform reactions on DNA as a substrate. The site-specific metallointercalator ^-1-Rh(MGP)_2phi^(5+) competitively disrupts the major groove binding of a transcription factor, yAP-1, from an oligonucleotide that contains a common binding site. The demonstration that metal complexes can prevent transcription factor binding to DNA site-specifically is an important step in using metallointercalators as therapeutics. The distinctive photochemistry of metallointercalators can also be applied to promote long range charge transport in DNA. Experiments using duplexes with regions 4 to 10 nucleotides long containing strictly adenine and thymine sequences of varying order showed that radical migration is more dependent on the sequence of bases, and less dependent on the distance between the guanine doublets. This result suggests that mechanistic proposals of long range charge transport must involve all the bases. RNA/DNA hybrids show charge migration to guanines from a remote site, thus demonstrating that nucleic acid stacking other than B-form can serve as a radical bridge. Double crossover DNA assemblies also provide a medium for charge transport at distances up to 100 Å from the site of radical introduction by a tethered metal complex. This radical migration was found to be robust to mismatches, and limited to individual, electronically distinct base stacks. In single DNA crossover assemblies, which have considerably greater flexibility, charge migration proceeds to both base stacks due to conformational isomers not present in the rigid and tightly annealed double crossovers. Finally, a rapid, efficient, gel-based technique was developed to investigate thymine dimer repair. Two oligonucleotides, one radioactively labeled, are photoligated via the bases of a thymine-thymine interface; reversal of this ligation is easily visualized by gel electrophoresis. This assay was used to show that the repair of thymine dimers from a distance through DNA charge transport can be accomplished with different photooxidants. Thus, nucleic acids that support long range charge transport have been shown to include A-track DNA, RNA/DNA hybrids, and single and double crossovers, and a method for thymine dimer repair detection using charge transport was developed. These observations underscore and extend the remarkable finding that DNA can serve a medium for charge transport via the heteroaromatic base stack.

Boron Rich Dna Metallointercalators

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Author : H. Y. Vincent Ching
language : en
Publisher:
Release Date : 2011

Boron Rich Dna Metallointercalators written by H. Y. Vincent Ching and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Boron-neutron capture therapy categories.

Potential Platinum Dna Metallointercalators

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Author : Claire Joanna Lawrence
language : en
Publisher:
Release Date : 1997*

Potential Platinum Dna Metallointercalators written by Claire Joanna Lawrence and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997* with categories.

A Study Of Some Ternary Tetradentate Complexes As Phenanthrene Based Chiral Metallointercalators

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Author : Susan F. Murphy Poulton
language : en
Publisher:
Release Date : 1998

A Study Of Some Ternary Tetradentate Complexes As Phenanthrene Based Chiral Metallointercalators written by Susan F. Murphy Poulton and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Chelates categories.

Investigations Of Dna Mediated Electron Transfer Reactions With Metallointercalators

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Author : Michelle R. Arkin
language : en
Publisher:
Release Date : 1997

Investigations Of Dna Mediated Electron Transfer Reactions With Metallointercalators written by Michelle R. Arkin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.

Metallointercalator Dna Conjugates

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Author : R. Erik Holmlin
language : en
Publisher:
Release Date : 1998

Metallointercalator Dna Conjugates written by R. Erik Holmlin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.

Structure Of A Metallointercalator Bound To Dna

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Author : Brian P. Hudson
language : en
Publisher:
Release Date : 1998

Structure Of A Metallointercalator Bound To Dna written by Brian P. Hudson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.

Long Range Charge Transfer In Dna I

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Author : Gary B. Schuster
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-03-24

Long Range Charge Transfer In Dna I written by Gary B. Schuster and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-03-24 with Science categories.