Metastatic Progression And Tumour Heterogeneity

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Metastatic Progression And Tumour Heterogeneity

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Author : Fred Hollande
language : en
Publisher: MDPI
Release Date : 2021-01-21

Metastatic Progression And Tumour Heterogeneity written by Fred Hollande and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-21 with Science categories.

Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors can display significant differences in their genomic content as well as in their overall behavior. Our capacity to better understand the heterogeneous make up of tumors has very important consequences on our ability to design efficient therapeutic strategies to improve patient survival. This book highlights several aspects of tumor heterogeneity in the context of metastatic development and summarize some of the challenges posed by heterogeneity for tumor diagnostics and therapeutic management of tumors.

Metastatic Progression And Tumour Heterogeneity

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Author : Fred Hollande
language : en
Publisher:
Release Date : 2020

Metastatic Progression And Tumour Heterogeneity written by Fred Hollande and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.

Improved understanding of the cellular and molecular makeup of tumors in the last 30 years has unraveled a previously unexpected level of heterogeneity among tumor cells as well as within the tumor microenvironment. The concept of tumor heterogeneity underlines the realization that different tumors can display significant differences in their genomic content as well as in their overall behavior. Our capacity to better understand the heterogeneous make up of tumors has very important consequences on our ability to design efficient therapeutic strategies to improve patient survival. This book highlights several aspects of tumor heterogeneity in the context of metastatic development and summarize some of the challenges posed by heterogeneity for tumor diagnostics and therapeutic management of tumors.

Tumour Heterogeneity During The Progression Of Metastatic Breast Cancer And Anti Tumour Effects Of The Novel Fak Inhibitor Bi 853520 In Breast Cancer

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Author : Stefanie Nicole Tiede
language : en
Publisher:
Release Date : 2020

Tumour Heterogeneity During The Progression Of Metastatic Breast Cancer And Anti Tumour Effects Of The Novel Fak Inhibitor Bi 853520 In Breast Cancer written by Stefanie Nicole Tiede and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.

Investigation Of Metastatic Breast Tumor Heterogeneity And Progression Using Dual Optical Spect Imaging

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Author :
language : en
Publisher:
Release Date : 2007

Investigation Of Metastatic Breast Tumor Heterogeneity And Progression Using Dual Optical Spect Imaging written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.

The goal of our project is to image the processes that occur during tumor growth and metastatic spread or regression including the fate of minimal residual disease. To do so it is necessary to test the limits of sensitivity of newly developed techniques: our technical goal is to develop integrated light emission and single photon emission tomography. We have made substantial progress in our techniques for the detection of metastases. We have demonstrated our capability to detect millimeter or sub-millimeter metastases in mice by light emission. To this end we have used Light Emission Tomography (LET), a technique based on bioluminescence of cancer cells infected with luciferase, to detect metastases in the lung and head. We have begun assessment of perfusion using fluorescence imaging. In addition, our technological focus is on the simultaneous use of Single-photon Emission Computed Tomography (SPECT), and to this end we have developed a new form of micro-SPECT based on cooled, electron-multiplied Charge-Coupled Devices (EMCCDs) with which we are performing ongoing imaging experiments. We have also collaborated on the assessment of a new, promising SPECT imaging agent, clioquinol or Iodinated hydroxyquinoline. We will use bioluminescence imaging to test if clioquinol imaging detects areas where tumor cells proliferate and establish metastases and to identify the relative times at which the images first appear.

Tumor Heterogeneity Diagnostics And Therapeutic Management Of Tumors

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Author : Joanna Murray
language : en
Publisher: Foster Academics
Release Date : 2023-09-26

Tumor Heterogeneity Diagnostics And Therapeutic Management Of Tumors written by Joanna Murray and has been published by Foster Academics this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-26 with Health & Fitness categories.

Tumor cells have a remarkable ability to survive in harsh circumstances, resist treatment and evade regulatory mechanisms like apoptosis and therapy. They alter their metabolism in order to sustain metastatic progression and uncontrolled growth. Functional and phenotypic heterogeneity in tumor cells gives them metastatic potential, aggressiveness and the capability to resist treatment. This heterogeneity is governed by a range of intrinsic and extrinsic stimuli involving the ones from the tumor microenvironment. Various tumor cells can exhibit heterogeneous phenotypic and morphological profiles comprising gene expression, metastatic potential, metabolism, proliferation, cellular morphology and motility. It have been detected in many types of cancer including breast cancer, head and neck cancer, gynecological carcinoma, multiple myeloma, leukemia, prostate cancer, colon cancer, bladder, brain cancer and liposarcoma. This book contains some path-breaking studies on tumor heterogeneity. It strives to provide a fair idea about tumor heterogeneity and to help develop a better understanding of the diagnostics and therapeutic management of tumors. This book will help new researchers by foregrounding their knowledge in this area of study.

Investigation Of Metastatic Breast Tumor Heterogeneity And Progression Using Dual Optical Spect Imaging Addendum

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Author :
language : en
Publisher:
Release Date : 2008

Investigation Of Metastatic Breast Tumor Heterogeneity And Progression Using Dual Optical Spect Imaging Addendum written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.

The goal of our project was to develop methods to image the processes that occur during tumor growth and metastatic spread or regression including the fate of minimal residual disease. The key to this was through the development of a dual modality imaging system capable of performing both optical and SPECT imaging in mice. To do so it is necessary to test the limits of sensitivity of newly developed techniques: our technical goal is to develop integrated light emission and single photon emission tomography. We have made substantial progress in our techniques for the detection of metastases. We have demonstrated our capability to detect millimeter or sub-millimeter metastases in mice by light emission. To this end we have used Light Emission Tomography (LET) a technique based on bioluminescence of cancer cells transfected with lucifernse to detect metastases in the lung bones and head. We have begun assessment of perfusion using fluorescence imaging. In addibon our technological focus is on the simultaneous use of Single-photon Emission Computed Tomography (SPECT) and to this end we have developed a new form of micro-SPECT based on cooled electron-multiplied Charge-Coupled Devices (EMCCDs).

Circulating Tumor Cells In Breast Cancer Metastatic Disease

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Author : Roberto Piñeiro
language : en
Publisher: Springer Nature
Release Date : 2020-04-17

Circulating Tumor Cells In Breast Cancer Metastatic Disease written by Roberto Piñeiro and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-17 with Medical categories.

This book is aimed to summarise the key aspects of the role of circulating tumour cells (CTCs) in breast cancer, with special attention to their contribution to tumour progression and establishment of metastatic disease. We aim to give a clear overview of the knowledge about CTCs, framed in the context of breast cancer, by analysing basic and clinical research carried out so far. In a broader sense, we will address what are the main clinical needs of this disease based on its molecular heterogeneity (subtypes) and lay out the knowledge and understanding that CTCs are giving about it and how they are contributing and can still improve the better monitoring and management of breast cancer patients. We will discuss the evidences of the use of CTCs as a tool to monitor cancer progression and therapy response, based on the prognostic and predictive value they have, as well as a tool to unravel mechanisms of resistance to therapy and to identify new biomarkers allowing to predict therapy success. Moreover, we will analyse the main aspects of ongoing clinical trials and how they can contribute to determine the clinical utility of CTCs as a breast cancer biomarker. We will also touch upon general knowledge or basic notions of the biology of the metastatic process in epithelial cancers, in order to understand the origin and biology of CTCs. In this sense, we will pay special attention to EMT (epithelial to mesenchymal transition), dormancy and minimal residual disease, three key aspects that determine the outcome of the disease. We will also cover general aspects on the isolation and characterization techniques applies to the study of CTCs, and also the possibilities that the study of CTCs, as a biomarker with biological function, is opening in terms of understanding the biology of metastatic cells and the identification of therapeutic targets based on the functional and molecular characterization of CTCs. Lastly, we will try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine.

Fundamental Aspects Of Cancer

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Author : Ronald H. Goldfarb
language : en
Publisher: Springer
Release Date : 1989

Fundamental Aspects Of Cancer written by Ronald H. Goldfarb and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medical categories.

Individual neoplastic diseases often show discrete growth direct effect of tumor metastases or to adverse consequences patterns subject to many modifications according to the associated with these therapeutic modes (e.g., complications stage of the disease, the species involved and the tumor type of immunosuppression which can lead to mortality arising concerned. Primary neoplasms are less difficult to treat in from infectious disease). contrast to secondary neoplasms. The chief type of secon It is therefore quite clear that there is a crucial need for dary neoplastic growth, metastasis, is also comparatively new methods for the detection of micrometastases and the development of new modalities for the treatment of estab less well understood. Phylogenetically, metastasis attains its highest level of development in the mammal and is best lished metastases. It is likely that such modalities must known in man, but is still far from being understood. overcome tumor heterogeneity and drug resistance to yield new therapeutic modalities with improved margin of safety The process of cancer growth and progression, from the initiation of neoplastic transformation of normal cells to the and efficacy over currently available anti-neoplastic drugs.

Tumor Progression And Metastasis

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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-04-08

Tumor Progression And Metastasis written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-08 with Medical categories.

This book offers significant coverage on different aspects of cancer from risk factors to the mechanisms leading to tumor progression and metastasis. Although tremendous progress has been made in cancer research and treatment, cancer metastasis remains a major unmet clinical need. The life and death of many cancer patients hangs on the degree of metastasis. This book provides new perspectives for diagnosis and cancer therapy. It includes new technologies and a new basis for current cancer therapies. To guarantee the high quality of this book, important topics are included and rigorously discussed in a simple and authentic way. The book addresses important challenges governing tumor progression and metastasis and brings new responses to both diagnosis and therapy. This book is a great source of knowledge and will be useful for researchers, medical doctors, oncologists, graduate and medical students, continued medical educators, health care providers, and all individuals interested in understanding cancer and its challenges.

Selected Aspects Of Cancer Progression Metastasis Apoptosis And Immune Response

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Author : Hans E. Kaiser
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-05-20

Selected Aspects Of Cancer Progression Metastasis Apoptosis And Immune Response written by Hans E. Kaiser and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-20 with Medical categories.

The processes of tumor metastasis, apoptosis and anti-tumor immune response are among the most complex yet rapidly advancing fields in the area of cancer research. This monograph, with its leading authorship, presents a comprehensive coverage of the recent advances in the various key concepts in these fundamental aspects of human cancer. It contains state-of-the-science reviews on invasion, metastasis, angiogenesis, apoptosis and immunologic aspects related to cancer.