Microfabrication Of Three Dimensional Complex Structures For Biomedical Applications
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Microfabrication Of Three Dimensional Complex Structures For Biomedical Applications
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Author : Sohyung Lee
language : en
Publisher:
Release Date : 2022
Microfabrication Of Three Dimensional Complex Structures For Biomedical Applications written by Sohyung Lee and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
The evolution of microfabrication has greatly contributed to the advances in biology and medicine, as it can interface with and manipulate the interactions between biological systems and materials with micrometer-scale precision. In addition, microfabrication allows the development of new materials with unique properties by providing the tools to tailor defined topography as well as overall geometry. In the field of tissue engineering, to provide suitable functional microenvironments for cells or tissues, there is a great need to structure artificial tissue constructs at the micrometer scale. In addition, micrometer-sized reactors with defined shape and spatial chemistries can be utilized for diagnostic applications to concentrate or enrich rare biomolecules or cells, otherwise not detectable. The dissertation reports on the development of novel multifunctional biomaterials to overcome current challenges in microfabrication techniques such as 3D bioprinting and microfluidics, highlighted in Chapter 1. In Chapter 2, we present a highly biocompatible and elastic bioink for fabrication of complex biomimetic structures such as vascularized cardiac tissue constructs. The 3D bioprinting of soft tissues has been challenging primarily due to the lack of suitable bioinks. To address these shortcomings, we use recombinant human tropoelastin as a novel bioink with high printability, biocompatibility, biomimicry, and proper mechanical properties. Using the freeform reversible embedding of suspended hydrogels (FRESH) printing method, we demonstrate bioprinting vascularized cardiac constructs using two-nozzles and we extensively characterize their functions in vitro and in vivo. In Chapter 3, we explore a scalable method to fabricate spatially functionalized microparticles for "lab on a particle" applications. For the design of a novel high throughput microfabrication method, we highlight the important role of thermodynamic factors, such as temperature and polymer concentrations, on intermolecular interactions, and therefore, the phase-separation behavior of a polymer mixture. These particles are utilized to analyze secretion phenotypes and heterogeneity of CHO DP-12 cells and to sort rare populations of high-yielding producer cells using fluorescence activated cell sorting (FACS). In Chapter 4, we prove the broad generalizability of this lab-on-a-particle platform by demonstrating their ability to screen and sort primary human T cells as well as genetically engineered chimeric antigen receptor (CAR)-T cells based on cytokine production. Overall, we believe the work presented here demonstrates the importance and utility of microfabrication techniques, especially 3D bioprinting and microfluidics. Combined with novel biomaterials, microfabrication methods can significantly upgrade conventional platforms, such that we can better recapitulate the in vivo microenvironment for tissue engineering or suggest an entirely new technology as with lab-on-a particle technology for single-cell analysis and sorting
Three Dimensional Microfabrication Using Two Photon Polymerization
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Author : Tommaso Baldacchini
language : en
Publisher: William Andrew
Release Date : 2019-10-31
Three Dimensional Microfabrication Using Two Photon Polymerization written by Tommaso Baldacchini and has been published by William Andrew this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-31 with Technology & Engineering categories.
Three-Dimensional Microfabrication Using Two-Photon Polymerization, Second Edition offers a comprehensive guide to TPP microfabrication and a unified description of TPP microfabrication across disciplines. It offers in-depth discussion and analysis of all aspects of TPP, including the necessary background, pros and cons of TPP microfabrication, material selection, equipment, processes and characterization. Current and future applications are covered, along with case studies that illustrate the book's concepts. This new edition includes updated chapters on metrology, synthesis and the characterization of photoinitiators used in TPP, negative- and positive-tone photoresists, and nonlinear optical characterization of polymers. This is an important resource that will be useful for scientists involved in microfabrication, generation of micro- and nano-patterns and micromachining. Discusses the major types of nanomaterials used in the agriculture and forestry sectors, exploring how their properties make them effective for specific applications Explores the design, fabrication, characterization and applications of nanomaterials for new Agri-products Offers an overview of regulatory aspects regarding the use of nanomaterials for agriculture and forestry
3d Laser Microfabrication
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Author : Hiroaki Misawa
language : en
Publisher: John Wiley & Sons
Release Date : 2006-08-21
3d Laser Microfabrication written by Hiroaki Misawa and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-21 with Technology & Engineering categories.
A thorough introduction to 3D laser microfabrication technology, leading readers from the fundamentals and theory to its various potent applications, such as the generation of tiny objects or three-dimensional structures within the bulk of transparent materials. The book also presents new theoretical material on dielectric breakdown, allowing a better understanding of the differences between optical damage on surfaces and inside the bulk, as well as a look into the future. Chemists, physicists, materials scientists and engineers will find this a valuable source of interdisciplinary knowledge in the field of laser optics and nanotechnology.
Biofabrication
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Author : Gabor Forgacs
language : en
Publisher: William Andrew
Release Date : 2013-03-18
Biofabrication written by Gabor Forgacs and has been published by William Andrew this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-18 with Science categories.
Biofabrication is a practical guide to the novel, inherently cross-disciplinary scientific field that focuses on biomanufacturing processes and a related range of emerging technologies. These processes and technologies ultimately further the development of products that may involve living (cells and/or tissues) and nonliving (bio-supportive proteins, scaffolds) components. The book introduces readers to cell printing, patterning, assembling, 3D scaffold fabrication, cell/tissue-on-chips as a coherent micro-/nano-fabrication toolkit. Real-world examples illustrate how to apply biofabrication techniques in areas such as regenerative medicine, pharmaceuticals and tissue engineering. In addition to being a vital reference for scientists, engineers and technicians seeking to apply biofabrication techniques, this book also provides an insight into future developments in the field, and potential new applications. Discover the multi-disciplinary toolkit provided by biofabrication and apply it to develop new products, techniques and therapies Covers a range of important emerging technologies in a coherent manner: cell printing, patterning, assembling, 3D scaffold fabrication, cell/tissue-on-chips... Readers develop the ability to apply biofabrication technologies through practical examples
Rapid Prototyping Of Biomaterials
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Author : Roger Narayan
language : en
Publisher: Woodhead Publishing
Release Date : 2019-10-18
Rapid Prototyping Of Biomaterials written by Roger Narayan and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-18 with Medical categories.
Rapid Prototyping of Biomaterials: Techniques in Additive Manufacturing, Second Edition, provides a comprehensive review of emerging rapid prototyping technologies, such as bioprinting, for biomedical applications. Rapid prototyping, also known as additive manufacturing, solid freeform fabrication, or 3D printing, can be used to create complex structures and devices for medical applications from solid, powder or liquid precursors. Sections explore a variety of materials, look at applications, and consider the use of rapid prototyping technologies for constructing organs. With its distinguished editor and international team of renowned contributors, this book is a useful, technical resource for scientists and researchers in academia, biomaterials and tissue regeneration. Presents a comprehensive review of established and emerging additive manufacturing technologies (such as bioprinting) for medical applications Contains chapters that explore the additive manufacturing of nanoscale biomaterials for a range of applications, from drug delivery, to organ printing Includes new information on 3D printing on a variety of material classes
3d Printing In Medicine
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Author : Deepak M. Kalaskar
language : en
Publisher: Woodhead Publishing
Release Date : 2022-10-18
3d Printing In Medicine written by Deepak M. Kalaskar and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-18 with Technology & Engineering categories.
3D Printing in Medicine, Second Edition examines the rapidly growing market of 3D-printed biomaterials and their clinical applications. With a particular focus on both commercial and premarket tools, the book looks at their applications within medicine and the future outlook for the field. The chapters are written by field experts actively engaged in educational and research activities at the top universities in the world. The earlier chapters cover the fundamentals of 3D printing, including topics such as materials and hardware. The later chapters go on to cover innovative applications within medicine such as computational analysis of 3D printed constructs, personalized 3D printing - including 3D cell and organ printing and the role of AI - with a subsequent look at the applications of high-resolution printing, 3D printing in diagnostics, drug development, 4D printing, and much more. This updated new edition features completely revised content, with additional new chapters covering organs-on-chips, bioprinting regulations and standards, intellectual properties, and socio-ethical implications of organs-on-demand. Reviews a broad range of biomedical applications of 3D printing biomaterials and technologies Provides an interdisciplinary look at 3D printing in medicine, bridging the gap between engineering and clinical fields Includes completely updated content with additional new chapters, covering topics such as organs-on-chips, bioprinting regulations, intellectual properties, medical standards in 3D printing, and more
3d Printing In Biomedical Engineering
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Author : Sunpreet Singh
language : en
Publisher: Springer Nature
Release Date : 2020-07-16
3d Printing In Biomedical Engineering written by Sunpreet Singh and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-16 with Technology & Engineering categories.
This book gives a comprehensive overview of the rapidly evolving field of three-dimensional (3D) printing, and its increasing applications in the biomedical domain. 3D printing has distinct advantages like improved quality, cost-effectiveness, and higher efficiency compared to traditional manufacturing processes. Besides these advantages, current challenges and opportunities regarding choice of material, design, and efficiency are addressed in the book. Individual chapters also focus on select areas of applications such as surgical guides, tissue regeneration, artificial scaffolds and implants, and drug delivery and release. This book will be a valuable source of information for researchers and professionals interested in the expanding biomedical applications of 3D printing.
Essentials Of 3d Biofabrication And Translation
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Author : Anthony Atala
language : en
Publisher: Academic Press
Release Date : 2015-07-17
Essentials Of 3d Biofabrication And Translation written by Anthony Atala and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-17 with Science categories.
Essentials of 3D Biofabrication and Translation discusses the techniques that are making bioprinting a viable alternative in regenerative medicine. The book runs the gamut of topics related to the subject, including hydrogels and polymers, nanotechnology, toxicity testing, and drug screening platforms, also introducing current applications in the cardiac, skeletal, and nervous systems, and organ construction. Leaders in clinical medicine and translational science provide a global perspective of the transformative nature of this field, including the use of cells, biomaterials, and macromolecules to create basic building blocks of tissues and organs, all of which are driving the field of biofabrication to transform regenerative medicine. Provides a new and versatile method to fabricating living tissue Discusses future applications for 3D bioprinting technologies, including use in the cardiac, skeletal, and nervous systems, and organ construction Describes current approaches and future challenges for translational science Runs the gamut of topics related to the subject, from hydrogels and polymers to nanotechnology, toxicity testing, and drug screening platforms
3d And 4d Printing In Biomedical Applications
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Author : Mohammed Maniruzzaman
language : de
Publisher: John Wiley & Sons
Release Date : 2018-12-03
3d And 4d Printing In Biomedical Applications written by Mohammed Maniruzzaman and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-03 with Science categories.
A professional guide to 3D and 4D printing technology in the biomedical and pharmaceutical fields 3D and 4D Printing in Biomedical Applications offers an authoritative guide to 3D and 4D printing technology in the biomedical and pharmaceutical arenas. With contributions from an international panel of academic scholars and industry experts, this book contains an overview of the topic and the most current research and innovations in pharmaceutical and biomedical applications. This important volume explores the process optimization, innovation process, engineering, and platform technology behind printed medicine. In addition, information on biomedical developments include topics such as on shape memory polymers, 4D bio-fabrications and bone printing. The book covers a wealth of relevant topics including information on the potential of 3D printing for pharmaceutical drug delivery, examines a new fabrication process, bio-scaffolding, and reviews the most current trends and challenges in biofabrication for 3D and 4D bioprinting. This vital resource: -Offers a comprehensive guide to 3D and 4D printing technology in the biomedical and pharmaceutical fields -Includes information on the first 3D printing platform to get FDA approval for a pharmaceutical product -Contains a review of the current 3D printed pharmaceutical products -Presents recent advances of novel materials for 3D/4D printing and biomedical applications Written for pharmaceutical chemists, medicinal chemists, biotechnologists, pharma engineers, 3D and 4D Printing in Biomedical Applications explores the key aspects of the printing of medical and pharmaceutical products and the challenges and advances associated with their development.
Biofabrication
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Author : Pranav Soman
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-03-18
Biofabrication written by Pranav Soman and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-18 with Medical categories.
Natural tissues have complex structural hierarchy and biological heterogeneity. Tissue engineering utilizes biomaterial scaffolds to mimic various natural properties in order to augment regeneration therapies. Current tissue engineering techniques typically incorporate imprecise scaffold geometries with random cell placement. As a result, little can be known about the specific influences of controlled changes in 3D scaffold properties on cell behavior and therefore making the results less predictive of how cell behaves in a 3D environment. Digital micromirror-assisted projection printing (DMD-PP) technology has become a promising tool to develop user-defined precise 3D microenvironments using complex biological components such as cells and native extracellular matrix (ECM). DMD-PP technology has been used in a variety of applications ranging from tissue engineering to cancer cell migration to neural stem cell culture, with the potential of patterning multiple cells in precise 3D locations. This chapter describes the novel use of DMD-PP technology in developing biomaterial scaffolds with tunable Poisson’s ratio, a fundamental aspect of mechanical property of all biomaterials.