Microvascular Mechanics
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Microvascular Mechanics
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Author : Jen-Shih Lee
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Microvascular Mechanics written by Jen-Shih Lee and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Technology & Engineering categories.
. . . we do not know a truth without knowing its cause. Aristotle Perhaps the greatest hope that may be entertained for a scientific work, whether experimental or theoretical, is that it leads to new thoughts and new avenues of investigation on the part of its readers. In microvascular mechanics, the interplay of rheology, anatomy, and cellular and organ function has only just begun to be addressed. To understand the operational behavior of microcirculation, there is a need to integrate studies at the cellular or molecu lar level with a quantitative, biomechanical description of the circulatory system. The symposium entitled "Frontiers in Cardiopulmonary Mechanics" held in June 1988 at the University of Virginia was intended to provide a fundamental approach to the description of the circulation from the per spective of microvascular mechanics and to examine new methodology that may advance this effort. This book arose out ofthe work presented at the symposium. Aristotle expressed well the need to pursue the causes of a phenomenon in order to achieve a truthful understanding of its nature. In this spirit has each of the quantitative sciences progressed, and in this spirit we hope that this book will provide some understanding of the microvascular events and bio mechanical mechanisms underlying the behavior of circulation in general, and of pulmonary and skeletal muscle microcirculation in particular. The integrated treatment of pulmonary and systemic microcirculation provided here is intended to encourage the cross-fertilization of these two research fields.
Microvascular Mechanics
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Author : Jen-shih Lee
language : en
Publisher:
Release Date : 1989-01-01
Microvascular Mechanics written by Jen-shih Lee and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-01-01 with Cardiopulmonary system categories.
Biofluid Mechanics
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Author : David A. Rubenstein
language : en
Publisher: Academic Press
Release Date : 2011-09-28
Biofluid Mechanics written by David A. Rubenstein and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-28 with Medical categories.
Mary D. Frame
Role Of Substrate Attachment In Cell Mechanics
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Author : Roca-Cusachs Soulere, Pere
language : en
Publisher:
Release Date : 2006
Role Of Substrate Attachment In Cell Mechanics written by Roca-Cusachs Soulere, Pere and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Microcirculation On A Chip
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Author : Sergey S. Shevkoplyas
language : en
Publisher:
Release Date : 2006
Microcirculation On A Chip written by Sergey S. Shevkoplyas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Abstract: The primary physiological function of the cardiovascular system, i.e. the delivery of oxygen and nutrients to and the removal of metabolic waste products from living tissues, is performed by the microcirculation. It is also where key events of the immune response such as leukocyte margination, rolling and subsequent diapedesis take place. Microvascular blood flow dynamics have a major impact on all of these vital processes. We used silicon micromachining and polydimethylsiloxane replica molding to create microchannel networks with dimensions and topology similar to the real microcirculation. These networks provide high quality of imaging and unprecedented control over all hemodynamically relevant parameters. We reproduced and documented a number of key blood flow dynamics and phenomena characteristic of the microcirculation in vivo using whole blood and blood cell suspensions of varying composition. This suggests the possibility to use this system as a convenient microfluidic platform for experimental studies of the mechanics of the microcirculation. The impact of blood cell rheology and interactions, plasma composition, network architecture and channel wall surface properties on microvascular network blood flow dynamics can now be addressed without interference from active biological regulation. This system will, for the first time, provide a viable bridge between computer simulations and experiments in vivo. Finally, we created a simple microfluidic device that takes advantage of plasma skimming and leukocyte margination to provide positive, continuous flow selection of leukocytes directly from microliter samples of whole blood. It produces a 34-fold enrichment of the leukocyte-to-erythrocyte ratio and requires no preliminary labeling of cells. This effortless, efficient and inexpensive technology can be used as a lab-on-a-chip component for initial whole blood sample preparation. Its integration into microanalytical devices that require leukocyte enrichment will enable accelerated transition of these devices into the field for point-of-care clinical testing.
Coronary Microvascular Obstruction In Acute Myocardial Infarction
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Author : Giampaolo Niccoli
language : en
Publisher: Academic Press
Release Date : 2018-07-20
Coronary Microvascular Obstruction In Acute Myocardial Infarction written by Giampaolo Niccoli and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-20 with Medical categories.
Coronary Microvascular Obstruction in Acute Myocardial Infarction: From Mechanisms to Treatment provides a comprehensive understanding of the phenomenon of coronary microvascular obstruction (CMVO) that is the main limitation of reperfusion therapies in ST-elevation myocardial infarction. It provides in-depth coverage of the phenomenon of CMVO which heavily affects prognosis by increasing the risk of death and heart failure at follow-up. A first of its kind reference dedicated solely to this topic, it is appropriate for a wide audience, from researchers, to those who aid in the management, prevention and treatment of CMVO. Provides in-depth coverage of coronary microvascular obstruction (CMVO), spanning research, management, prevention and treatment Includes the most up-to-date information on CMVO as presented from top experts around the word Provides access to a companion website with extra material, including tables, additional references and instructional videos Gives extensive coverage on how to measure CMVO, including in-depth indexes that can be used to detect and quantify the phenomenon
Biofluid Mechanics
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Author : David Rubenstein
language : en
Publisher: Academic Press
Release Date : 2021-03-13
Biofluid Mechanics written by David Rubenstein and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-13 with Science categories.
Biofluid Mechanics: An Introduction to Fluid Mechanics, Macrocirculation, and Microcirculation, Third Edition shows how fluid mechanics principles can be applied not only to blood circulation, but also to air flow through the lungs, joint lubrication, intraocular fluid movement, renal transport, and other specialty circulations. This new edition contains new homework problems and worked examples, including MATLAB-based examples. In addition, new content has been added on such relevant topics as Womersley and Oscillatory Flows. With advanced topics in the text now denoted for instructor convenience, this book is particularly suitable for both senior and graduate-level courses in biofluids. Uses language and math that is appropriate and conducive for undergraduate and first-year graduate learning Contains new worked examples and end-of-chapter problems Covers topics in the traditional biofluids curriculum, also addressing other systems in the body Discusses clinical applications throughout the book, providing practical applications for the concepts discussed Includes more advanced topics to help instructors teach an undergraduate course without a loss of continuity in the class
Mechanical Microvascular Anastomosis
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Author : Rafn Ragnarsson
language : en
Publisher:
Release Date : 1988
Mechanical Microvascular Anastomosis written by Rafn Ragnarsson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with categories.
Coronary Microvascular Dysfunction
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Author : Filippo Crea
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-08-15
Coronary Microvascular Dysfunction written by Filippo Crea and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-15 with Medical categories.
In the past two decades a number of studies have shown that abnormalities in the function and structure of coronary microcirculation can be detected in several cardiovascular diseases. On the basis of the clinical setting in which it occurs, coronary microvascular dysfunction (CMD) can be classified into four types: CMD in the absence of any other cardiac disease; CMD in myocardial diseases; CMD in obstructive epicardial coronary artery disease; and iatrogenic CMD. In some instances CMD represents an epiphenomenon, whereas in others it represents an important marker of risk or may contribute to the pathogenesis of myocardial ischemia, thus becoming a possible therapeutic target. This book provides an update on coronary physiology and a systematic assessment of microvascular abnormalities in cardiovascular diseases, in the hope that it will assist clinicians in prevention, detection and management of CMD in their everyday activity.
Microvascular Reconstruction
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Author : Ralph T. Manktelow
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Microvascular Reconstruction written by Ralph T. Manktelow and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Reconstructive microvascular surgery is now in its teens. At first many thought this new child was a whim and would fail to thrive. Some were un certain, others with vision either supported or became actively involved in this new area of surgical endeavour. Although initial interest was focused on the replantation of amputated parts, it has been the one stage free trans fer of living tissue to a distant site which has launched microsurgery into the surgical spotlight. From its humble beginnings we have witnessed a revolution in this branch of plastic surgery; many of the long established methods of recon struction have, like barricades, fallen before the advances made in this field. In its infancy there were relatively few procedures available. There was a tendency to make the patient's problem fit the operation, rather than the reverse, and this frequently led to an inferior result. The then known flaps, such as the groin flap and the deltopectoral flap, were employed. Unfortunately they were sites which posed many technical problems; namely those of vascular anomaly, a short pedicle and vessels of small cal ibre. Long operations were the norm, and vascular thrombosis was not un common. Hospital routine often was disrupted and there was a danger that these new techniques would fall into disrepute. Over the last decade this state of affairs has changed dramatically.