Minimal Residual Disease In Melanoma
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Minimal Residual Disease In Melanoma
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Author : U. Reinhold
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Minimal Residual Disease In Melanoma written by U. Reinhold and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Knowledge about diagnostic procedures in melanoma has in creased rapidly within the past few years. Single tumor cells have been identified in normal tissue such as sentinel lymph nodes, as well as in bone marrow, peripheral blood, and other bodily fluids and cells, by molecular technologies. The introduction of polymerase chain reaction-based methods can be regarded as a prototype of this dramatic development towards molecular approaches in new diagnostic procedures. This fact opens up the possibility of clinical use in patients and of influencing treatment strategies. Considerable discrepancies have been described, how ever, in the success rates of these new techniques for the detec tion of minimal residual disease in cancer patients. Despite fav orable results reported by different groups of investigators, it will take several years to define the clinical and pathophysiological relevance of new diagnostic procedures. The 1st International Symposium "Minimal Residual Disease in Melanoma: Biology, Detection and Clinical Relevance of Microme tastases", held in September 1999 in Homburg/Saar, Germany, fo cused on recent developments in this particular area of cancer re search. The purpose of the meeting was to stimulate discussion and exchange of new data and ideas by renowned international scientists. The aim of this volume is to summarize major topics of basic research and clinical investigations presented by invited experts in this fascinating but still. controversial field of melanoma re search.
Minimal Residual Disease In Melanoma
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Author : U. Reinhold
language : en
Publisher: Springer
Release Date : 2000-09-14
Minimal Residual Disease In Melanoma written by U. Reinhold and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-09-14 with Medical categories.
Knowledge about diagnostic procedures in melanoma has in creased rapidly within the past few years. Single tumor cells have been identified in normal tissue such as sentinel lymph nodes, as well as in bone marrow, peripheral blood, and other bodily fluids and cells, by molecular technologies. The introduction of polymerase chain reaction-based methods can be regarded as a prototype of this dramatic development towards molecular approaches in new diagnostic procedures. This fact opens up the possibility of clinical use in patients and of influencing treatment strategies. Considerable discrepancies have been described, how ever, in the success rates of these new techniques for the detec tion of minimal residual disease in cancer patients. Despite fav orable results reported by different groups of investigators, it will take several years to define the clinical and pathophysiological relevance of new diagnostic procedures. The 1st International Symposium "Minimal Residual Disease in Melanoma: Biology, Detection and Clinical Relevance of Microme tastases", held in September 1999 in Homburg/Saar, Germany, fo cused on recent developments in this particular area of cancer re search. The purpose of the meeting was to stimulate discussion and exchange of new data and ideas by renowned international scientists. The aim of this volume is to summarize major topics of basic research and clinical investigations presented by invited experts in this fascinating but still. controversial field of melanoma re search.
Abstracts For The International Symposium Minimal Residual Disease In Melanoma
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Author :
language : en
Publisher:
Release Date : 1999
Abstracts For The International Symposium Minimal Residual Disease In Melanoma written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
Biological Mechanisms Of Minimal Residual Disease And Systemic Cancer
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Author : Julio A. Aguirre-Ghiso
language : en
Publisher: Springer
Release Date : 2018-11-22
Biological Mechanisms Of Minimal Residual Disease And Systemic Cancer written by Julio A. Aguirre-Ghiso and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-22 with Medical categories.
This book focuses on the biological mechanisms of minimal residual disease (MRD) and recurrence. It integrates this biology in solid cancers and in hematological malignancies. It reports also on technological advancements for monitoring MRD, derived from mechanistic insights. Chapters in solid and hematological malignancies address stem cell biology, genetics, epigenetics and micro-environmental regulation of dormant MRD. Novel insight into technologies for molecular phenotyping of MRD and monitoring of CTCs, DTCs and cell free RNA and DNA are also addressed extensively. Five chapters explore the above concepts in solid cancers such as prostate, breast, melanoma, head and neck and esophageal. Two chapters also explore the basic mechanisms of vascular biology targeting and epigenetic mechanisms regulating pluripotency programs during dormancy. Similar biology is explored in hematological malignancies such as T-ALL, CML, AML and multiple myeloma in additional four chapters. This book is edited and prefaced by Dr. Julio Aguirre-Ghiso, an expert in dormancy and recurrence. The chapters are written by world-recognized experts Drs. Ravi Bahtia, Samir Parekh, Russel Taichman, Monica Guzman, David Hoon, Denis Schewe, Irmela Jeremias, Cyrus Ghajar, Maria Soledad Sosa and Nicholas Stoecklein. The topic of this book is of particular interest to both basic cancer cell biologists and physician scientists that are working to provide a more integrated view of the biology of MRD and to those interested in working on or learning about this paradigm. The integrated and cross-disciplinary focus of the book from biology to medicine seeks to help bridge gaps to improve cancer care and prevent recurrences.
Biological Mechanisms Of Minimal Residual Disease And Systemic Cancer
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Author : Julio A. Aguirre-Ghiso
language : en
Publisher: Springer
Release Date : 2018-11-08
Biological Mechanisms Of Minimal Residual Disease And Systemic Cancer written by Julio A. Aguirre-Ghiso and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-08 with Medical categories.
This book focuses on the biological mechanisms of minimal residual disease (MRD) and recurrence. It integrates this biology in solid cancers and in hematological malignancies. It reports also on technological advancements for monitoring MRD, derived from mechanistic insights. Chapters in solid and hematological malignancies address stem cell biology, genetics, epigenetics and micro-environmental regulation of dormant MRD. Novel insight into technologies for molecular phenotyping of MRD and monitoring of CTCs, DTCs and cell free RNA and DNA are also addressed extensively. Five chapters explore the above concepts in solid cancers such as prostate, breast, melanoma, head and neck and esophageal. Two chapters also explore the basic mechanisms of vascular biology targeting and epigenetic mechanisms regulating pluripotency programs during dormancy. Similar biology is explored in hematological malignancies such as T-ALL, CML, AML and multiple myeloma in additional four chapters. This book is edited and prefaced by Dr. Julio Aguirre-Ghiso, an expert in dormancy and recurrence. The chapters are written by world-recognized experts Drs. Ravi Bahtia, Samir Parekh, Russel Taichman, Monica Guzman, David Hoon, Denis Schewe, Irmela Jeremias, Cyrus Ghajar, Maria Soledad Sosa and Nicholas Stoecklein. The topic of this book is of particular interest to both basic cancer cell biologists and physician scientists that are working to provide a more integrated view of the biology of MRD and to those interested in working on or learning about this paradigm. The integrated and cross-disciplinary focus of the book from biology to medicine seeks to help bridge gaps to improve cancer care and prevent recurrences.
Adjuvant Therapies And Markers Of Post Surgical Minimal Residual Disease Ii
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Author : Gianni Bonadonna
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Adjuvant Therapies And Markers Of Post Surgical Minimal Residual Disease Ii written by Gianni Bonadonna and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
1978 Annual Plenary Meeting of the European Organization for Research on Treatment of Cancer, Paris, June 1978
Minimal Residual Disease In Melanoma
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Author : U. Reinhold
language : en
Publisher: Springer
Release Date : 2000-09-14
Minimal Residual Disease In Melanoma written by U. Reinhold and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-09-14 with Medical categories.
Knowledge about diagnostic procedures in melanoma has in creased rapidly within the past few years. Single tumor cells have been identified in normal tissue such as sentinel lymph nodes, as well as in bone marrow, peripheral blood, and other bodily fluids and cells, by molecular technologies. The introduction of polymerase chain reaction-based methods can be regarded as a prototype of this dramatic development towards molecular approaches in new diagnostic procedures. This fact opens up the possibility of clinical use in patients and of influencing treatment strategies. Considerable discrepancies have been described, how ever, in the success rates of these new techniques for the detec tion of minimal residual disease in cancer patients. Despite fav orable results reported by different groups of investigators, it will take several years to define the clinical and pathophysiological relevance of new diagnostic procedures. The 1st International Symposium "Minimal Residual Disease in Melanoma: Biology, Detection and Clinical Relevance of Microme tastases", held in September 1999 in Homburg/Saar, Germany, fo cused on recent developments in this particular area of cancer re search. The purpose of the meeting was to stimulate discussion and exchange of new data and ideas by renowned international scientists. The aim of this volume is to summarize major topics of basic research and clinical investigations presented by invited experts in this fascinating but still. controversial field of melanoma re search.
Minimal Residual Disease In Hematologic Malignancies
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Author : Raanani P Ed
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 2004
Minimal Residual Disease In Hematologic Malignancies written by Raanani P Ed and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Blood categories.
Detection of minimal residual disease (MRD) is increasingly used in the management of leukemia patients. A wide variety of methods have been developed and include technologies designed to detect residual malignant cells beyond the sensitivity of conventional approaches such as morphology and banding cytogenetics in leukemia. The choice of the best method depends on the biology of the individual malignancy, i.e. on the determination of specific markers which are useful to differentiate between leukemic cells and normal hematopoiesis in leukemic patients. These markers include leukocyte differentiation antigens, fusion transcripts, transcripts overexpressed by mutated or nonmutated genes, rearranged genes, and individual markers like polymorphic repetitive DNA sequences. The major technologies for MRD detection, their advantages and disadvantages and their clinical applications are discussed in this special issue - from 'bench to bedside'. Providing a comprehensive overview on the significance of MRD in the evaluation, treatment and follow-up of hematologic malignancies, it will be of great value to hematologists, researchers interested in leukemias and lymphomas as well as laboratory technicians.
Cancer Stem Cell Resistance To Targeted Therapy
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Author : Cristina Maccalli
language : en
Publisher: Springer
Release Date : 2020-08-14
Cancer Stem Cell Resistance To Targeted Therapy written by Cristina Maccalli and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-14 with Medical categories.
This book represents an up-dated summary of the state of the art of the characterization of cancer stem cell/ cancer initiating cell (CSC/CIC) properties. An overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies is provided. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.
Paediatric Haematology And Oncology
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Author : Simon Bailey
language : en
Publisher: Oxford University Press, USA
Release Date : 2010
Paediatric Haematology And Oncology written by Simon Bailey and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
While survival rates for children with cancer have increased in recent times, the increased use of more aggressive therapies has brought with it significant adverse effects. Therefore, the aim of pediatric oncologists has become to achieve "cure at least cost" by the appropriate reduction of the intensity and/or duration of treatment in carefully identified good prognosis patients. By comprehensively covering these issues, this handbook aims to provide residents in pediatric hematology and oncology, as well as staff in related medical or other healthcare disciplines, with an easily accessible source of information about the basic principles of childhood cancer and leukemia, as well as much of the more detailed specialist knowledge required to care for children with these conditions. Divided into sections to allow quick access to the necessary information, the handbook covers general principles of diagnosis and treatment, short and long term care, and oncological emergencies before moving on to chapters on specific disease. Normal values and useful websites are also included for reference.
