Modulating Gene Expression By Antisense Oligonucleotides To Understand Neural Functioning
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Modulating Gene Expression By Antisense Oligonucleotides To Understand Neural Functioning
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Author : Margaret M. McCarthy
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Modulating Gene Expression By Antisense Oligonucleotides To Understand Neural Functioning written by Margaret M. McCarthy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
When first introduced, antisense oligonucleotides were hailed as the long awaited magic bullet that would provide an unprecedented level of specificity in controlling gene expression. Following this initial enthusiasm, antisense oligonucleotides have been maligned as nonspecific, toxic, and essentially useless. However, application of antisense oligonucleotide technology in the nervous system stands apart from the use of this technique in peripheral systems, largely because of its enormous success. The source of this success remains a matter of some controversy. Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning addresses the origins of that controversy and determines whether the nervous system is a privileged site for antisense oligonucleotide action and not subject to the same vagaries and pitfalls as non-neuronal systems. Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning contains chapters by experts in the field that focus on the use of this technique in a variety of behavioral systems, as well as rapid and nonspecific effects and the uptake and metabolism of antisense oligonucleotides by the nervous system. Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning features: experts in the field reporting on the use of antisense oligonucleotide technology in a variety of behavioral systems, including pain control, circadian rhythms, ingestion and control of water balance, and reproductive behaviors; the novel use of plasmids to express antisense RNA in the nervous system; the biodistribution and metabolism of antisense oligonucleotides in the nervous system; rapid and unusual effects; and non-specific effects.
Antisense Technology Part B Applications
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Author :
language : en
Publisher: Elsevier
Release Date : 1999-11-10
Antisense Technology Part B Applications written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-11-10 with Science categories.
Antisense technology is the ability to manipulate gene expression within mammalian cells providing powerful experimental approaches for the study of gene function and gene regulation. For example, methods which inhibit gene expression permit studies probing the normal function of a specific product within a cell. Such methodology can be used in many disciplines such as pharmacology, oncology, genetics, cell biology, developmental biology, molecular biology, biochemistry, and neurosciences. This volume will be a truly important tool in biomedically-oriented research. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today-truly an essential publication for researchers in all fields of life sciences.
Triple Helix Forming Oligonucleotides
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Author : Claude Malvy
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Triple Helix Forming Oligonucleotides written by Claude Malvy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Sequence-specific DNA binding ligands, amongst which triple helix forming oligonucleotides are the most efficient as yet, represent promising tools in a number of fields. One of their most promising applications is as antiviral tools: they can specifically target a viral gene, even if it is integrated into the host genome, and be used to specifically inactivate the viral gene or even destroy the cells harboring this gene. However, from science fiction to science there remains a gap; and we are at the moment on the threshold of this fascinating field. Triple Helix Forming Oligonucleotides considers the different aspects of the design and improvement, current or future, of these molecules and their structural analysis, as well as their applications, with special emphasis on the attempts to obtain biological effects of these potentially important tools. What emerges is that the current state of the research is encouraging, and that these molecules are already useful in some biotechnology applications.
Manual Of Antisense Methodology
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Author : Gunther Hartmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Manual Of Antisense Methodology written by Gunther Hartmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
In the past few years, antisense methodology has moved from in vitro studies to in vivo studies and first human trials. While the basic concept of antisense technology is simple, the methodological problems associated with its use are numerous and complex. Antisense- based methods have proven to be a field of research where careful attention to experimental protocols and appropriate controls is necessary. The Manual of Antisense Methodology emphasizes the application of antisense oligonucleotides, and is a guide for the identification of antisense and non-antisense effects in different experimental settings. The work is organized into three sections: antisense application in vitro, antisense application in vivo (animal models) and finally, clinical antisense studies. Where at all possible, the methods are described in sufficient detail to allow reproduction of a given experiment. The Manual of Antisense Methodology will be of interest to researchers in immunology, cancer research, pharmacology and internal medicine; and physicians conducting clinical studies in these fields.
Applications Of Antisense Therapies To Restenosis
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Author : LeRoy E. Rabbani
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Applications Of Antisense Therapies To Restenosis written by LeRoy E. Rabbani and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Restenosis, the proliferation of smooth muscle cells (SMC) that line blood vessels, often follows angioplasty. Despite advances in cardiology, restenosis continues to affect up to 40% of the over 500,000 patients who undergo angioplasty each year. Applications of Antisense Therapies to Restenosis is the first volume to address the potential of using antisense therapies to inhibit the restenosis that occurs after percutaneous transluminal angioplasty and coronary stenting. The work critically examines the application of various antisense therapies for inhibiting restenosis.
Behavioral Endocrinology
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Author : Jill B. Becker
language : en
Publisher: MIT Press
Release Date : 2002
Behavioral Endocrinology written by Jill B. Becker and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.
The second edition of a popular introduction to the field of behavioral endocrinology.
Antisense Technology In The Central Nervous System
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Author : Ronald A. Leslie
language : en
Publisher: Oxford University Press, USA
Release Date : 1999
Antisense Technology In The Central Nervous System written by Ronald A. Leslie and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
"Antisense Technology in the Central Nervous System describes the promises and the pitfalls of this approach, and compares it to other approaches. The practical experience of leading researchers is combined with a thorough description of the theoretical foundation of the technique, making the book ideal for researchers and clinicians alike."--BOOK JACKET.
Cumulated Index To The Books
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Author :
language : en
Publisher:
Release Date : 1999
Cumulated Index To The Books written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with American literature categories.
American Book Publishing Record
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Author :
language : en
Publisher:
Release Date : 1999
American Book Publishing Record written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with American literature categories.
Book Review Index
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Author :
language : en
Publisher:
Release Date : 2000
Book Review Index written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Books categories.
Every 3rd issue is a quarterly cumulation.