Modulation Of Signal Transduction Of Heptahelical Receptors By Other Receptors And G Proteins
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Modulation Of Signal Transduction Of Heptahelical Receptors By Other Receptors And G Proteins
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Author : Ain Uustare
language : en
Publisher:
Release Date : 2006
Modulation Of Signal Transduction Of Heptahelical Receptors By Other Receptors And G Proteins written by Ain Uustare and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Cellular signal transduction categories.
Oligomerization And Allosteric Modulation In G Protein Coupled Receptors
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-12-02
Oligomerization And Allosteric Modulation In G Protein Coupled Receptors written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology. Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research. Contributions from leading authorities Informs and updates on all the latest developments in the field
Allosteric Modulation Of G Protein Coupled Receptors
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Author : Robert Laprairie
language : en
Publisher: Academic Press
Release Date : 2022-02-05
Allosteric Modulation Of G Protein Coupled Receptors written by Robert Laprairie and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-05 with Business & Economics categories.
Allosteric Modulation of G Protein-Coupled Receptors reviews fundamental information on G protein-coupled receptors (GPCRs) and allosteric modulation, presenting original research in the area and collectively providing a comprehensive description of key issues in GPCR allosteric modulation. The book provides background on core concepts of molecular pharmacology while also introducing the most important advances and studies in the area. It also discusses key methodologies. This is an essential book for researchers and advanced students engaged in pharmacology, toxicology and pharmaceutical sciences training and research. Many of the GPCR-targeted drugs released in the past decade have specifically worked via allosteric mechanisms. Unlike direct orthosteric-acting compounds that occupy a similar receptor site to that of endogenous ligands, allosteric modulators alter GPCR-dependent signaling at a site apart from the endogenous ligand. Recent methodological and analytical advances have greatly improved our ability to understand the signaling mechanisms of GPCRs. We now know that allostery is a common regulatory mechanism for all GPCRs and not – as we once believed – unique to a few receptor subfamilies. Introduces background on core concepts of molecular pharmacology, including statistical analyses, non-linear regression, complex models and GPCR-dependent signal transduction as they relate to allosteric modulation Discusses critical advances and landmark studies, including discoveries in the area of GPCR allosteric modulation, which are reviewed for their importance in positive and negative regulation, protein-protein interactions, and small molecule drug discovery Includes key methodologies used to study allosteric modulation at the in silico, in vitro, and in vivo levels of drug discovery and characterization
Signal Transduction By G Protein Coupled Receptors
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Author : Paul H. J. Nederkoorn
language : en
Publisher:
Release Date : 2014-01-15
Signal Transduction By G Protein Coupled Receptors written by Paul H. J. Nederkoorn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
G Protein Coupled Receptors
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Author : Gabriel Berstein
language : en
Publisher: CRC Press
Release Date : 2019-04-24
G Protein Coupled Receptors written by Gabriel Berstein and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-24 with Medical categories.
Covering recently developed methods in membrane-bound receptors, this book emphasizes receptor structure and function, knowledge of which is essential to the study of signal transduction. G Protein-Coupled Receptors has culled contributors from domestic and international sources, providing a broad base of knowledge. Some topics covered are the r
Molecular Mechanisms Of Signal Transduction
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Author : Johannes Lukas Bos
language : en
Publisher: IOS Press
Release Date : 2000
Molecular Mechanisms Of Signal Transduction written by Johannes Lukas Bos and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Science categories.
This book contains overviews of topics that have been discussed. It includes contributions from leading experts in the field on small GTPases, protein kinesis, receptors and transcription factors. A particular focus was the influence of oxygen radicals on signalling processes. It also contains the contributions of scientists early in their career, who have made an excellent contribution to the institute.
Modulation Of G Protein Coupled Receptor Intracellular Trafficking And Signal Transduction
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Author : Jessica L. Esseltine
language : en
Publisher:
Release Date : 2012
Modulation Of G Protein Coupled Receptor Intracellular Trafficking And Signal Transduction written by Jessica L. Esseltine and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
The seven transmembrane-spanning G Protein-coupled Receptor (GPCR) super family is the largest family of cell-surface receptors, comprising greater than 650 members. GPCRs represent the primary targets of most therapeutic drugs. Desensitization, endocytosis and recycling are major mechanisms of receptor regulation and intracellular trafficking of GPCRs is linked to the Rab family of small G proteins. In the present study, we examined whether multiple Rab GTPase regulate receptor trafficking through endosomal cellular compartments as a consequence of their direct association with GPCRs. We find that Rab4, Rab7 and Rab11 all bind to the last 10 amino acid residues of the angiotensin II Type 1 (AT1R) carboxyl-terminal tail. We show that the Rab GTPases compete with one another for receptor binding and that Rab4 effectively displaces Rab11 from the receptor. In contrast, Rab11 overexpression does not prevent Rab4 binding to the AT1R. Overexpression of wild-type Rab4, but not Rab11, facilitates AT1R dephosphorylation, and a constitutively active Rab4-Q67L mutant reduces AT1R desensitization and promotes AT1R resensitization. We also find that Rab8, a RabGTPase involved in the regulation of secretory/recycling vesicles, modulation of the actin cytoskeleton and cell polarity, interacts with the carboxyl-terminal tail of metabotropic glutamate receptor 1 (mGluR1a) and attenuates mGluR1a signalling and endocytosis in a protein kinase C-dependent manner. Finally, we have examined several previously uncharacterised but naturally occurring single nucleotide polymorphisms (SNPs) in mGluR1a that have been associated with cancer that may alter mGluR1a signalling. We find that SNPs found within the ligand binding domain of mGluR1a result in both decreased cell surface expression and basal inositol 1,4,5, trisphosphate formation and bias mGluR1a signalling via the ERK1/2 pathway. Additional mGluR1a SNPs localized to the mGluR1a glutamate binding site, intracellular regulatory domains and Homer binding site also result in changes in mGluR1a subcellular localization, signalling and cell morphology. Taken together, these results indicate that GPCR signalling is significantly modulated by the association of intracellular regulatory proteins that can be influenced by receptor structure.
Principles Of Endocrinology And Hormone Action
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Author : Antonino Belfiore
language : en
Publisher: Springer
Release Date : 2018-02-08
Principles Of Endocrinology And Hormone Action written by Antonino Belfiore and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-08 with Medical categories.
This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.
Neuromorphic Olfaction
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Author : Krishna C. Persaud
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Neuromorphic Olfaction written by Krishna C. Persaud and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Many advances have been made in the last decade in the understanding of the computational principles underlying olfactory system functioning. Neuromorphic Olfaction is a collaboration among European researchers who, through NEUROCHEM (Fp7-Grant Agreement Number 216916)-a challenging and innovative European-funded project-introduce novel computing p
Receptor Receptor Interactions
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Author : Kjell Fuxe
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-13
Receptor Receptor Interactions written by Kjell Fuxe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-13 with Computers categories.