Molecular Aspects Of Botulinum Neurotoxin
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Molecular Aspects Of Botulinum Neurotoxin
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Author : Keith A. Foster
language : en
Publisher: Springer
Release Date : 2014-07-08
Molecular Aspects Of Botulinum Neurotoxin written by Keith A. Foster and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-08 with Science categories.
Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation with a focus on clinical application. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins and is both up to date and authoritative.
Molecular Basis Of The Endopeptidase Activity Of Type A Botulinum Neurotoxin
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Author : Li Li
language : en
Publisher:
Release Date : 2000
Molecular Basis Of The Endopeptidase Activity Of Type A Botulinum Neurotoxin written by Li Li and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Botulinum toxin categories.
Molecular Basis For The Therapeutic Uses Of Botulinum Neurotoxin For Arthritic Pain
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Author : Sanjaykummar Boddul
language : en
Publisher:
Release Date : 2014
Molecular Basis For The Therapeutic Uses Of Botulinum Neurotoxin For Arthritic Pain written by Sanjaykummar Boddul and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Molecular And Immunological Characteristics Of Type A Botulinum Neurotoxin Complex
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Author : Anne-Marie Bryant
language : en
Publisher:
Release Date : 2012
Molecular And Immunological Characteristics Of Type A Botulinum Neurotoxin Complex written by Anne-Marie Bryant and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Chemistry categories.
Botulinum And Tetanus Neurotoxins
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Author : B.R. DasGupta
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Botulinum And Tetanus Neurotoxins written by B.R. DasGupta and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
Three days in Madison have thoroughly modified my view on clostridial neurotoxins. While still realizing the numerous activating, modifying and protective inputs, I cannot judge the meaningfulness of the meeting impartially. Neither may the reader expect a complete summary of all presentations. Collected in this volume, they speak for themselves without requiring an arbiter. Instead I shall write down my very personal opinions as a researcher who has studied clostridial neurotoxins for nearly 25 years. Comparable conferences have been rare during this time. A comprehensive symposium 4 on C. botulinum neurotoxins has been organized at Ft. Detrick. International conferences on tetanus have been held regularly under the auspices of the Wodd Health Organization. One or maximally two days of these meetings have been devoted to tetanus toxin and its actions whereas the sponsor and the majority of the participants have been interested mainly in epidemiology, prevention and treatment of tetanus as a disease (see refs. 5,6). Some aspects of clostridial neurotoxins have been addressed in the context of bacterial toxins, in particular in the biennial European workshops. 1-3,7,8 The Madison meeting differed from the previous ones in three aspects. First, it covered both tetanus and botulinum neurotoxins. The fusion was justified because of their huge similarities in primary structure, in their mode of action and in their cellular targets. Second, the meeting was not limited to toxins but drew some lines on which modern neurobiology might proceed.
Botulinum Neurotoxins
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Author : Andreas Rummel
language : en
Publisher: Springer
Release Date : 2015-01-29
Botulinum Neurotoxins written by Andreas Rummel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-29 with Medical categories.
The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.
Molecular Basis For The Therapeutic Uses Of Botulinum Toxin For Chronic Pain
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Author : Jianghui Meng
language : en
Publisher:
Release Date : 2008
Molecular Basis For The Therapeutic Uses Of Botulinum Toxin For Chronic Pain written by Jianghui Meng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Anatomy Botulinum Toxin Injections
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Author : FABIO INGALLINA, MD
language : en
Publisher: E2e
Release Date :
Anatomy Botulinum Toxin Injections written by FABIO INGALLINA, MD and has been published by E2e this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
In order to get the best results possible while minimizing any undesirable after effects, the physician must have a keen knowledge not only of anatomy, but also the dynamic of all muscles in play. Knowledge of anatomy for botulinum toxin is developed in our atlas-like format. Our expansive experience in cadaver dissection allowed us to create a book in which a surgical approach to the anatomy of facial muscles is combined with an analytical evaluation of the effects on expression wrinkles, produced as a result of muscle contraction. In order for the reader to get the most out of this book, we chose an atlas-like format, one which gave us the possibility to insert full page image accompanied by concise, easy to follow descriptions of the relevant muscles. Our aim is to take the readers on a journey, starting from an anatomical base, then on to an aesthetic analysis of the targeted areas, and finally reaching the injection sites on their appropriate techniques. The anatomical structures are clearly detailed. The contents are clear, comprehensive and easy to use. Each chapter is dedicated to detailing one given muscle: the full muscle profile, progressive dissections showing the targeted muscle, connections with the more important anatomical structure of the region, the correlation with its external clinical elements on the skin which allow us to better find the origin and injection points, the innervation, and the motor endplates localization, and finally the injection techniques and doses. The enclosed DVD allows the reader to see the reconstruction of the head and its facial muscles in 3D and the full dissection on cadavers of the targeted muscles with the injection points clearly indicated. My hope is that experienced surgeons and young colleagues alike will appreciate and value this book. I also hope that like me they will find that serious, detailed studies about facial anatomy as well as understanding of facial muscles dynamics will aid in improving their techniques. Fabio M Ingallina, MD
Atlas Of Surgical Therapy For Migraine And Tension Type Headache
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Author : Edoardo Raposio
language : en
Publisher: Springer Nature
Release Date : 2019-11-05
Atlas Of Surgical Therapy For Migraine And Tension Type Headache written by Edoardo Raposio and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-05 with Medical categories.
The approaches to the complex field of chronic headache are rapidly evolving; accordingly, this timely and well-illustrated volume offers an in-depth description of all currently available surgical options for the treatment of migraine and headache (MH). With more than 300 high-quality figures, and written by an international panel of experts, this first edition of the Atlas of Surgical Therapy for Migraine and Tension-Type Headache, provides detailed, step-by-step instructions on how to perform state-of-the-art MH surgical techniques, while reviewing relevant anatomical issues and their implications for treatment. In light of the interdisciplinary nature of migraine treatment, this book will prove an invaluable resource for MH practitioners from the resident plastic surgeon to the neurosurgeon and neurologist, and health care professionals across various fields of clinical medicine.
Neuropharmacological Characterization Of Botulinum Neurotoxin
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Author : Lance Simpson
language : en
Publisher:
Release Date : 1997
Neuropharmacological Characterization Of Botulinum Neurotoxin written by Lance Simpson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.
The binding of iodinated botulinum toxin to nerve membranes was studied by using rat and mouse preparations. The toxin was examined both in the single-chain and in the proteolytically processed dichain form, and binding sites both in the spinal cord and in various brain regions were assayed. Rat and mouse brains possessed specific binding sites for botulinum toxin. The binding of botulinum toxin to rat brain membranes was not antagonized by a polyclonal antibody against the cytosolic domain of synaptotagmin 1 or by a monoclonal antibody directed against the luminal domain of synaptotagmin 1. In addition, these antibodies did not protect the mouse phrenic nerve-hemidiaphragm from toxin-induced neuromuscular blockade. Extraction of whole-brain niRNA and injection into Xenopus oocytes led to expression of binding sites for botulinum toxin. Extraction and injection of cerebellar mRNA led to expression of a higher density of binding sites. The number of binding sites was not diminished when oocytes were pretreated with antibodies against the cytosolic and luminal domains of synaptotagmin 1.