Molecular Components Of Hepatitis B Virus
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Molecular Components Of Hepatitis B Virus
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Author : M. Feitelson
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular Components Of Hepatitis B Virus written by M. Feitelson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Since the discovery of Australia antigen and its association with type B hepatitis, molecular characterization of the components making up hepatitis B virus (RBV) have been pursued with worldwide interest. Over the past two decades, such characterization has led to the development of sensitive assays to screen and exclude contaminated units from blood banks and has recently resulted in the licensing of several RBV vaccines. That more than 200 million people worldwide are chronically infected with RBV, and that they are at a high risk for the development of chronic hepatitis and hepatocellular carcinoma, still represent formidable problems in our understanding of host-virus relationships on the molecular level. In the absence of a suitable tissue culture system, and with a very limited host range of infection, characterization of RBV on the molecular level has made remarkable progress recently with the advent of genome cloning, sequencing and expression of individual virus genes by recombinant DNA technology. The presence of hepatitis B-like viruses in an expanding number of animal hosts, and the possibility of virus replication in cells other than hepatocytes, provide great promise that future work will elucidate the molecular mechanisms operative in the various outcomes of RBV infection.
Molecular Biology Of The Hepatitis B Virus
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Author : Alan McLachlan
language : en
Publisher: CRC Press
Release Date : 2018-05-04
Molecular Biology Of The Hepatitis B Virus written by Alan McLachlan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-04 with Science categories.
Molecular Biology of the Hepatitis B Virus presents a comprehensive account of the various molecular aspects of the life cycle of the hepatitis B virus (HBV). Topics covered include the animal model systems, sequence data on the hepadnavirus genomes, the transcripts coded for the biral genome and sequence elements involved in regulating their expression, hepadnavirus replication, and analysis of the various HBV gene products and their role in virion synthesis and assembly. Other important features of the book include its discussions of the consequences of long term exposure to hepadnavirus infection and its association with hepatocellular carcinoma, the use of recombinant technologies in the generation of second generation vaccines, and the utilization of recombinant technologies to analyze an immune mediated disease. Researchers studying hepadnaviruses will find a wealth of information in this essential reference volume.
Hepatitis B Virus Molecular Mechanisms In Disease And Novel Strategies For Therapy
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Author : Wolfgang Helmut Caselmann
language : en
Publisher: World Scientific
Release Date : 1998-06-30
Hepatitis B Virus Molecular Mechanisms In Disease And Novel Strategies For Therapy written by Wolfgang Helmut Caselmann and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-06-30 with Science categories.
The book covers both the molecular aspects of hepatitis B virus replication and gene expression in vivo and in model systems, and the clinical impact of genetic variants or immunological response in chronic infection. Major emphasis is laid on the molecular mechanisms underlying hepatitis B virus-associated liver carcinogenesis and their possible relevance to therapy and to the prevention of infection. Rational approaches to design novel vaccines or cytokine treatments, as well as strategies to develop vectors for liver-directed gene therapy, are discussed.
Molecular Biology Of Human Hepatitis Viruses
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Author : Joao Monjardino
language : en
Publisher: World Scientific
Release Date : 1998-05-30
Molecular Biology Of Human Hepatitis Viruses written by Joao Monjardino and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-05-30 with Medical categories.
Hepatitis A and B viruses have infected nearly half the current world population; and as many as 500 million people are still infected with the hepatitis B or C virus today. Hepatitis B vaccination is effective but not universally adopted and no vaccine is available against hepatitis C. Treatment is prohibitively expensive for areas of high endemicity or prevalence and not universally effective.This important and timely book covers recent advances in understanding the molecular biology of hepatitis viruses. The advances have contributed new insights into the molecular mechanisms involved in replication of genetic information and in gene expression; and have translated into diagnostics; prevention and development of antiviral drugs.
Hepatitis B Virus And Liver Disease
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Author : Jia-Horng Kao
language : en
Publisher: Springer
Release Date : 2018-01-12
Hepatitis B Virus And Liver Disease written by Jia-Horng Kao and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-12 with Medical categories.
This book provides a comprehensive, state-of-the art review of HBV infection and liver disease. It discusses new data on basic and translational medicine, including the viral life cycle, the immunopathogenesis of virus-induced chronic hepatitis, viral and host genetic factors affecting disease progression, and the mechanism of virus-induced hepatocarcinogenesis, as well as their potential applications in daily clinical practice. The clinical aspects of chronic HBV infection are examined in chapters on the global epidemiology, efficacy of HBV vaccination, natural history, co-infections with HCV, HDV or HIV, and management of special populations including children, pregnant women and patients undergoing immunosuppressive therapy. Further, it describes the advances and perspectives in the development of novel antiviral treatments as possible cures for HBV infection. The book is a valuable resource for medical students, physicians, and researchers who are interested in managem ent of patients with chronic HBV infection and investigation of HBV infection.
Viral Hepatitis Molecular Biology Diagnosis And Control
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Author : Isa K. Mushahwar
language : en
Publisher: Gulf Professional Publishing
Release Date : 2004
Viral Hepatitis Molecular Biology Diagnosis And Control written by Isa K. Mushahwar and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
The last forty years have witnessed the discovery of five human hepatitis viruses: hepatitis virus A, B, C, D, and E, and two related blood-borne viruses: GB virus C and TT virus. Viral Hepatitis provides a comprehensive overview of the latest developments and research studies in human viral hepatitis. Written by leading international scientists in the field, this book covers topics ranging from the history of these viruses to their molecular biology, diagnosis, epidemiology and control. It will be an invaluable reference source for hepatitis researchers, reference and diagnostic laboratories, clinicians, public health officers and graduate and medical students. Book jacket.
Molecular Investigation Of Aberrant Hepatitis B Virus Hbv Infections
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Author : Jae Hag Lee
language : en
Publisher:
Release Date : 1993
Molecular Investigation Of Aberrant Hepatitis B Virus Hbv Infections written by Jae Hag Lee and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with categories.
The Liver
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Author : Irwin M. Arias
language : en
Publisher: John Wiley & Sons
Release Date : 2020-03-09
The Liver written by Irwin M. Arias and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-09 with Medical categories.
Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.
Hepatitis B And D Protocols
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Author : Robert K. Hamatake
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-01
Hepatitis B And D Protocols written by Robert K. Hamatake and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-01 with Medical categories.
Despite the availability of an effective vaccine, there are still 400 million people, worldwide who are chronically infected with hepatitis B virus (HBV). For them, the vaccine, as currently applied, has no value. Given the possible consequences of HBV infection, the number of those chronically infected with HBV presents an enormous public health challenge. For example, the major etiology of hepatocellular carcinoma (HCC) is chronic infection with HBV. Although fifth in cancer incidence, worldwide, HCC/liver cancer is the third leading cause of cancer death. The high mortality as- ciated with HCC arises because the disease is often detected late and is unresponsive to treatment. The number of deaths caused by PHCC is expected to rise over the next 20 years. Those chronically infected with HBV have a life risk of death to HCC of between 10 and 25%. Even the limited efficacy of drugs for the treatment of chronic HBV helps underscore the point that this disease is responsive to therapy. Drugs that target the polymerase (e. g. , hepsera and lamivudine) and interferon alpha represent two distinct strategies and show that both conventional antiviral and immunothe- peutic approaches can be used in management. However, the current inventory of therapeutics is inadequate. Interferon alpha is of limited value, only parenterally ava- able, and fraught with adverse reactions.
Liver Pathophysiology
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Author : Pablo Muriel
language : en
Publisher: Academic Press
Release Date : 2017-03-02
Liver Pathophysiology written by Pablo Muriel and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-02 with Medical categories.
Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies. Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury. Provides in vivo and in vitro models to study human liver pathology. Explains the beneficial effects of antioxidants on liver diseases. Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation.