Molecular Interactions In Bioseparations
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Molecular Interactions In Bioseparations
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Author : That T. Ngo
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Molecular Interactions In Bioseparations written by That T. Ngo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
Rapid advances in molecular biology have accelerated the production of a great number of protein-based therapeutic agents. The major cost in producing these proteins appears to be associated with their purification from the complex mixture of the crude extract. A major challenge to the protein biochemist and the biochemical engineer is the development of rapid, efficient, and cost-effective purification systems. This volume presents state-of-the-art reviews of current methods used in the purifica tion of biological macromolecules that are based on molecular interactions. Thus, the major emphasis is placed on affinity-related techniques. Part I provides a general introduction to affinity chromatography and includes a chapter describing an interesting new technique called "slalom chromatography" for DNA fractionations. Affinity chromatography using molecules of biological origin as the affinity ligand is covered in Part II. Part III describes the use of a special class of biomolecules, antibodies, as affinity ligands. Affinity chromatography with biomimetic ligands is discussed in Part IV. Newer concepts and their applications in bioseparation are presented in Part V. Part VI covers affinity-related techniques such as affinity-based extracorporeal shunts, affinity electrophoresis, affinity precipitation, and affinity extraction. I would like to express my sincere thanks to all the authors, who are recognized experts in their respective fields, for their cooperation and contributions. I thank the editorial staff of Plenum Press for their professionalism, and Mary Phillips Born, Senior Editor, for her encouragement. The support of my family (Ping and Peilin) made it possible to complete editing this book. That T.
Principles Of Bioseparations Engineering
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Author : Raja Ghosh
language : en
Publisher: World Scientific Publishing Company
Release Date : 2006-10-23
Principles Of Bioseparations Engineering written by Raja Ghosh and has been published by World Scientific Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10-23 with Technology & Engineering categories.
Bioseparations engineering deals with the scientific and engineering principles involved in large-scale separation and purification of biological products. It is a key component of most chemical engineering/biotechnology/bioprocess engineering programmes. This book discusses the underlying principles of bioseparations engineering written from the perspective of an undergraduate course. It covers membrane based bioseparations in much more detail than some of the other books on bioseparations engineering. Based largely on the lecture notes the author developed to teach the course, this book is especially suitable for use as an undergraduate level textbook, as most other textbooks are targeted at graduate students.
Engineering Processes For Bioseparations
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Author : LAURENCE R. WEATHERLEY
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Engineering Processes For Bioseparations written by LAURENCE R. WEATHERLEY and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Technology & Engineering categories.
The use of biotechnology in chemical synthesis offers up numerous advantages to the engineer in the process industries, but it also presents a number of fundamental challenges and difficulties which impinge directly on separation process requirements. The use of biochemical separations has grown significantly during the past decade, and is especially used in process industries such as healthcare and food processing. However it is becoming increasingly more important in areas such as recycling and waste-water treatment and as industry shifts towards cleaner processes biochemical separations will continue to grow. The two main objectives of this book are to focus on the application of existing separation process techniques to the recovery and purification of biologically derived products and to examine the state of knowledge of new techniques which have future potential. Within these objectives the complexities and breadth of problems associated with biological separations are discussed, specific engineering techniques are featured and their adaptation to biochemical separations are highlighted.
Process Scale Bioseparations For The Biopharmaceutical Industry
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Author : Abhinav A. Shukla
language : en
Publisher: CRC Press
Release Date : 2006-07-07
Process Scale Bioseparations For The Biopharmaceutical Industry written by Abhinav A. Shukla and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-07 with Medical categories.
The biopharmaceutical industry has become an increasingly important player in the global economy, and the success of these products depends on the development and implementation of cost-effective, robust and scaleable production processes. Bioseparations-also called downstream processing- can be a key source of competitive advantageto biopharmaceut
Bioseparation Processes In Food
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Author : Singh
language : en
Publisher: CRC Press
Release Date : 1995-05-16
Bioseparation Processes In Food written by Singh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-05-16 with Technology & Engineering categories.
Offers in-depth coverage of the latest advances in new and traditional separation technologies as they are used in a variety of ways to produce value-added products. Examines both fundamental and applied aspects of separation techniques.
Protein Bioseparation Using Ultrafiltration Theory Applications And New Developments
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Author : Raja Ghosh
language : en
Publisher: World Scientific
Release Date : 2003-06-11
Protein Bioseparation Using Ultrafiltration Theory Applications And New Developments written by Raja Ghosh and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-06-11 with Science categories.
Ultrafiltration is a pressure-driven, membrane-based separation process, which is used for a broad variety of applications, ranging from the processing of biological macromolecules to wastewater treatment. It has significant advantages over competing separation technologies. Food and biotechnological applications account for nearly 40% of the current total usage of ultrafiltration membranes. Protein bioseparation is an important component of this application segment. Ultrafiltration is used for protein concentration, desalting, clarification and fractionation (i.e. protein-protein separation). Concentration, desalting and clarification are technologically less demanding and have been in used in the bioprocess industry for some time. Protein fractionation, on the other hand, is a challenging proposition and is definitely a more recent development. This book focuses primarily on protein fractionation./a
Bioseparations Engineering
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Author : Michael R. Ladisch
language : en
Publisher: Wiley-Interscience
Release Date : 2001-03-27
Bioseparations Engineering written by Michael R. Ladisch and has been published by Wiley-Interscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-03-27 with Science categories.
Multidisciplinary resource for graduate studies and the biotechnology industry Knowledge of the genetic basis of biological functioning continues to grow at an astronomical rate, as do the challenges and opportunities of applying this information to the production of therapeutic compounds, specialty biochemicals, functional food ingredients, environmentally friendly biocatalysts, and new bioproducts from renewable resources. While genetic engineering of living organisms transforms the science of genomics into treatments for cancer, diabetes, and heart disease, or products for industry and agriculture, the science and technology of bioseparations are the keys to delivering these products in a purified form suitable for use by people. The methods, theory, and materials that reduce the science of bioseparations to practice, whether in the laboratory or the plant, are the subjects of Bioseparations Engineering. Examples address purification of biomolecules ranging from recombinant proteins to gene therapy products, with footnotes detailing economics of the products. Mechanistic analysis and engineering design methods are given for: * Isocratic and gradient chromatography * Sedimentation, centrifugation, and filtration * Membrane systems * Precipitation and crystallization Topics addressed within this framework are: stationary phase selection; separations development; modeling of ion exchange, size exclusion, reversed phase, hydrophobic interaction, and affinity chromatography; the impact of regulatory issues on chromatography process design; organization of separation strategies into logical sequences of purification steps; and bridges between molecular biology, combinatorial methods, and separations science. A result of teaching and developing the subject matter over ten years, Bioseparations Engineering is an ideal text for graduate students, as well as a timely desk book for process engineers, process scientists, researchers, and research associates in the pharmaceutical, food, and life sciences industries.
Molecular Conformation And Biological Interactions
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Author : Sivaraj Ramaseshan
language : en
Publisher:
Release Date : 1991
Molecular Conformation And Biological Interactions written by Sivaraj Ramaseshan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Biochemistry categories.
Downstream Processing And Bioseparation
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Author : Jean-François Hamel
language : en
Publisher: Washington, D.C. : American Chemical Society
Release Date : 1990
Downstream Processing And Bioseparation written by Jean-François Hamel and has been published by Washington, D.C. : American Chemical Society this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Science categories.
This new volume examines the state of the art of several important separation processes as they relate to biotechnology. Focusing on isolation and purification of downstream processing, it presents recent research results of several promising techniques. Its 15 chapters cover extraction and membrane processing, processes using biospecific interaction with proteins, and novel isolation and purification processes. Many of the chapters contain data that have not been published before. This volume presents the spectrum of current thinking and activities on bioseparation, specifically of large molecules such as proteins and polysaccharides.
Host Guest Molecular Interactions
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
Host Guest Molecular Interactions written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Science categories.
Composed of contributions from experts in the chemical and biological sciences, it explores host-guest molecular interactions leading to the formation of molecular assemblies containing two or more species. Exciting applications are emerging in this field and it is expected that improved understanding of the interactions in synthetic host molecule complexes will lead to a better understanding of the more complex biological systems. Topics include biomimetic chemistry, preorganization, self-assembly, template-directed synthesis, antibiotic binding to peptides and DNA, interactions between proteins and other molecules.