Molecular Mechanisms In Legionella Pathogenesis
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Molecular Mechanisms In Legionella Pathogenesis
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Author : Hubert Hilbi
language : en
Publisher: Springer
Release Date : 2013-11-27
Molecular Mechanisms In Legionella Pathogenesis written by Hubert Hilbi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-27 with Medical categories.
Legionnaires’ disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.
Biology And Pathogenesis Of Legionella
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Author : Hayley Newton
language : en
Publisher: Frontiers Media SA
Release Date : 2018-12-07
Biology And Pathogenesis Of Legionella written by Hayley Newton and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-07 with categories.
Legionella pneumophila was first isolated as the causative agent of a deadly infectious pneumonia at a convention of the American Legion forty years ago. Since then, Legionnaires’ disease continues to be a significant public health concern. Today, our understanding of the Legionella genus, comprising environmental bacteria and opportunistic human pathogens, has dramatically increased. The study of how pathogenic Legionella interact with host cells, both protozoan and mammalian, has not only taught us about host-pathogen interactions but has revealed novel and unexpected insights into human cell biology and immunology. The capacity of pathogenic Legionella to commandeer cellular processes such as eukaryotic vesicular trafficking to establish an ER-like replicative niche, reflects the exquisite ability of this pathogen to manipulate eukaryotic cell biology in order to replicate in an intracellular compartment. This requires the specific and targeted action of a cohort of translocated bacterial effector proteins. In addition, we have learnt much about cell autonomous innate immune sensing of intracellular bacteria through the inability of L. pneumophila to avoid intracellular mammalian defense mechanisms. Now, in the age of large-scale comparative “omics”, it is clear that different Legionella species utilize different cohorts of effectors to replicate inside eukaryotic cells. While we understand some of the strategies employed by L. pneumophila and L. longbeachae to replicate within eukaryotic cells, there is still much to learn about many aspects of the Legionella life cycle. This Research Topic highlights the latest findings regarding the biology of Legionella species, their interactions with eukaryotic host cells, and how the application of various technologies has increased our understanding of this important pathogen.
Molecular Mechanisms In Legionella Pathogenesis
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Author : Hubert Hilbi
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-07-08
Molecular Mechanisms In Legionella Pathogenesis written by Hubert Hilbi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-08 with Medical categories.
Legionnaires’ disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.
Legionella
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Author : Klaus Heuner
language : en
Publisher: Caister Academic Press Limited
Release Date : 2008
Legionella written by Klaus Heuner and has been published by Caister Academic Press Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Science categories.
Legionellosis is a disease of significant medical and public interest. Legionella is commonly found in aquatic habitats where its ability to survive and to multiply within different protozoa equips the bacterium to be transmissible and pathogenic to humans. In addition Legionella has become a favored model system to analyse the mechanisms of bacterial survival, acquisition of nutrients and intracellular replication. Following the recent publication of the genome sequences of four L. pneumophila strains it is now feasible to investigate the whole genome in silico, the transcriptome via micro arrays and the proteome by two-dimensional gel electrophoresis. Research in the fields of clinical features, diagnosis, treatment and epidemiology continues to generate new data. The topics covered by this volume range from the history of the identification of Legionella and clinical disease treatment, to the microbe's gene expression and secretion systems as well as its strategies for intracellular multiplication and nutrient acquisition. The main focus of the book is the current state of many of the most critical features of Legionella. Internationally renowned authors have contributed chapters describing and discussing the latest research findings with an emphasis on molecular aspects. The editors and authors have produced an excellent book that will be an extremely useful reference source. This comprehensive publication is aimed at readers with teaching or research interests in microbiology, genetics, genomics, infectious diseases or clinical research. A recommended book for all microbiology and clinical research laboratories.
Molecular Mechanisms Of The Interaction Of Legionella Pneumophila With The Pulmonary Epithelium
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Author : Dje Philippe Pacome N'Guessan
language : en
Publisher:
Release Date : 2013
Molecular Mechanisms Of The Interaction Of Legionella Pneumophila With The Pulmonary Epithelium written by Dje Philippe Pacome N'Guessan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Virulence And Pathogenic Mechanisms Of Legionella Pneumophila
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Author : Ann Rawkins
language : en
Publisher:
Release Date : 1994
Virulence And Pathogenic Mechanisms Of Legionella Pneumophila written by Ann Rawkins and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with categories.
Management Of Legionella In Water Systems
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2020-02-20
Management Of Legionella In Water Systems written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-20 with Medical categories.
Legionnaires' disease, a pneumonia caused by the Legionella bacterium, is the leading cause of reported waterborne disease outbreaks in the United States. Legionella occur naturally in water from many different environmental sources, but grow rapidly in the warm, stagnant conditions that can be found in engineered water systems such as cooling towers, building plumbing, and hot tubs. Humans are primarily exposed to Legionella through inhalation of contaminated aerosols into the respiratory system. Legionnaires' disease can be fatal, with between 3 and 33 percent of Legionella infections leading to death, and studies show the incidence of Legionnaires' disease in the United States increased five-fold from 2000 to 2017. Management of Legionella in Water Systems reviews the state of science on Legionella contamination of water systems, specifically the ecology and diagnosis. This report explores the process of transmission via water systems, quantification, prevention and control, and policy and training issues that affect the incidence of Legionnaires' disease. It also analyzes existing knowledge gaps and recommends research priorities moving forward.
Type Ii Secretion Of Virulence Factors And Iron Acquisition Mechanisms Of Legionella Pneumophila
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Author : Mark Russell Liles
language : en
Publisher:
Release Date : 1998
Type Ii Secretion Of Virulence Factors And Iron Acquisition Mechanisms Of Legionella Pneumophila written by Mark Russell Liles and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Survival and growth within the intracellular environment of an alveolar macrophage requires Legionella pneumophila to subvert the normal phagocytic pathway and acquire limiting nutrients, such as iron. Many pathogens excrete siderophores to chelate iron from host proteins. Biochemical investigations revealed that L. pneumophila supernatants contain multiple iron-binding molecules: the melanin homogentisic acid, the media component cysteine, and an unidentified low molecular weight molecule produced only in some strains of L. pneumophila. To identify iron uptake mechanisms by a genetic approach, transposon-generated mutants were screened for resistance to the iron-activated drug streptonigrin. While sequencing the L. pneumophila DNA downstream of the transposon in the mutant NU218, genes were discovered whose predicted proteins have strong homology to PilB, PilC, and PilD of Pseudomonas aeruginosa, proteins all required for type IV pilus biogenesis. Northern blot analysis demonstrated that the L. pneumophila pilBCD genes are expressed as an operon, and that pilBCD expression is greater at 30$\sp\circ$C than at 37$\sp\circ$C. This temperature-regulated pilBCD expression was correlated with an increase in piliation at 30$\sp\circ$C. Other investigators recently discovered the L. pneumophila type IV pilin subunit (PilE$\rm\sb{L}),$ and found that a $pilE\sb{L}$ mutant lacks type IV pili, but is fully competent for intracellular replication. Since PilD, the prepilin peptidase, is also required for type II protein secretion in other gram-negative bacteria, a pilD mutant was constructed to establish whether L. pneumophila exports proteins through a type II apparatus and whether this process contributes to pathogenesis. The pilD mutant exhibits a unique colony morphology, lacks type IV pili, and is impaired in replication within cultured human macrophages and amoebae. Additionally, the pilD mutant does not cause respiratory distress, high fever, weight loss, or death in guinea pigs, and is rapidly cleared from the lungs of infected animals. From these data it can be concluded that L. pneumophila has a type II secretion system, and that one or more proteins exported via this pathway are important for the virulence of L. pneumophila.
Intracellular Parasitism
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Author : James W. Moulder
language : en
Publisher: CRC Press
Release Date : 2020-10-28
Intracellular Parasitism written by James W. Moulder and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-28 with Science categories.
This publication is a collection of essays on the biology of intracellular parasitisms where both bacterial and protozoan parasites are discussed. The juxtaposition of authors representing fields of research emphasizes the many common problems facing intracellular parasites and the hosts that harbor them. In addition, numerous illustrations of how different parasites and host attempt to solve these problems in different ways are provided. The book includes one or more chapters on Bdellovibrio, Chlamydia, Rickettsia, Coxiella, Legionella, Shigellae, Mycobacterium, Microsporidium, Plasmodium, and Toxoplasma. The authors frequently speculate and generalize on the subject matter discussed.
Microbiology Of Waterborne Diseases
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Author :
language : en
Publisher: Academic Press
Release Date : 2013-11-08
Microbiology Of Waterborne Diseases written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-08 with Science categories.
The second edition of Microbiology of Waterborne Diseases describes the diseases associated with water, their causative agents and the ways in which they gain access to water systems. The book is divided into sections covering bacteria, protozoa, and viruses. Other sections detail methods for detecting and identifying waterborne microorganisms, and the ways in which they are removed from water, including chlorine, ozone, and ultraviolet disinfection. The second edition of this handbook has been updated with information on biofilms and antimicrobial resistance. The impact of global warming and climate change phenomena on waterborne illnesses are also discussed. This book serves as an indispensable reference for public health microbiologists, water utility scientists, research water pollution microbiologists environmental health officers, consultants in communicable disease control and microbial water pollution students. Focuses on the microorganisms of most significance to public health, including E. coli, cryptosporidium, and enterovirus Highlights the basic microbiology, clinical features, survival in the environment, and gives a risk assessment for each pathogen Contains new material on antimicrobial resistance and biofilms Covers drinking water and both marine and freshwater recreational bathing waters
