Molecular Mechanisms Of Soft Tissue Regeneration And Bone Formation In Mice Implications In Fracture Repair And Wound Healing In Humans
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Molecular Mechanisms Of Soft Tissue Regeneration And Bone Formation In Mice Implications In Fracture Repair And Wound Healing In Humans
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Author :
language : en
Publisher:
Release Date : 2000
Molecular Mechanisms Of Soft Tissue Regeneration And Bone Formation In Mice Implications In Fracture Repair And Wound Healing In Humans written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.
The primary goal of the proposed work is to identify genes which play an anabolic role in bone and soft tissue function and to clarify the function of these genes. Three hypotheses have been proposed: (1) The high bone density gene in chromosome I in our CAST/B6 congenic mice can be cloned; (2) Genes that regulate soft and hard tissue regeneration can be identified by using appropriate mouse strains that exhibit differences in regeneration; and (3) ENU mutagenesis, applied to our mouse model, will lead to the identity of genes that regulate soft and hard tissue function. During the first twelve months of the funding period, we have proposed several specific objectives for each of the above-mentioned hypotheses. As disclosed in the progress report, we have successfully accomplished all of the specific objectives. Our work during the first year of the funding period has resulted in four manuscripts in press, four submitted manuscripts, one manuscript in preparation, and four abstracts. We believe that the successful accomplishment of the proposed studies will provide a better understanding of the molecular mechanisms involved in hard- and soft-tissue regeneration and will provide a framework for future development of therapies for hard and soft tissue injuries.
Molecular Mechanisms Of Soft Tissue Regeneration And Bone Formation In Mice Implication In Fracture Repair And Wound Healing In Humans
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Author :
language : en
Publisher:
Release Date : 2008
Molecular Mechanisms Of Soft Tissue Regeneration And Bone Formation In Mice Implication In Fracture Repair And Wound Healing In Humans written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
The primary goal of the proposed work is to identify genes which play an anabolic role in bone and soft tissue function and to clarify the function of these genes. Three hypotheses have been proposed: I) The high bone density gene in chromosome I in our CAST/B6 congenic mice can be cloned; 2) Genes that regulate soft- and hard-tissue regeneration can be identified by using appropriate mouse strains that exhibit differences in regeneration; and 3) ENU mutagenesis, applied to our mouse model, will lead to the identity of genes that regulate soft and hard tissue function. During the last funding period, we have proposed several specific objectives for each of the above-mentioned hypotheses. As disclosed in the progress report, we have successfully accomplished all of the specific objectives. Our work during the first year of the funding period has resulted in two manuscripts in press, two published manuscripts, and three abstracts. We believe that the successful accomplishment of the proposed studies will provide a better understanding of the molecular mechanisms involved in hard- and soft-tissue regeneration and will provide a framework for future development of therapies for hard and soft tissue injuries.
Bone Tissue Engineering
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Author : Jeffrey O. Hollinger
language : en
Publisher: CRC Press
Release Date : 2004-10-14
Bone Tissue Engineering written by Jeffrey O. Hollinger and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-10-14 with Medical categories.
Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t
Indwelling Neural Implants
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Author : William M. Reichert
language : en
Publisher: CRC Press
Release Date : 2007-12-17
Indwelling Neural Implants written by William M. Reichert and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-17 with Medical categories.
Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwel
Advanced Techniques In Bone Regeneration
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Author : Alessandro Rozim Zorzi
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-08-31
Advanced Techniques In Bone Regeneration written by Alessandro Rozim Zorzi and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-31 with Medical categories.
Advanced Techniques in Bone Regeneration is a book that brings together over 15 chapters, written by leading practitioners and researchers, of the latest advances in the area, including surgical techniques, new discoveries, and promising methods involving biomaterials and tissue engineering. This book is intended for all who work in the treatment of disorders involving problems with the regeneration of bone tissue, are doctors or dentists, as well as are researchers and teachers involved in this exciting field of scientific knowledge.
Nutritional Aspects Of Bone Health
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Author : Susan A. New
language : en
Publisher: Royal Society of Chemistry
Release Date : 2003
Nutritional Aspects Of Bone Health written by Susan A. New and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.
A review of the role of diet in the development and maintenance of bone health throughout the lifecycle and prevention of osteoporosis in later life, this reference includes key areas such as epidemiology, genetics and the impact of non-nutritional exogenous factors influencing the skeleton.
Oral Wound Healing
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Author : Hannu Larjava
language : en
Publisher: John Wiley & Sons
Release Date : 2012-05-15
Oral Wound Healing written by Hannu Larjava and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-15 with Medical categories.
Oral Wound Healing: Cell Biology and Clinical Management brings experts from around the world together to provide an authoritative reference on the processes, principles and clinical management of wound healing in the oral mucosa. Promoting a thorough understanding of current research on the topic, this new resource draws together thinking on the basic biological processes of wound healing in the oral environment, as well as providing more detailed information and discussion on processes such as inflammation, reepithelialization and angiogenesis. Beyond this, the book goes on to examine topics pertinent to the effective clinical management of oral wound healing, bringing together chapters on large dento-facial defects, dental implants, periodontal regeneration, and pulp healing.An essential synthesis of current research and clinical applications, Oral Wound Healing will be an indispensable resource for dental specialists, oral and maxillofacial surgeons as well as researchers in oral medicine and biology.
The Burden Of Musculoskeletal Diseases In The United States
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Author : Gunnar Andersson
language : en
Publisher:
Release Date : 2008
The Burden Of Musculoskeletal Diseases In The United States written by Gunnar Andersson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
This study measures the incidence and prevalence of musculoskeletal conditions and projects trends, presenting the latest national data illuminating the physical and economic costs. Several professional organizations concerned with musculoskeletal health and the mission of the U.S. Bone and Joint Decade collaborated to tabulate the data, to educate health care professionals, policy makers and the public.--Publisher's description.
Cell Engineering And Regeneration
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Author : Heinz Redl
language : en
Publisher: Springer
Release Date : 2017-02-16
Cell Engineering And Regeneration written by Heinz Redl and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-16 with Technology & Engineering categories.
This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.
Cutaneous Wounds
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Author : F. Joseph Dagher
language : en
Publisher: Blackwell/Futura
Release Date : 1985
Cutaneous Wounds written by F. Joseph Dagher and has been published by Blackwell/Futura this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Medical categories.