Molecular Pathogenesis Of Colorectal Cancer
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Molecular Pathogenesis Of Colorectal Cancer
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Author : Kevin M. Haigis, Ph.D.
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-02
Molecular Pathogenesis Of Colorectal Cancer written by Kevin M. Haigis, Ph.D. and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-02 with Medical categories.
Colorectal cancer has for more than two decades served as the paradigm for the multi-step concept of cancer initiation and progression. Perhaps more than any other organ site, cancer of the colon is extensively characterized at the molecular level. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. The book will focus on the progression from the identification of mutations that drive colorectal cancer initiation and progression to the search for novel therapies to treat the disease.
Molecular Pathogenesis Of Colorectal Cancer
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Author : Kevin M. Haigis
language : en
Publisher:
Release Date : 2013-10-31
Molecular Pathogenesis Of Colorectal Cancer written by Kevin M. Haigis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-31 with categories.
Advances In The Molecular Understanding Of Colorectal Cancer
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Author : Eva Segelov
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-02-06
Advances In The Molecular Understanding Of Colorectal Cancer written by Eva Segelov and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-06 with Medical categories.
An understanding of the molecular pathogenesis of colorectal cancer by researchers and clinicians is essential to facilitate progress in improving patient outcomes in this common cancer that still carries a poor prognosis if not identified early. This book covers the major areas of importance in the field, incorporating new knowledge that has arisen due to the advancement of molecular techniques and the ability to correlate molecular changes with clinical behaviour of tumours. Each chapter is a summary written by experts, concisely summarising current data as well as highlighting potential areas for advancement. Appreciating the differences between tumours on a molecular level is the key to developing and delivering precision medicine, and nowhere is this more critically required than in the field of colorectal cancer.
Survivin And Molecular Pathogenesis Of Colorectal Cancer
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Author : Paul Joseph Kim
language : en
Publisher:
Release Date : 2004
Survivin And Molecular Pathogenesis Of Colorectal Cancer written by Paul Joseph Kim and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medicine categories.
Advances In The Molecular Understanding Of Colorectal Cancer
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Author : Eva Segelov
language : en
Publisher:
Release Date : 2019
Advances In The Molecular Understanding Of Colorectal Cancer written by Eva Segelov and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Neoplasms. Tumors. Oncology. Including cancer and carcinogens categories.
An understanding of the molecular pathogenesis of colorectal cancer by researchers and clinicians is essential to facilitate progress in improving patient outcomes in this common cancer that still carries a poor prognosis if not identified early. This book covers the major areas of importance in the field, incorporating new knowledge that has arisen due to the advancement of molecular techniques and the ability to correlate molecular changes with clinical behaviour of tumours. Each chapter is a summary written by experts, concisely summarising current data as well as highlighting potential areas for advancement. Appreciating the differences between tumours on a molecular level is the key to developing and delivering precision medicine, and nowhere is this more critically required than in the field of colorectal cancer.
Molecular Pathogenesis In Hereditary Non Polyposis Colorectal Cancer Hnpcc Syndrome
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Author : Reetta Kariola
language : en
Publisher:
Release Date : 2004
Molecular Pathogenesis In Hereditary Non Polyposis Colorectal Cancer Hnpcc Syndrome written by Reetta Kariola and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Molecular Pathology Of Gastroenterological Cancer
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Author : Eiichi Tahara
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Molecular Pathology Of Gastroenterological Cancer written by Eiichi Tahara and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
Twenty years have passed since I became a professor in the First Department of Pathology, Hiroshima University School of Medicine. It is my great pleas ure that Molecular Pathology o[ Gastroenterological Cancer-Application to Clinical Practice has been published by Springer-Verlag Tokyo to commemo rate the 20th anniversary of my professorship. Seeing the academic achievements of our department during these 20 years, I am confident that we could establish a department of oncology to research the pathogenesis of human cancer through systemic application of a variety of molecular techniques. We have demonstrated that the develop me nt and progression of esophageal, gastric, and colon cancer require mul tiple alterations affecting DNA mismatch repair genes, oncogenes, and tumorsuppressor genes, and that common and uncommon genetic changes exist for esophageal, gastric, and colorectal carcinomas. In addition to these genetic changes, the majority of gastrointestinal cancers express telomerase activity, with overexpression of telomerase RNA, indicating a powerful addi tional tool for early detection of gastrointestinal cancer. By transferring these basic observations to the clinic, we now are able to make accurate cancer diagnoses, thus determing the grade of malignancy and patient prognosis. We also can identify patients at high risk for developing cancer and create new therapeutic approaches. In fact, we have routinely implemented a new molecular diagnosis strategy at the Hiroshima City Medi cal Association Clinical Laboratory since August 1993.
Colorectal Cancer
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Author : Luis Rodrigo
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-09-07
Colorectal Cancer written by Luis Rodrigo and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-07 with Medical categories.
Colorectal cancer (CRC) is a major health problem because it represents around 10% of all cancers and achieves a worldwide estimate of 1.4 million newly diagnosed cases annually, resulting in approximately 700,000 deaths. Approximately 19-31% of patients present liver metastases. At diagnosis, a further 23-38% will develop extra-hepatic disease. Over the past decade, the widespread use of modern chemotherapeutic and biological agents, combined with laparoscopic surgical techniques, has improved the prognosis of metastatic CRC. A better understanding of the biology of the tumor, along with high efficiency of diagnostic and therapeutic methods, as well as the spread of screening programs, will improve the survival of the CRC patients in the near future.
Molecular Pathology Of Colorectal Cancer Predisposing Syndromes
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Author : Marjo van Puijenbroek
language : en
Publisher:
Release Date : 2008
Molecular Pathology Of Colorectal Cancer Predisposing Syndromes written by Marjo van Puijenbroek and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Molecular Pathology
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Author : William B. Coleman
language : en
Publisher: Academic Press
Release Date : 2009-03-10
Molecular Pathology written by William B. Coleman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-10 with Medical categories.
Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular medicine. It also discusses concepts in molecular biology and genetics, recent scientific and technological advances in modern pathology, the concept of ""molecular pathogenesis"" of disease, and how disease evolves from normal cells and tissues due to perturbations in molecular pathways. The book describes the integration of molecular and cellular pathogenesis using a bioinformatics approach and a systems biology approach to disease pathogenesis. It also discusses current and future strategies in molecular diagnosis of human disease, and the impact of molecular diagnosis on treatment decisions and the practice of personalized medicine. This book is a valuable resource for students, biomedical researchers, practicing physician-scientists who undertake disease-related basic science and translational research, and pathology residents and other postdoctoral fellows. * Exam Master® web site will host "Self-assessment" questions that students can use to study for the molecular section of the board exam * Companion Web Site – will host a complete set of PowerPoint slides: to include images from the book and additional images for teaching; course materials; lecture materials * Teaches from the perspective of “integrative systems biology, which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease * Outlines the principles and practice of molecular pathology * Explains the practice of “molecular medicine and the translational aspects of molecular pathology