Mrna Impfstoff
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Mrna Impfstoff
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Author : Fouad Sabry
language : de
Publisher: One Billion Knowledgeable
Release Date : 2022-10-12
Mrna Impfstoff written by Fouad Sabry and has been published by One Billion Knowledgeable this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-12 with Technology & Engineering categories.
Was ist ein mRNA-Impfstoff Die immunologische Reaktion, die durch eine als mRNA-Impfstoff bekannte Impfung induziert wird, wird durch die Verabreichung einer Kopie eines Moleküls hervorgerufen, das als Messenger bekannt ist RNA (mRNA). Der Impfstoff fügt mRNA-Moleküle, die für Antigene kodieren, in Immunzellen ein. Die Immunzellen verwenden dann die manipulierte mRNA als Vorlage, um ein fremdes Protein zu konstruieren, das dem ähnelt, das typischerweise von einer Krebszelle oder einer Krankheit erzeugt wird. Diese Proteinmoleküle aktivieren eine adaptive Immunantwort, die den Körper dazu bringt, die passenden Krebszellen oder Krankheitserreger zu erkennen und zu eliminieren. Es hat sich gezeigt, dass adaptive Immunantworten wirksamer sind als traditionelle Immunantworten. Die Abgabe der mRNA wird durch die Verwendung einer Co-Formulierung erreicht, die aus der Umhüllung der RNA in Lipid-Nanopartikeln besteht. Diese Nanopartikel dienen dazu, die RNA-Stränge zu konservieren und ihre Aufnahme in die Zellen zu unterstützen. Ihr Nutzen (I) Einblicke und Validierungen zu die folgenden Themen: Kapitel 1: mRNA-Impfstoff Kapitel 2: Impfstoff Kapitel 3: PEGylierung Kapitel 4: Festes Lipid Nanopartikel Kapitel 5: Moderna Kapitel 6: COVID-19-Impfstoff Kapitel 7: Moderna COVID-19-Impfstoff Kapitel 8 : Jason McLellan Kapitel 9: BioNTech Kapitel 10: RNA-Therapeutika Kapitel 11: Pfizer-BioNTech COVID-19-Impfstoff Kapitel 12: Özlem Türeci Kapitel 13: Nucleosid-modifizierte Boten-RNA Kapitel 14: ALC-0315 Kapitel 15: Distearoylphosphatidylcholin Kapitel 16: SM-102 Kapitel 17: Einsatz von COVID-19-Impfstoffen Kapitel 18: Geschichte der COVID-19-Impfstoffentwicklung Kapitel 19: CureVac COVID-19-Impfstoff Kapitel 20: N1-Methylpseudouridin Kapitel 21: Klinische Forschung zum COVID-19-Impfstoff ch (II) Beantwortung der wichtigsten öffentlichen Fragen zum mRNA-Impfstoff. (III) Beispiele aus der Praxis für die Verwendung von mRNA-Impfstoffen in vielen Bereichen. (IV) 17 Anhänge zur kurzen Erläuterung von 266 neuen Technologien in jeder Branche, um ein umfassendes 360-Grad-Verständnis der mRNA-Impfstofftechnologien zu erhalten. Für wen ist dieses Buch gedacht Fachleute, Studenten und Doktoranden, Enthusiasten, Bastler und diejenigen, die über das grundlegende Wissen oder die Informationen für jede Art von mRNA-Impfstoff hinausgehen möchten.
Mrna Vaccines
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Author : Dong Yu
language : en
Publisher: Springer Nature
Release Date : 2023-01-03
Mrna Vaccines written by Dong Yu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-03 with Medical categories.
The formulation and the technological advancements in RNA biology, chemistry, stability, and encapsulated delivery systems that have enabled the development of fully synthetic mRNA vaccines are discussed in this volume. The applications of the mRNA technology is covered, focusing on infectious diseases but also touching on other indications, such as immunotherapies and molecular therapies. Potent and long-lasting immune responses observed in animal models, encouraging data from early human clinical studies, together with the success of two mRNA-based COVID-19 vaccines support the use of mRNA-based vaccination as an attractive alternative to conventional vaccine approaches. Consequently, the development progress of the technology, particularly on production, capabilities, and clinical development is reviewed. Topics on safety, regulatory issues, and possible challenges to the mRNA vaccination approach round off this book. Thanks to their high potency, the prospect for generic, low-cost manufacturing processes, and entirely synthetic nature, the future for mRNA vaccines is highly promising. Importantly, mRNA vaccines have the potential to minimize the time between pathogen identification and vaccine release with a huge impact on public health. As the mRNA-based vaccination technology has been progressing rapidly, the book is intended to be an end-to-end review series, covering everything from basic RNA biology and preclinical studies to the manufacturing strategy, clinical development and regulatory approval. It provides established RNA researchers and developers with updates on the latest advancements in the field and allows for a quick but comprehensive overview of this transformative technology, its application, and future potential.
Mrna Therapeutics
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Author : Sarfaraz K. Niazi
language : en
Publisher: CRC Press
Release Date : 2022-12-06
Mrna Therapeutics written by Sarfaraz K. Niazi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-06 with Medical categories.
This book is the most comprehensive and complete treatise on nucleic acid therapeutic products, including mRNA vaccines, their manufacturing, formulations, and testing for safety and efficacy. Details include cGMP-compliant manufacturing and regulatory filing steps. A new concept of “biosimilar” mRNA vaccine is presented to secure fast approval of copies of mRNA vaccines. Projections of financial plans to establish RNA manufacturing facilities are provided, along with details of supply chain management. Finally, the future of nucleic acid products in gene therapy and other newer applications is presented, along with a perspective that all new vaccines will be the nucleic acid type that will further provide first-time prevention of autoimmune disorders. It is projected that both big pharma and start-ups will enter this field, and we can expect significant additions to our drug armamentarium soon.
Mrna Therapeutics
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Author : Sarfaraz Niazi
language : en
Publisher: CRC Press
Release Date : 2023
Mrna Therapeutics written by Sarfaraz Niazi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
"This book is the most comprehensive and complete treatise on nucleic acid therapeutic products, including mRNA vaccines, their manufacturing, formulations, and testing for safety and efficacy testing. Details include cGMP-compliant manufacturing and regulatory filing steps. A new concept of "biosimilar" mRNA vaccine is presented to secure fast approval of copies of mRNA vaccines. Projections of financial plans to establish RNA manufacturing facilities are provided, along with details of supply chain management. Finally, the future of nucleic acid products in gene therapy and other newer applications is presented, along with a perspective that all new vaccines will be the nucleic acid type that will further provide first-time prevention of autoimmune disorders. It is projected that both big pharma and startups will enter this field, and we can expect significant additions to our drug armamentarium soon"--
The Marathon Of The Messenger
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Author : Jérôme Lemonnier
language : en
Publisher: Springer Nature
Release Date : 2023-12-03
The Marathon Of The Messenger written by Jérôme Lemonnier and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-03 with Medical categories.
The Covid-19 pandemic changed the world. Indeed a real race took place worldwide between SARS-CoV-2 on the one hand and researchers on the other – especially those specializing in messenger RNA vaccines. Four years after its emergence, the pandemic is not over, but some decisive battles have been won, thanks to the great success of mRNA vaccines. The Marathon of The Messenger presents the history of these mRNA vaccines, combining a scientific background with historical and economic perspectives. It appears that an important page in the history of these new vaccines was written in Europe, thanks to the crucial work of German and French scientists; this effort began in 1993 and continues to this day. In the face of a prevailing single-mindedness, these researchers pushed through a new therapeutic concept and defined the biotechnological keys that would open the way to the production of therapeutic messenger RNA in the fight against cancer and viral infections. Written for a broad audience and accompanied by humorous cartoons, this book will appeal to anyone looking for scientific and historical answers about mRNA vaccines. Readers will discover not only the technical and scientific knowledge of how these vaccines work, but also the economic levers that were necessary to create this technology. This book has been written in collaboration with Dr. Steve Pascolo, former director of CureVac, and the RNA messenger expert Professor Chantal Pichon. It also features a preface by Dr. Pierre Meulien, former director of the European Union public-private partnership Innovative Medicines Initiative (IMI).
Messenger Rna Therapeutics
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Author : Stefan Jurga
language : en
Publisher: Springer Nature
Release Date : 2022-09-20
Messenger Rna Therapeutics written by Stefan Jurga and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-20 with Medical categories.
This book focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine. Thus, this handbook is an essential resource for researchers in academia and industry contributing to the development of this new area of therapeutics.
The Marathon Of The Messenger
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Author : Jérôme Lemonnier
language : en
Publisher: Springer
Release Date : 2023-11-09
The Marathon Of The Messenger written by Jérôme Lemonnier and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-09 with Medical categories.
The Covid-19 pandemic changed the world. Indeed a real race took place worldwide between SARS-CoV-2 on the one hand and researchers on the other – especially those specializing in messenger RNA vaccines. Four years after its emergence, the pandemic is not over, but some decisive battles have been won, thanks to the great success of mRNA vaccines. The Marathon of The Messenger presents the history of these mRNA vaccines, combining a scientific background with historical and economic perspectives. It appears that an important page in the history of these new vaccines was written in Europe, thanks to the crucial work of German and French scientists; this effort began in 1993 and continues to this day. In the face of a prevailing single-mindedness, these researchers pushed through a new therapeutic concept and defined the biotechnological keys that would open the way to the production of therapeutic messenger RNA in the fight against cancer and viral infections. Written for a broad audience and accompanied by humorous cartoons, this book will appeal to anyone looking for scientific and historical answers about mRNA vaccines. Readers will discover not only the technical and scientific knowledge of how these vaccines work, but also the economic levers that were necessary to create this technology. This book has been written in collaboration with Dr. Steve Pascolo, former director of CureVac, and the RNA messenger expert Professor Chantal Pichon. It also features a preface by Dr. Pierre Meulien, former director of the European Union public-private partnership Innovative Medicines Initiative (IMI).
The Medical Revolution Of Messenger Rna
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Author : Fabrice Delaye
language : en
Publisher:
Release Date : 2023
The Medical Revolution Of Messenger Rna written by Fabrice Delaye and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
"To the casual onlooker, it took just 10 months to apply a revolutionary new technology to develop a vaccine against COVID-19. Messenger RNA (mRNA), the long-chain molecule at the heart of these vaccines, is now regarded as something of a global savior. What most people don't know, however, is that this technology had been in the works for three frustrating decades. Even before that came 30 more years of fundamental research, setting the stage now for no less than a medical revolution where our cells produce the drugs we need. This is the story of how mRNA's potential was finally harnessed for medical therapy, having long been shunned by mainstream molecular biologists"--
Breakthrough
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Author : Stephanie Sammartino McPherson
language : en
Publisher: Twenty-First Century Books (Tm)
Release Date : 2023
Breakthrough written by Stephanie Sammartino McPherson and has been published by Twenty-First Century Books (Tm) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with Young Adult Nonfiction categories.
"Breakthrough chronicles the life, hard work, and accomplishments of Katalin Karikó, one of the pioneering mRNA researchers whose work led to COVID-19 vaccines, depicting her as an inspirational figure for readers interested in science"--
A Shot To Save The World
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Author : Gregory Zuckerman
language : en
Publisher: Penguin UK
Release Date : 2021-10-28
A Shot To Save The World written by Gregory Zuckerman and has been published by Penguin UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-28 with Medical categories.
'Thrilling, inspiring and informative page-turner.' Walter Isaacson, author of The Code Breaker You know what went wrong. This is the untold story of what went right. Few were ready when a mysterious respiratory illness emerged in Wuhan, China, in January 2020. Politicians, government officials, business leaders and public-health professionals were unprepared for the most devastating pandemic in a century. Many of the world's biggest drug and vaccine makers were slow to react or couldn't muster an effective response. It was up to a small group of unlikely and untested scientists and executives to save civilization. A French businessman dismissed by many as a fabulist. A Turkish immigrant with little virus experience. A quirky Midwesterner obsessed with insect cells. A Boston scientist employing questionable techniques. A British scientist resented by his peers. Far from the limelight, each had spent years developing innovative vaccine approaches. Their work was met with scepticism and scorn. By 2020, these individuals had little proof of progress. Yet they and their colleagues wanted to be the ones to stop a virulent virus holding the world hostage. They scrambled to turn their life's work into life-saving vaccines in a matter of months, each gunning to make the big breakthrough - and to beat each other for the glory that a vaccine guaranteed. A number-one New York Times bestselling author and award-winning Wall Street Journal investigative journalist, Zuckerman takes us inside the top-secret laboratories, corporate clashes and high-stakes government negotiations that led to effective shots. Deeply reported and endlessly gripping, this is a dazzling, blow-by-blow chronicle of the most consequential scientific breakthrough of our time. It's a story of courage, genius and heroism. It's also a tale of heated rivalries, unbridled ambitions, crippling insecurities and unexpected drama. A Shot to Save the World is the story of how science saved the world. ***LONGLISTED FOR THE FT MCKINSEY BUSINESS BOOK OF THE YEAR 2021***