Nanobody Based Approaches For The Therapeutic Targeting Of Conserved T Cell Subsets In Cancer
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Nanobody Based Approaches For The Therapeutic Targeting Of Conserved T Cell Subsets In Cancer
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Author :
language : en
Publisher:
Release Date : 2017
Nanobody Based Approaches For The Therapeutic Targeting Of Conserved T Cell Subsets In Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Nanobody Based Cancer Immunotherapy And Immunoimaging
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Author : Zahra Sharifzadeh
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-07
Nanobody Based Cancer Immunotherapy And Immunoimaging written by Zahra Sharifzadeh and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-07 with Science categories.
Understanding Gamma Delta T Cell Multifunctionality Towards Immunotherapeutic Applications
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Author : Kenth Gustafsson
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-02
Understanding Gamma Delta T Cell Multifunctionality Towards Immunotherapeutic Applications written by Kenth Gustafsson and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-02 with categories.
Immune Regulation
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Author : Marc Feldmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Immune Regulation written by Marc Feldmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Leukocyte culture conferences have a long pedigree. This volume records some of the scientific highlights of the 16th such annual con ference, and is a witness to the continuing evolution and popularity of leukocyte culture and of immunology. There is strong evidence of the widening horizons of immunology, both technically, with the obviously major impact of molecular biology into our understanding of cellular processes, and also conceptually. Traditionally, the 'proceedings' of these conferences have been published. But have the books produced really recorded the major part of the conference, the informal, friendly, but intense and some times heated exchanges that take place between workers in tackling very similar problems and systems and which are at the heart of every successful conference? Unfortunately this essence cannot be incorpo rated by soliciting manuscripts. For this reason, we have changed the format of publication, retaining published versions of the symposium papers, but requesting the workshop chairmen to produce a summary of the major new observations and areas of controversy highlighted in their sessions, as a vehicle for defining current areas of interest and debate. Not an easy task, as the workshop topics were culled from the abstracts submitted by the participants, rather than being on predefined topics. The unseasonal warmth in Cambridge was reflected in the atmos phere of the conference, the organization of which benefited from the administrative skills of Jean Bacon, Philippa Wells, Mr. Peter Irving, and Mrs.
Lymphocyte Activation
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Author : L.E. Samelson
language : en
Publisher:
Release Date : 1994
Lymphocyte Activation written by L.E. Samelson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.
Targeted Drug Strategies For Cancer And Inflammation
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Author : Ann L. Jackman
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-05-05
Targeted Drug Strategies For Cancer And Inflammation written by Ann L. Jackman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-05 with Medical categories.
Folate pathways are essential in metabolism and macromolecule synthesis. Antifolate drugs that are largely transported via a high capacity folate transporter (i.e. the reduced-folate carrier) and inhibit folate-dependent enzymes include the dihydrofolate reductase inhibitor, methotrexate, and the thymidylate synthase inhibitors, raltitrexed and pemetrexed. Major advances in folate research made within the last decade include (i) the approval of pemetrexed for the treatment of lung cancer and mesothelioma, and (ii) the demonstration that cell membrane-anchored folate receptors (FR) are exploitable for cancer and inflammatory disease management. FRs are not widely distributed in normal tissues, except on some luminal surfaces; however, they are accessible to systemically administered agents when expressed on many cancers as well as on activated macrophages involved in various inflammatory diseases. High affinity folate-radioisotope conjugates have been developed for imaging pathogenic FR-positive diseases, including cancer. Since the FR transports folates via a low capacity but high affinity endocytic pathway, a variety of FR-targeted antifolate drugs and folate conjugates bearing a wide range of payloads (including cytotoxic drugs) are currently being developed which exploit this property. The FR is also being utilized in immunotherapy approaches for the treatment of overexpressing cancers.
Phage Display
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Author : Tim Clackson
language : en
Publisher: OUP Oxford
Release Date : 2004-03-04
Phage Display written by Tim Clackson and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-03-04 with Science categories.
This new book is designed to enable researchers to design and undertake all aspects of a phage display project, from designing an experimental strategy and constructing a library to performing selections and analyzing the results.All of the protocols and chapters are extensively cross-referenced, allowing readers to move beyond the specific examples provided in order to customize the procedures for their own protein or selection system of interest. Phage Display is an up-to-date, comprehensive and integrated experimental guide to the technique, which is essential reading for anyone currently using, or wishing to use the technique for basic research and drug discovery.
Immunotherapy Of Infections
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Author : K. Noel Masihi
language : en
Publisher: CRC Press
Release Date : 1994-07-15
Immunotherapy Of Infections written by K. Noel Masihi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-07-15 with Medical categories.
Based on the International Symposium on Immunotherapy of Infections held recently at the Robert Koch Institute, Berlin, Germany, this work discusses cytokines as well as synthetic and natural immunomodulators and their applications in the immunotherapy of bacterial, viral, parasitic and fungal infections.;The contributors describe innovative treatment concepts that act as adjuncts to established therapies for the control of both existing and newly emerging infectious diseases.
Microbiome And Cancer
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Author : Erle S. Robertson
language : en
Publisher: Springer
Release Date : 2019-02-20
Microbiome And Cancer written by Erle S. Robertson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-20 with Medical categories.
This book ventures into a new and exciting area of discovery that directly ties our current knowledge of cancer to the discovery of microorganisms associated with different types of cancers. Recent studies demonstrate that microorganisms are directly linked to the establishment of cancers and that they can also contribute to the initiation, as well as persistence of, the cancers. Microbiome and Cancer covers the current knowledge of microbiome and its association with human cancers. It provides important reading for novices, senior undergraduates in cancer and microbiology, graduate students, junior investigators, residents, fellows and established investigators in the fields of cancer and microbiology. We cover areas related to known, broad concepts in microbiology and how they can relate to the ongoing discoveries of the micro-environment and the changes in the metabolic and physiologic states in that micro-environment, which are important for the ongoing nurturing and survival of the poly-microbial content that dictates activities in that micro-environment. We cover the interactions of microorganisms associated with gastric carcinomas, which are important for driving this particular cancer. Additional areas include oral cancers, skin cancers, ovarian cancers, breast cancers, nasopharyngeal cancers, lung cancers, mesotheliomas, Hodgkin’s and non-Hodgkin’s lymphomas, glioblastoma multiforme, hepatocellular carcinomas, as well as the inflammatory response related to the infectious agents in cancers. This book covers the metabolic changes that occur because of infection and their support for development of cancers, chronic infection and development of therapeutic strategies for detection and control of the infection. The field of microbiome research has exploded over the last five years, and we are now understanding more and more about the context in which microorganisms can contribute to the onset of cancers in humans. The field of microbiome research has demonstrated that the human body has specific biomes for tissues and that changes in these biomes at the specific organ sites can result in disease. These changes can result in dramatic differences in metabolic shifts that, together with genetic mutations, will produce the perfect niche for establishment of the particular infection programmes in that organ site. We are just beginning to understand what those changes are and how they influence the disease state. Overall, we hope to bring together the varying degrees of fluctuations in the microbiome at the major organ sites and how these changes affect the normal cellular processes because of dysregulation, leading to proliferation of the associated tissues.
Antibody Fusion Proteins
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Author : Steven M. Chamow
language : en
Publisher: Wiley-Liss
Release Date : 1999-04-13
Antibody Fusion Proteins written by Steven M. Chamow and has been published by Wiley-Liss this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04-13 with Science categories.
Thoroughly detailed and illustrated, this book examines the construction, properties, applications, and problems associated with specific types of fusion molecules used in clinical and research medicine. The editors present an overview of the field, followed by nine chapters divided into two general sections based on the two primary parts of the antibody molecule: Fab fusion proteins and Fc fusion proteins. In addition, numerous renowned scientists in the field have contributed outlines demonstrating man-made molecules that will be required not only to overcome the limitations of monoclonal antibodies, but also to extend the principle of selective targeting. Divided into specific, accessible sections, Antibody Fusion Proteins includes: * Chapters describing Fc fusion proteins, as well as several classes of antigen-binding proteins * Complete details on the design and molecular construction of genetically engineered fusion molecules * Useful information on molecular purification, large-scale production, practical applications, and their therapeutic potential * The latest data on forming fusion proteins with toxins, cytokines, or enzymes that can activate a prodrug