Nanoconstructs For Targeting Imaging And Photothermal Therapy Of Cancer
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Nanoconstructs For Targeting Imaging And Photothermal Therapy Of Cancer
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Author : Dickson Kiprono Kirui
language : en
Publisher:
Release Date : 2011
Nanoconstructs For Targeting Imaging And Photothermal Therapy Of Cancer written by Dickson Kiprono Kirui and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Nanomaterials are becoming attractive for a variety of medical applications with over 250 nanotechnology-based products in U.S. pharmaceutical pipelines. Nanoparticle-based targeting has the potential to improve upon the limitations of conventional pharmaceuticals and increase the efficacy of drug delivery, therapy and imaging systems while reducing the side effects to healthy tissues. Due to the unique properties at nanometer scale, metallic nanomaterials have increasingly garnered interest as potential agents for selective molecular targeting, imaging, therapy, drug delivery and therapeutic applications. Research efforts that initially focused on rational design of passively delivered therapeutic system have recently progressed to the development of "second-generation" systems that can actively seek out cell markers and specific organs or cells based on over-expressed surface markers such as antigens expressed on cancer cells. This thesis reports on the development of second-generation targeted metallic-based therapy and diagnostic agents for potential heat-induced therapy and for magnetic resonancebased (MR) imaging. Here, we have developed selectively targeted metallic nanostructures that are conjugated to antibodies and have demonstrated their uses in molecular targeting, multimodal imaging, and in thermotherapy (photothermal therapy) applications both using in vitro as well as in animal models. Initially, we have synthesized and designed iron oxide-gold hybrid nanoparticles (HNPs) to make stabile water-soluble particles with suitable end functional groups that allow attachment of targeting antibodies. Next, the HNPs have been tested for cytotoxicity using targeted colorectal cancer cell lines. Further experiments were used to test the potential uses of these hybrid nanoparticles for dual functions for photothermal therapy as well as for MRI. On the basis of promising in vitro results, HNPs were tested in xenograft mice to illuminate the ability to achieve localized particle delivery following systemic injection. Particle localization was visualized by optimal fluorescence imaging and corroborated by non-invasive MR imaging and by histological tissue staining. After local particle delivery, effective photothermal therapy application has been demonstrated where tumor damage was observed posttreatment. Gold nanorods have become attractive for deep tissue in vivo photothermal therapy applications. We have demonstrated a novel method of coating with polyacrylate, resulting in stabile water-soluble nanorods. Further, the heating capacity of nanorods solution and selective in vitro photothermal therapy applications has been demonstrated.
Targeted Cancer Imaging
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Author : Mehdi Azizi
language : en
Publisher: Academic Press
Release Date : 2021-11-24
Targeted Cancer Imaging written by Mehdi Azizi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-24 with Medical categories.
Targeted Cancer Imaging: Design and Synthesis of Nanoplatforms based on Tumour Biology reviews and categorizes imaging and targeting approaches according to cancer type, highlighting new and safe approaches that involve membrane-coated nanoparticles, tumor cell-derived extracellular vesicles, circulating tumor cells, cell-free DNAs, and cancer stem cells, all with the goal of pointing the way to developing precise targeting and multifunctional nanotechnology-based imaging probes in the future. This book is highly multidisciplinary, bridging the knowledge gap between tumor biology, nanotechnology, and diagnostic imaging, and thus making it suitable for researchers ranging from oncology to bioengineering. Although considerable efforts have been conducted to diagnose, improve and treat cancer in the past few decades, existing therapeutic options are insufficient, as mortality and morbidity rates remain high. One of the best hopes for substantial improvement lies in early detection. Recent advances in nanotechnology are expected to increase our current understanding of tumor biology, allowing nanomaterials to be used for targeting and imaging both in vitro and in vivo experimental models. Gives understanding of cancer biology that is appropriate for students and researchers in engineering and nanotechnology Demonstrates cancer targeting strategies of multifunctional nanotechnology-based imaging probes Shows how to design, synthesize and apply cancer imaging nanostructures
Nanomaterials For Tumor Targeting Theranostics A Proactive Clinical Perspective
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Author : Mingqian Tan
language : en
Publisher: World Scientific
Release Date : 2016-02-22
Nanomaterials For Tumor Targeting Theranostics A Proactive Clinical Perspective written by Mingqian Tan and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-22 with Science categories.
Nanomaterials offer great potential for effective tumor diagnosis and therapy combing diagnostic agents and therapeutic drugs into one platform. In this book, the most recent progress of main nanomaterials and their applications in tumor targeting theranostics is presented. It summarizes the recent advances of current principal nanomaterials in tumor theranostics, including magnetic nanomaterials, quantum dots, mesoporous silica nanoparticles, gold nanomaterials, polymeric nanosystem, carbon nanomaterials, lipopolyplex nanoparticles, microbubbles, upconversion nanomaterials and dendrimers. It will enable readers to get a more realistic understanding of both the advantages and limitations of nanomaterials for potential tumor targeting theranosis. The publication of this book will accelerate the spread of ideas that are currently trickling through the scientific literature. Also a greater understanding of the potential and challenge of nanomaterials for tumor targeting theranostics is highly anticipated for practical clinical use.
Advances In Nanotheranostics Ii
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Author : Zhifei Dai
language : en
Publisher: Springer
Release Date : 2016-01-11
Advances In Nanotheranostics Ii written by Zhifei Dai and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-11 with Technology & Engineering categories.
This book surveys recent advances in theranostics based on magnetic nanoparticles, ultrasound contrast agents, silica nanoparticles and polymeric micelles. It presents magnetic nanoparticles, which offer a robust tool for contrast enhanced MRI imaging, magnetic targeting, controlled drug delivery, molecular imaging guided gene therapy, magnetic hyperthermia, and controlling cell fate. Multifunctional ultrasound contrast agents have great potential in ultrasound molecular imaging, multimodal imaging, drug/gene delivery, and integrated diagnostics and therapeutics. Due to their diversity and multifunctionality, polymeric micelles and silica-based nanocomposites are highly capable of enhancing the efficacy of multimodal imaging and synergistic cancer therapy. This comprehensive book summarizes the main advances in multifunctional nanoprobes for targeted imaging and therapy of gastric cancer, and explores the clinical translational prospects and challenges. Although more research is needed to overcome the substantial obstacles that impede the development and availability of nanotheranostic products, such nontrivial nanoagents are expected to revolutionize medical treatments and help to realize the potential of personalized medicine to diagnose, treat, and follow-up patients with cancer. Zhifei Dai is a Professor at the Department of Biomedical Engineering, College of Engineering, Peking University, China.
New Nanomaterials And Techniques For Tumor Targeted Systems
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Author : Rongqin Huang
language : en
Publisher: Springer Nature
Release Date : 2020-09-28
New Nanomaterials And Techniques For Tumor Targeted Systems written by Rongqin Huang and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-28 with Medical categories.
This book summarizes the latest advances in nanomaterials and techniques in the field of tumor-targeted diagnosis and therapy. It provides valuable information for beginners and senior researchers, and stimulates new research directions by offering novel and provocative insights into the properties and technical principles of nanomaterials. The book systemically discusses the challenges in tumor treatment, current tumor-targeted strategies, drug-release strategies, diagnosis and therapeutic patterns, and also explores newly developed multifunctional nanomaterials and related systems.
A Minimally Invasive Multifunctional Nano Enabled Approach For Selective Targeting And Near Infrared Photothermal Therapy Of Malignant Tumors
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Author : Hadiyah-Nicole Green
language : en
Publisher:
Release Date : 2012
A Minimally Invasive Multifunctional Nano Enabled Approach For Selective Targeting And Near Infrared Photothermal Therapy Of Malignant Tumors written by Hadiyah-Nicole Green and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Cancer categories.
This dissertation describes how the mastery of active tumor targeting and subsequent tumor regression is a great challenge for cancer therapy. Near infrared (NIR) photothermal therapy (PTT) as a localized minimally invasive therapy utilizes nanoparticles (NPs) as a physical contrast agent. The NIR laser irradiation, transparent to normal tissue, overlaps with plasmon resonance absorption of gold nanoparticles (AuNPs). The AuNPs convert the absorbed NIR light energy into thermal energy and cause localized destruction of surrounding tissue. To improve efficiency for targeting of AuNPs to malignant tumors, we developed a technique for conjugating gold nanoparticles to tumor-specific antibodies. We demonstrated that the binding efficiency of the antibodies conjugated to the polyethylene glycol coated (PEGylated) gold nanorods (AuNRs) is 33.9% greater than PEGylated antibody-GNR conjugates as reported by Liao, "Gold Nanorod Bioconjugates" in Chem. Mater., 2005, 17, pp 4636-4641. We report the in vivo feasibility of a minimally invasive modality that combines active targeting, fluorescent imaging, and NIR photothermal treatment of malignant tumors as a potential approach for a variety of cancer types that over-express the epidermal growth factor receptor (EGFR). The anti-EGFR antibody was labeled with a NIR fluorescent dye and conjugated to PEGylated AuNRs (dye-antibody-AuNR). The optimal molar ratio determination and conjugation of dye-antibody-AuNR facilitated the targeted delivery of the nanorods to the tumor site. The conjugation did not reduce the binding affinity of the antibody to the EGFR, the fluorescence of the IRDye, or the therapeutic qualities of the AuNRs. NIR photothermal treatment with the dye-antibody-nanorod conjugate sufficiently killed approximately 90% of tumor cells in vitro and provided a reduction in tumor size in vivo post intravenous tail injection. Intratumoral injections of AuNRs followed by a one-time 10-minute near infrared laser treatment resulted in ~100% tumor regression as monitored grossly and confirmed by histology. The change of tumor volume was dramatically different for the combination AuNR and laser treatment group as compared to the control groups: no treatment, laser only, and nanorods only.
Cancer Nanotechnology
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Author : Sang Hyun Cho
language : en
Publisher: CRC Press
Release Date : 2013-01-08
Cancer Nanotechnology written by Sang Hyun Cho and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-08 with Medical categories.
Rapid advances in nanotechnology have enabled the fabrication of nanoparticles from various materials with different shapes, sizes, and properties, and efforts are ongoing to exploit these materials for practical clinical applications. Nanotechnology is particularly relevant in the field of oncology, as the leaky and chaotic vasculature of tumors—a hallmark of unrestrained growth—results in the passive accumulation of nanoparticles within tumors. Cancer Nanotechnology: Principles and Applications in Radiation Oncology is a compilation of research in the arena of nanoparticles and radiation oncology, which lies at the intersection of disciplines as diverse as clinical radiation oncology, radiation physics and biology, nanotechnology, materials science, and biomedical engineering. The book provides a comprehensive, cross-disciplinary survey of basic principles, research techniques, and outcomes with the goals of eventual clinical translation. Coverage includes A general introduction to fabrication, preferential tumor targeting, and imaging of nanoparticles The specific applications of nanomaterials in the realms of radiation therapy, hyperthermia, thermal therapy, and normal tissue protection from radiation exposure Outlooks for future research and clinical translation including regulatory issues for ultimate use of nanomaterials in humans Reflecting profound advances in the application of nanotechnology to radiation oncology, this comprehensive volume demonstrates how the unique physicochemical properties of nanoparticles lead to novel strategies for cancer treatment and detection. Along with various computational and experimental techniques, each chapter highlights the most promising approaches to the use of nanoparticles for radiation response modulation.
Multifunctional Gold Nanostars For Cancer Theranostics
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Author : Yang Liu
language : en
Publisher: Springer
Release Date : 2018-03-15
Multifunctional Gold Nanostars For Cancer Theranostics written by Yang Liu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-15 with Science categories.
This thesis presents the development of theranostic gold nanostars (GNS) for multimodality cancer imaging and therapy. Furthermore, it demonstrates that a novel two-pronged treatment, combining immune-checkpoint inhibition and GNS-mediated photothermal nanotherapy, can not only eradicate primary treated tumors but also trigger immune responses to treat distant untreated tumors in a mouse animal model. Cancer has become a significant threat to human health with more than eight million deaths each year, and novel methods for cancer management to improve patients’ overall survival are urgently needed. The developed multifunctional GNS nanoprobe with tip-enhanced plasmonics in the near-infrared region can be combined with (1) surface-enhanced Raman spectroscopy (SERS), (2) two-photon photoluminescence (TPL), (3) X-ray computed tomography (CT), (4) magnetic resonance imaging (MRI), (5) positron emission tomography (PET), and (6) photothermal therapy (PTT) for cancer imaging and treatment. The ability of the GNS nanoprobe to detect submillimeter intracranial brain tumors was demonstrated using PET scan – a superior non-invasive imaging modality – in a mouse animal model. In addition, delayed rechallenge with repeated cancer cell injection in cured mice did not lead to new tumor formation, indicating generation of a memorized immune response to cancer. The biocompatible gold nanostars with superior capabilities for cancer imaging and treatment have great potential for translational medicine applications.
Organic Nanomaterials For Cancer Phototheranostics
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Author : Manzar Abbas
language : en
Publisher: Elsevier
Release Date : 2023-09-15
Organic Nanomaterials For Cancer Phototheranostics written by Manzar Abbas and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-15 with Technology & Engineering categories.
Organic Nanomaterials for Cancer Phototheranostics highlights the use of biocompatible building blocks to make nanomaterials that can aid in medical treatment through better diagnostic and antitumor efficacy. It synthesizes the current literature on synthetic strategies and designs based on peptides, proteins, polymers, lipids, and their conjugates, as well as composites and complexes with metals and inorganic components used to form the nanomaterials. Mechanistic approaches, clinical problems, and therapeutic and diagnostics mechanisms are covered in each chapter. Cellular interactions and uptake, pharmacokinetics, biodistribution, drug delivery efficiency, and safety concerns of these types of nanomaterials are discussed, as well. Other topics looked at include photostability, clearance, metabolism, in-vitro and in-vivo mechanisms, therapeutic efficacy, imaging, and toxicology. Outlines fabrication and design strategies of peptides, proteins, polymers, lipids, composites, and complexes with metals and inorganic components Discusses the limitations and challenges of organic nanomaterials in clinical use, including their mechanisms of penetration into cancer cells and tissue, photostability, clearance, and metabolism Covers clinical problems and therapeutic and diagnostics mechanisms
Targeted Nanomedicine For Breast Cancer Therapy
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Author : Shivani Rai Paliwal
language : en
Publisher: Academic Press
Release Date : 2022-08-06
Targeted Nanomedicine For Breast Cancer Therapy written by Shivani Rai Paliwal and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-06 with Business & Economics categories.
Targeted Nanomedicine for Breast Cancer Therapy provides a compilation of treatment approaches for breast cancer, including conventional receptor targeting methods and novel strategies like stimuli responsive methods and tumor micro-environment responsive strategies. This book compiles the most important information on the state-of-the-art therapeutics, including breast cancer biomarkers and design principles of bio-responsive nanosystems. Presented in two parts, sections cover basic and receptor mediated targeting approaches and examine tumor microenvironment mediated approaches. This is a useful book for pharmaceutical scientists and basic and clinical scientists working in the research area of breast cancer and drug discovery both from academics and industry.Worldwide, breast cancer is the most common cancer in women, however, breast cancer therapy is always challenging. This book aims to help researchers remain updated on the most targeted nanomedicine research available. Highlights promising breast cancer targets to help design nanomedicines and stimuli-triggered methods for cancer imaging and treatments Provides in-depth exploration of targeted breast cancer therapy, along with highlights to quickly understand the most important points Explores cutting-edge research in the area of targeted nanomedicine and drug delivery, including nanotheranostics for breast cancer therapy