Nanoplatform Based Molecular Imaging
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Nanoplatform Based Molecular Imaging
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Author : Xiaoyuan Chen
language : en
Publisher: John Wiley & Sons
Release Date : 2011-04-20
Nanoplatform Based Molecular Imaging written by Xiaoyuan Chen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-20 with Technology & Engineering categories.
The cutting-edge guide on advancing the science of molecular imaging using nanoparticles Nanoplathform-Based Molecular Imaging provides rationale for using nanoparticle-based probes for molecular imaging, then discusses general strategies for this underutilized, yet promising, technology. It addresses general strategies of particle synthesis and surface chemistry, applications in computed tomography optical imaging, magnetic resonance imaging, ultrasound, multimodality imaging, theranostics, and finally, the clinical perspectives of nanoimaging. This comprehensive volume summarizes the opinions of those in the forefront of research and describes the latest developments by emphasizing fundamentals and initiating hands-on application.
Targeted Cancer Imaging
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Author : Mehdi Azizi
language : en
Publisher: Academic Press
Release Date : 2021-11-24
Targeted Cancer Imaging written by Mehdi Azizi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-24 with Medical categories.
Targeted Cancer Imaging: Design and Synthesis of Nanoplatforms based on Tumour Biology reviews and categorizes imaging and targeting approaches according to cancer type, highlighting new and safe approaches that involve membrane-coated nanoparticles, tumor cell-derived extracellular vesicles, circulating tumor cells, cell-free DNAs, and cancer stem cells, all with the goal of pointing the way to developing precise targeting and multifunctional nanotechnology-based imaging probes in the future. This book is highly multidisciplinary, bridging the knowledge gap between tumor biology, nanotechnology, and diagnostic imaging, and thus making it suitable for researchers ranging from oncology to bioengineering. Although considerable efforts have been conducted to diagnose, improve and treat cancer in the past few decades, existing therapeutic options are insufficient, as mortality and morbidity rates remain high. One of the best hopes for substantial improvement lies in early detection. Recent advances in nanotechnology are expected to increase our current understanding of tumor biology, allowing nanomaterials to be used for targeting and imaging both in vitro and in vivo experimental models. Gives understanding of cancer biology that is appropriate for students and researchers in engineering and nanotechnology Demonstrates cancer targeting strategies of multifunctional nanotechnology-based imaging probes Shows how to design, synthesize and apply cancer imaging nanostructures
Nanomaterials For Molecular Imaging
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Author : Sixiang Shi
language : en
Publisher:
Release Date : 2016
Nanomaterials For Molecular Imaging written by Sixiang Shi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Molecular imaging, the "visualization, characterization, and measurement of biological processes at the molecular and cellular levels in humans and other living systems", has played an important role in cancer diagnosis. With the advances in nanotechnology, nanomaterials have emerged as a promising candidate for molecular imaging, due to their unique properties. Graphene is one of the most promising nanomaterials, which is intrinsically useful for drug loading and photo therapy of cancer. However, in vivo biodistribution and tumor targeting with graphene nanomaterial is an underexplored area. In this dissertation, we designed a radiolabeled antibody conjugated reduced graphene oxide (RGO) nanoplatform for in vivo positron emission tomography (PET) and tumor vasculature targeting. Excellent tumor uptake was achieved with 64Cu-NOTA-RGO-TRC105, compared to non-targeted RGO conjugate (64Cu-NOTA-RGO). Various experiments were performed, demonstrating that the vasculature targeting is highly specific (Chapter 2). In the following study, graphene oxide (GO), another subtype of graphene nanomaterials, was conjugated with anti-angiogenesis protein vascular endothelial growth factor 121 (VEGF121) to further validate the active targeting and imaging of graphene nanomaterials. Significantly enhanced tumor accumulation (>8 %ID/g) as well as high tumor-to-muscle contrast was achieved, showing great potential for future tumor targeted imaging (Chapter 3). Although traditional chelators are generally utilized in radiolabeling and PET imaging of nanomaterials, a novel chelator-free radiolabeling approach was designed with graphene nanoparticles (Chapter 4). The chelator-free radiolabeled RGO possesses decent labeling efficiency and enhanced in vivo radiostability over NOTA-chelated RGO, making it especially suitable for nanoparticle-based radiolabeling. Bypassing the use of chemical chelator, the intrinsically radiolabeled nanoparticles are able to maintain the native pharmacokinetics, and therefore more accurately reflect the distribution in vivo. Besides graphene, layered double hydroxide (LDH) and molybdenum disulfide (MoS2) nanoparticles were also employed for chelator-free radiolabeling and examined in vivo (Chapter 5 and 6). Excellent tumor uptake and in vivo integrity were observed, further validating the potential of chelator-free labeling in molecular imaging. Taking advantaging of molecular imaging and nanotechnology, a promising multifunctional nanoplatform can be designed for in vivo cancer management. Further efforts are necessary to thoroughly understand the in vivo behavior of nanoparticles and apply them in clinic
Nanomaterial Based Biomedical Applications In Molecular Imaging Diagnostics And Therapy
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Author : Amitabha Acharya
language : en
Publisher: Springer Nature
Release Date : 2020-05-23
Nanomaterial Based Biomedical Applications In Molecular Imaging Diagnostics And Therapy written by Amitabha Acharya and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-23 with Medical categories.
This book comprehensively reviews the recent advances in nanomaterial-based molecular imaging, diagnostics, and personalized therapy. It discusses the novel biocompatible fluorescent nanomaterials, their synthesis, and modern state of art characterization, as well as the various strategies for immobilization of biomacromolecules on the nanomaterial surface and approaches for increasing their stability. In addition, the book describes the synthesis of lectin nanoconjugates using different types of biocompatible raw materials and their systematic characterization. Lastly, it presents our current understanding of the biomolecular carona, which affects nanoparticle-based targeted drug delivery, and examines the conceptual approaches to improve the in-vivo efficacy of targeted drug delivery.
Transferring Biomarker Into Molecular Probe
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Author :
language : en
Publisher:
Release Date : 2014
Transferring Biomarker Into Molecular Probe written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Developing multifunctional and easily prepared nanoplatforms with integrated different modalities is highly challenging for molecular imaging. Here, we report the successful transfer of an important molecular target, melanin, into a novel multimodality imaging nanoplatform. Melanin is abundantly expressed in melanotic melanomas and thus has been actively studied as a target for melanoma imaging. In our work, the multifunctional biopolymer nanoplatform based on ultrasmall (
Nanotechnology Based Approaches For Targeting And Delivery Of Drugs And Genes
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Author : Vijay Mishra
language : en
Publisher: Academic Press
Release Date : 2017-05-23
Nanotechnology Based Approaches For Targeting And Delivery Of Drugs And Genes written by Vijay Mishra and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-23 with Medical categories.
Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes provides an overview of the important aspects of nanomedicine in order to illustrate how to design and develop novel and effective drug delivery systems using nanotechnology. The book is organized into three sections, beginning with an introduction to nanomedicine and its associated issues. Section two discusses the latest technologies in nanomedicine, while the third section covers future developments and challenges in the field. By focusing on the design, synthesis, and application of a variety of nanocarriers in drug and gene delivery, this book provides pharmaceutical and materials science students, professors, clinical researchers, and industry scientists with a valuable resource aimed at tackling the challenges of delivering drugs and genes in a more targeted manner. Explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advances in cutting-edge nanomedical technologies Contains contributions from world-renowned experts and researchers working in the area of nanomedicine and drug delivery Covers the associated challenges and potential solutions to working with nanotechnology in drug delivery Highlights crucial topics, such as biopharmaceutical and toxicity issues, quality by design, drug targeting, and more
Nanotechnology For Biomedical Imaging And Diagnostics
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Author : Mikhail Y. Berezin
language : en
Publisher: John Wiley & Sons
Release Date : 2015-02-02
Nanotechnology For Biomedical Imaging And Diagnostics written by Mikhail Y. Berezin and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-02 with Technology & Engineering categories.
Nanotechnology for Biomedical Imaging and Diagnostics: From Nanoparticle Design to Clinical Applications reflects upon the increasing role of nanomaterials in biological and medical imaging, presenting a thorough description of current research as well as future directions. With contributions from experts in nanotechnology and imaging from academia, industry, and healthcare, this book provides a comprehensive coverage of the field, ranging from the architectural design of nanomaterials to their broad imaging applications in medicine. Grouped into three sections, the book: Elucidates all major aspects of nanotechnology and bioimaging Provides comprehensive coverage of the field, ranging from the architectural design of nanomaterials to their broad imaging applications in medicine Written by well-recognized experts in academia, industry, and healthcare, will be an excellence source of reference With a multidisciplinary approach and a balance of research and diagnostic topics, this book will appeal to students, scientiests, and healthcare professionals alike
Nanobiomedicine
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Author : Shailendra K. Saxena
language : en
Publisher: Springer Nature
Release Date : 2020-02-03
Nanobiomedicine written by Shailendra K. Saxena and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-03 with Medical categories.
This book provides a comprehensive overview of the recent trends in various Nanotechnology-based therapeutics and challenges associated with its development. Nanobiotechnology is an interdisciplinary research that has wide applications in the various fields of biomedical research. The book discusses the various facets of the application of Nanotechnology in drug delivery, clinical diagnostics, Nanomedicine and treatment of infectious and chronic diseases. The book also highlights the recent advancements on important devices and applications that are based on Nanotechnology in medicine and brief the regulatory and ethical issues related to nanomedical devices. It also reviews the toxicological profile of various nanomaterials and emphasizes the need for safe nanomaterials for clinical use. Finally, the book discusses the recent developments of potential commercial applications of Nanotechnology.
Hybrid Organic Inorganic Interfaces
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Author : Marie Helene Delville
language : en
Publisher: John Wiley & Sons
Release Date : 2018-04-09
Hybrid Organic Inorganic Interfaces written by Marie Helene Delville and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-09 with Technology & Engineering categories.
Hybrid organic-inorganic materials and the rational design of their interfaces open up the access to a wide spectrum of functionalities not achievable with traditional concepts of materials science. This innovative class of materials has a major impact in many application domains such as optics, electronics, mechanics, energy storage and conversion, protective coatings, catalysis, sensing and nanomedicine. The properties of these materials do not only depend on the chemical structure, and the mutual interaction between their nano-scale building blocks, but are also strongly influenced by the interfaces they share. This handbook focuses on the most recent investigations concerning the design, control, and dynamics of hybrid organic-inorganic interfaces, covering: (i) characterization methods of interfaces, (ii) innovative computational approaches and simulation of interaction processes, (iii) in-situ studies of dynamic aspects controlling the formation of these interfaces, and (iv) the role of the interface for process optimization, devices, and applications in such areas as optics, electronics, energy and medicine.
Biotechnology Products In Everyday Life
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Author : Menka Khoobchandani
language : en
Publisher: Springer
Release Date : 2018-11-03
Biotechnology Products In Everyday Life written by Menka Khoobchandani and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-03 with Technology & Engineering categories.
This book explores a sampling of the most powerful and enterprising efforts to achieve biotechnological goals by means of various interdisciplinary approaches. From the fabrication of extremely small units to achieve specific objectives through nano-bio-technology, to devices with artificial intelligence, gene therapy for cerebrovascular anomalies, biodegradable plastics, the use of phyto-stem cells in cosmetology, CarT cell immune therapy, targeted therapies for cancer, 3D printed bones developed by the University of Wollongong in Australia, the sickle cell chip developed by IIT Bombay, and innovative sustainable energy solutions, the book includes a colorful spectrum of reviews on current and future biotech products. Gathering contributions by an international team of researchers, this book offers its audience, and particularly younger readers, revealing information on current and upcoming smart technologies.
