Nanosponges
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Nanosponges For Environmental Remediation
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Author : Shikha Gulati
language : en
Publisher: Springer Nature
Release Date : 2023-11-12
Nanosponges For Environmental Remediation written by Shikha Gulati and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-12 with Science categories.
The book covers the chemistry of various nanosponges, as well as the methods for synthesizing them and altering them chemically, as well as their characterization and uses in environmental remediation. Sensors, adaptable materials for oil clean-up in the sea, the removal of dangerous organic and inorganic pollutants from wastewater, the adsorption of various poisonous and greenhouse gases from the air, and more are just a few of the environmental uses for nanosponges. This book aims to provide broad coverage of recent research progress or up-to-date knowledge addressing various aspects in this field. With this book, we aim to provide the readers with the opportunity to learn about different facets of environmental remediation using nanosponges. Thus, this book scrutinizes the state-of-the-art research and discovery in the use of nanosponges in environmental applications, highlighting the scope to which these novel materials have been incorporated by the community. Beyond bestowing a summary of recent research by major groups in the field, the book presents the approaches behind recent developments, providing a long-lasting situation for experienced researchers and novices in the field. This book also emphasizes the challenges with previous signs of progress and way for further research, details relating to the current pioneering technology, and future perspectives with a multidisciplinary approach. Furthermore, it presents up-to-date information on the economics, toxicity, and regulations related to these novel materials. This book is of interest to those in environmental science and applications, particularly graduate students, young faculty, and others exploring nanosponges.
Nanosponges
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Author : Francesco Trotta
language : en
Publisher: John Wiley & Sons
Release Date : 2019-08-05
Nanosponges written by Francesco Trotta and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-05 with Technology & Engineering categories.
An excellent overview of the field, covering in detail a wide range of different types of constituent materials, such as polymers, metals and metal oxides. It discusses their production and synthetic routes, as well as applications in several areas, including catalysis, drug delivery and environmental science. A must-have for scientists in academia and industry, as well as a valuable resource for both newcomers and more established researchers working in the field.
Nanosponges For Advanced Drug Delivery
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Author : Asanka Sajini Yapa
language : en
Publisher:
Release Date : 2017
Nanosponges For Advanced Drug Delivery written by Asanka Sajini Yapa and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
A novel type of supramolecular aggregate, named "nanosponge" was synthesized through the interaction of novel supramolecular building blocks with trigonal geometry. The cholesterol-(K/D)[subscript n]DEVDGC)3-trimaleimide unit consists of a trigonal maleimide linker to which homopeptides (either K or D) of variable lengths (n = 5, 10, 15, 20) and a consensus sequence for executioner caspases (DEVDGC) are added via Michael addition. Upon mixing in aqueous buffer, cholesterol-(K)[subscript n]DEVDGC)3-trimaleimides, as well as a 1:1 mixture of cholesterol-(K/D)[subscript n]DEVDGC)3-trimaleimides form stable nanosponges, whereas cholesterol-(D)[subscript n]DEVDGC)3-trimaleimide is unable to form supramolecular aggregates by itself. The structure of the novel nanosponges was revealed through explicit solvent and then coarse-grained molecular dynamics (MD) simulations. The nanosponges are between 80nm and several micrometers in diameters and virtually non-toxic to monocyte/macrophage-like cells. Furthermore, the structure of novel binary nanosponges consisting of cholesterol-(K/D)[subscript n]DEVDGC)3-trimaleimide units possessing a trigonal maleimide linker, to which either lysine (K)20 or aspartic acid (D)20 are tethered, has been elucidated by means of TEM. A high degree of agreement between these findings and structure predictions through explicit solvent and then coarse-grained molecular dynamics (MD) simulations has been found. Based on the nanosponges' structure and dynamics, caspase-6 mediated release of the model drug 5(6)-carboxyfluorescein has been demonstrated. Moreover, the binary (DK20) nanosponges have been found virtually non-toxic in cultures of neural progenitor cells. Additionally, DK20 nanosponges were taken up efficiently by leucocytes (WBC) in peripheral blood within 3h of exposure. The percentage of live cells among the WBC was not significantly decreased by the DK20 nanosponges. Therefore, this novel material holds great promise for improved cell-mediated therapy. Two different nanosponges loaded with the anticancer agent perillyl alcohol (POH) were developed to test the suitability of nanosponges for cell-based cancer therapy. Drug-loaded nanoshuttles featuring trigonal supramolecular building blocks, type (D-POH)10K20 and (D-POH)10R20 were synthesized, purified, and characterized by Dynamic Light Scattering (DLS) and Atomic Force Microscopy (AFM). They were then tested in cell cultures of murine glioma cells (GL26) and murine neural progenitor cells (NPC). The two nanosponges exhibited significantly different biophysical properties (size distribution and zeta potentials). Consequently, different efficacies in killing GL26 and NPC were observed in both, serum free and serum containing culture media. The results from these experiments confirmed that type (D-POH)10K20 nanosponge is an excellent candidate for the cytotherapy of glioblastoma.
New Applications Of Cyclodextrin Nanosponges
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Author : Pravin K. Shende
language : en
Publisher: LAP Lambert Academic Publishing
Release Date : 2014-01
New Applications Of Cyclodextrin Nanosponges written by Pravin K. Shende and has been published by LAP Lambert Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01 with categories.
Recently nanosponges emerge as one of the promising area in nanotechnology because of their remarkable results in various fields like medicine, agriculture, water purification, etc. Broadly, nanosponges have been prepared from many different organic or inorganic materials by interacting with cross-linker/s and possess characterizing nano or smaller dimensions. This book is highly engaging and focusing on different applications of cyclodextrin nanosponges as drug, insecticide and flame retardant carriers by using different cross-linking agents. New methods invented for the preparation of nanosponges are also incorporated.
Cyclodextrin Nanosponges
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Author : Rekha Rao
language : en
Publisher:
Release Date : 2019
Cyclodextrin Nanosponges written by Rekha Rao and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Electronic books categories.
Nanotechnology showed great promise and impact on administration of therapeutic agents owing to its advantages over contemporary delivery systems. Nanoscale carriers like nanosponges represent a novel category of hyper cross-linked polymer structures with nanosized cavities which can be filled with variety of active moieties (hydrophilic as well as hydrophobic). These nanocarriers can circulate around the body until they found the specific target site and adhere on the surface and release the active moiety in a predictable and controlled manner, resulting in more effective delivery of a given dosage. Nanosponge technology helps to reduce drug associated side effects, improve stability, increase elegance and improve the flexibility of formulations, administered orally, parenterally and topically. Among nanosponges, cyclodextrin-based nanosponges (CDNS) are smart versatile carriers studied widely for drug delivery applications. Statistically, it have presented that approximately 40% of active moieties marketed currently and about 90% of active moieties in their preliminary phase confront problems regarding to solubility. In the past decade, the number of studies describing CDNS has dramatically increased. In the present chapter, scientists working in arena of nanotechnology can get an idea of fabrication, characterization and therapeutic utilities of nanosponges.
Recent Pharmaceutical Developments In The Treatment Of Cancer Using Nanosponges
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Author : Bhupendra Gopalbhai Prajapati
language : en
Publisher:
Release Date : 2020
Recent Pharmaceutical Developments In The Treatment Of Cancer Using Nanosponges written by Bhupendra Gopalbhai Prajapati and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Medical categories.
Nanosponges are a class of nanoparticles characterized by their sponge-like surface that ensures high loading capacity. Cancer causes high mortality and requires precise treatment without harming the body. Hence, nanoparticles are required to target medications to tumor. Nanosponges may be synthesized from various polymers and metals, giving them distinct properties. The majority of polymer synthesis entails crosslinking, while metal synthesis entails the isolation of metal nanoparticles accompanied by their assembly into sponges. Nanosponges must be functionalized to precisely attack tumors. There are several patents on nanosponges synthesis and their use. Future trends in the usage of nanosponges include simultaneous distribution of several molecules and expanding the spectrum of use from medicinal delivery to substance encapsulation for a multitude of applications. As their usage in the pharmaceutical industry grows, more emphasis should be put on toxicity-related aspects induced by the near association of cell membrane and nanosponge resulting in intracellular dissolution or reactive oxygen species (ROS) generation, which in turn damages various cellular components. Many techniques have been created to reduce toxicity, including functionalization with various materials such as antioxidants, polymers and altering nanosponges composition. As the application of nanosponges increases in many industries, the phenomenon related to toxicity must be further explored through research.
Nanosponges
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Author : Francesco Trotta
language : en
Publisher: John Wiley & Sons
Release Date : 2019-01-29
Nanosponges written by Francesco Trotta and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-29 with Technology & Engineering categories.
An excellent overview of the field, covering in detail a wide range of different types of constituent materials, such as polymers, metals and metal oxides. It discusses their production and synthetic routes, as well as applications in several areas, including catalysis, drug delivery and environmental science. A must-have for scientists in academia and industry, as well as a valuable resource for both newcomers and more established researchers working in the field.
Polyester Based Nanosponges As A Delivery Platform For Diverse Therapeutics To Advance The Treatment Of A Broad Range Of Diseases
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Author : Alice E. Van der Ende
language : en
Publisher:
Release Date : 2010
Polyester Based Nanosponges As A Delivery Platform For Diverse Therapeutics To Advance The Treatment Of A Broad Range Of Diseases written by Alice E. Van der Ende and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Drug delivery systems categories.
Biofunctionalization Of Cyclodextrin Nanosponges Using Cholesterol
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Author :
language : en
Publisher:
Release Date : 2018
Biofunctionalization Of Cyclodextrin Nanosponges Using Cholesterol written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Development Of Nanosponges From Erythrocyte Ghosts For Removal Of Streptolysin O And Haemolysin From Mammalian Blood
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Author : Vikesh Nandkishore Chhabria
language : en
Publisher:
Release Date : 2017
Development Of Nanosponges From Erythrocyte Ghosts For Removal Of Streptolysin O And Haemolysin From Mammalian Blood written by Vikesh Nandkishore Chhabria and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.