Nature S Approach Toward Ring Formation And Structural Diversity In Ergot Alkaloid Biosynthesis
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Nature S Approach Toward Ring Formation And Structural Diversity In Ergot Alkaloid Biosynthesis
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Author : Johnathan Zandrew Cheng
language : en
Publisher:
Release Date : 2011
Nature S Approach Toward Ring Formation And Structural Diversity In Ergot Alkaloid Biosynthesis written by Johnathan Zandrew Cheng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Ergot alkaloids are fungal-derived secondary metabolites well known for a diverse array of pharmacological effects both beneficial and detrimental to human health. Historically, the ergot alkaloids have been known to cause ergotism in populations that consume grain contaminated by ergot alkaloid producing fungus. However, naturally isolated and semi-synthetic derivatives of certain ergot alkaloids have also been used to treat migraines, Parkinsonism, and tumor growth. Different fungal species such as Aspergillusfumigatus, Claviceps purpurea, and Neotyphodium lolii produce ergot alkaloids that have distinct structural features yet share a common tetracyclic ergoline ring scaffold. Mechanistic details regarding the formation of the common ergoline ring are not well understood, though the genes encoding the enzymes that carry out these cyclizations are believed to be well conserved across divergent fungal species. Here we describe in vivo gene disruption experiments in Aspergillusfumigatus that allowed us to identify candidate enzymes that were directly involved with the intramolecular cyclization of the ergoline ring. Additionally, we discuss the cloning and heterologous expression of these genes to further characterize their catalytic function. Old Yellow Enzyme homologues from the ergot gene clusters of Aspergillus fumigatus and Neotyphodium loii were shown to catalyze the formation of the D ring of the ergoline skeleton. These enzymes catalyzed either reductase or isomerase type reactions to yield distinct pathway intermediates. Mutational analysis was used to engineer an Old Yellow Enzyme that displayed both reductase and isomerase activities, thereby elucidating the mechanistic basis behind this switch in enzymatic activity. These findings present a mechanistic rationale behind nature's biosynthetic strategy toward ring cyclization and the introduction of structural diversity into the ergot alkaloid class of natural products.
Fungal Metabolites
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Author : Jean-Michel Mérillon
language : en
Publisher:
Release Date :
Fungal Metabolites written by Jean-Michel Mérillon and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with Fungi categories.
Alkaloid Synthesis
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Author : Hans-Joachim Knoelker
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-13
Alkaloid Synthesis written by Hans-Joachim Knoelker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-13 with Science categories.
Lycopodium Alkaloids: Isolation and Asymmetric Synthesis, by Mariko Kitajima and Hiromitsu Takayama.- Synthesis of Morphine Alkaloids and Derivatives, by Uwe Rinner and Tomas Hudlicky.- Indole Prenylation in Alkaloid Synthesis, by Thomas Lindel, Nils Marsch and Santosh Kumar Adla.- Marine Pyrroloiminoquinone Alkaloids, by Yasuyuki Kita and Hiromichi Fujioka.- Synthetic Studies on Amaryllidaceae and Other Terrestrially Derived Alkaloids, by Martin G. Banwell, Nadia Yuqian Gao, Brett D. Schwartz and Lorenzo V. White.- Synthesis of Pyrrole and Carbazole Alkaloids, by Ingmar Bauer and Hans-Joachim Knölker.-
Ergot
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Author : Vladimir Kren
language : en
Publisher: CRC Press
Release Date : 1999-04-08
Ergot written by Vladimir Kren and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04-08 with Health & Fitness categories.
This volume provides readers with biotechnological aspects of ergot alkaloid production and genetic and physiological data. Toxicology and environmental risks of ergot infection and contamination of food and forage are also detailed
Natural Product Biosynthesis
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Author : Christopher T. Walsh
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-04-28
Natural Product Biosynthesis written by Christopher T. Walsh and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-28 with Science categories.
This textbook describes the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era.
Ergot Alkaloids And Related Compounds
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Author : B. Berde
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Ergot Alkaloids And Related Compounds written by B. Berde and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
With contribution by numerous experts
Medicinal Natural Products
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Author : Paul M. Dewick
language : en
Publisher: John Wiley & Sons
Release Date : 2002-01-03
Medicinal Natural Products written by Paul M. Dewick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-01-03 with Medical categories.
This guide covers classes of natural products in medicine, whether derived from plants, micro-organisms or animals. Structured according to biosynthetic pathway, it is written from a chemistry-based approach.
Recent Advances In Natural Products Analysis
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Author : Seyed Mohammad Nabavi
language : en
Publisher: Elsevier
Release Date : 2020-03-07
Recent Advances In Natural Products Analysis written by Seyed Mohammad Nabavi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-07 with Science categories.
Recent Advances in Natural Products Analysis is a thorough guide to the latest analytical methods used for identifying and studying bioactive phytochemicals and other natural products. Chemical compounds, such as flavonoids, alkaloids, carotenoids and saponins are examined, highlighting the many techniques for studying their properties. Each chapter is devoted to a compound category, beginning with the underlying chemical properties of the main components followed by techniques of extraction, purification and fractionation, and then techniques of identification and quantification. Biological activities, possible interactions, levels found in plants, the effects of processing, and current and potential industrial applications are also included. Focuses on the latest analytical techniques used for studying phytochemical and other biological compounds Authored and edited by the top worldwide experts in their field Discusses the current and potential applications and predicts future trends of each compound group
The Chemistry Of Mycotoxins
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Author : Stefan Bräse
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-02-14
The Chemistry Of Mycotoxins written by Stefan Bräse and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-14 with Science categories.
The biological activity of mycotoxins ranges from weak and/or sometimes positive effects, such as antibacterial activity (see penicillin derivatives derived from Penicillium strains) to strong mutagenic (e. g. aflatoxins, patulin), carcinogenic (e. g. aflatoxins), teratogenic, neurotoxic (e. g. ochratoxins), nephrotoxic (e. g. fumonisins, citrinin), hepatotoxic, and immunotoxic (e. g. ochratoxins, diketopiperazines) activity. Nowadays, many laboratories around the world are specialized in the detection of mycotoxins in food products and contaminated material found in housing. In this volume, a focus on the most important classes of mycotoxins is provided and their chemistry of the last ten years is discussed. In each Section, the individual biological impact is outlined. Sections are arranged according to mycotoxin classes (e. g. aflatoxins) and/or structural classes (e. g. resorcinyl lactones, diketopiperazines). The biology of mycotoxins is also described.
Comprehensive Natural Products Iii
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Author :
language : en
Publisher: Elsevier
Release Date : 2020-07-22
Comprehensive Natural Products Iii written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-22 with Science categories.
Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience