Neuronal Cytoskeleton
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The Neuronal Cytoskeleton Motor Proteins And Organelle Trafficking In The Axon
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Author :
language : en
Publisher: Academic Press
Release Date : 2016-01-12
The Neuronal Cytoskeleton Motor Proteins And Organelle Trafficking In The Axon written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-12 with Science categories.
The Neuronal Cytoskeleton, Motor Proteins, and Organelle Trafficking in the Axon, a new volume in the Methods in Cell Biology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in neuronal cells, and includes sections on such topics as actin transport in axons and neurofilament transport. Covers an increasingly appreciated field in cell biology Includes both established and new technologies Contributed by experts in the field
Shaping The Brain By Neuronal Cytoskeleton From Development To Disease And Regeneration
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Author : C. Laura Sayas
language : en
Publisher: Frontiers Media SA
Release Date : 2020-03-25
Shaping The Brain By Neuronal Cytoskeleton From Development To Disease And Regeneration written by C. Laura Sayas and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-25 with categories.
The Neuronal Cytoskeleton
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Author : Robert D. Burgoyne
language : en
Publisher: Wiley-Liss
Release Date : 1991-02-27
The Neuronal Cytoskeleton written by Robert D. Burgoyne and has been published by Wiley-Liss this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-02-27 with Medical categories.
This text examines the organization and structure of cytoskeletal proteins, their regulation and precise roles in neuronal development and function. Using a wide range of techniques including ultrastructural, biochemical and molecular biological approaches, the chapters examine such particular components as microtubule-associated proteins, microtubules and microtubule assembly, actin and related proteins and neurofilaments. Also describes the functional importance of the neuronal cytoskeleton during neuronal development and in axonal transport and neurotransmitter release. Designed to stand alone as self-contained reviews of a particular aspect of the field, the chapters amount to a comprehensive view of the neuronal cytoskeleton and its functions.
Cytoskeleton Of The Nervous System
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Author : Ralph A. Nixon
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-02-04
Cytoskeleton Of The Nervous System written by Ralph A. Nixon and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-04 with Medical categories.
This monograph begins with a general description of the cytoskeleton in axonal development and pathology and then moves to more detailed descriptions of particular components, including microtubules and associated proteins, neurofilaments and interacting proteins, actin and its binding proteins, and glial fibrillary acidic protein. The later chapters focus on the functional significance of the neuronal cytoskeleton in axonal transport and its regulation in health and disease states. The Cytoskeleton of the Nervous System will encourage further development of unifying principles and stimulate new conceptual and technical approaches toward a better understanding of cytoskeleton functions in health and disease.
Neuronal Cytoskeleton
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Author : Hirokawa
language : en
Publisher: CRC Press
Release Date : 1994-01-12
Neuronal Cytoskeleton written by Hirokawa and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-01-12 with Science categories.
This book discusses the primary functions of microtubule-associated proteins (MAPs) such as MAP2 and tau in neuronal morphogenesis, as well as relationships between neuronal differentiation and the expression of neuronal intermediate filaments (nestin, alpha internexin, and neurofilament triplet proteins). It emphasizes the importance of several cytoskeletal proteins for neuronal differentiation and morphogenesis, organelle transport, and synaptic functions. The book considers the involvement of tau MAPs in the formation of paired helical filaments in Alzheimer's disease, and it examines the mechanisms of organelle transports and molecular motors such as kinesin, braindynein, and kinesin superfamily proteins. Cytoskeletal proteins involved in synaptic formation and transmitter release and new synaptic junctional-associated proteins are explored as well.
Nanoneuroscience
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Author : Nancy J. Woolf
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-04
Nanoneuroscience written by Nancy J. Woolf and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-04 with Technology & Engineering categories.
Nanoneuroscience is the study of computationally relevant biomolecules found inside neurons. Because of recent technological advances at the nanometer scale, scientists have at their disposal increasingly better ways to study the brain and the biophysics of its molecules. This book describes how biomolecules contribute to the operations of synapses and perform other computationally relevant functions inside dendrites. These biomolecular operations considerably expand the brain-computer analogy - endowing each neuron with the processing power of a silicon-based multiprocessor. Amazingly, the brain contains hundreds of billions of neurons.
Alterations In The Neuronal Cytoskeleton In Alzheimer Disease
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Author : George Perry
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Alterations In The Neuronal Cytoskeleton In Alzheimer Disease written by George Perry and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The neuronal cytoskeleton is a complex structure responsive to both intrinsic and extrinsic factors. Defined populations of neurons in the brains of patients with Alzheimer and several other neurodegenerative diseases contain abnormal filamentous accumulations which share elements with the cytoskeleton. Although there is a general consensus that these abnormal filaments do contain cytoskeletal elements, much debate remains regarding which cytoskeletal elements are incorporated and whether the cytoskeletal rearrangement is primary or secondary to other cellular changes. In this book these questions are addressed in a historical perspect ive in light of new data that allows the reinterpretation of previously reported results. Contributions are based on many of the major tech niques of modern biology including biochemistry, molecular biology, electron microscopy and immunocytochemistry. In the view of the editor, this volume is being written at a time when our understanding of the cytopathology of Alzheimer disease is moving from predominantly descriptive to both analytical and mechanistic. I hope that this contribution will provide impetus to speed this transi tion. George Perry Cleveland, Ohio vii ACKNOWLEDGEMENT The support of the Fidia Pharmaceutic Corporation for the computer generated color figure on page 65 is gratefully acknowledged.
Cytoskeleton Of The Nervous System
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Author :
language : en
Publisher:
Release Date : 2011-04-11
Cytoskeleton Of The Nervous System written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-11 with categories.
The Interaction Of Maps And Kinesin Motors With The Neuronal Cytoskeleton
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Author : Jawdat Al-Bassam
language : en
Publisher:
Release Date : 2003
The Interaction Of Maps And Kinesin Motors With The Neuronal Cytoskeleton written by Jawdat Al-Bassam and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Biochemistry categories.
The development of neuronal architecture requires the microtubule and f-actin cytoskeleton. In developing neurons, the organization and dynamics of these cytoskeletal polymers are regulated by a diverse group of microtubule and f-actin associated proteins. However, microtubules and f-actin remain essential for the maintenance of neuronal architecture, as they are utilized as tracks by motor proteins for the transport a diverse organelles and macromolecules to and from the axons and dendrites. In this work, we investigate the conformations and biochemical activities of these two general classes of proteins. In chapter I, we show that although MAP2 and tau are unstructured in solution, they bind and fold onto the outer ridges of microtubule protofilaments. The extended MAP2 and tau conformations suggest that they stabilize microtubules by bridging multiple tubulins along protofilaments. Even though MAP2 and tau share homologous microtubule binding domains, we show in chapter II that this region of MAP2, but not the homologous region of tau, bind and bundles f-actin. We show that the MAP2-actin binding interaction is necessary for neurite initiation in cells. Based on this work, we propose that MAP2 may coordinate f-actin with microtubules during the neurite initiation process. In Chapter III, we studied the conformations of Unc104 kinesin; we show that the [alpha]-helices of the Unc104 neck can make two types of interactions: an intramolecular coiled coil in a monomeric motor, or an intermolecular coiled coil in a dimeric motor. Our work suggests the self-folding of the Unc104 neck regulates its dimerization, which is necessary for activation of fast processive motility. In chapter IV, we compared the microtubule binding interactions of Unc104 and conventional kinesin in the weak ADP state. We show that Unc104 and conventional kinesin bind microtubules with different binding modes; the Unc104.ADP binding is primarily mediated by the class conserved K-loop, whereas kinesin.ADP binding is mediated by the motor domain. However, MAP2 acts primarily as a competitive inhibitor of both motors binding to microtubules, in spite of their unique binding modes. A comparison of microtubule bound motor and MAP structures explains these biochemical observations, and suggests that steric hindrance due to the overlap of MAP and motor binding sites is primarily responsible for these inhibition effects. Our work suggests that the binding of MAPs and kinesins to microtubules must be locally regulated to prevent MAPS from interfering with organelle transport mediated by motor proteins. Our work suggests that MAPs and Kinesins utilize different strategies to bind the neuronal cytoskeleton. Furthermore, our work provides a number of examples supporting the notion that the evolution of different MAPs and kinesins has specified their polymer binding modes to their specialized functions in the cell.
Molecular And Cellular Studies Of The Neuronal Cytoskeleton
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Author : Conrad Leung
language : en
Publisher:
Release Date : 1999
Molecular And Cellular Studies Of The Neuronal Cytoskeleton written by Conrad Leung and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.