New Frontiers Of Metabolomics
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New Frontiers Of Metabolomics
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Author : Sergey Tumanov
language : en
Publisher:
Release Date : 2015
New Frontiers Of Metabolomics written by Sergey Tumanov and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Metabolites categories.
Technological achievements in the field of bioanalytical chemistry and bioinformatics have allowed for spearheading of metabolomics towards absolute metabolite quantification in biological systems. In the past decade metabolomics community strongly emphasized importance of quantitative data in biological studies as they describe accurately the absolute level of metabolites of interest. Nevertheless, more than 90% of published metabolomics studies still describe relative or semiquantitative data, whilst only 10% of published metabolomics related articles are based on absolute metabolite quantification. Although, this extremely challenging area is heavily relies on bioinformatics tools, current state of metabolomics combined with available genome sequencing data and other system-wide approaches was found to be a powerful hypothesis generating tool which has been widely employed and demonstrated its uniqueness in modern biology. This PhD thesis represents a metabolomics study which includes a method development for absolute non-targeted quantitation of metabolites followed by application of the developed method for quantitative metabolite profiling of Sauvignon blanc grape juice and wine aiming to better understanding Saccharomyces cerevisiae metabolism involved in volatile thiol biosynthesis during wine fermentation. A novel calibration curve-free GC-MS method based on isotope-coded derivatisation for absolute non-targeted quantitation of metabolites accompanied by novel free R-based software MetabQ is presented. MetabQ was created for automated data processing of generated GC-MS data files performing extraction and calculation of absolute metabolite values. Developed method was validated and applied for analysis of more than 250 Sauvignon blanc grape juice and wine from three vintages as part of Sauvignon blanc II Programme. Generated data sets revealed that trace amounts of unsaturated fatty acids in grape juice had strong effect of on yeast metabolism and on development of aroma compounds, and led to a new series of experiments involving shotgun lipidomics and quantitative fatty acid analysis. The lipidomics study demonstrated that juice lipidome consists of less than 15% of free fatty acids that could be acquired by Saccharomyces cerevisiae, and yet, has a strong effect on yeast metabolism. This insight together with finding from Dr. Pinu’s study resulted in set of juice manipulation experiments in order to validate the hypotheses using laboratory-scale wine fermentations.
Food Metabolomics A New Frontier In Food Analysis And Its Application To Understanding Fermented Foods
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Author : Oluwafemi Ayodeji Adebo
language : en
Publisher:
Release Date : 2017
Food Metabolomics A New Frontier In Food Analysis And Its Application To Understanding Fermented Foods written by Oluwafemi Ayodeji Adebo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Science categories.
The emergence of food metabolomics, otherwise known as foodomics, has opened new frontiers and possibilities for scientists to characterize and simultaneously determine and obtain the comprehensive profile of the food metabolome. Qualitative and quantitative determinations of this metabolome offer insights into the underlying processes involved and details about the content of the food analytes. This had seemed technically challenging and impossible over time, but can now be done due to the advent of sophisticated analytical equipment and chemometric tools. The application of this technique offers enormous opportunities to obtain detailed information that can be correlated to various properties, functionalities and potentials in fermented foods. This chapter thus evaluated and documented studies presented in the literature on the food metabolomics study of fermented foods, with a view of appraising its prospects, applications and subsequent utilization in the study of fermented foods.
Metabolomics
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Author : M. Tomita
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-06-18
Metabolomics written by M. Tomita and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-18 with Science categories.
Metabolism is the sum of the chemical reactions in cells that produce life-sustaining chemical energy and metabolites. In the post-genome era, metabolism has taken on new significance for biological scientists: metabolites are the chemical basis of phenotypes that are final expressions of genomic information. This book covers research on metabolomics, ranging from the development of specialized chemical analytical techniques to the construction of databases and methods for metabolic simulation. The authors have been directly involved in the development of all the subject areas, including capillary electrophoresis, liquid chromatography, mass spectrometry, metabolic databases, and metabolic simulation. Breakthrough achievements and the future of metabolome studies are described, making this book a valuable source for researchers in metabolomics in diverse fields, such as plant, animal, cellular, microbial, pharmaceutical, medical, and genetic sciences.
Metabolomics
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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-07-01
Metabolomics written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-01 with Science categories.
This book is mainly for researchers interested in the new developments and applications of metabolomics. It is also important for physicians using metabolomic approaches in the diagnosis of diseases or treatment, and for postgraduate students starting their research projects on metabolomics. The book is divided into two sections as indicated from its title, namely: new insights into biology and new insights into medicine. It gives examples of the different applications of metabolomics from the production of biosurfactants by marine microorganisms to the applications of data from fecal metabolomics, serum metabolomics, and metabolomics of microbiota, as well as the use of Chinese medicines for cancer treatment. Overall, this is a well-written book, containing some very interesting research avenues and cutting-edge approaches. Finally, the editing of this book was of special interest to me and I hope that readers will also find it stimulating.
Plant Metabolomics In Full Swing
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Author :
language : en
Publisher: Academic Press
Release Date : 2021-01-24
Plant Metabolomics In Full Swing written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-24 with Science categories.
Plant Metabolics, Volume 98, the latest release in the Advances in Botanical Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of intriguing topics, including Developmental metabolomics to decipher and improve fleshy fruit quality, Specialized metabolites in seeds, Untangling plant immune responses through metabolomics, Plant metabolomics to the benefit of crop protection and growth stimulation, Metabolomics in plant-microbe interactions in the roots, A practical guide to implementing metabolomics in plant ecology and biodiversity research, Plant metabolomics and breeding, Plant genome-scale metabolic networks, Metabolite imaging by mass spectrometry: A new discovery tool, MS- and NMR-metabolomic tools for the discrimination of wines: Applications for authenticity Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Botanical Research series Updated release includes the latest information on the Plant Metabolics
Correlation Based Network Analysis Of Cancer Metabolism
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Author : Emily G. Armitage
language : en
Publisher: Springer
Release Date : 2014-05-12
Correlation Based Network Analysis Of Cancer Metabolism written by Emily G. Armitage and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-12 with Science categories.
With the rise of systems biology as an approach in biochemistry research, using high throughput techniques such as mass spectrometry to generate metabolic profiles of cancer metabolism is becoming increasingly popular. There are examples of cancer metabolic profiling studies in the academic literature; however they are often only in journals specific to the metabolomics community. This book will be particularly useful for post-graduate students and post-doctoral researchers using this pioneering technique of network-based correlation analysis. The approach can be adapted to the analysis of any large scale metabolic profiling experiment to answer a range of biological questions in a range of species or for a range of diseases.
Mass Spectrometry Based Metabolomics
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Author : Sastia Prama Putri
language : en
Publisher: CRC Press
Release Date : 2014-11-19
Mass Spectrometry Based Metabolomics written by Sastia Prama Putri and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-19 with Science categories.
Mass Spectrometry-Based Metabolomics: A Practical Guide is a simple, step-by-step reference for profiling metabolites in a target organism. It discusses optimization of sample preparation for urine, serum, blood, tissue, food, and plant and animal cell samples. Encompassing three different technical fields—biology, analytical chemistry, and informatics— mass spectrometry-based metabolomics can be challenging for biologists without special training in quantitative mass spectrometry. This book is designed to overcome this limitation by providing researchers with the knowledge they need to use metabolomics technology in their respective disciplines. The book summarizes all steps in metabolomics research, from experimental design to sample preparation, analytical procedures, and data analysis. Case studies are presented for easy understanding of the metabolomics workflow and its practical applications in different research fields. The book includes an in-house library and built-in software so that those new to the field can begin to analyze real data samples. In addition to being an excellent introductory text, the book also contains the latest advancements in this emerging field and can thus be a useful reference for metabolomics specialists.
Metabolomics In Crop Research Current And Emerging Methodologies
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Author : Marta Sousa Silva
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-18
Metabolomics In Crop Research Current And Emerging Methodologies written by Marta Sousa Silva and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-18 with categories.
The plant metabolome is highly complex, being composed of over 200,000 metabolites. The characterization of these small molecules has been crucial to study plant growth and development as well as their response to environmental changes. The potential of metabolomics in plant research, particularly if applied to crop plants, is also extremely valuable in the discovery of biomarkers and in the improvement of crop yield and quality. This Frontiers Research Topic addresses many applications of metabolomics to crop research, based on different analytical platforms, including mass spectrometry, and nuclear magnetic resonance. It comprises 13 articles from 109 authors that show the importance and the contribution of metabolomics in the analysis of crop’s traceability and genetic variation, in the study of fruit development, and in the understanding of the plant’s response to the environment and to different biotic and abiotic stresses.
Metabolomics In Crop Research Current And Emerging Methodologies
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Author : Marta Sousa Silva
language : en
Publisher:
Release Date : 2019
Metabolomics In Crop Research Current And Emerging Methodologies written by Marta Sousa Silva and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Mass Spectrometry Based Metabolomics In Clinical And Herbal Medicines
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Author : Aihua Zhang
language : en
Publisher: John Wiley & Sons
Release Date : 2021-08-20
Mass Spectrometry Based Metabolomics In Clinical And Herbal Medicines written by Aihua Zhang and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-20 with Science categories.
Highlights the importance and benefit of mass spectrometry-based metabolomics for identifying biomarkers that accurately screen for potential biomarkers of diseases Mass spectrometry-based metabolomics offer new opportunities for biomarker discovery in complex diseases and may provide pathological understanding of diseases beyond traditional technologies. It is the systematic analysis of low-molecular-weight metabolites in biological samples and has been applied to discovering and identifying the perturbed pathways. Currently, mass spectrometry-based metabolomics has become an important tool in clinical research and the diagnosis of human disease. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines comprehensively presents the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics such as metabolites analysis, biomarker discovery, technical challenges, discovery of natural product, mechanism interpretation of action, discovery of active ingredients, clinical application and precision medicine, and enhancing their biomedical value in a real world of biomedicine, shedding light on the potential for spectrometry-based metabolomics. It highlights the value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, especially, to link phytochemical analysis with the assessment of pharmacological effect and therapeutic potential. Each chapter has been laid out with introduction, method, up-to-date literature, identification of biomarker, and applications Covers the current state, challenges, and applications of high-throughput mass spectrometry-based metabolomics in the discovery of biomarker, active ingredients, natural product, etc. Constitutes a unique and indispensable practical guide for any phytochemistry or related laboratory, and provides hands-on description of new techniques Provides a guide for new practitioners of pharmacologists, pharmacological scholars, drug developers, botanist, researchers of traditional medicines. Mass Spectrometry-Based Metabolomics in Clinical and Herbal Medicines provides a landmark of mass spectrometry-based metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all biomedical science fields.