New Methods In Glycoconjugate Syntheses
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New Methods In Glycoconjugate Syntheses
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Author : François D. Tropper
language : en
Publisher:
Release Date : 1992
New Methods In Glycoconjugate Syntheses written by François D. Tropper and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Glycolipids categories.
As a second topic, phase transfer catalysis has been shown to be a very useful glycosylating methodology for the preparation of 1,2-trans-$\beta$-D-glycosides. Mild reaction conditions, using various peracetylated glycosyl halides (chlorides and bromides) as glycosyl donors, including 2-deoxy-, 2-acetamido-2-deoxy sugars and disaccharides, have been developed which allow quick and facile glycosylations of a wide range of nucleophiles. Aromatic alcohols, aryl and alkyl thiols, phenylselenol, carboxylic acids, dibenzyl phosphate, O-ethyl xanthate, azide, thiocyanate, N-hydroxy succinimide, a diimide (Barbital) and enolates have all been successfully glycosylated by a phase transfer catalysis strategy. Glycosylations were shown to be completely stereospecific, and proceed by an S$\sb{\rm N2}$ mechanism with inversion of configuration at the anomeric center. p-Nitro and p-formylphenyl glycosides, prepared by phase transfer catalysed glycosylation of substituted phenols, have been derivatized into useful neoglycoprotein and glycopolymer conjugates.
Glycochemical Synthesis
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Author : Shang-Cheng Hung
language : en
Publisher: John Wiley & Sons
Release Date : 2016-09-12
Glycochemical Synthesis written by Shang-Cheng Hung and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-12 with Science categories.
This book is a comprehensive and concise review on principles, strategies, and crucial advances in glycochemistry. It focuses on synthesis and practical applications and emphasizes state-of-the-art approaches to the assembly and design of sugars. • Provides detailed discussion on specific topics like oligosaccharide assembly and design of sugars, techniques in glycoconjugate preparation, multivalency, and carbohydrate-based drug design • Uses notable examples, like solution-based one-pot methods and automated methods for sugar assembly, to illustrate important concepts and advances in a rapidly emerging field • Discusses practical applications of carbohydrates, like medicine, therapeutics, drug and vaccine development
Recent Trends In Carbohydrate Chemistry
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Author : Amélia Pilar Rauter
language : en
Publisher: Elsevier
Release Date : 2020-05-13
Recent Trends In Carbohydrate Chemistry written by Amélia Pilar Rauter and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-13 with Science categories.
Recent Trends in Carbohydrate Chemistry: Synthesis and Biomedical Applications of Glycans and Glycoconjugates covers biomedically relevant bacterial cell wall carbohydrates including recent findings on biosynthetic aspects, advances in the chemical assembly of bacterial lipopolysaccharide fragments and teichoic acids, and modern NMR approaches to unravel structural details. The first part introduces and provides the relevant background for synthetic glycoconjugate vaccines. The second section focuses on synthetic carbohydrate-based vaccines of therapeutic potential that are licensed or under development. This second volume of Recent Trends in Carbohydrate Chemistry is ideal for researchers working as synthetic organic chemists, as well as those interested in glycoconjugation, protein chemists, immunologists, and microbiologists, in academia as well as in industry. Highlights important features of bacterial glycoproteins Illustrates modern chemical synthesis and structural analysis of bacterial glycans Demonstrates the importance of carbohydrate chemistry for the synthesis of lipopolysaccharides and teichoic acid Covers recent findings on glycan ligation Gives an overview of the most recent developments on carbohydrate-based vaccines
Modern Synthetic Methods In Carbohydrate Chemistry
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Author : Daniel B. Werz
language : en
Publisher: John Wiley & Sons
Release Date : 2013-12-23
Modern Synthetic Methods In Carbohydrate Chemistry written by Daniel B. Werz and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-23 with Science categories.
The fields of glycochemistry and glycoscience are rich and varied and where much can be learned from Nature. As Nature is not always able to produce carbohydrates in quantities useful for not only in research but also as therapeutic agents, new ways need to be found to optimize the yield. This book presents an overview of the latest developments in the field of carbohydrates, ranging from de-novo approaches via cyclodextrin chemistry to the synthesis of such highly complex glycoconjugates as glycosphingolipids and GPI anchors. The main emphasis remains on the synthetic aspects making the book an excellent source of information for those already involved in carbohydrate chemistry, as well as for those organic chemists who are beginners in this field. Equally of interest to synthetic chemists, as well as medicinal chemists and biochemists.
Modern Methods In Carbohydrate Synthesis
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Author : Shaheer H. Khan
language : en
Publisher: CRC Press
Release Date : 2020-08-26
Modern Methods In Carbohydrate Synthesis written by Shaheer H. Khan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-26 with Science categories.
Modern Methods in Carbohydrate Synthesis presents in one volume a sequence of chapters leading from classical methods through to today's newest state-of -the-art technology for oligosaccharide synthesis. It places particular emphasis on the most recent breakthroughs in the field, including emerging technologies for both oligosaccharide and glycoconjugate synthesis. Chapters describing the synthesis of increasingly important glycosidic linkage analogs, as well as the oligosaccharides containing derivatives and analogs of natural sugars are included. While chemical-synthetic methods constitute the major part of the book, completing the volume is a section on the rapidly expanding and important field of enzymatic synthesis, also covering combined chemical and enzymatic synthesis. Chapters are written by leading experts in the field. Wherever possible, methods of synthesis are provided in sufficient detail to allow the reader to implement the techniques described. More than 1700 references are provided in the 21 chapters comprising the book. This volume should provide a wealth of information to a large number of synthetic organic chemists, medicinal chemists, protein chemists, biochemists, glycobiologists and cell biologists, including students in these fields.
Glycoscience
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Author : Joachim Thiem
language : en
Publisher: Springer Science & Business Media
Release Date : 1997
Glycoscience written by Joachim Thiem and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Carbohydrates categories.
Annotation This book presents the state of the art in the synthesis very complex saccharide structures, written by leading scientists at the forefront of this rapidly growing field. Reflecting the particular significance in recent years of efficient and selective procedures employing enzymes for preparative purposes in the carbohydrate field, a major proportion of the articles focus on these biocatalytic methods. In addition, recent strategies for the construction of unusual carbohydrates structures employing novel and creative methodologies are highlighted. Further, particular emphasis is placed on very complex saccharide structures as well as on special solutions to problems that are particularly challenging.
Synthesis And Biological Applications Of Glycoconjugates
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Author : Olivier Renaudet
language : en
Publisher: Bentham Science Publishers
Release Date : 2011
Synthesis And Biological Applications Of Glycoconjugates written by Olivier Renaudet and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Science categories.
The interactions between carbohydrates and proteins have been extensively explored in a wide range of physiological and pathological processes over several decades. The recent emergence of glycomics has strengthened this interest and notably contributed t
Recent Trends In Carbohydrate Chemistry
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Author : Amélia Pilar Rauter
language : en
Publisher: Elsevier
Release Date : 2020-05-13
Recent Trends In Carbohydrate Chemistry written by Amélia Pilar Rauter and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-13 with Science categories.
Carbohydrate chemistry provides access to carbohydrate-based natural products and synthetic molecules as useful biologically active structures relevant to many health care and disease-related biological processes. Recent Trends in Carbohydrate Chemistry: Synthesis, Structure, and Function of Carbohydrates covers green and sustainable reactions, organometallic carbohydrate chemistry, synthesis of glycomimetics, multicomponent reactions, and chemical transformations leading to molecular diversity based on carbohydrates. These include inhibitors of glycogen phosphorylase, which are relevant in controlling type 2 diabetes and sugar sulfates. Polysaccharides, which are commonly modified chemically, are also examined with contributions covering polysaccharide synthesis and modification of polysaccharides to obtain new structures and properties. Recent Trends in Carbohydrate Chemistry: Synthesis, Structure, and Function of Carbohydrates is ideal for researchers working as synthetic organic chemists, and for those interested in biomolecular chemistry, green chemistry, organometallic chemistry, and material chemistry in academia as well as in industry Demonstrates the importance of carbohydrate chemistry as green and sustainable chemistry Details monosaccharide syntheses and transformations toward biologically active small molecular entities Provides the most recent findings on polysaccharide synthesis and bioapplications
Selective Glycosylations
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Author : Clay S. Bennett
language : en
Publisher: John Wiley & Sons
Release Date : 2017-01-19
Selective Glycosylations written by Clay S. Bennett and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-19 with Science categories.
A comprehensive summary of novel approaches to the stereoselective construction of glycosidic linkages, covering modern glycosylation methods and their use and application in natural product synthesis and drug discovery. Clearly divided into five sections, the first describes recent advances in classical methodologies in carbohydrate chemistry, while the second goes on to deal with newer chemistries developed to control selectivity in glycosylation reactions. Section three is devoted to selective glycosylation reactions that rely on the use of catalytic promoters. Section four describes modern approaches for controlling regioselectivity in carbohydrate synthesis. The final section focuses on new developments in the construction of "unusual" sugars and is rounded off by a presentation of modern procedures for the construction of glycosylated natural products. By providing the latest advances in glycosylation as well as information on mechanistic aspects of the reaction, this is an invaluable reference for both specialists and beginners in this booming interdisciplinary field that includes carbohydrate chemistry, organic synthesis, catalysis, and biochemistry.
Glycopolymer Code
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Author : C. Remzi Becer
language : en
Publisher: Royal Society of Chemistry
Release Date : 2015-03-23
Glycopolymer Code written by C. Remzi Becer and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-23 with Science categories.
Glycopolymers are important for cell signalling, recognition pathways, and their role in the immune system. They are gaining attention for new applications in tissue engineering and drug delivery. Glycopolymer Code discusses the preparation, characterization and applications of glycopolymers providing a complete overview of the topic with examples from the latest research. Specific chapters cover both basic and advanced synthesis techniques to prepare glycopolymers, the analytical techniques used to investigate lectin receptor glycopolymer interactions, the properties and types of lectins that are widely used to understand the multivalent interactions and various applications of synthetic glycopolymers. With contributions from leading researchers in the field, the book is a unique source for graduates and academics new to the subject and already working in the area of glycopolymers.