New Technology And Techniques For Needle Based Magnetic Resonance Image Guided Prostate Focal Therapy
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New Technology And Techniques For Needle Based Magnetic Resonance Image Guided Prostate Focal Therapy
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Author : Jeremy J. Cepek
language : en
Publisher:
Release Date : 2013
New Technology And Techniques For Needle Based Magnetic Resonance Image Guided Prostate Focal Therapy written by Jeremy J. Cepek and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
The most common diagnosis of prostate cancer is that of localized disease, and unfortunately the optimal type of treatment for these men is not yet certain. Magnetic resonance image (MRI)-guided focal laser ablation (FLA) therapy is a promising potential treatment option for select men with localized prostate cancer, and may result in fewer side effects than whole-gland therapies, while still achieving oncologic control. The objective of this thesis was to develop methods of accurately guiding needles to the prostate within the bore of a clinical MRI scanner for MRI-guided FLA therapy. To achieve this goal, a mechatronic needle guidance system was developed. The system enables precise targeting of prostate tumours through angulated trajectories and insertion of needles with the patient in the bore of a clinical MRI scanner. After confirming sufficient accuracy in phantoms, and good MRI-compatibility, the system was used to guide needles for MRI-guided FLA therapy in eight patients. Results from this case series demonstrated an improvement in needle guidance time and ease of needle delivery compared to conventional approaches. Methods of more reliable treatment planning were sought, leading to the development of a systematic treatment planning method, and Monte Carlo simulations of needle placement uncertainty. The result was an estimate of the maximum size of focal target that can be confidently ablated using the mechatronic needle guidance system, leading to better guidelines for patient eligibility. These results also quantified the benefit that could be gained with improved techniques for needle guidance.
Image Guided Prostate Cancer Treatments
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Author : Robert L. Bard
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-18
Image Guided Prostate Cancer Treatments written by Robert L. Bard and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-18 with Medical categories.
Image-Guided Prostate Cancer Treatments is a comprehensive reference and practical guide on the technology and application of ultrasound and MRI in the male pelvis, with special attention to the prostate. The book is organized into three main sections, the first of which is devoted to general aspects of imaging and image-guided treatments. The second section provides a systematic overview of the application of ultrasound and MRI to the diagnosis and treatment of diseases of the lower urinary tract. Performance of the ultrasound and MRI studies is explained, and the normal and abnormal pathological anatomy is reviewed. Correlation with the ultrasound in the same plane is provided to assist in understanding the MRI sequences. Biopsy and interventional procedures, ultrasound-MRI fusion techniques, and image-guided therapies, including focused ultrasound, photodynamic therapy, microwave and laser ablation, are all fully covered. The third section focuses on securing treatment effectiveness and the use of follow-up imaging to ensure therapeutic success and detect tumor recurrence at an early stage, which is vital given that prompt focal treatment of recurrence is very successful. Here, particular attention is paid to the role of Doppler ultrasound and DCE-MRI technologies. This book, containing a wealth of high-quality illustrations based on high-end equipment, will acquaint beginners with the basics of prostate ultrasound and MRI, while more advanced practitioners will learn new skills, means of avoiding pitfalls, and ways of effectively relating the imaging and image-guided treatments to the clinical situation. The information provided will permit a tailored approach in dealing with specific pathologic issues.
Imaging And Focal Therapy Of Early Prostate Cancer
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Author : Thomas J. Polascik
language : en
Publisher: Springer
Release Date : 2017-02-22
Imaging And Focal Therapy Of Early Prostate Cancer written by Thomas J. Polascik and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-22 with Medical categories.
This text encompass an up-to-date, comprehensive review of the state-of-the-art for gland preserving therapies. Fully updated and revised, this text evaluates the scientific evidence for the evolving trend to treat intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, is discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on patient selection and outcomes utilizing both advanced imaging techniques and pathologic evaluation. Current and new approaches to image cancer foci within the prostate (multiparametric ultrasonography, multiparametric magnetic resonance image, etc) are presented along with various biopsy techniques, including robotics to map prostate cancer. Patient selection based on imaging and genomic classification, adjuvants to enhance therapy, treatment strategy, outcomes and patient centered concerns is discussed, providing an acceptable balance between cancer control and improved quality of life for patients. Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer, Second Edition is designed as a comprehensive resource for urologists, radiation oncologists, medical oncologists, radiologists, uropathologists, molecular biologists, biomedical engineers, other clinicians –- residents, fellows, nurses and allied professionals -- and researchers with an interest in the diagnosis and novel treatment of prostate cancer. It will provide insight into the latest research and clinical applications of image-guided diagnosis and minimally invasive focal, gland-preserving treatment for prostate cancer.
Computer Assisted Navigation Techniques For Mri Guided Percutaneous Interventions
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Author : Xinzhou Li
language : en
Publisher:
Release Date : 2021
Computer Assisted Navigation Techniques For Mri Guided Percutaneous Interventions written by Xinzhou Li and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
Image-guided minimally invasive percutaneous interventions, including needle-based targeted biopsy and focal therapy, play key roles in cancer diagnosis and treatment. With excellent soft tissue contrast and the absence of ionizing radiation, magnetic resonance imaging (MRI) has become a promising imaging modality for intra-procedural and real-time guidance of percutaneous interventions. However, MRI-guided percutaneous interventions still face two main challenges: limited access to patients inside the scanner and tissue displacement due to physiological motion. MRI-compatible remotely controlled systems for instrument manipulation inside the scanner are being developed to address the first challenge. To address the second challenge, computer-assisted navigation methods using intra-procedural and real-time MRI are being investigated to provide essential information regarding tissue and instrument positions to guide percutaneous interventions. Accurate tissue motion tracking and automatic needle localization techniques are the core components for computer-assisted navigation. Respiratory motion remains the main challenge for procedures in abdominal organs. The tissue target tracking accuracy is negatively impacted by the system latency of the MRI acquisition, reconstruction, and processing pipeline. In addition, passive needle tracking using MR images is challenged by variations of the needle-induced signal void feature in different situations. Discrepancies between the needle feature position on MRI and the underlying physical needle position could increase needle localization errors during procedures. Therefore, this dissertation aims to address these challenges by establishing new computer-assisted navigation techniques for MRI-guided interventions, including prediction of tissue motion due to respiration using fusion-based multi-rate Kalman filtering and deep learning-based needle localization methods. Firstly, this work investigated image-based and surrogate-based motion tracking methods using real-time golden-angle radial MRI to achieve real-time MRI guidance for interventions in organs affected by respiration (e.g., liver). Images with different temporal footprints were reconstructed from the same golden-angle radial MRI data stream to simultaneously enable image-based and surrogate-based tracking at 10 Hz. Phantom experiments confirmed that the median online tracking error of image-based tracking was lower than surrogate-based methods, however, with higher median system latency. This work proposed a new fusion-based respiratory motion prediction framework to combine the lower tracking error of image-based tracking with the lower latency of surrogate-based tracking. The fusion-based method was evaluated in retrospective studies using in vivo real-time free-breathing liver MRI. The motion prediction accuracy of the proposed framework achieved low-latency feedback with improved accuracy compared with image-based and surrogate-based methods. Next, to develop an automatic needle tracking algorithm for MRI-guided interventions, this work adapted the Mask Region Proposal-Based Convolutional Neural Network (R-CNN) to localize the passive needle features on MRI. Mask R-CNN was adapted and trained to segment the needle feature using intra-procedural images from MRI-guided prostate biopsy cases and real-time images from MRI-guided needle insertion in ex vivo tissue. The segmentation masks were passed into a needle feature localization algorithm to extract the needle feature tip location and axis orientation. The proposed algorithm was evaluated on MR images from in vivo intra-procedural prostate biopsy cases and ex vivo real-time MRI experiments with a range of different conditions. It achieved pixel-level tracking accuracy in real time and has the potential to assist MRI-guided percutaneous interventions. Lastly, to overcome in-plane and through-plane discrepancies between the needle feature position on MRI and the underlying physical needle position, this work developed a deep learning-based framework to automatically localize the physical needle position using single-slice and 3- slice MRI. The proposed framework consists of two Mask R-CNN stages. Physics-based simulations were performed to generate single-slice and 3-slice images with needle features from a range of underlying needle positions and MRI parameters to form datasets for training the single-slice and 3-slice physical needle Mask R-CNN models. Using the single-slice model, the proposed physics-driven Mask R-CNN framework achieved sub-millimeter physical needle localization accuracy on single-slice images aligned with the needle. The 3-slice model further reduced the through-plane physical needle localization error in situations where the imaging plane may be misaligned with the needle. Both frameworks can achieve physical needle localization in real time for interventional MRI.
Mathematics And Physics Of Emerging Biomedical Imaging
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Author : Committee on the Mathematics and Physics of Emerging Dynamic Biomedical Imaging
language : en
Publisher: National Academies Press
Release Date : 1996-03-13
Mathematics And Physics Of Emerging Biomedical Imaging written by Committee on the Mathematics and Physics of Emerging Dynamic Biomedical Imaging and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-03-13 with Science categories.
This cross-disciplinary book documents the key research challenges in the mathematical sciences and physics that could enable the economical development of novel biomedical imaging devices. It is hoped that the infusion of new insights from mathematical scientists and physicists will accelerate progress in imaging. Incorporating input from dozens of biomedical researchers who described what they perceived as key open problems of imaging that are amenable to attack by mathematical scientists and physicists, this book introduces the frontiers of biomedical imaging, especially the imaging of dynamic physiological functions, to the educated nonspecialist. Ten imaging modalities are covered, from the well-established (e.g., CAT scanning, MRI) to the more speculative (e.g., electrical and magnetic source imaging). For each modality, mathematics and physics research challenges are identified and a short list of suggested reading offered. Two additional chapters offer visions of the next generation of surgical and interventional techniques and of image processing. A final chapter provides an overview of mathematical issues that cut across the various modalities.
Active Surveillance For Localized Prostate Cancer
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Author : Laurence Klotz
language : en
Publisher: Humana
Release Date : 2018-08-26
Active Surveillance For Localized Prostate Cancer written by Laurence Klotz and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-26 with Medical categories.
This fully updated and revised new edition provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in prostate cancer. The book reviews new data about molecular characteristics of the disease, profiles the new grading system for prostate cancer introduced in 2015, and provides new perspectives about imaging of prostate cancer, as well as the role of targeted biopsies. The text summarizes the role of biomarkers and MRI in patient selection and management and details the world wide results of active surveillance. Specific chapters address communication and ethical issues, QOL outcomes, economic aspects, and psycho-social aspects of surveillance. The role of focal therapy for low risk disease is summarized, and the data supporting preventive interventions during surveillance reviewed. This text will serve as a very useful resource for physicians and researchers dealing with, and interested in this common malignancy, as it provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.
Mri Guided Focused Ultrasound Surgery
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Author : Ferenc A. Jolesz
language : en
Publisher: CRC Press
Release Date : 2007-09-26
Mri Guided Focused Ultrasound Surgery written by Ferenc A. Jolesz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-26 with Medical categories.
MRI-Guided Focused Ultrasound Surgery will be the first publication on this new technology, and will present a variety of current and future clinical applications in tumor ablation treatment. This source helps surgeons and specialists evaluate, analyze, and utilize MRI-guided focused ultrasound surgery - bridging the gap between phase 3 clinical tr
Focal Therapy In Prostate Cancer
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Author : Hashim Uddin Ahmed
language : en
Publisher: John Wiley & Sons
Release Date : 2011-12-27
Focal Therapy In Prostate Cancer written by Hashim Uddin Ahmed and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-27 with Medical categories.
This book comprehensively reviews the potential of focal therapy and discusses why the changing face of prostate cancer warrants a change in the way we treat men with the disease. It deals with the mechanisms by which disease can be localized within the gland and then the different technologies used for focal ablation. Bringing together eminent contributors in one accessible reference, this book introduces focal therapy to all urologists, oncologists, and radiologists who are involved in the treatment of men with prostate cancer.
High Resolution Neuroimaging
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Author : Ahmet Mesrur Halefoğlu
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-03-14
High Resolution Neuroimaging written by Ahmet Mesrur Halefoğlu and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-14 with Medical categories.
Dr. Ahmet Mesrur Halefoğlu mostly deals with research fields in body imaging and neuroradiology with multidetector computed tomography and high-resolution magnetic resonance imaging. He has served as postdoctoral research fellow at Johns Hopkins Hospital. Currently, he is working as an associate professor of radiology in Istanbul, Turkey. He has more than 50 high-impact-factor publications and has written 3 book chapters. He is a member of Turkish Society of Radiology and European Society of Radiology. During the recent years, there have been major breakthroughs in MRI due to developments in scanner technology and pulse sequencing. These important achievements have led to remarkable improvements in neuroimaging and advanced techniques, including diffusion imaging, diffusion tensor imaging, perfusion imaging, magnetic resonance spectroscopy, and functional MRI. These advanced neuroimaging techniques have enabled us to achieve invaluable insights into tissue microstructure, microvasculature, metabolism, and brain connectivity.
Tumor Ablation
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Author : Eric van Sonnenberg
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-09-08
Tumor Ablation written by Eric van Sonnenberg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-08 with Medical categories.
There is an enormous sense of excitement in the communities of cancer research and cancer care as we move into the middle third of the ?rst decade of the 21st century. For the ?rst time,there is a true sense of c- ?dence that the tools provided by the human genome project will enable cancer researchers to crack the code of genomic abnormalities that allow tumor cells to live within the body and provide highly speci?c, virtually non-toxic therapies for the eradication,or at least ?rm control of human cancers. There is also good reason to hope that these same lines of inquiry will yield better tests for screening, early detection, and prev- tion of progression beyond curability. While these developments provide a legitimate basis for much op- mism, many patients will continue to develop cancers and suffer from their debilitating effects, even as research moves ahead. For these in- viduals, it is imperative that the cancer ?eld make the best possible use of the tools available to provide present day cancer patients with the best chances for cure, effective palliation, or, at the very least, relief from symptoms caused by acute intercurrent complications of cancer. A modality that has emerged as a very useful approach to at least some of these goals is tumor ablation by the use of physical or physiochemical approaches.