Non Canonical Autophagy
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Non Canonical Autophagy
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Author : Giulia Petroni
language : en
Publisher: Academic Press
Release Date : 2021-04-21
Non Canonical Autophagy written by Giulia Petroni and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-21 with Science categories.
Non-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between ‘canonical’ and ‘non-canonical’ forms of autophagy, highlighting the discoveries concerning the molecular mechanisms underlying these unconventional forms of autophagy and the advancements in pathophysiological features of ‘non-canonical’ autophagy. The book discusses all forms of ‘non-canonical’ autophagy and the complexity of autophagy-dependent cell death. Readers will gain a better understanding of mechanisms underlying ‘non-canonical’ autophagy so that they can interpret the biological effects of autophagy correctly and identify reliable, novel and effective treatment strategies. Presents the most advanced information surrounding the molecular mechanisms underlying non-canonical autophagy Outlines the increasing evidence regarding the involvement of non-canonical autophagy in multiple physiological and pathological processes Discusses the therapeutic potential of autophagy modulators and the obstacles that have limited their development
A Study On Non Canonical Autophagy Signalling
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Author : Cansu Karabiyik
language : en
Publisher:
Release Date : 2021
A Study On Non Canonical Autophagy Signalling written by Cansu Karabiyik and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
Regulation Of B Cell Responses By Non Canonical Autophagy
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Author : Paula Maldonado Villavicencio
language : en
Publisher:
Release Date : 2019
Regulation Of B Cell Responses By Non Canonical Autophagy written by Paula Maldonado Villavicencio and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Atg8 Regulation And Function In Non Canonical Autophagy
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Author : Katherine Sloan
language : en
Publisher:
Release Date : 2020
Atg8 Regulation And Function In Non Canonical Autophagy written by Katherine Sloan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Canonical And Non Canonical Autophagy Modulation In Human Primary Macrophages And Its Effect On The Adaptive Immune System
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Author : Rebecca Bohn
language : en
Publisher:
Release Date : 2017
Canonical And Non Canonical Autophagy Modulation In Human Primary Macrophages And Its Effect On The Adaptive Immune System written by Rebecca Bohn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Novel Mechanisms Of Atg16l1 Recruitment In Non Canonical Autophagy
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Author : Katherine Anne Fletcher
language : en
Publisher:
Release Date : 2019
Novel Mechanisms Of Atg16l1 Recruitment In Non Canonical Autophagy written by Katherine Anne Fletcher and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
The Non Canonical Role Of Autophagy Components In The Secretion Of Neural Peptide Hormones
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Author :
language : en
Publisher:
Release Date : 2016
The Non Canonical Role Of Autophagy Components In The Secretion Of Neural Peptide Hormones written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Electronic books categories.
The canonical autophagy pathway has primarily been described as a degradative mechanism, which clears the cell of old damaged organelles, protein aggregates and pathogens. Central to the pathway is the de novo formation of a vesicle structure called the autophagosome, which fuses with lysosomes to degrade its content. The Atg8a/MAP1-LC3 protein family is essential for the formation of the autophagosome, and Atg8a mutations result in a variety of defects related to decreased autophagic function. Recently, we have observed a phenotype in Atg8a mutant Drosophila that is consistent with secretory defects of the peptide hormone Bursicon, which is responsible for wing expansion and cuticle hardening upon eclosion. This observation is in accordance with other recent findings which show that components of the autophagy pathway are also involved in the secretion of bioactive molecules. However, the intersection of autophagy and secretory pathways is not yet fully understood. Here, we show that along with Bursicon two additional peptide hormones are differentially secreted and show impaired hemolymph profiles when autophagic function is lowered in the fly nervous system. This includes the release of the pigment dispersing factor (PDF, circadian cycle) and the mesencephalic astrocyte-derived neurotrophic factor (dMANF, stress response), which is highlighted by the aberrant sleep-circadian behaviors (PDF) and trauma-mediated sensitivity (MANF) associated with Atg8a1 mutant flies. Based on the Bursicon wing phenotype, we conducted a secretion-based screen using the GAL4/UAS-dsRNAi knockdown system and identified Atg8a and other autophagy components involved with organelle initiation and membrane expansion that show impaired Bursicon release upon knockdown. Furthermore, this did not include genes involved with selective autophagy (aggrephagy) or endosomal-lysosomal trafficking. Findings from this research will have broad implications toward understanding complex secretory defects and the intersection of autophagy with other vesicle trafficking pathways.
Non Canonical Functions On The Essential Autophagy Protein Atg5 In Antigen Processing And Presentation
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Author : Christian Wolfgang Keller
language : en
Publisher:
Release Date : 2017
Non Canonical Functions On The Essential Autophagy Protein Atg5 In Antigen Processing And Presentation written by Christian Wolfgang Keller and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Canonical And Non Canonical Roles Of Macroautophagy Proteins In Synaptic Plasticity And Neuronal Physiology
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Author : Akrivi Dimitra Daskalaki
language : en
Publisher:
Release Date : 2023
Canonical And Non Canonical Roles Of Macroautophagy Proteins In Synaptic Plasticity And Neuronal Physiology written by Akrivi Dimitra Daskalaki and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
Thèse. Biologie. Médecine. 2023
Autophagy
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Author : Sunaina Singh
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-09-03
Autophagy written by Sunaina Singh and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-03 with Medical categories.
Various proteins are now known to be transported to the cell surface or are secreted independently of the canonical ER–Golgi pathway. Some examples of such cargoes that are transported in the vesicular mode are acyl-CoA binding protein, cystic fibrosis transmembrane conductance regulator (CFTR), and some of the interleukins. For this form of conserved mechanism of unconventional secretion, there is an emerging role for autophagy and the Golgi-associated protein GRASP. Biogenesis of such unconventional vesicles, as shown in a recent study in yeast, occurs at unique regions near ER exit sites known as CUPS (compartments for unconventional protein secretion). CUPS are devoid of Golgi or endosomal proteins but harbor GRASP, proteins implicated in autophagy and the ESCRT process. However, the molecular details regarding the nature of these vesicles and what sets them apart from a typical autophagosomal fate have not been elucidated. Future work should reveal additional components that impart cargo and destination selectivity to these vesicles, and identify critical modulators of this understated unconventional secretory pathway.