Novel Immunologic Adjuvants
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Novel Immunologic Adjuvants
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Author : Rino Rappuoli
language : en
Publisher: Future Medicine Ltd
Release Date : 2011
Novel Immunologic Adjuvants written by Rino Rappuoli and has been published by Future Medicine Ltd this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Immune response categories.
The study of adjuvants substances added to vaccine formulations to increase efficacy is one of the fastest growing disciplines in immunology and vaccine development. This book reviews the state-of-the-art of development of novel adjuvants and the science that supports them. There is an increasing need of novel adjuvants for preventive vaccines targeting infectious diseases for which conventional formulations have failed. New adjuvants are also needed to improve existing vaccines in the elderly, infants and chronically infected individuals that mount a suboptimal immune response. In addition, adjuvants could be very useful for the development of effective therapeutic vaccines against chronic infections and cancer. In this context, the book provides an overview of vaccine adjuvants with a special focus on their composition and mechanism of action.
Novel Immunologic Adjuvants
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Author :
language : en
Publisher:
Release Date : 2011
Novel Immunologic Adjuvants written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Immunomic Discovery Of Adjuvants And Candidate Subunit Vaccines
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Author : Darren R. Flower
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-09
Immunomic Discovery Of Adjuvants And Candidate Subunit Vaccines written by Darren R. Flower and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-09 with Medical categories.
This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.
Immunologic Adjuvant Research
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Author : Antonio Benvenuto
language : en
Publisher: Nova Biomedical Books
Release Date : 2009
Immunologic Adjuvant Research written by Antonio Benvenuto and has been published by Nova Biomedical Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Immunological adjuvants categories.
In immunology, an adjuvant refers to any agent that stimulates the immune system and thus, increases the response to a vaccine. Optimal conditions for effective processing of the antigen are provided by the appropriate adjuvants. This book discusses the role of such immunologic adjuvants in diseases such as cancer, their clinical use and their potential future applications. Cancer is often associated with an increasingly impaired immune response against a tumour. Escape mechanisms of the tumour affect the ability of the immune system to build up an effective response against the growing tumour. The roles of such adjuvants in cancer vaccinations are described. Toll like receptors (TLRs) are part of the innate immune system. They are considered as major targets for the development of agonists that could serve as adjuvants and agents of immunotherapy. The development of TLR agonists for clinical use are discussed as well. CpG-ODN (oligodeoxynucleotide) is described as well as how it could be effective as an adjuvant for humoral and cellular immunities. Additionally, a transcutaneous vaccination as an effective approach for the development of tumour vaccines is explained. The development of effective vaccines for malaria, tuberculosis and HIV represents one of the most important scientific public health challenges of our time. Novel concepts in malaria proteins are examined as well as recent advances in the design of synthetic vaccine candidates and antigen delivery systems based on immuno-potentiating reconstituted influenza virosomes. The majority of vaccines presently under investigation represents highly pure recombinant proteins or subunits of pathogens and hence lacks most of the features of the original pathogens. Thus, the development of safe and potent immunologic adjuvants that can enhance and direct vaccine-specific immunity is urgently needed. Aluminium hydroxide (alum) is currently the only vaccine adjuvant approved for human use world-wide. Thus, recent developments in immunology are examined as well as Toll-like receptors and other innate immune receptors. Finally, interleukin-6 plays a crucial role in CFA-augmented immune reactions. Studies that shed light on the involvement of interleukin-6 in the augmentation of immune response by immunologic adjuvants are thus explained.
Vaccine Adjuvants And Delivery Systems
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Author : Manmohan Singh
language : en
Publisher: John Wiley & Sons
Release Date : 2007-08-03
Vaccine Adjuvants And Delivery Systems written by Manmohan Singh and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-03 with Science categories.
The authoritative reference on recent developments in vaccinology New technologies, including recombinant protein and DNA, have sparked phenomenal progress in vaccine development and delivery systems. This unique resource brings scientists up to date on recent advances and provides the information they need to select candidate adjuvants. With chapters written by leading experts in their fields, Vaccine Adjuvants and Delivery Systems: * Provides a comprehensive overview of the rapidly evolving field and developing formulation methods * Covers cutting-edge technologies and gives the current status of adjuvants in clinical trials and those still in the pre-clinical stage * Includes detailed information on specific vaccine adjuvants, including MF59, TLR4 agonists, new iscoms, cytokines, polyphosphazenes, and more * Provides a historical perspective on the development of vaccine adjuvants and discusses the mechanisms of adjuvant actions * Covers some novel adjuvants and delivery systems and the safety evaluation of adjuvants A great reference for researchers, scientists, and students in vaccinology, biotechnology, immunology, and molecular biology, this resource is also valuable for researchers and scientists in veterinary medicine who work to prevent diseases in animals.
Immunopotentiators In Modern Vaccines
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Author : Virgil Schijns
language : en
Publisher: Academic Press
Release Date : 2016-11-02
Immunopotentiators In Modern Vaccines written by Virgil Schijns and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-02 with Medical categories.
Immunopotentiators in Modern Vaccines, Second Edition, provides in-depth insights and overviews of the most successful adjuvants, those that have been included in licensed products, also covering the most promising technologies that have emerged in recent years. In contrast to existing books on the subject, the chapters here provide summaries of key data on the mechanisms of action of the individual vaccine adjuvants. In addition, the book covers key aspects of how the technologies might be further developed and what might be their limitations, while also giving an overview of what made the most advanced adjuvant technologies successful. Provides contributions from leading international authorities in the field Features immunopotentiators classified by function, with well-illustrated, informative figures presenting the interaction between the immunopotentiators and the host immune system Lists advantages and potential hurdles for achieving a practical application for each specific immunopotentiator Offers US FDA perspectives which highlight how future adjuvants will be approved for new generation vaccines
Novel Immune Potentiators And Delivery Technologies For Next Generation Vaccines
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Author : Manmohan Singh
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-03
Novel Immune Potentiators And Delivery Technologies For Next Generation Vaccines written by Manmohan Singh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-03 with Medical categories.
Development of new-generation vaccines is now more challenging than ever, as identifying, purifying and evaluating vaccine antigens is a complex undertaking. Most importantly, once the relevant antigens have been identified, key focus then shifts to the development of suitable delivery systems and formulations to achieve maximum in vivo potency with minimum potential side effects. These novel formulations—many of which will be nanoparticulates—can deliver the antigens to the desired site, to the relevant antigen presenting cells, and prevent systemic exposure of the immune potentiators. The proposed book will outline all the critical steps that need to be considered for successful development of various types of nanoparticulate delivery systems for vaccine antigens. These contributions from leading experts in the area of vaccine formulation and delivery systems will tie in what is the most current status, including clinical evaluations with these novel vaccine technologies.
Vaccine Adjuvants
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Author : Gwyn Davies
language : en
Publisher: Humana
Release Date : 2016-08-23
Vaccine Adjuvants written by Gwyn Davies and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Medical categories.
Spanning from discoveries in fundamental immunology to industrial and commercial concerns, the study of vaccine adjuvants has developed into an exciting area of work with great, vital potential in innovating techniques in which adjuvants may steer the immune system towards the responses required by unmet vaccination needs. In Vaccine Adjuvants: Methods and Protocols, expert researchers in the field provide clear and concise guidance on how to go about assessing the activity of adjuvant products. Rather than describing individual adjuvants, the volume strives to include detailed, practical information on measuring the responses produced by adjuvants in order to be relevant to the widest array of experiments. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and versatile, Vaccine Adjuvants: Methods and Protocols will enable those already pursuing vaccine adjuvant research, while also serving to stimulate discussion on how to best standardize adjuvant testing in order to facilitate meaningful comparisons, and above all, to aid in the prediction of which new products will most effectively and safely help to solve the current challenges in vaccination.
Vaccine Adjuvants
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Author : Charles J. Hackett
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-05
Vaccine Adjuvants written by Charles J. Hackett and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-05 with Medical categories.
A cutting-edge review of the major research areas of adjuvant discovery, design, development, and use. The authors lay down a rational basis for vaccine adjuvant function and analyze a number of significantly distinct adjuvant-active molecules to illuminate the principles of their function and use. The focus is on specific receptor-ligand interactions, including the molecular features needed for a compound to possess adjuvant activity. The critical interface zone between the innate and adaptive immune systems is also analyzed to show how adjuvants exert their effects on T- and B-cell activation. Additional chapters address the possibility of tailoring adjuvants to yield optimally safe and effective responses.
Vaccine Design
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Author : Michael F. Powell
language : en
Publisher: Springer
Release Date : 2012-12-06
Vaccine Design written by Michael F. Powell and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
When my interest was first drawn to the phenomenon of vaccination for virus diseases in the late 1930s, the state of the art and the science of vaccine design was not far advanced beyond the time of Jenner at the end of the 18th century and of Pasteur a century later. In the 1930s it was still believed that for the induction of immunity to a virus-caused disease the experience of infection was required, but not for a toxin-caused disease such as diphtheria or tetanus, for which a chemically detoxified antigen was effective for immu nization. This prompted the question as to whether it might be possible to produce a similar effect for virus diseases using nonreplicating antigens. When in the 1930s and 1940s it was found possible to propagate influenza viruses in the chick embryo, protective effects could be induced without the need to experience infection by the use of a sufficient dose of a noninfectious influenza virus preparation. Later in the 1940s, it became possible to propagate polio and other viruses in cultures of human and monkey tissue and to immunize against other virus diseases in the same way. Later, with the advent of the era of molecular biology and genetic engineering, antigens and vaccines could be produced in new and creative ways, using either replicating or nonreplicating forms of the appropriate antigens for inducing a dose-related protective state.
