Novel Strategies For The Identification And Characterization Of Selective Estrogen Receptor Modulators Serms
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Novel Strategies For The Identification And Characterization Of Selective Estrogen Receptor Modulators Serms
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Author :
language : en
Publisher:
Release Date : 2004
Novel Strategies For The Identification And Characterization Of Selective Estrogen Receptor Modulators Serms written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Estrogens promote growth of breast and endometrial cancers. Selective estrogen receptor modulators (SERMs) block the activity of estrogen in selective tissues and control the growth of these cancers while avoiding many unwanted side effects associated with the use of antiestrogens. The goal of our work is to identify mechanisms regulating the activity of SERMs and to develop strategies for the identification of novel SERMs. SERMs exert their activities by binding to the two estrogen receptors, ERalpha and ERbeta. while the characterization of ligand-bound ERs by X-ray crystallography gave many insights into ligand binding, they do not provide a coherent explanation for the tissue- and receptor isotype-specific activities displayed by many ligands. Our results indicate that the F-domain, a C-terminal extension of the ligand binding domain (LED) regulates ligand and coregulator binding in a receptor-specific manner. Moreover, SERMs might differ from pure agonists or antagonists in terms of the dynamics rather than the nature of the ligand-induced structural changes. We have constructed a series of fluorescent ER LED derivatives that will not only give novel insights into the actions of SERMs but also provide a powerful strategy for the identification of novel SERMs for breast cancer therapy.
Estrogen Receptor And Breast Cancer
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Author : Xiaoting Zhang
language : en
Publisher: Humana Press
Release Date : 2019-11-08
Estrogen Receptor And Breast Cancer written by Xiaoting Zhang and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-08 with categories.
The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.
Cancer Drug Resistance
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Author : Beverly A. Teicher
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-09
Cancer Drug Resistance written by Beverly A. Teicher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-09 with Medical categories.
Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.
Estrogen Receptors In Human Breast Cancer
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Author : William L. McGuire
language : en
Publisher:
Release Date : 1975
Estrogen Receptors In Human Breast Cancer written by William L. McGuire and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with Medical categories.
Chemoresistance And Metastasis In Breast Cancer Molecular Mechanisms And Novel Clinical Strategies
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Author : Qifeng Yang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-18
Chemoresistance And Metastasis In Breast Cancer Molecular Mechanisms And Novel Clinical Strategies written by Qifeng Yang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-18 with Medical categories.
Index Medicus
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Author :
language : en
Publisher:
Release Date : 2004
Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medicine categories.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1999
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medicine categories.
Women S Health Research
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2010-10-27
Women S Health Research written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-27 with Medical categories.
Even though slightly over half of the U.S. population is female, medical research historically has neglected the health needs of women. However, over the past two decades, there have been major changes in government support of women's health research-in policies, regulations, and the organization of research efforts. To assess the impact of these changes, Congress directed the Department of Health and Human Services (HHS) to ask the IOM to examine what has been learned from that research and how well it has been put into practice as well as communicated to both providers and women. Women's Health Research finds that women's health research has contributed to significant progress over the past 20 years in lessening the burden of disease and reducing deaths from some conditions, while other conditions have seen only moderate change or even little or no change. Gaps remain, both in research areas and in the application of results to benefit women in general and across multiple population groups. Given the many and significant roles women play in our society, maintaining support for women's health research and enhancing its impact are not only in the interest of women, they are in the interest of us all.
How Tobacco Smoke Causes Disease
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Author :
language : en
Publisher:
Release Date : 2010
How Tobacco Smoke Causes Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Government publications categories.
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Endocrine Therapy In Breast Cancer
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Author : William R. Miller
language : en
Publisher: CRC Press
Release Date : 2002-03-08
Endocrine Therapy In Breast Cancer written by William R. Miller and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-03-08 with Medical categories.
This reference evaluates and describes the latest strategies for hormone suppression and blockade in the management of early and advanced stage breast cancer and explores the effects of tamoxifen, selective estrogen receptor modulators (SERMs), aromatase inhibitors, and their combination on both breast cancers and normal tissues. Endocrine T