Novel Uses Of Isotope Effects To Elucidate Enzyme Reaction Mechanisms
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Novel Uses Of Isotope Effects To Elucidate Enzyme Reaction Mechanisms
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Author : Jeffrey D. Hermes
language : en
Publisher:
Release Date : 1983
Novel Uses Of Isotope Effects To Elucidate Enzyme Reaction Mechanisms written by Jeffrey D. Hermes and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Enzymes categories.
Enzyme Mechanism From Isotope Effects
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Author : Paul F. Cook
language : en
Publisher: CRC Press
Release Date : 1991-09-20
Enzyme Mechanism From Isotope Effects written by Paul F. Cook and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-09-20 with Medical categories.
Isotope effects have become one of the most powerful tools available to the enzymologist for probing enzymic mechanisms. Enzyme Mechanism from Isotope Effects presents the basic theory underlying isotope effects, including the latest findings on proton tunneling and coupled atomic notions. Specific theoretical applications are emphasized in regard to the types of information that can be obtained using isotope effects. The book also examines recent theoretical treatments of the product dependence of deuterium isotope effects, multiple isotope effects and isotope effects on intermediate partitioning. Other topics include a complete discussion of methods for measuring isotope effects, including a detailed description of the use of the isotope ratio mass spectrometer to obtain isotope effects, and a review of the literature regarding mechanistic information obtained from isotope effects for individual classes of enzyme-catalyzed reactions. Enzyme Mechanism from Isotope Effects is an excellent reference source for investigators using isotope effects in their research. The book is also valuable for reference libraries and instructors teaching courses in enzyme mechanism.
Isotope Effects In Chemistry And Biology
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Author : Amnon Kohen
language : en
Publisher: CRC Press
Release Date : 2005-11-01
Isotope Effects In Chemistry And Biology written by Amnon Kohen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-01 with Medical categories.
The field of isotope effects has expanded exponentially in the last decade, and researchers are finding isotopes increasingly useful in their studies. Bringing literature on the subject up to date, Isotope Effects in Chemistry and Biology covers current principles, methods, and a broad range of applications of isotope effects in the physical, biolo
Determination Of Isotope Effects To Elucidate Enzyme Mechanisms
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Author : John Sears Blanchard
language : en
Publisher:
Release Date : 1979
Determination Of Isotope Effects To Elucidate Enzyme Mechanisms written by John Sears Blanchard and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Enzymes categories.
The Use Of Isotope Effects As A Probe Of Enzyme Reaction Mechanisms
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Author : Paul Martin Karl Weiss
language : en
Publisher:
Release Date : 1987
The Use Of Isotope Effects As A Probe Of Enzyme Reaction Mechanisms written by Paul Martin Karl Weiss and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with categories.
Measurement And Analysis Of Kinetic Isotope Effects
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Author :
language : en
Publisher: Academic Press
Release Date : 2017-09-12
Measurement And Analysis Of Kinetic Isotope Effects written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-12 with Medical categories.
Experimental Analysis of Enzyme Mechanism Using Isotope Effects, Volume 596, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this comprehensive update include Measurement of enzyme binding isotope effects, Chemical ligation and isotope labeling to locate dynamic effects, Measurement of heavy enzyme isotope effects, Extracting kinetic isotope effects from a global analysis of reaction progress curves, KIE of metabolic flux and enzymes, Solvent and Primary KIE on Flavin Enzymes, and The Rapid Determination of Primary Deuterium Isotope Effects on Enzyme-Catalyzed Proton Transfer at Carbon in 50/50 HOH/DOD. Readers who are interested in applying or understanding this research will find useful methods currently used for measuring isotope effects on solution and enzyme reactions. Written by pioneers of modern isotope effect research Is the only collection of modern kinetic isotope effect methods currently available
The Elucidation Of Mechanism And Transition State Structure For Enzyme And Non Enzyme Catalyzed Reactions With The Aid Of Novel Methods For The Measurement Of Oxygen 18 Isotope Effects
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Author : Steven Rosenberg
language : en
Publisher:
Release Date : 1978
The Elucidation Of Mechanism And Transition State Structure For Enzyme And Non Enzyme Catalyzed Reactions With The Aid Of Novel Methods For The Measurement Of Oxygen 18 Isotope Effects written by Steven Rosenberg and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with categories.
Use Of Isotope Effects To Determine Enzymatic And Nonenzymatic Mechanisms
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Author : Mark Alan Rishavy
language : en
Publisher:
Release Date : 2000
Use Of Isotope Effects To Determine Enzymatic And Nonenzymatic Mechanisms written by Mark Alan Rishavy and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.
Isotope Effects On Enzyme Catalyzed Reactions
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Author : William Wallace Cleland
language : en
Publisher:
Release Date : 1977
Isotope Effects On Enzyme Catalyzed Reactions written by William Wallace Cleland and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Science categories.
Application Of Kinetic Isotope Effects And Theoretical Calculations To The Study Of Interesting Reaction Mechanisms
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Author : Jennifer Sue Hirschi
language : en
Publisher:
Release Date : 2010
Application Of Kinetic Isotope Effects And Theoretical Calculations To The Study Of Interesting Reaction Mechanisms written by Jennifer Sue Hirschi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
A variety of biological and organic reaction mechanisms are studied using powerful tools from experimental and theoretical chemistry. These tools include the precise measurement of kinetic isotope effects (KIEs) and the use of theoretical calculations to predict KIEs as well as determine factors that contribute to reaction acceleration and selectivity. Theoretical analysis of the Swain-Schaad relationship involves the prediction of a large number of isotope effects and establishes the semiclassical boundaries of the relationship. Studies on the mechanism of oxidosqualene cyclase involve the determination of a large number of precise KIEs simultaneously. Transition state models for the Sharpless asymmetric epoxidation have been developed that explain the versatility, high selectivities, and ligand accelerated catalysis of the reaction. Theoretical predictions on the proposed enzymatic mechanism of flavin dependent amine oxidation suggest a hydride transfer mechanism and rules out mechanisms involving covalent intermediates. Finally, a theoretical analysis of Diels-Alder reactions successfully describes the unexpected exo selectivity in some of these reactions.