Nuclear Receptors As Drug Targets
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Nuclear Receptors As Drug Targets
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Author : Eckhard Ottow
language : en
Publisher: John Wiley & Sons
Release Date : 2008-09-08
Nuclear Receptors As Drug Targets written by Eckhard Ottow and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-08 with Medical categories.
Edited by two experts working at the pioneering pharmaceutical company and major global player in hormone-derived drugs, this handbook and reference systematically treats the drug development aspects of all human nuclear receptors, including recently characterized receptors such as PPAR, FXR and LXR. Authors from leading pharmaceutical companies around the world present examples and real-life data from their own work.
Taloudellisesti Oikeista Poistoista Ja Verotuksen Suhteesta Niihin
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Author :
language : en
Publisher:
Release Date : 1927
Taloudellisesti Oikeista Poistoista Ja Verotuksen Suhteesta Niihin written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1927 with categories.
Nuclear Receptors
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Author : European Molecular Biology Organization
language : en
Publisher:
Release Date : 2010
Nuclear Receptors written by European Molecular Biology Organization and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Nuclear Hormone Receptors As Drug Targets
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Author :
language : en
Publisher:
Release Date : 2003
Nuclear Hormone Receptors As Drug Targets written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Drug targeting categories.
This program specifically deals with: - the location of hormone receptors within the cell taking both glucocorticoids and oestrogens as examples - the biological effects of oestrogens - the speed of response following receptor activation - the detailed structure of the receptors and how interaction takes place with the ligand including the involvement of HSP90 and the "zinc fingers"--The nature of drug receptor binding - facilitation of gene transcription - the uses of the agonists and antagonists at the oestrogen receptor There is a short MCQ section which students can use to test themselves on the information and understanding they have acquired.
Computational Approaches To Nuclear Receptors
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Author : Pietro Cozzini
language : en
Publisher: Royal Society of Chemistry
Release Date : 2012
Computational Approaches To Nuclear Receptors written by Pietro Cozzini and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
Nuclear receptors (NR) are ligand-induced activated transcription factors that are involved in numerous biological processes. Since the 1990's when the first structures were determined by means of X ray diffraction, the number of NR structures has increased considerably. Moreover several "omics" projects (genomics, pharmcogenomics and proteomics) have opened up great opportunities for the discovery of new targets, the characterization of abnormal protein patterns, the selection of "tailored" drugs and the evaluation of drug efficacy even with a lack of structural data. Furthermore, structure-based drug design, computational methods for in silico screening and nanobiotechnology- based tools are simplifying this time-consuming and money-intensive research of lead compounds and, possibly, new drugs. Biological interactions such as those that occur between a protein and ligand are concerted events where flexible molecules interact. Thus understanding flexibility of large molecules or biological complexes is of primary importance to help define the right model to approximate the reality for drug discovery, virtual screening, food safety analysis, etc. NRs are known as flexible targets, with many structural similarities, in particular for their Ligand Binding Domain: these similarities could be assumed to share behavioural qualities that belong to this class of compounds. Thus to supply a possible, complete and exhaustive answer to questions about the behaviour of NRs, their interactions with new potential drugs, endocrine disruptors such as animal and human food toxins, food additives or industry residuals, it is mandatory to approach the problem from a different point of view: a molecular modelling approach, steered synthesis, and in vitro and in vivo tests, etc. The aim of this book is to provide a state of the art review on investigations into Nuclear Receptors.
Selective Interactions Of Nuclear Receptors And Cofactors
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Author : Joel Fulton
language : en
Publisher:
Release Date : 2012
Selective Interactions Of Nuclear Receptors And Cofactors written by Joel Fulton and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Nuclear Receptors As Molecular Targets For Cardiometabolic And Central Nervous System Diseases
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Author : J.L. Junien
language : en
Publisher: IOS Press
Release Date : 2008-07-16
Nuclear Receptors As Molecular Targets For Cardiometabolic And Central Nervous System Diseases written by J.L. Junien and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-07-16 with Medical categories.
Nuclear receptors are a family of transcription factors consisting of 49 members identified in the human genome. Nuclear receptors regulate transcription by binding to response elements in the regulatory regions of target genes and thereby affect expression of genes involved in differentiation, growth, lipid homeostasis, inflammation and immunity. Over the past two decades significant advances have been made in the understanding of the regulation of gene expression by nuclear receptors. The knowledge on nuclear receptors has delivered novel therapies for lipid control and hormone replacement, and for management of cancer and diabetes. Therefore, nuclear receptors are attractive molecular targets for design of therapy for diabetes, obesity, atherosclerosis, cancer, inflammation and neurodegeneration. The focus of this volume is centered on the mechanistic involvement of nuclear receptors in cardiological, metabolic and neurological disorders, on possible explanation of pathways involved in pathogenesis, on susceptibility to and prevention of metabolic and neurological disorders and on the aspects of drug finding including chemistry and rational drug design. This volume reviews recent progress on nuclear receptors critically and will intrigue those pursuing interest in physiology, pathology and medicine.
Orphan Nuclear Receptors
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Author : Allan B. Haberman
language : en
Publisher:
Release Date : 2002
Orphan Nuclear Receptors written by Allan B. Haberman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
Nuclear Receptors In Drug Metabolism
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Author : Wen Xie
language : en
Publisher: John Wiley & Sons
Release Date : 2008-11-03
Nuclear Receptors In Drug Metabolism written by Wen Xie and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-03 with Science categories.
This book gives you an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development and equips you with the interdisciplinary understanding of these receptors and how they can be regulated. Pharmaceutical researchers will find this extremely useful in developing drugs for cancer, heart disease, and diabetes treatment. This comprehensive resource collects scattered materials into one handy, informative volume.
Therapeutic Targets
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Author : Luis M. Botana
language : en
Publisher: John Wiley & Sons
Release Date : 2012-04-20
Therapeutic Targets written by Luis M. Botana and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-20 with Medical categories.
The Latest Applications For Cellmechanism Research in Drug Discovery Designed to connect research on cell mechanisms with the drug discovery process, Therapeutic Targets: Modulation, Inhibition, and Activation introduces readers to a range of new concepts and novel approaches to drug screening and therapeutic drug targeting to help inform future avenues of drug research. Highly topical, this accessible edited volume features chapters contributed by respected experts from around the globe. The book helps postgraduate students and professional scientists working in academia and industry understand the molecular mechanisms of pharmacology, current pharmacological knowledge, and future perspectives in drug discovery, focusing on important biochemical protein targets and drug targeting strategies for specific diseases. Examining the pharmacology of therapeutically undefined targets and their potential applications, it includes chapters on traditional therapeutic targets, including enzymes (phosphodiesterases and proteases), ion channels, and G protein-coupled receptors, as well as more recently identified avenues of exploration, such as lipids, nuclear receptors, gene promoters, and more. Since different diseases require different targeting techniques, the book also includes dedicated chapters on strategies for investigating Alzheimer's, diabetes, pain, and inflammation treatments. Concluding with a cross-sectional look at new approaches in drug screening, Therapeutic Targets is an invaluable resource for understanding where the next generation of drugs are likely to emerge.