Nucleotide Metabolism
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Nucleotide Metabolism
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Author : J. Frank Henderson
language : en
Publisher: Academic Press
Release Date : 2014-06-28
Nucleotide Metabolism written by J. Frank Henderson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-28 with Science categories.
Nucleotide Metabolism: An Introduction is a textbook exclusively focusing on the study of the aspects of nucleotide metabolism. The book intends to present the chemistry and metabolism of nucleotides, one of the oldest subjects of biochemistry. The text is divided in two parts. Part I considers the general aspects of nucleotide metabolism such as the history of the discovery of nucleotides; functions of nucleotides in cells; and group-transfer reactions during nucleotide metabolism. Part II deals with the synthesis, formation, and conversion of purine ribonucleotides. Biochemists, pharmacologists, and researchers in the fields of medicine and pharmaceuticals will find the book invaluable.
Plant Nucleotide Metabolism
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Author : Hiroshi Ashihara
language : en
Publisher: John Wiley & Sons
Release Date : 2020-01-23
Plant Nucleotide Metabolism written by Hiroshi Ashihara and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-23 with Science categories.
All organisms produce nucleobases, nucleosides, and nucleotides of purines and pyrimidines. However, while there have been a number of texts on nucleotide metabolism in microorganisms and humans, the presence of these phenomena in plant life has gone comparatively unexplored. This ground-breaking new book is the first to focus exclusively on the aspects of purine nucleotide metabolism and function that are particular to plants, making it a unique and essential resource. The authors provide a comprehensive break down of purine nucleotide structures and metabolic pathways, covering all facets of the topic. Furthermore, they explain the role that purine nucleotides can play in plant development, as well as the effects they may have on human health when ingested. Plant Nucleotide Metabolism offers a unique and important resource to all students, researchers, and lecturers working in plant biochemistry, physiology, chemistry, agricultural sciences, nutrition, and associated fields of research.
Metabolism Of Nucleotides
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Author : U Satyanarayana
language : en
Publisher: Elsevier Health Sciences
Release Date : 2014-11-07
Metabolism Of Nucleotides written by U Satyanarayana and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-07 with Medical categories.
Metabolism of nucleotides Metabolism of nucleotides
Genetic Consequences Of Nucleotide Pool Imbalance
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Author : Frederick De Serres
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Genetic Consequences Of Nucleotide Pool Imbalance written by Frederick De Serres and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This book is concerned with the genetic consequences of nu cleotide pool imbalance. There are a number of ways in which this state can be achieved and the majority of papers in this volume de scribe the effects of nucleotide pool imbalance on DNA replication and repair, and the induction of gene mutations in various organisms. This book grew out of a Conference on "Genetic Consequences of Nu cleotide Pool Imbalance" which was held at the National Institute of Environmental Health Sciences on May 9-11, 1983. The Organizing Com mittee consisted of Drs. Diana Anderson (BIBRA), Robert Haynes (York University), Bernard Kunz (NIEHS), Barry Glickman (NIEHS), and Frederick J. de Serres (NIEHS), Chairman. The meeting was org- ized by the staff of the Office of the Associate Director for Genetics and was financed solely by the National Institute of Environmental Health Sciences. Frederick J. de Serres, Ph.D. Associate Director for Genetics v CONTENTS SECTION I. INTRODUCTION Molecular Mechanisms in Genetic Stability and Change: 1 The Role of Deoxyribonucleotide Pool Balance •••••• Robert H. Haynes SECTION II. NUCLEOTIDE METABOLISM 25 Metabolic Effects of Poly(ADP-ribose) Inhibitors •••••••• Kathryn M. Milam and James E. Cleaver Ribonucleotide Reductase and Deoxyribonucleotide 33 POQ 1 s ............................................ . Peter Reichard 47 Enzymatic Channeling of DNA Precursors •••••••••••••••••• Christopher K. Mathews A Possible Secondary Role for Thymine-Containing DNA 67 Precursors ....................................... . Robert J. Melamede and Susan S. Wallace Multiple Mechanisms of Adenosine Toxicity in an Adenosine Sensitive Mutant of Baby Hamster 103 Kidney (BHK) Cells ............................... .
Identification Development And Evaluation Of Small Molecule Modulators Of Nucleotide Metabolism
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Author : Ethan Rosser
language : en
Publisher:
Release Date : 2020
Identification Development And Evaluation Of Small Molecule Modulators Of Nucleotide Metabolism written by Ethan Rosser and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
This dissertation describes the identification, development, and evaluation of small- molecule modulators of nucleotide metabolism. Nucleotides, well-known for their role as the "backbone" of DNA, are essential for a variety of cell processes including energy transfer, formation of lipid membranes, and DNA and RNA synthesis. Small molecule-mediated inhibition of enzymes involved in nucleotide metabolism has shown promise in various therapeutic settings, and our group has demonstrated that inhibition of deoxycytidine kinase combined with perturbations to other nucleotide-producing enzymes can effectively treat acute lymphoblastic leukemia in mouse models. Chapter One details the development and evaluation of inhibitors of deoxycytidine kinase. Expanding upon a scaffold previously identified by our group, structure-activity-relationship studies were undertaken in pursuit of a clinically-viable inhibitor. With the goal of eliminating the presence of a stereocenter within our lead compound while maintaining low- nanomolar affinity for deoxycytidine kinase, a series of analogs containing a gem-dimethyl moiety was produced. In addition, the preclinical pharmacology of the lead compound, DI-87, was evaluated with the aid of PET imaging. Chapter Two describes the development and application of a cell-based metabolic modifier screening platform that leverages the redundancy in pyrimidine metabolism for the discovery of selective uridine monophosphate biosynthesis modulators. In evaluating a library of protein kinase inhibitors, multiple compounds which possess nucleotide metabolism modifying activity were identified. The JNK inhibitor JNK-IN-8 was found to potently inhibit nucleoside transport and engage ENT1. Additionally, the PDK1 inhibitor OSU-03012 and the RAF inhibitor TAK-632 were shown to inhibit the therapeutically relevant enzyme DHODH, and their affinities were unambiguously confirmed through in vitro assays and co-crystallization with human DHODH.
Metabolism Of Nucleotides Nucleosides And Nucleobases In Microorganisms
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Author : Agnete Munch-Petersen
language : en
Publisher:
Release Date : 1983
Metabolism Of Nucleotides Nucleosides And Nucleobases In Microorganisms written by Agnete Munch-Petersen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Medical categories.
Purine And Pyrimidine Nucleotide Metabolism
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Author :
language : en
Publisher:
Release Date : 1978
Purine And Pyrimidine Nucleotide Metabolism written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with categories.
Nucleotide Metabolism During Synchronized Cell Division In Tetr
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Author : Paul Plesner
language : en
Publisher:
Release Date : 1964
Nucleotide Metabolism During Synchronized Cell Division In Tetr written by Paul Plesner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1964 with categories.
Nucleotide Metabolism In Higher Plants
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Author : Mary Elizabeth Wallis
language : en
Publisher:
Release Date : 1968
Nucleotide Metabolism In Higher Plants written by Mary Elizabeth Wallis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1968 with DNA. categories.
Factors Influencing Muscle Purine Nucleotide Metabolism
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Author :
language : en
Publisher:
Release Date : 2006
Factors Influencing Muscle Purine Nucleotide Metabolism written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Exercise categories.
The experiments in this thesis were designed to investigate the factors influencing the metabolism of purine nucleotides in human skeletal muscle, plasma and urine. Study one investigated the influence of the number of intermittent sprint bouts and the subsequent accumulation of plasma purines and urinary purine excretion. Study two investigated the influence of sprint training on urinary purine loss following intense exercise. Study three examined the influence of allopurinol on urinary purine loss after repeated sprint exercise in humans. The final study examined the combined effects of allopurinol and sprint training on purine nucleotide metabolism in humans at rest.