P Rolas De Um Legado
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O Panorama
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Author :
language : en
Publisher:
Release Date : 1842
O Panorama written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1842 with categories.
Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Opusculos Controversias E Estudios Historicos
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Author : Alexandre Herculano
language : es
Publisher:
Release Date : 1843
Opusculos Controversias E Estudios Historicos written by Alexandre Herculano and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1843 with Portugal categories.
La Otra Mitad De Nosotros
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Author : F. Rubi
language : en
Publisher: Palibrio
Release Date : 2012-01-11
La Otra Mitad De Nosotros written by F. Rubi and has been published by Palibrio this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-11 with Philosophy categories.
Uno de los grandes males que agobian al mundo actualmente, es la desesperanza. Una desesperanza nacida de la frustración, propiciada por la gran crisis económica que nos atosiga y que parece no tener solución, por lo menos en el corto plazo. La idea que se nos vendió, avalada por los medios masivos de comunicación, de un mundo globalizado promisorio, con oportunidades para todos, se desmoronó como un castillo de naipes al primer soplo de inestabilidad. Pero esta situación que ahora padecemos, producto de la avaricia y la falta de escrúpulos más ruin que pueda imaginarse, no se dio de un día para otro; se fue incubando, por años, al interior del sistema financiero internacional como un mal bicho que al hacer su aparición de manera intempestiva, cogió a todo mundo desprevenido y sin saber qué medidas tomar para remediar la situación. Los expertos, emocionados con un sistema económico en expansión, nunca se imaginaron que algo podría salirse del carril desbarrancándose, y arrastrara consigo a la mayoría de los países que participaban en el juego. No pensaron que las triquiñuelas de las que echaron mano, durante tanto tiempo, para enriquecer a unos cuantos vivales, tuvieran un efecto tan expansivo y, por lo mismo, tan devastador, en la mayoría de las sociedades inmiscuidas y por eso mismo, atrapadas irremediablemente en la debacle financiera. LA OTRA MITAD DE NOSOTROS toca el tema de manera puntual, lo mismo que los temas de la injusticia, la educación, la política (la mala política, que acostumbra sentar sus reales en muchos países en el mundo y de la que es muy difícil desprenderse), la religión y la música; de ésta última y de manera especial, hace una semblanza novedosa y conmovedora de Los Beatles, el genial cuarteto de Liverpool, que influyó de manera decisiva y profunda en el ánimo de toda una generación y que sigue causando expectativas y comentarios en los corrillos discográficos, con una visión original y muy personal del autor. No hay tema de importancia relevante que esta obra no toque y lo hace a través de un lenguaje simple, enriquecido con todo tipo de florituras lingüísticas que no solo lo hacen único, sino completamente comprensible y disfrutable en todo momento. La obra consta de ocho capítulos y una posdata; cada capítulo lleva por título, el título de una canción conocida de la década de los setentas y nos atreveríamos a decir que pocas veces en la historia de la literatura universal, el nombre del capítulo tiene tanta afinidad con el tema que retrata, pero, y esto es lo verdaderamente importante, los capítulos se podrían alterar, entremezclar o leerse como un ente individual y aún así, no perdería ni su sentido ni su frescor. De la mano del personaje principal, vamos descubriendo el sub mundo incomprensible, a veces absurdo y hostil, en el que nos movemos constantemente sin percatarnos apenas de su presencia. Vivimos el día a día y los actos que rigen nuestra conducta para con los demás, aquellos que nos son ajenos o extraños son, en el mejor de los casos, de una total arrogancia. En no pocas ocasiones, los miramos con un desprecio poco disimulado, porque los consideramos seres sin valor, objetos que se pueden comprar o vender, insultar o lastimar sin que sintamos culpa por ello. Los valores que regían nuestra conducta, hasta bien entrada la última parte del siglo veinte, se han ido perdiendo poco a poco, para dar paso a una nueva visión del mundo, con enfoques que a muchos nos parecen ruines y perversos. Pero no se piense, por esto, que todo está perdido. A lo largo de su periplo, nuestro personaje recibe constantes muestras de solidaridad y afecto aún de los que nada tienen, de aquellos menos favorecidos por la suerte, lo que demuestra que los seres humanos somos capaces de superar los escollos más difíciles que se nos presenten con un poco de ayuda y que nuestra capacidad de reacción, en momentos críticos y ante los embates del destino, demuestran que nuestra mayor
The Book Of Disquiet
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Author : Fernando Pessoa
language : en
Publisher: Serpent's Tail
Release Date : 2017-08-17
The Book Of Disquiet written by Fernando Pessoa and has been published by Serpent's Tail this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-17 with Fiction categories.
The Book of Disquiet is one of the great literary works of the twentieth century. Written over the course of Fernando Pessoa's life, it was first published in 1982, pieced together from the thousands of individual manuscript pages left behind by Pessoa after his death in 1935. Now this fragmentary modernist masterpiece appears in a major new edition that unites Margaret Jull Costa's celebrated translation with the most complete version of the text ever produced. It is presented here, for the first time in English, by order of original composition, and accompanied by facsimiles of the original manuscript. Narrated principally by an assistant bookkeeper named Bernardo Soares - an alias of sorts for Pessoa himself - The Book of Disquiet is 'the autobiobraphy of someone who never existed', a mosaic of dreams, of hope and despair; a hymn to the streets and cafs of 1930s Lisbon, and an extraordinary record of the inner life of one of the century's most important writers. This new edition represents the most complete vision of Pessoa's genius.
Rosa Laureada Entre Los Santos Epitalamios Sacros De La Corte Aclamaciones De Espa A Al Feliz Desposorio Que Celebro En La Gloria Con Christo La Beata Virgen Rosa De Santa Maria De La Tercera Orden De Predicadores Patrona Del Per Y Beatificacion Solemne Que Promulgo Clemente Nono En 15 De Abril De 1668
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Author : Jacinto de la Parra (O.P.)
language : es
Publisher:
Release Date : 1670
Rosa Laureada Entre Los Santos Epitalamios Sacros De La Corte Aclamaciones De Espa A Al Feliz Desposorio Que Celebro En La Gloria Con Christo La Beata Virgen Rosa De Santa Maria De La Tercera Orden De Predicadores Patrona Del Per Y Beatificacion Solemne Que Promulgo Clemente Nono En 15 De Abril De 1668 written by Jacinto de la Parra (O.P.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1670 with categories.
Of Triton
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Author : Anna Banks
language : en
Publisher: Feiwel & Friends
Release Date : 2013-05-28
Of Triton written by Anna Banks and has been published by Feiwel & Friends this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-28 with Young Adult Fiction categories.
Emma has just learned that her mother is a long-lost Poseidon princess, and now struggles with an identity crisis: As a Half-Breed, she's a freak in the human world and an abomination in the Syrena realm. Syrena law states all Half-Breeds should be put to death. As if that's not bad enough, her mother's reappearance in the Syrena world turns the two kingdoms—Poseidon and Triton—against one another. Which leaves Emma with a decision to make: Should she comply with Galen's request to keep herself safe and just hope for the best? Or should she risk it all and reveal herself—and her Gift—to save a people she's never known? Once again, Anna Banks infuses Emma and Galen's points of view with humor, intrigue, and waves of romance.
Alivio De Tristes E Consolacam De Queixosos Etc
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Author : Matheus Ribeyro
language : pt-BR
Publisher:
Release Date : 1688
Alivio De Tristes E Consolacam De Queixosos Etc written by Matheus Ribeyro and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1688 with categories.
Historia Universal De La Vida Y Peregrinacion De El Hijo De Dios En El Mundo
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Author : Pedro Gomez Duran
language : es
Publisher:
Release Date : 1610
Historia Universal De La Vida Y Peregrinacion De El Hijo De Dios En El Mundo written by Pedro Gomez Duran and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1610 with categories.
Jimmy Page In Brazil
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Author : Leandro Souto Maior
language : en
Publisher: Garota FM Books
Release Date : 2021-07-13
Jimmy Page In Brazil written by Leandro Souto Maior and has been published by Garota FM Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-13 with Biography & Autobiography categories.
immy Page is still recognized as one of the most influential guitarists of all time and one of the most important rock composers worldwide. And Page's relationship with Brazil is old: in addition to having starred in many meetings with national music stars, the Led Zeppelin guitarist spent seasons in Bahia and inaugurated Casa Jimmy to house homeless youth in the capital of Rio de Janeiro – which earns him the title of Honorary Citizen of Rio de Janeiro. This intense story is the theme of Jimmy Page in Brazil, a bilingual book (Portuguese / English) by journalist and musician Leandro Souto Maior. The book has a preface by Ed Motta, one of the greatest collectors and connoisseurs of Led Zeppelin's work in Brazil, and postscript by young guitarist Sebastião Reis, the son of musician Nando Reis, what confirms that the band has crossed generations. The layout and cover bear the signature of Tomás Paoni, the artistic director of the project. The cover photo is by Marcos Hermes, a great photographer in the Brazilian music market. The edition is signed by Chris Fuscaldo, director of Garota FM Books.