P Rolas E Diamantes
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Grain Quality Evaluation Of World Rices
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Author : Bienvenido O. Juliano
language : en
Publisher: Int. Rice Res. Inst.
Release Date : 1993
Grain Quality Evaluation Of World Rices written by Bienvenido O. Juliano and has been published by Int. Rice Res. Inst. this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Technology & Engineering categories.
Introduction; Materials and methods; Results and discussion; Asia; North, Central, and South America; South America; Europe; Africa; Oryza glaberrima and other wild rices; General disucssion and conclusions; Institutions and organizations supplying rice samples; Sources of 1990 grain quality information in national programs; Cross reference index of variety names; Acronyms of rice varieties/lines.
The Book Of Disquiet
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Author : Fernando Pessoa
language : en
Publisher: Serpent's Tail
Release Date : 2017-08-17
The Book Of Disquiet written by Fernando Pessoa and has been published by Serpent's Tail this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-17 with Fiction categories.
The Book of Disquiet is one of the great literary works of the twentieth century. Written over the course of Fernando Pessoa's life, it was first published in 1982, pieced together from the thousands of individual manuscript pages left behind by Pessoa after his death in 1935. Now this fragmentary modernist masterpiece appears in a major new edition that unites Margaret Jull Costa's celebrated translation with the most complete version of the text ever produced. It is presented here, for the first time in English, by order of original composition, and accompanied by facsimiles of the original manuscript. Narrated principally by an assistant bookkeeper named Bernardo Soares - an alias of sorts for Pessoa himself - The Book of Disquiet is 'the autobiobraphy of someone who never existed', a mosaic of dreams, of hope and despair; a hymn to the streets and cafs of 1930s Lisbon, and an extraordinary record of the inner life of one of the century's most important writers. This new edition represents the most complete vision of Pessoa's genius.
Vocabulario Portuguez Latino
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Author : Rafael Bluteau
language : pt-BR
Publisher:
Release Date : 1720
Vocabulario Portuguez Latino written by Rafael Bluteau and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1720 with categories.
Almanach De Lembran As Luso Brasileiro Para
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Author :
language : pt-BR
Publisher:
Release Date : 1855
Almanach De Lembran As Luso Brasileiro Para written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1855 with Almanacs categories.
Divertimento Erud To Para Os Curiosos De Noticias Historicas Escolasticas Politicas E Naturaes Sagradas E Profanas
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Author :
language : pt-BR
Publisher:
Release Date : 1744
Divertimento Erud To Para Os Curiosos De Noticias Historicas Escolasticas Politicas E Naturaes Sagradas E Profanas written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1744 with categories.
Vocabulario Portuguez E Latino Etc
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Author : Raphael Bluteau
language : pt-BR
Publisher:
Release Date : 1727
Vocabulario Portuguez E Latino Etc written by Raphael Bluteau and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1727 with categories.
Vocabulario Portuguez E Latino
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Author : Rafael Bluteau
language : pt-BR
Publisher:
Release Date : 1720
Vocabulario Portuguez E Latino written by Rafael Bluteau and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1720 with Latin language categories.
Almanach De Lembranc As Luso Brazileiro
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Author :
language : pt-BR
Publisher:
Release Date : 1854
Almanach De Lembranc As Luso Brazileiro written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1854 with Almanacs, Brazilian categories.
Discipline And Punish
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Author : Michel Foucault
language : en
Publisher: Vintage
Release Date : 2012-04-18
Discipline And Punish written by Michel Foucault and has been published by Vintage this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-18 with Social Science categories.
A brilliant work from the most influential philosopher since Sartre. In this indispensable work, a brilliant thinker suggests that such vaunted reforms as the abolition of torture and the emergence of the modern penitentiary have merely shifted the focus of punishment from the prisoner's body to his soul.