Pain Models
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Pain Models
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Author : Hermann O. Handwerker
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2015-06-01
Pain Models written by Hermann O. Handwerker and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-01 with Medical categories.
The neurobiology and mechanisms discovered in animals often do not translate to patients with a chronic pain condition. To help researchers and clinicians develop and use models that can help translate data from animals into humans, this book presents experimental animal models, with a focus on how they may translate into humans human experimental pain models, including details about pain induction and assessment human surrogate pain models clinical applications of pain models models that may link mechanisms of pain and pruritus Pain Models contains 29 chapters by internationally recognized experts. It is a comprehensive survey of pain models at different levels, and commentaries by clinicians directly address clinical perspectives. This unique book is unprecedented in its content. It's a quick reminder of the hard work needed to investigate the complex issue of pain perception. With the advent of increasingly sensitive noninvasive investigational tools, the authors want readers to know that basic research is still needed to help develop new drugs. This book will enrich anyone who wishes to know all that goes into conducting pain research with a lab-based pain model.
Verification Of Animal Pain Models By Reverse Translation
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Author : Robert M. Caudle
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-06
Verification Of Animal Pain Models By Reverse Translation written by Robert M. Caudle and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-06 with Science categories.
Animal Models Of Pain
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Author : Chao Ma
language : en
Publisher: Humana Press
Release Date : 2016-08-23
Animal Models Of Pain written by Chao Ma and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Medical categories.
With the loss of work days, the price of health care and payments for compensation, litigation, and malpractice, and the overwhelming cost of human suffering, chronic pain syndromes affect humanity enormously on both an economic and personal level. In Animal Models of Pain, expert investigators in the field provide a consolidated review of the current state of pain research by capturing the diversity of animal models that are used to investigate pain mechanisms, which range from surgical incision to mechanical compression and from spinal cord injury to cutaneous/local inflammation and beyond. As a volume in the respected Neuromethods series, this book delivers its vital content through detailed descriptions of a wide variety of step-by-step laboratory methods. Authoritative and cutting-edge, Animal Models of Pain seeks to lead scientists closer to the ultimate goal of improving the quality of life and relieving the unbearable burden of chronic pain for millions of people throughout the world.
Development And Evaluation Of Translational Pain Models Using Objective Neurophysiological Markers
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Author : Emily Davies
language : en
Publisher:
Release Date : 2012
Development And Evaluation Of Translational Pain Models Using Objective Neurophysiological Markers written by Emily Davies and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Acute pain plays a fundamental role in survival, providing protection from potentially damaging stimuli. However, chronic pain is much less useful and is hugely detrimental to quality of life. An inadequately low number of chronic pain patients get meaningful analgesic treatment benefit, and very few novel analgesics have become available in recent years. This is due in part to a high failure rate of new analgesics in early clinical trials. with a significant number of these failures being due to lack of efficacy, thus questioning whether current animal models, and/or how pain is assessed in these models, sufficiently predict clinical efficacy. Development of translational pain models will bridge this gap between preclinical animal and human clinical research by providing experimental models that have similar underlying mechanisms. Additionally. use of translational objective measures of pain as pharmocodynamic endpoints will aid drug development. The work described in this thesis aimed to address these two critical issues, namely that animal and human pain models are often mechanistically different and are quantified using different outcome measures. The main focus of this project was translational inflammatory pain models with a central sensitisation component, a cardinal clinical feature or chronic pain. As secondary mechanical hyperalgesia results from central sensitisation. the work focused on development of models ill which secondary mechanical hyperalgesia is exhibited, combined with objective assessment of this mechanical hyperalgesia. The key findings of this project were two-fold. Firstly, a novel objective neurophysiological measure of mechanical pain was developed and validated in healthy human volunteers. Secondly, the occurrence of secondary mechanical hyperalgesia was investigated in an established translational inflammatory pain model in the rat (the ultraviolet-B (UV -13) model). and in a novel model which combines UV-B with heat rekindling to prolong central sensitisation. Finally. to bring the two aspects of the project together. the objective measure of mechanical pain in humans was used to investigate secondary mechanical hyperalgesia in a translational experimental inflammatory pain model in healthy human volunteers. The development of translational experimental models of inflammatory pain. with emphasis on the clinically relevant phenomenon of central sensitisation, will improve transition of novel analgesics into the clinic. The objective measure of mechanical pain in humans described here is a neurophysiological technique that will aid future pain research when used alongside subjective measures of pain, creating a multidimensional approach to pain assessment. It also has the potential to be back-translated to the laboratory rat for future quantification of secondary mechanical hyperalgesia and central sensitisation ill translational models such as the UV-B model.
Animal Models Of Pain
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Author : Chao Ma
language : en
Publisher: Humana Press
Release Date : 2010-10-11
Animal Models Of Pain written by Chao Ma and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-11 with Medical categories.
With the loss of work days, the price of health care and payments for compensation, litigation, and malpractice, and the overwhelming cost of human suffering, chronic pain syndromes affect humanity enormously on both an economic and personal level. In Animal Models of Pain, expert investigators in the field provide a consolidated review of the current state of pain research by capturing the diversity of animal models that are used to investigate pain mechanisms, which range from surgical incision to mechanical compression and from spinal cord injury to cutaneous/local inflammation and beyond. As a volume in the respected Neuromethods series, this book delivers its vital content through detailed descriptions of a wide variety of step-by-step laboratory methods. Authoritative and cutting-edge, Animal Models of Pain seeks to lead scientists closer to the ultimate goal of improving the quality of life and relieving the unbearable burden of chronic pain for millions of people throughout the world.
Pain
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Author : Alan L. Goldberg
language : en
Publisher:
Release Date : 1982*
Pain written by Alan L. Goldberg and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982* with categories.
Translational Pain Research
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Author : Lawrence Kruger
language : en
Publisher: CRC Press
Release Date : 2009-11-24
Translational Pain Research written by Lawrence Kruger and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-24 with Health & Fitness categories.
One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practical
Human Experimental Pain Models
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Author : Helène Schulte
language : en
Publisher:
Release Date : 2005
Human Experimental Pain Models written by Helène Schulte and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
Pain Research
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Author : Z. David Luo
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Pain Research written by Z. David Luo and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Medical categories.
The detrimental impacts of pain on the quality of our daily life have drawn increasing attention from researchers, health care providers, policymakers, and social workers. The reality of effective painkillers specifically designed for different types of pain states has been obscured by missing knowledge of the mechanisms of different types of pain. Thus, studying the complexity of pain transduction, which includes various insults to the peripheral nervous systems, sensitized spinal circuits, and altered signals ascending to or descending from the brain, has emerged as a high priority task on the agenda of pharmaceutical companies and other private as well as public agencies. To accomplish this mission, one requires a combination of well-integrated systems, such as a- mal models resembling the pathological conditions of pain transduction, and an understanding of the interactions among pain transducers and mediators at the molecular level. Thanks to rapid advancements in the development of novel cellular and molecular biology techniques, as well as in our understanding of physiology, and of the behavioral pharmacology of pain transduction, the time is now ripe for dissecting the molecular mechanisms of pain transduction using multidisciplinary approaches. Indeed, my acceptance of the invitation from the series editor, Dr. John Walker, to assemble a book of methods and protocols for pain research was inspired by these emerging needs. The purpose of Pain Research: Methods and Protocols is to provide st- by-step methods and protocols of multidisciplinary approaches related to the study of pain transduction.
Experimental Pain Models For The Evaluation Of Next Generation Analgesics In Clinical Pharmacology Studies
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Author :
language : en
Publisher:
Release Date : 2022
Experimental Pain Models For The Evaluation Of Next Generation Analgesics In Clinical Pharmacology Studies written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
