Pathways To The Stacks
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Author :
language : en
Publisher: Cambridge University Press
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written by and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Energy Landscapes Of Nanoscale Systems
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Author : David J. Wales
language : en
Publisher: Elsevier
Release Date : 2022-06-08
Energy Landscapes Of Nanoscale Systems written by David J. Wales and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-08 with Technology & Engineering categories.
Energy Landscapes of Nanoscale Systems provides a snapshot of the state-of-the-art in energy landscapes theory and applications. The book's chapters reflect diversity and knowledge transfer that is a key strength of the energy landscape approach. To reflect the breadth of this field, contributions include applications for clusters, biomolecules, crystal structure prediction and glassy materials. Chapters highlighting new methodologies, especially enhanced sampling techniques are included. In particular, the development and application of global optimization for structure prediction, methods for treating broken ergodicity on multifunnel landscapes, and treatment of rare event dynamics that reflect the state-of-the-art are featured. This book is an important reference source for materials scientists and energy engineers who want to understand more about how nanotechnology applies to the energy landscape approach. This volume is dedicated to Prof. Roy L. Johnston, who was formerly Co-Editor of the Frontiers of Nanoscience series, and who passed away in 2019. - Outlines applications and advances in theory and simulation of energy systems at the nanoscale - Explores how the energy landscapes approach is being applied to nanoscale materials - Assesses major challenges in applying nanomaterials for energy applications on an industrial scale
Intelligent Strategies For Pathway Mining
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Author : Qingfeng Chen
language : en
Publisher: Springer
Release Date : 2013-12-17
Intelligent Strategies For Pathway Mining written by Qingfeng Chen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-17 with Computers categories.
This book is organized into thirteen chapters that range over the relevant approaches and tools in data integration, modeling, analysis and knowledge discovery for signaling pathways. Having in mind that the book is also addressed for students, the contributors present the main results and techniques in an easily accessed and understood way together with many references and instances. Chapter 1 presents an introduction to signaling pathway, including motivations, background knowledge and relevant data mining techniques for pathway data analysis. Chapter 2 presents a variety of data sources and data analysis with respect to signaling pathway, including data integration and relevant data mining applications. Chapter 3 presents a framework to measure the inconsistency between heterogenous biological databases. A GO-based (genome ontology) strategy is proposed to associate different data sources. Chapter 4 presents identification of positive regulation of kinase pathways in terms of association rule mining. The results derived from this project could be used when predicting essential relationships and enable a comprehensive understanding of kinase pathway interaction. Chapter 5 presents graphical model-based methods to identify regulatory network of protein kinases. A framework using negative association rule mining is introduced in Chapter 6 to discover featured inhibitory regulation patterns and the relationships between involved regulation factors. It is necessary to not only detect the objects that exhibit a positive regulatory role in a kinase pathway but also to discover those objects that inhibit the regulation. Chapter 7 presents methods to model ncRNA secondary structure data in terms of stems, loops and marked labels, and illustrates how to find matched structure patterns for a given query. Chapter 8 shows an interval-based distance metric for computing the distance between conserved RNA secondary structures. Chapter 9 presents a framework to explore structural and functional patterns of RNA pseudoknot structure according to probability matrix. Chapter 10 presents methods to model miRNA data and identify miRNA interaction of cross-species and within-species. Chapter 11 presents an approach to measure the importance of miRNA site and the adjacent base by using information redundancy and develops a novel measure to identify strongly correlated infrequent itemsets. The discover association rules not only present important structural features in miRNAs, but also promote a comprehensive understanding of regulatory roles of miRNAs. Chapter 12 presents bioinformatics techniques for protein kinase data management and analysis, kinase pathways and drug targets, and describes their potential application in pharmaceutical industry. Chapter 13 presents a summary of the chapters and give a brief discussion to some emerging issues.
Advance In Structural Bioinformatics
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Author : Dongqing Wei
language : en
Publisher: Springer
Release Date : 2014-11-11
Advance In Structural Bioinformatics written by Dongqing Wei and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-11 with Science categories.
This text examines in detail mathematical and physical modeling, computational methods and systems for obtaining and analyzing biological structures, using pioneering research cases as examples. As such, it emphasizes programming and problem-solving skills. It provides information on structure bioinformatics at various levels, with individual chapters covering introductory to advanced aspects, from fundamental methods and guidelines on acquiring and analyzing genomics and proteomics sequences, the structures of protein, DNA and RNA, to the basics of physical simulations and methods for conformation searches. This book will be of immense value to researchers and students in the fields of bioinformatics, computational biology and chemistry. Dr. Dongqing Wei is a Professor at the Department of Bioinformatics and Biostatistics, College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, China. His research interest is in the general area of structural bioinformatics.
Functional Ultrastructure
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Author : Margit Pavelka
language : en
Publisher: Springer
Release Date : 2015-04-24
Functional Ultrastructure written by Margit Pavelka and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-24 with Science categories.
This atlas provides a detailed insight into the complex structure and organization of cells and tissues, and highlights their specific functions as well as the dynamics of diverse intracellular processes. Highly informative electron micrographs are complemented by explanatory texts, selected references and schemes. The concept that subcellular organelles provide the structural foundation for fundamental processes of living organisms is emphasized. The first part covers the cellular organelles and changes caused by experiments or occurring under pathological conditions. The second part employs selected examples to illustrate the principles of functional tissue organization and typical changes resulting from experimental induction or pathological situations. The third edition of the atlas, revised and extended by 23 plates, thus provides an invaluable resource for scientists and students of medicine and biological sciences, particularly of histology, cell and molecular biology. Moreover, it will serve as a handy reference guide for diagnostic and research electron microscopy laboratories in clinical, industrial, and academic settings.
The Regulated Secretory Pathway In Neuroendocrine Cells
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Author : Rafael Vazquez-Martinez
language : en
Publisher: Frontiers E-books
Release Date : 2014-08-06
The Regulated Secretory Pathway In Neuroendocrine Cells written by Rafael Vazquez-Martinez and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-06 with Diseases of the endocrine glands. Clinical endocrinology categories.
The regulated secretory pathway is a hallmark of neuroendocrine cells. This process comprises many sequential steps, which include ER-associated protein synthesis, post-translational modification of proteins in the Golgi complex, sorting and packing of secretory proteins into carrier granules, cytoskeleton-based granule transport towards the plasma membrane and tethering, docking and fusion of granules with specialized releasing zones. Each stage is subjected to a rigorous regulation by a plethora of factors that function in a spatially and temporarily coordinated fashion. Much effort has been devoted to characterize the precise role of the regulatory proteins participating in the different steps of this process and to identify new factors in order to obtain a unifying picture of the secretory pathway. In spite of this and given the enormous complexity of the process, certain stages are not fully understood yet and many players remain to be identified. The aim of this Research Topic is to gather review articles and original research papers on the molecular mechanisms that govern and ensure the correct release of neuropeptides.
Biochemistry And Molecular Biology Of Plants
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Author : Bob B. Buchanan
language : en
Publisher: John Wiley & Sons
Release Date : 2015-07-02
Biochemistry And Molecular Biology Of Plants written by Bob B. Buchanan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-02 with Science categories.
Biochemistry and Molecular Biology of Plants, 2nd Edition has been hailed as a major contribution to the plant sciences literature and critical acclaim has been matched by global sales success. Maintaining the scope and focus of the first edition, the second will provide a major update, include much new material and reorganise some chapters to further improve the presentation. This book is meticulously organised and richly illustrated, having over 1,000 full-colour illustrations and 500 photographs. It is divided into five parts covering: Compartments, Cell Reproduction, Energy Flow, Metabolic and Developmental Integration, and Plant Environment and Agriculture. Specific changes to this edition include: Completely revised with over half of the chapters having a major rewrite. Includes two new chapters on signal transduction and responses to pathogens. Restructuring of section on cell reproduction for improved presentation. Dedicated website to include all illustrative material. Biochemistry and Molecular Biology of Plants holds a unique place in the plant sciences literature as it provides the only comprehensive, authoritative, integrated single volume book in this essential field of study.
The Golgi Apparatus And The Plant Secretory Pathway
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Author : David G. Robinson
language : en
Publisher: CRC Press
Release Date : 2003
The Golgi Apparatus And The Plant Secretory Pathway written by David G. Robinson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.
The Golgi apparatus is a key component of plant and animal cells. Its primary role is to orchestrate the targeting of proteins and lipids to specific cellular destinations. With advances in our understanding of how the Golgi apparatus operates in plants, it will become possible to manipulate both the timing and the site of delivery of macromolecules, thus influencing plant growth and development. This volume concentrates on the major developments of the last few years, drawing attention to the distinct differences between the plant and non-plant Golgi apparatus and highlighting unsolved problems. A chapter is included on the yeast Golgi apparatus.
The Golgi Apparatus
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Author : Alexander A. Mironov
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-03-04
The Golgi Apparatus written by Alexander A. Mironov and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-04 with Science categories.
This book summarizes all new data obtained after development of methods of Golgi complex sub fractionation, molecular biology and microscopy. It collects the full range of expertise, different points of view and different approaches. The book is devoted to molecular modes of the function of the Golgi apparatus as a whole, taking into account all experimental data. The book aims to make the functional organization of the Golgi apparatus more understandable.
Progress In Cell Cycle Research
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Author : Laurent Meijer
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Progress In Cell Cycle Research written by Laurent Meijer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Now in its second year, Progress in Cell Cycle Research was conceived to serve as an up to date introduction to various aspects of the cell division cycle. Although an annual review in any field of scientific investigation can never be as current as desired, especially in the cell cycle field, we hope that this volume will be helpful to students, to recent graduates considering a de1liation in subject and to investigators at the fringe of the cell cycle field wishing to bridge frontiers. An instructive approach to many subjects in biology is often to make comparisons between evolutionary distant organisms. If one is willing to accept that yeast represent a model primitive eukaryote, then it is possible to make some interesting comparisons of cell cycle control mechanisms between mammals and our little unicellular cousins. By and large unicellular organisms have no need for intracellular communication. With the exception of the mating phenomenon in S. cerevisiae and perhaps some nutritional sensing mechanisms, cellular division of yeast proceeds with complete disregard for neighbourly communication. Multicellular organisms on the other hand, depend entirely on intracellular communication to maintain structural integrity. Consequently, elaborate networks have evolved to either prevent or promote appropriate cell division in multicellular organisms. Yet, as described in chapter two the rudimentary mechanisms for fine tuning the cell division cycle in higher eukaryotes are already apparent in yeast.