Pattern Recognition Receptors And Cancer
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Pattern Recognition Receptors And Cancer
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Author : Anton G. Kutikhin
language : en
Publisher: Frontiers Media SA
Release Date : 2015-10-08
Pattern Recognition Receptors And Cancer written by Anton G. Kutikhin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-08 with Immunologic diseases. Allergy categories.
The group of pattern recognition receptors (PRRs) includes families of Toll-like receptors (TLRs), NOD-like receptors (NLRs), C-type lectin receptors (CLRs), RIG-I-like receptors (RLRs), and AIM-2-like receptors (ALRs). Conceptually, receptors constituting these families are united by two general features. Firstly, they directly recognize common antigen determinants of virtually all classes of pathogens (so-called pathogen-associated molecular patterns, or simply PAMPs) and initiate immune response against them via specific intracellular signaling pathways. Secondly, they recognize endogenous ligands (since they are usually released during cell stress, they are called damage-associated molecular patterns, DAMPs), and, hence, PRR-mediated immune response can be activated without an influence of infectious agents. So, pattern recognition receptors play the key role performing the innate and adaptive immune response. In addition, many PRRs have a number of other vital functions apart from participation in immune response realization. The fundamental character and diversity of PRR functions have led to amazingly rapid research in this field. Such investigations are very promising for medicine as immune system plays a key role in vast majority if not all human diseases, and the process of discovering the new aspects of the immune system functioning is rapidly ongoing. The role of Toll-like receptors in cancer was analyzed in certain reviews but the data are still scattered. This collection of reviews systematizes the key information in the field.
Pattern Recognition Receptors And Cancer
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Author :
language : en
Publisher:
Release Date : 2015
Pattern Recognition Receptors And Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
The group of pattern recognition receptors (PRRs) includes families of Toll-like receptors (TLRs), NOD-like receptors (NLRs), C-type lectin receptors (CLRs), RIG-I-like receptors (RLRs), and AIM-2-like receptors (ALRs). Conceptually, receptors constituting these families are united by two general features. Firstly, they directly recognize common antigen determinants of virtually all classes of pathogens (so-called pathogen-associated molecular patterns, or simply PAMPs) and initiate immune response against them via specific intracellular signaling pathways. Secondly, they recognize endogenous ligands (since they are usually released during cell stress, they are called damage-associated molecular patterns, DAMPs), and, hence, PRR-mediated immune response can be activated without an influence of infectious agents. So, pattern recognition receptors play the key role performing the innate and adaptive immune response. In addition, many PRRs have a number of other vital functions apart from participation in immune response realization. The fundamental character and diversity of PRR functions have led to amazingly rapid research in this field. Such investigations are very promising for medicine as immune system plays a key role in vast majority if not all human diseases, and the process of discovering the new aspects of the immune system functioning is rapidly ongoing. The role of Toll-like receptors in cancer was analyzed in certain reviews but the data are still scattered. This collection of reviews systematizes the key information in the field.
Genomics Of Pattern Recognition Receptors
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Author : Anton G. Kutikhin
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-08-28
Genomics Of Pattern Recognition Receptors written by Anton G. Kutikhin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-28 with Science categories.
This book offers comprehensive information on the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, the structure and function of Toll-like and NOD-like receptors are examined in detail. The main focus is on the role of inherited variation in PRRs and their correlation to cancer and cardiovascular diseases. A review of all epidemiological investigations is included, and a concept of genomic risk markers for the prevention of various diseases is also discussed.
Recent Advances In Immunology To Target Cancer Inflammation And Infections
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Author : Jagat Kanwar
language : en
Publisher: IntechOpen
Release Date : 2012-05-09
Recent Advances In Immunology To Target Cancer Inflammation And Infections written by Jagat Kanwar and has been published by IntechOpen this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-09 with Medical categories.
Immunology is the branch of biomedical sciences to study of the immune system physiology both in healthy and diseased states. Some aspects of autoimmunity draws our attention to the fact that it is not always associated with pathology. For instance, autoimmune reactions are highly useful in clearing off the excess, unwanted or aged tissues from the body. Also, generation of autoimmunity occurs after the exposure to the non-self antigen that is structurally similar to the self, aided by the stimulatory molecules like the cytokines. Thus, a narrow margin differentiates immunity from auto-immunity as already discussed. Hence, finding answers for how the physiologic immunity turns to pathologic autoimmunity always remains a question of intense interest. However, this margin could be cut down only if the physiology of the immune system is better understood. The individual chapters included in this book will cover all the possible aspects of immunology and pathologies associated with it. The authors have taken strenuous effort in elaborating the concepts that are lucid and will be of reader's interest.
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Author : Shalom Arush
language : en
Publisher:
Release Date : 2008
written by Shalom Arush and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Husband and wife categories.
Pattern Recognition Receptors Advances In Research And Application 2013 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2013-06-21
Pattern Recognition Receptors Advances In Research And Application 2013 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-21 with Medical categories.
Pattern Recognition Receptors—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Pattern Recognition Receptors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Pattern Recognition Receptors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Polymorphisms Of Pattern Recognition Receptors In Correlation With Skin Cancer Development In Organ Transplant Recipients
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Author : Anaïs Schneider
language : de
Publisher:
Release Date : 2014
Polymorphisms Of Pattern Recognition Receptors In Correlation With Skin Cancer Development In Organ Transplant Recipients written by Anaïs Schneider and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Damp Sensing Pattern Recognition Receptors In Digestive Tract Inflammatory Responses
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Author : Daming Zuo
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-17
Damp Sensing Pattern Recognition Receptors In Digestive Tract Inflammatory Responses written by Daming Zuo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-17 with Medical categories.
Role Of Toll Like Receptor Tlr Signaling In Cancer Progression And Treatment
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Author : Shyam Babu Prasad
language : en
Publisher:
Release Date : 2022
Role Of Toll Like Receptor Tlr Signaling In Cancer Progression And Treatment written by Shyam Babu Prasad and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with Medical categories.
Toll-like receptors (TLRs) are the most essential pattern recognition receptors in mediating the effects of innate immunity. It plays a pivotal role in inducing immune response against a number of pathogens, various diseases conditions including pathogenesis of cancer. Inflammation is often associated with the development and progression of most of cancer, where TLRs interplay very crucial roles. Moreover, TLRs activation can impact the initiation, progression and treatment of cancer by modulating the inflammatory microenvironment. Rapidly growing number of evidences related to TLRs function and expression in cancer cells, suggests its critical association with chemoresistance and tumourigenesis. The current chapter describes the development of various agonist and antagosist for TLRs and their application in cancer therapeutics. The aim of this book chapter is to highlights basic features of TLRs, and its role in cancer progression. It also addresses, how a defect in the TLRs signaling pathway can contributes towards carcinogenesis and recent development of cancer therapeutics that target TLR signaling pathways.
Toll Like Receptors Practice And Methods
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Author : Claire McCoy
language : en
Publisher: Methods in Molecular Biology
Release Date : 2018-04-15
Toll Like Receptors Practice And Methods written by Claire McCoy and has been published by Methods in Molecular Biology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-15 with Medical categories.
