Peptidomics

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Peptidomics

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Author : Mikhail Soloviev
language : en
Publisher: John Wiley & Sons
Release Date : 2007-12-21

Peptidomics written by Mikhail Soloviev and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-21 with Science categories.

The definitive guide to peptidomics- a hands-on lab reference The first truly comprehensive book about peptidomics for protein and peptide analysis, this reference provides a detailed description of the hows and whys of peptidomics and how the techniques have evolved. With chapters contributed by leading experts, it covers naturally occurring peptides, peptidomics methods and new developments, and the peptidomics approach to biomarker discovery. Explaining both the principles and the applications, Peptidomics: Methods and Applications: * Features examples of applications in diverse fields, including pharmaceutical science, toxicity biomarkers, and neuroscience * Details the successful peptidomic analyses of biological material ranging from plants to mammals * Describes a cross section of analytical techniques, including traditional methodologies, emerging trends, and new techniques for high throughput approaches An enlightening reference for experienced professionals, this book is sufficiently detailed to serve as a step-by-step guide for beginning researchers and an excellent resource for students taking biotechnology and proteomics courses. It is an invaluable reference for protein chemists and biochemists, professionals and researchers in drug and biopharmaceutical development, analytical and bioanalytical chemists, toxicologists, and others.

Peptidomics

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Author : Michael Schrader
language : en
Publisher: Springer Nature
Release Date :

Peptidomics written by Michael Schrader and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.

Proteomics And Peptidomics

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Author : Gyorgy Marko-Varga
language : en
Publisher: Elsevier
Release Date : 2005-12-23

Proteomics And Peptidomics written by Gyorgy Marko-Varga and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-23 with Language Arts & Disciplines categories.

Proteomics and peptidomics is the detailed understanding of the role that proteins and peptides play in health and disease and is a necessary compliment to genetic analysis. The functional expression analysis of both proteins and peptides plays a central role in modern drug discovery as well as drug development, and is also a key research area in systems biology. Proteomics and Peptidomics captures the width as well as the depth within the area and exemplifies the variety as well as the traditional basis of analytical chemistry that is needed in order to move forward in expression analysis studies. As a fast emerging field, it gives and overview of parts within the field combined with highly specialized and dedicated topics that are intended to compliment each other.

Peptidomics

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Author : Mikhail Soloviev
language : en
Publisher: Humana Press
Release Date : 2010-04-29

Peptidomics written by Mikhail Soloviev and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-29 with Science categories.

Despite being known and studied for years, peptides have never before attracted enough attention to necessitate the invention of the term "peptidomics" in order to specify the study of the complement of peptides from a cell, organelle, tissue or organism. In Peptidomics: Methods and Protocols, expert researchers present a comprehensive range of analytical techniques for the analysis of the peptide contents of complex biological samples with an emphasis often on higher throughput techniques, suitable for the analysis of large numbers of peptides typically present in the peptidomes. Encompassing a number of species ranging from bacteria to man, the methods presented intensively cover topics such as organism handling, tissue and organ dissection, cellular and subcellular fractionation, peptide extraction, fractionation and purification, structural characterization, molecular cloning, and sequence analysis. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Peptidomics: Methods and Protocols brings this ten year old field fully up-to-date in order to inspire novices and experts alike with the easy-to-follow practical advice needed to set up and carry out analysis of the peptide contents of complex biological samples.

Peptidomics Of Cancer Derived Enzyme Products

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Author :
language : en
Publisher: Academic Press
Release Date : 2017-10-30

Peptidomics Of Cancer Derived Enzyme Products written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-30 with Medical categories.

Peptidomics of Cancer-Derived Enzyme Products, Volume 42, the latest in The Enzymes series, is ideal for researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, with this volume featuring high-caliber, thematic articles on the topic of peptidomics of cancer-derived enzyme products. Specific chapters cover Circulating peptidome and tumor-resident proteolysis, Colon tumor secretopeptidome, Chemoenzymatic method for glycomics, Human plasma peptidome for pancreatic cancer, Lipoproteomics and quantitative proteomics, Salivaomics: Protein markers/extracellular RNA/DNA in saliva, and Enzyme-responsive vectors for cancer therapy. Presents some of the most recent advances in the identification and function of enzymes changes in cancer Features authoritative expertise from recognized contributors to the field

Peptidomics Of The Mouse

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Author : Kurt Boonen
language : en
Publisher: LAP Lambert Academic Publishing
Release Date : 2009-06-29

Peptidomics Of The Mouse written by Kurt Boonen and has been published by LAP Lambert Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-29 with categories.

Peptidomics is a recent technology that is based on mass spectrometry. It aims to identify all peptides present in a cell, tissue or organism at a certain time. Peptidomics can be used for the discovery of new bioactive peptides (of which neuropeptides are a special class). Proteolysis has to be strictly controlled if peptidomics is used for this purpose. In this book, the aspects that contribute to a succesfull peptidomics experiment are described in detail. The integrated appraoch of sample handling, separation and mass spectrometric techniques and bioinformatics are discussed. The last part introduces a new perspective on how peptides are used for intercellular signalling. Cells use the peptidome, rather than a single peptide species, to regulate their physiology. Peptidomics, together with systems biology, will be able to create accurate models of intercellular signalling in the future.

Advancing Qualitative And Quantitative Proteomics Peptidomics Via Development Of Novel Mass Spectrometry Based Approaches

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Author : Qing Yu
language : en
Publisher:
Release Date : 2017

Advancing Qualitative And Quantitative Proteomics Peptidomics Via Development Of Novel Mass Spectrometry Based Approaches written by Qing Yu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.

Liquid chromatography mass spectrometry (LC-MS) has evolved as a powerful tool in protein and peptide identification and quantitation. It has the capability to monitor thousands of proteins and peptides simultaneously and therefore is a critical component in the study of underlying biological mechanisms and the discovery of novel therapeutic targets. This dissertation is devoted to the development and application of novel LC-MS based techniques to characterize proteomics and peptidomics qualitatively and quantitatively by incorporating various sample preparation strategies, novel MS methods and isobaric labeling technology. A portion of this dissertation describes the design and evaluation of several dimethylated amino acid tags and their potentials to be used as isobaric labeling reagents for protein and peptide quantitation. Their utilities are further demonstrated through their application in the study of global proteomic changes in models of restenosis. Although isobaric tags are originally designed for higher-energy collisional dissociation (HCD), we expand their use by enabling them to be coupled with electron-transfer/higher-energy collision dissociation (EThcD) fragmentation. The benefits of using such strategy in quantitative proteomics, especially phosphorylation studies, are recounted in this dissertation. Quantitative strategies presented in this dissertation are complemented by advances in MS-based protein and endogenous peptide sequencing methodologies. We established a workflow to sequence intact glycopeptides, enabling detailed investigation of complex protein glycosylation and its microheterogeneity. The application of this improved workflow revealed a hyperglycosylation trend from day 0 to day 7 post angioplasty along the progression of restenosis. Similarly, by employing a further modified strategy, this dissertation documented the discovery of O-linked glycosylation on endogenous signaling peptides, specifically insulin and its related peptide hormones. The significance of such discovery can be critical toward diabetes research and treatment. Meanwhile, this dissertation also describes the strategy to characterize large neuropeptides in a species with no genome information, which can be greatly useful for future neuropeptide research. Furthermore, we employ ion mobility MS (IM-MS) to study peptide structures and conformations, leading to discovery of D-amino acid containing peptides based on subtle changes in gas-phase conformations despite identical mass-to-charge ratio. The IM-MS strategy enables the study of this unique isobaric post-translational modification (PTM) in neuropeptides occurring via amino acid isomerization. Overall, this dissertation research not only improves upon isobaric labeling technique by exploring novel chemical tags and new fragmentation methods, but also presents a useful platform to enable in-depth investigation on complex PTMs and subtle conformational differences. Collectively, we expect that the technology advancements presented in this work will enable broad applications in various biological systems and lead to improved understanding of underlying molecular mechanisms.