Personalized Mechanical Ventilation Plasma Srage And Survival In Ards
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Personalized Mechanical Ventilation Plasma Srage And Survival In Ards
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Author : Erwan Laroche
language : en
Publisher:
Release Date : 2017
Personalized Mechanical Ventilation Plasma Srage And Survival In Ards written by Erwan Laroche and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Computed tomography (CT) scan lung attenuation has contributed to the recognition of focal and nonfocal phenotypes (or morphotypes), with distinct prognosis and therapeutic responses among patients with acute respiratory distress syndrome (ARDS). Plasma soluble receptor for advanced glycation end-products (sRAGE) is a marker of alveolar type I cell injury, of impaired alveolar fluid clearance, and of a nonfocal morphotype that correlates with the severity and outcome of ARDS. The objectives were to verify whether baseline plasma sRAGE discriminates between focal and nonfocal ARDS and correlates with the severity and clinical outcomes of ARDS. In addition, this stuy investigated whether changes in plasma sRAGE could inform on prognosis in ARDS and wherher plasma sRAGE kinetics over the first days following ARDS onset would be impacted differentially in focal and nonfocal morphotypes by a personalized morphotpe-targeted ventilation strategy compared to the use of a more conventional mow tidal volume strategy. Plasma sRAGE levels were measured from 235 subjects enrolled in a large multicenter randomized controlled trial of lung imaging for ventilator setting in ARDS (LIVE study). Baseline plasma sRAGE was higher in patients with nonfocal ARDS than in those with focal ARDS (median [IQR], 3,577 [2,113-8,480] pg.mL ̄1vs. 2,346 [1,133-3,218] pg.mL ̄1, P = 0.0001), and it was associated with an increased severity of ARDS. Baseline plasma sRAGE was independently associated wiht 90-day mortality in patients ventiladed with a personalized strategy, but not in those ventilated wiht a conventional low tidal volume strategy. Higher day two-to-day zero and day three-to-day zero plasma sRAGE ratios were both associated with higher 90-day mortality (HR 1.08; 95% CI 1.01 to 1.15; P = 0.02 and 1.08; 95% CI 1.02 to 1.14; P = 0.01, respectively), regardless of the study group and ARDS morphotype. There was a significant decrease in plasma sRAGE on days two and three (P = 0.02 for both timepoints) in patients with focal ARDS ventiladed with a personalized strategy. In contrast, there was a significant increase in plasma sRAGE at all timepoints (P= 0.02, 0.004, 0.01, 0.01, and 0.001 for days one, two, three, four, and six, respectively) in patients with focal ARDS ventilated with a strategy combining higher positive end-expiratory pressure and recruitment maneuvers. Plasma sRAGE decreased at all timepoints in nonfocal ARDS when the morphotype was correctly classified at baseline, but it only decreased on days three and four when it was not. Changes in plasma sRAGE at days two and three following ARDS onset were associated whit higher 90-day mortality in patients with ARDS, regardless of the study group and ARDS morphotype. A personalized approach to the ventilation of patients with focal or nonfocal ARDS may be beneficial, in part by decreasing injury to the alveolar epithelium. Plama sRAGE is a promising biomarker for endotyping patients with ARDS and for monitoring responses to ventilator settings in ARDS.
Oncologic Critical Care
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Author : Joseph L. Nates
language : en
Publisher: Springer
Release Date : 2019-10-30
Oncologic Critical Care written by Joseph L. Nates and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-30 with Medical categories.
This major reference work is the most comprehensive resource on oncologic critical care. The text reviews all significant aspects of oncologic ICU practices, with a particular focus on challenges encountered in the diagnosis and management of the critically ill cancer patient population. Comprised of over 140 chapters, the text explores such topics as the organization and management of an oncologic ICU, diseases and complications encountered in the oncologic ICU, multidisciplinary care, surgical care, transfusion medicine, special patient populations, critical care procedures, ethics, pain management, and palliative care. Written by worldwide experts in the field, Oncologic Critical Care is a valuable resource for intensivists, advance practice providers, nurses, and other healthcare providers, that will help close significant knowledge and educational gaps within the realm of medical care for critically ill cancer patients.
Pediatric Acute Respiratory Distress Syndrome
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Author : Steven L. Shein
language : en
Publisher: Springer Nature
Release Date : 2019-08-22
Pediatric Acute Respiratory Distress Syndrome written by Steven L. Shein and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-22 with Medical categories.
This book provides a concise yet comprehensive overview of pediatric acute respiratory distress syndrome (PARDS). The text reviews the emerging science behind the new PARDS definition; explores epidemiology, pathobiology, etiologies, and risk factors; reviews state-of-the-art treatment modalities and strategies; and discusses clinical outcomes. Written by experts in the field, Pediatric Acute Respiratory Distress Syndrome: A Clinical Guide is a valuable resource for clinicians and practitioners who specialize in pediatric critical care.
Continuous Renal Replacement Therapy
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Author : John A. Kellum
language : en
Publisher: Oxford University Press
Release Date : 2016
Continuous Renal Replacement Therapy written by John A. Kellum and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Medical categories.
Continuous Renal Replacement Therapy provides concise, evidence-based, bedside guidance for the management of critically ill patients with acute renal failure, offering quick reference answers to clinicians' questions about treatments and situations encountered in daily practice.
Oxford Textbook Of Critical Care
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Author : Webb
language : en
Publisher: Oxford University Press
Release Date : 2020-01-10
Oxford Textbook Of Critical Care written by Webb and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-10 with Medical categories.
Now in paperback, the second edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely this text takes a problem-orientated approach providing a key resource for daily clinical issues in the intensive care unit. The text is organized into short topics allowing readers to rapidly access authoritative information on specific clinical problems. Each topic refers to basic physiological principles and provides up-to-date treatment advice supported by references to the most vital literature. Where international differences exist in clinical practice, authors cover alternative views. Key messages summarise each topic in order to aid quick review and decision making. Edited and written by an international group of recognized experts from many disciplines, the second edition of the Oxford Textbook of Critical Careprovides an up-to-date reference that is relevant for intensive care units and emergency departments globally. This volume is the definitive text for all health care providers, including physicians, nurses, respiratory therapists, and other allied health professionals who take care of critically ill patients.
50 Studies Every Intensivist Should Know
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Author : Edward A. Bittner
language : en
Publisher: Oxford University Press
Release Date : 2018
50 Studies Every Intensivist Should Know written by Edward A. Bittner and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Medical categories.
This title presents key studies that have shaped the practice of critical care medicine. Selected using a rigorous methodology, the studies cover topics including: sedation and analgesia, resuscitation, shock, ARDS, nutrition, renal failure, trauma, infection, diabetes, and physical therapy
Annual Update In Intensive Care And Emergency Medicine 2021
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Author : Jean-Louis Vincent
language : en
Publisher: Springer Nature
Release Date : 2021-09-03
Annual Update In Intensive Care And Emergency Medicine 2021 written by Jean-Louis Vincent and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-03 with Medical categories.
The Annual Update compiles reviews of the most recent developments in experimental and clinical intensive care and emergency medicine research and practice in one comprehensive book. The chapters are written by well recognized experts in these fields. The book is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.
Oxford Desk Reference Critical Care
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Author : Carl Waldmann
language : en
Publisher: OUP Oxford
Release Date : 2008-11-27
Oxford Desk Reference Critical Care written by Carl Waldmann and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-27 with Medical categories.
Critical care medicine is an evolving speciality in which the amount of available information is growing daily and spread across a myriad of books, journals and websites. This essential guide brings together this information in an easy-to-use format. Up-to-date, relevant, and evidence-based information on the management of the critically ill is combined in one resource, ideal for the use of Intensive Care Units, High Dependency Units, acute medical or surgical wards, Accident and Emergency departments and operating theatres. The book is designed such that each subject will form a self-contained topic in its own right, laid out across two or four pages to facilitate the key aim of rapid and easy access to information. This makes the information included simple to find, read and absorb, so that the book can be consulted in the clinic or ward setting for information on the optimum management of a particular condition. With chapters written by internationally renowned critical care specialists and edited by the three of the leading figures in UK Critical Care, this book should be an essential resource for all critical care physicians.
Oxford Textbook Of Cardiothoracic Anaesthesia
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Author : R. Peter Alston
language : en
Publisher: Oxford Textbook in Anaesthesia
Release Date : 2015
Oxford Textbook Of Cardiothoracic Anaesthesia written by R. Peter Alston and has been published by Oxford Textbook in Anaesthesia this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Medical categories.
Part of the Oxford Textbooks in Anaesthesia series, this title covers the anatomy and physiology, pharmacology, post-operative complications, critical care, and all clinical aspects of cardiac and thoracic anaesthesia. Practical aspects, such as team working, and designing and equipping cardiothoracic theatre and critical care, are also included. The expert and international author team use their experience to ensure this title reflects current world-wide practice across the globe.
Noninvasive Mechanical Ventilation
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Author : ANTONIO ESQUINAS
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-08-12
Noninvasive Mechanical Ventilation written by ANTONIO ESQUINAS and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-08-12 with Medical categories.
Noninvasive mechanical ventilation is an effective technique for the management of patients with acute or chronic respiratory failure. This comprehensive and up-to-date book explores all aspects of the subject. The opening sections are devoted to theory and equipment, with detailed attention to the use of full-face masks or helmets, the range of available ventilators, and patient-ventilator interactions. Clinical applications are then considered in depth in a series of chapters that address the use of noninvasive mechanical ventilation in chronic settings and in critical care, both within and outside of intensive care units. Due attention is also paid to weaning from conventional mechanical ventilation, potential complications, intraoperative applications, and staff training. The closing chapters examine uses of noninvasive mechanical ventilation in neonatal and pediatric care. This book, written by internationally recognized experts, will be an invaluable guide for both clinicians and researchers.