Pharmacology Of Immunotherapeutic Drugs
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Pharmacology Of Immunotherapeutic Drugs
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Author : Clinton B. Mathias
language : en
Publisher: Springer Nature
Release Date : 2019-10-18
Pharmacology Of Immunotherapeutic Drugs written by Clinton B. Mathias and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-18 with Medical categories.
Medicine has entered a golden age in which therapeutic agents are becoming widely available due to advances in basic science and technology. As such, many drugs have been developed that target inflammatory processes and/or the immune system. This book is intended for health professionals examining the modulation of inflammation by immunotherapeutic drugs. The immune system fills the primordial role of host defense and resistance to infections with pathogenic microorganisms. Several hematopoietic-derived cells constituting the innate and adaptive immune systems cooperate to provide barriers for microbial colonization and/or promote pathogen destruction within the host. Conversely, many immune cells are also involved in the pathogenesis and propagation of chronic inflammatory diseases. The beginning of this book details various components of the immune system including the cell types, lymphoid tissues, soluble cytokines and surface molecules that are essential for host defense. Breakdowns in immune tolerance, or dysregulated immune responses to antigens derived from self tissues or innocuous sources, can lead to the development of autoimmunity or chronic inflammatory diseases. Pathophysiologic roles for the immune system are detailed in corresponding chapters on autoimmunity, epithelial surfaces (lungs, skin, intestine), and transplantation, with special emphasis placed on immunotherapeutic drug targets. The last section of the book focuses on treatments that stimulate our immune system to specifically target and fight infectious diseases and cancer. In each chapter, the medications used to treat various diseases/conditions in terms of their mechanism of action and other pharmacologic properties are detailed. Chapters begin with a table showing drug names and classifications. The importance of basic science and clinical trials cannot be understated in the context of drug development. As such, the discovery of certain medications that had a lasting impact in medicine and pharmacy are highlighted in chapter subsections named “Bench to Bedside.” Several clinical applications of immunotherapeutic drugs are described within end-of -chapter case studies including practice questions. The Pharmacology of Immunotherapeutic Drugs is a reference for immunologists and clinicians (medical doctors, pharmacists, nurses) examining the modulation of inflammatory processes by a variety of medications targeting the cells and mediators of our immune system.
Novel Immunotherapeutic Approaches To The Treatment Of Cancer
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Author : Paul D. Rennert
language : en
Publisher: Springer
Release Date : 2016-05-30
Novel Immunotherapeutic Approaches To The Treatment Of Cancer written by Paul D. Rennert and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-30 with Medical categories.
Cancer care is undergoing a radical transformation as novel technologies are directed toward new treatments and personalized medicine. The most dramatic advances in the treatment of cancer have come from therapeutics that augment the immune response to tumors. The immune checkpoint inhibitors are the best-known and most highly advanced examples of Immune Therapeutics targeting tumor cells and include approved antibody drugs directed at the cell surface proteins CTLA4 and PD-1. These are now considered foundational treatments for several solid tumor indications, and that list of indications is growing quickly. More broadly, antibodies have become workhorse molecules across the entire immunotherapy landscape. Antibodies to novel targets modulate the activity of diverse immune cell regulatory proteins. Engineered antibodies can induce tumor cell death or expose tumor cells to poisonous toxins (ADCC and ADC, respectively). Bi-specific antibodies can engage multiple tumor targets simultaneously, or can redirect lymphocytes to attack tumor cells. The antigen-binding domains within antibodies can be spliced onto cell stimulatory domains and transduced into T cells or NK cells, creating remarkable tumor-specific cellular therapeutics (CAR-T, CAR-NK). Beyond antibody-based therapies there are highly diverse and differentiated technology tool kits being applied to immunotherapy. Small molecule drugs are being developed to attack the tumor microenvironment, novel tumor vaccine approaches are showing great promise, patient lymphocytes are being isolated, expanded and reintroduced to patients, gene-editing techniques are becoming widely deployed, and a vast number of new tumor targets, and mutated tumor proteins (neoantigens), are being discovered. The past decade has seen unprecedented success in the treatment of diverse cancers. The authors of this volume have been asked to not only review progress to date, but importantly, to look ahead, and anticipate the evolution of cancer treatment across diverse Immune Therapeutic approaches. Our hypothesis is that the advances we are seeing across the immunotherapy landscape will further evolve and synergize, leading us finally to outright cures for many cancers.
Cancer Pharmacology
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Author : Ashkan Emadi, MD, PhD
language : en
Publisher: Springer Publishing Company
Release Date : 2023-10-06
Cancer Pharmacology written by Ashkan Emadi, MD, PhD and has been published by Springer Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-06 with Medical categories.
Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs, Second Edition is a visually engaging reference detailing the essential basic and clinical science of all approved, effective, and life-prolonging drug therapies in oncology. Now with a greater emphasis on clinical context, application, and management in each chapter, this significantly revised edition provides both early-career and seasoned clinicians with a practical, bench-to-bedside approach and patient-oriented guide. The book provides detailed coverage of the major advances in cancer pharmacology at the forefront of our standards of care for solid tumors and hematologic malignancies, in addition to the basic science that is directly necessary and applicable when at the patient’s bedside. Everything from traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents is explored, in addition to a new chapter covering pharmacogenomics. Accompanied by elegant illustrations, each chapter details the tumor microenvironment, chemical structures of agents, pharmacodynamics, pharmacokinetics, pharmacogenomic and molecular properties of the various agents, and their mechanisms of action. The book covers alkylating agents, antimetabolites, antimitotics, epigenetic modulators, hormonal agents, targeted therapies, monoclonal antibodies, immunotherapeutic agents, and much more. Thoroughly updated to include new FDA-approved treatments and applications, and written by leading experts in cancer pharmacology, this second edition continues to be a “must have” for anyone involved in the basic, translational, or clinical aspects of oncology and hematology, including clinicians, pharmacists, nurses, and trainees. Key Features: Over 150 beautiful illustrations depict structures, pharmacokinetics, pharmacodynamics, and pharmacogenomics associated with each class of agents Contains more than 160 high-yield hematology and oncology board-style chapter review questions (more than double the previous edition) with descriptive rationales Describes how chemotherapy, targeted therapy, immunotherapy, and hormonal therapy work, and why they are expected to work adjuvantly, neoadjuvantly, and in combination with other treatment modalities Thoroughly updated and revised chapters cover new FDA drug approvals, disease-site indications, clinical applications and management of drug-to-drug interactions, and toxicities Discusses challenges related to drug development, drug approval, and regulatory issues in relation to anticancer treatments Provides important pharmacotherapy context with clinical pearls in each chapter that help support a patient-oriented, bedside approach
Immunotherapy A Novel Facet Of Modern Therapeutics
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Author : Sujata P. Sawarkar
language : en
Publisher: Springer Nature
Release Date : 2020-12-16
Immunotherapy A Novel Facet Of Modern Therapeutics written by Sujata P. Sawarkar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-16 with Medical categories.
This book illustrates the significance and relevance of immunotherapy in modern-day therapeutics. Focusing on the application of immunotherapy in oncology, neurodegenerative and autoimmune diseases, it discusses the drug delivery systems, and pre-clinical and clinical methodologies for immunotherapy-based drugs. It also comprehensively reviews various aspects of immunotherapy, such as regulatory affairs, quality control, safety, and pharmacovigilance. Further, the book discusses the in vitro validation of therapeutic strategies prior to patient application and management of immunotherapy-related side effects and presents case studies demonstrating the design and development (pre-clinical to clinical) of immunotherapy for various diseases. It also describes various design considerations and the scale-up synthesis of immunotherapeutics and screening methods. Lastly, it explores the important aspect of cost-effectiveness and rational immunotherapy strategies.
The Easy Book Of Cancer Pharmacology
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Author : Esther Una Cidon
language : en
Publisher: Nova Science Publishers
Release Date : 2016
The Easy Book Of Cancer Pharmacology written by Esther Una Cidon and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Antineoplastic agents categories.
This book represents the efforts of young oncologists, haematologists, pharmacists and oncology nurses who are highly motivated and encouraged by the significant development of new effective anticancer drugs. Since the discovery of antimetabolites and alkylating agents in the 1940s and 1950s, many new products have been introduced into our daily arsenal not only through chemotherapy agents, but also by means of biological or immunotherapeutic drugs whose side effects differ significantly. The idea of this book was born from a simple observation and confirmation of fact. New doctors in training experience high levels of stress and lack of confidence when confronting cancer patients and explaining a treatment or managing frequent side effects. Patients questions will only add more nervousness, and this will lead to a failure in the doctor-patient relationship, causing the patients mistrust and doctors frustration. Nurses dealing with these patients will suffer pressure too, as many questions regarding antineoplastic drugs will be asked of them and patients expect them to ease their doubts. This feeling of vulnerability in front of a patient, though a part of the maturation process when becoming a professional caretaker, causes discomfort and incertitude. In this context, it is crucial to gain great knowledge about pharmacokinetic and pharmacological features of each active anticancer drug used, as well as the indications, dosages, interactions and toxicities, to be able to face the daily practice of oncology without concerns and manage daily therapeutic complications easily. This may be considered very difficult, taking into account the huge number of active agents doctors manage routinely, but doctors have accepted the challenge and designed a straightforward, comprehensible book to solve this issue. The Easy Book of Cancer Pharmacology provides the means to overcome the problem. It is conceived as an accessible, concise and yet exhaustive tool which displays a vast amounts of knowledge in a very schematic way. It is easy to consult and offers a very practical expertise to develop the ability of managing effectively each antineoplastic agent quickly. It gives the necessary insights to explain this to the patients with confidence. Each chapter reviews one active drug and shows the information with a pragmatic style, and they are divided into different sections. Each section covers distinct aspects of the agent, from general characteristics to more specific details related to clinical pharmacology. In quickly advancing fields such as oncology, such a book is necessary to help update the ever-developing and expanding knowledge of clinicians and patients in an efficient and effective manner.
Advances In Immunopharmacology
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Author : J. Hadden
language : en
Publisher: Elsevier
Release Date : 2016-04-19
Advances In Immunopharmacology written by J. Hadden and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Advances in Immunopharmacology documents the proceedings of the First International Conference on Immunopharmacology held in Brighton, England, in July 1980. The volume contains 60 papers organized into 10 parts. The papers in Part I examine the pharmacology of immunotherapeutic drugs and immunotoxicology. Part II presents studies on thymic hormones. Part III is devoted to immunopharmacologic approaches to diseases other than cancer. Part IV deals with mechanisms of chemotaxis degranulation and microbicidal action. Part V focuses on cancer immunopharmacology and immunotherapy while Part VI covers the mechanisms of inflammatory and allergic processes. Part VII takes up the immune testing of the actions of immunotherapeutic agents. Part VIII discusses prostaglandins and macrophage suppression. Part IX is devoted to selected topics such as mechanism of action of soluble immune response suppressor and new approaches to the therapy of allergic diseases. Part X presents discussions during the therapy communication sessions.
Advances In Immunopharmacology
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Author :
language : en
Publisher: Academic Press
Release Date : 2021-06-05
Advances In Immunopharmacology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-05 with Medical categories.
Advances in Pharmacology, Volume 91, the latest release in this well-received series, presents the latest information in the field, with this update including chapters on Modulation of inflammation and immune response by the stress-activated transcription factor Nrf2, Therapeutic modulation of macrophage phenotype to treat acute and chronic liver diseases, Immodulation by cannabinoids, The use of nanomaterials to target immunity, Next generation in cancer immunotherapy, checkpoint inhibitors, Vaccines as a therapy for food allergy, Role of inflammation/immune system in depression, Therapeutic targeting of tumor-associated macrophages, Mast cells, and more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
Immunopharmacology Reviews
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Author : J.W. Hadden
language : en
Publisher: Springer
Release Date : 1990-01-31
Immunopharmacology Reviews written by J.W. Hadden and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-01-31 with Medical categories.
Immunopharmacology as a field of scientific endeavor had its origins more than thirty years ago in the application of antibody-based techniques to assays of hormones and drugs in tissues and body fluids. More recently, the field has been redefined to include a primary focus on the immune system as a target of xenobiotic action. Advances in the field of immunology have made it apparent that the immune system, like other organ systems, declines in its function as a result of aging, viral infections like AIDS, and other immunotoxic influences, giving rise to secondary immunodeficiency. Deficiencyof the immune system in turn leads to infections, autoimmune diseases, and an increased incidence of certain cancers. The notion of treating the failing immune system is relatively new; however, more than a decade of research on cancer and AIDS has created the burgeoning new clinical field of immunotherapy. Immunopharmacology then stands as the preclinical and clinical science of immune manipulation. As such, like its parent field of pharmacology, it includes within its scope basic studies of immune mechanisms as they relate to the pathogenesis of inflammation and immunologic disturbances. As with pharma cology, the perspective is always a therapeutic one. Studies of immune and inflammatory processes emphasize the use of pharmacologic probes and drugs to elucidate the underlying biochemical pharmacology.
Immunopharmacology Reviews
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Author : J. W. Hadden
language : en
Publisher:
Release Date : 2014-01-15
Immunopharmacology Reviews written by J. W. Hadden and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
Immunotherapy And Biomarkers In Neurodegenerative Disorders
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Author : Martin Ingelsson
language : en
Publisher: Methods in Pharmacology and To
Release Date : 2018-04-28
Immunotherapy And Biomarkers In Neurodegenerative Disorders written by Martin Ingelsson and has been published by Methods in Pharmacology and To this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-28 with Medical categories.
This practical volume examines a number of topics that explore the current status of immunotherapy and diagnostic markers for neurodegenerative disorders. With a focus on Alzheimer's disease, the first sections of the book examine immunotherapeutic approaches for the aforementioned disease as well as for Parkinson's disease and Huntington's disease, amongst others. The last section of the book covers the importance of biomarker techniques to catch these diseases early enough for the treatments to be most useful. Written for the Methods in Pharmacology and Toxicology series, this book contains the kind of detailed descriptions and implementation advice that will offer a smooth transition into the lab. Authoritative and useful, Immunotherapy and Biomarkers in Neurodegenerative Disorders aims to aid in the continued progress in the development of novel immune-based drugs and diagnostic tools for these devastating brain diseases.
