Phthalocyanines For Photodynamic Therapy

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Silicon Phthalocyanines For Photodynamic Therapy

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Author : Jeffrey C. Berlin
language : en
Publisher:
Release Date : 2006

Silicon Phthalocyanines For Photodynamic Therapy written by Jeffrey C. Berlin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.

Phthalocyanines For Photodynamic Therapy

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Author : Yun Liu
language : en
Publisher:
Release Date : 2010

Phthalocyanines For Photodynamic Therapy written by Yun Liu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.

In order to develop methods for controlling the photostability of phthalocyanines used in photodynamic therapy, the stability of their toluene solutions in presence of radical sources and air under white light was investigated. The results show that phthalocyanines photodecompose in the presence of alkenes or amino groups, and that their photodecomposition is strongly influenced by the nature of the radical source. Based on this study, four sets of silicon phthalocyanines bearing ligands which can act as radical sources or silicon phthalocyanines bearing ligands which can act as reference ligands were synthesized and characterized, and their photostability was studied. One set was composed of three alkoxysilicon phthalocyanines, the second of eight carboxysilicon phthalocyanines, another of a siloxysilicon phthalocyanine and the last of seven carboxylate salts of SiPc[OSi(CH3)2(CH2)3NH(CH3)2]2. The members of the first set are SiPc[O(CH2)4CH3]2, Pc 307, SiPc[OCH2CH=C(CH3)(CH2)2CH=C(CH3)2]2, Pc 302 and SiPc[O(CH2CH=C(CH3)CH2)2CH2CH=C(CH3)2]2, Pc 303; of the second are SiPc[OC(O)(CH2)16CH3]2, Pc 294, SiPc[OC(O)(CH2)7CH=CH(CH2)7CH3]2, Pc 295, SiPc[OC(O)(CH2)6(CH2CH=CH)2(CH2)4CH3]2, Pc 296, SiPc[OC(O)(CH2)6(CH2CH=CH)3CH2CH3]2, Pc 297, SiPc[OC(O)(CH2)2(CH2CH=CH)4(CH2)4CH3]2, Pc 299, SiPc[OC(O)CH2(CH2CH=CH)6CH2CH3]2, Pc 300, SiPc[OC(O)(CH2)3(CH2CH=CH)3(CH2)4CH3]2, Pc 298 and SiPc[OC(O)(CH=C(CH3)CH=CH)2C6H6(CH3)3]2, Pc 301; of the third is SiPc[OSi(CH=CH2)3]2, Pc 279; and of the last are of the type SiPc[OSi(CH3)2(CH2)3NH(CH3)2]22+ [OC(O)R]-2 where the carboxylate anions are stearate, oleate, linoleate, linolenate, arachidonate, retinoate and docosahexaenoate. The results further show that the photodecomposition of phthalocyanines by radicals is strongly influenced by the nature of the radical source. The penetration properties of a Pc 4 - ethanol-propylene glycol formulation, of Pc 4 - Vanicream® formulations with or without Tween® 80, and of Pc 4 salt-Vanicream® formulations with or without Tween® 80 through a model membrane (polydimethylsiloxane) were investigated with a Franz vertical diffusion cell system. An attempt to study the penetration properties of Pc 4 and Pc 4-salt formulations through pig keratomes also was made. Four phthalocyanines designed to release their excited-state energy in a specific direction in space were synthesized and characterized. These were MPc[2,3-O(C2H4CH(CH3)CH2)2C2H4CH(CH3)2]2 where M is H2, Ni, Co or Zn. A better route was developed for the synthesis of the Pc 4 reference compound HOSiPcOSi(CH3)2(CH2)3N(C2H5)2, Pc 34. The Pc 12 naphthalocyanine analogue, SiNc[OSi(CH3)2(CH2)3N(CH3)2]2, was synthesized and characterized.

Photodynamic Therapy Microform Enhancement Of Phthalocyanine Targeting From Modifications On The Macrocycle To The Use Of Protein Delivery Vehicles

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Author : Cynthia M. (Cynthia Marie) Allen
language : en
Publisher: National Library of Canada = Bibliothèque nationale du Canada
Release Date : 2001

Photodynamic Therapy Microform Enhancement Of Phthalocyanine Targeting From Modifications On The Macrocycle To The Use Of Protein Delivery Vehicles written by Cynthia M. (Cynthia Marie) Allen and has been published by National Library of Canada = Bibliothèque nationale du Canada this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.

Silicon Phthalocyanines For Photodynamic Therapy Studies

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Author :
language : en
Publisher:
Release Date : 2008

Silicon Phthalocyanines For Photodynamic Therapy Studies written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.

Synthesis Of Phthalocyanines As Photosensitizers For Photodynamic Therapy

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Author : Hongqiao Wu
language : en
Publisher:
Release Date : 2000

Synthesis Of Phthalocyanines As Photosensitizers For Photodynamic Therapy written by Hongqiao Wu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.

Water Soluble Phthalocyanines For Photodynamic Therapy

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Author : Kieron D. Legge
language : en
Publisher:
Release Date : 2004

Water Soluble Phthalocyanines For Photodynamic Therapy written by Kieron D. Legge and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.

Synthesis Of Novel Unsymmetrical Zinc Ii Phthalocyanines For Photodynamic Therapy

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Author : Lei Duan
language : en
Publisher:
Release Date : 2005

Synthesis Of Novel Unsymmetrical Zinc Ii Phthalocyanines For Photodynamic Therapy written by Lei Duan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Photochemotherapy categories.

Synthesis Of Phthalocyanines And Naphthalocyanines For Photodynamic Therapy And Photothermal Therapy Studies

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Author : Xinzhan Peng
language : en
Publisher:
Release Date : 2001

Synthesis Of Phthalocyanines And Naphthalocyanines For Photodynamic Therapy And Photothermal Therapy Studies written by Xinzhan Peng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.

Chemical Mechanisms In Photodynamic Therapy With Phthalocyanines

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Author : David R.. Phillips
language : en
Publisher:
Release Date : 1997

Chemical Mechanisms In Photodynamic Therapy With Phthalocyanines written by David R.. Phillips and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.

Novel Water Soluble Phthalocyanines For Photodynamic Therapy And Nuclear Imaging Microform

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Author : Wesley M. (Wesley Milton) Sharman
language : en
Publisher: National Library of Canada = Bibliothèque nationale du Canada
Release Date : 1997

Novel Water Soluble Phthalocyanines For Photodynamic Therapy And Nuclear Imaging Microform written by Wesley M. (Wesley Milton) Sharman and has been published by National Library of Canada = Bibliothèque nationale du Canada this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.