Physicochemical Approaches To The Characterization Of Pharmaceutical Systems
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Physicochemical Approaches To The Characterization Of Pharmaceutical Systems
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Author : Nicola de Zordi
language : en
Publisher:
Release Date : 2019-01-15
Physicochemical Approaches To The Characterization Of Pharmaceutical Systems written by Nicola de Zordi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-15 with Medical categories.
Physicochemical Approaches to the Characterization of Pharmaceutical Systems provides consistent data analysis on the basic physics and chemistry involved in pharmaceutical systems that are carried out using various theoretical models. The book explores states of matter and thermodynamics, how to estimate chemical properties, solubility and distribution phenomena, kinetic processes and drug delivery, and thermodynamics versus the shape of molecules. It supplies several guidelines for achieving better estimations of properties associated with complex molecular geometries, such as important drug, polymer and biopolymer characteristics. Researchers will find it to be a crucial resource for studies in pharmaceutical science and chemical engineering. Covers a wide range of pharmaceutical systems, with an emphasis on chemical physics and thermodynamics Considers contemporary issues in pharmaceutical sciences through interdisciplinary frameworks Suggests novel approaches to complex molecular structures Serves as a comprehensive guide for academic and industrial researchers across pharmaceutical disciplines
Characterization Of Pharmaceutical Nano And Microsystems
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Author : Leena Peltonen
language : en
Publisher: John Wiley & Sons
Release Date : 2020-10-27
Characterization Of Pharmaceutical Nano And Microsystems written by Leena Peltonen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-27 with Science categories.
Learn about the analytical tools used to characterize particulate drug delivery systems with this comprehensive overview Edited by a leading expert in the field, Characterization of Pharmaceutical Nano- and Microsystems provides a complete description of the analytical techniques used to characterize particulate drug systems on the micro- and nanoscale. The book offers readers a full understanding of the basic physicochemical characteristics, material properties and differences between micro- and nanosystems. It explains how and why greater experience and more reliable measurement techniques are required as particle size shrinks, and the measured phenomena grow weaker. Characterization of Pharmaceutical Nano- and Microsystems deals with a wide variety of topics relevant to chemical and solid-state analysis of drug delivery systems, including drug release, permeation, cell interaction, and safety. It is a complete resource for those interested in the development and manufacture of new medicines, the drug development process, and the translation of those drugs into life-enriching and lifesaving medicines. Characterization of Pharmaceutical Nano- and Microsystems covers all of the following topics: An introduction to the analytical tools applied to determine particle size, morphology, and shape Common chemical approaches to drug system characterization A description of solid-state characterization of drug systems Drug release and permeation studies Toxicity and safety issues The interaction of drug particles with cells Perfect for pharmaceutical chemists and engineers, as well as all other industry professionals and researchers who deal with drug delivery systems on a regular basis, Characterization of Pharmaceutical Nano- and Microsystems also belongs on bookshelves of interested students and faculty who interact with this topic.
Analytical Approaches To Physicochemical Characterization Of Colloid Drug Carriers
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Author : Mustafa Mohammed Abdelaziz Elsayed
language : en
Publisher:
Release Date : 2011
Analytical Approaches To Physicochemical Characterization Of Colloid Drug Carriers written by Mustafa Mohammed Abdelaziz Elsayed and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Use of colloidal carriers in drug delivery continues to grow. This created a need in the pharmaceutical field for better understanding of the physical and physicochemical properties of such, often complex, colloidal systems. This dissertation aims at improving this understanding and at developing simple characterization techniques to assist in colloidal drug carrier development. Chapter 1 provides a short introduction. In Chapter 2 I introduce and explain a new analytical approach to analyzing potentiometric data measured with lipid vesicle suspensions. The proposed model for the first time properly considers the Coulombic electrostatic interaction in addition to the hydrophobic interactions underlying drug-carrier association. Chapter 3 revisits vesicle-to-micelle transformation in phosphatidylcholine-cholate mixtures, and pays special attention to the lipid bilayer curvature effects. The emerging picture of the studied vesicle-to-micelle transformation is richer, but also more complex, than previously known. In Chapter 4 I investigate the applicability of UV/Vis spectrometry to characterization of submicroscopic drug carriers, such as lipid vesicles. The results suggest that the measured turbidity spectra contain sufficient information for accurate, fast, and viscosity-independent characterization of submicroscopic drug carriers. The advanced analytical approaches developed and investigated in this dissertation lend themselves to applications in pharmaceutical research and quality control, but also more generally in colloidal carriers characterization.
Physicochemical Basis Of Pharmaceuticals
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Author : Humphrey Moynihan
language : en
Publisher: Oxford University Press, USA
Release Date : 2009-07-23
Physicochemical Basis Of Pharmaceuticals written by Humphrey Moynihan and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-23 with Business & Economics categories.
What are the physical and chemical properties that determine how a drug interacts with the body? What determines which dosage form is best, if it will reach its intended target, and how it will be metabolised once it has entered the body? The Physicochemical Basis of Pharmaceuticals explores the phenomena which affect the formulation and bio-availability of drug substances to give a straightforward, accessible treatment of the essential concepts affecting the absorption and distribution of drugs. It provides the reader with the conceptual 'tool-kit' necessary to understand the physicochemical aspects of drug design and action, and shows how these concepts apply in practice. The book introduces key underlying physical chemistry principles before exploring pharmaceutical solutions, the pharmaceutical solid phase, solid - liquid dispersal systems, biological interfaces, absorption, distribution, metabolism and excretion, to give a complete view of the field. Focusing at all times on the essential principles and concepts, The Physicochemical Basis of Pharmaceuticals avoids excessive detail, presenting the key facts, backed up with pertinent examples and easy-to-digest illustrations, making it the ideal primer for those who need to understand physicochemical issues in the context of their broader field of study. Online Resource Centre For registered adopters of the text: · Figures from the book in electronic format, ready to download For students: · A hyperlinked bibliography of references given in the text.
Physico Chemical And Computational Approaches To Drug Discovery
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Author : Javier Luque
language : en
Publisher: Royal Society of Chemistry
Release Date : 2012
Physico Chemical And Computational Approaches To Drug Discovery written by Javier Luque and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
This title covers a wide range of topics relevant to the development of drugs. It provides a comprehensive description of the major methodological strategies available for rational drug discovery.
Analytical Techniques In The Pharmaceutical Sciences
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Author : Anette Müllertz
language : en
Publisher: Springer
Release Date : 2016-08-30
Analytical Techniques In The Pharmaceutical Sciences written by Anette Müllertz and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-30 with Medical categories.
The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build. To effectively design and exploit drug delivery systems, the underlying characteristic of a dosage form must be understood--from the characteristics of the individual formulation components, to how they act and interact within the formulation, and finally, to how this formulation responds in different biological environments. To achieve this, there is a wide range of analytical techniques that can be adopted to understand and elucidate the mechanics of drug delivery and drug formulation. Such methods include e.g. spectroscopic analysis, diffractometric analysis, thermal investigations, surface analytical techniques, particle size analysis, rheological techniques, methods to characterize drug stability and release, and biological analysis in appropriate cell and animal models. Whilst each of these methods can encompass a full research area in their own right, formulation scientists must be able to effectively apply these methods to the delivery system they are considering. The information in this book is designed to support researchers in their ability to fully characterize and analyze a range of delivery systems, using an appropriate selection of analytical techniques. Due to its consideration of regulatory approval, this book will also be suitable for industrial researchers both at early stage up to pre-clinical research.
Physico Chemical Methods In Drug Discovery And Development
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Author : Zoran Mandic
language : en
Publisher: IAPC Publishing
Release Date : 2012
Physico Chemical Methods In Drug Discovery And Development written by Zoran Mandic and has been published by IAPC Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Physicochemical Characterization Of Pharmaceuticals
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Author : C. Novak
language : en
Publisher: Springer Verlag
Release Date : 2006-01-01
Physicochemical Characterization Of Pharmaceuticals written by C. Novak and has been published by Springer Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-01 with Science categories.
Drug performance is a vital part of drug development, drawing on expertise from both pharmaceutics and pharmacokinetics disciplines. This book offers readers step-wise information to develop quality pharmaceuticals. It consists of sections introducing key concepts and advances in the areas of dissolution, BA/BE, BCS, IVIC, and product quality.
The Application Of Physicochemical Methods For The Analysis Of Small And Complex Pharmaceutical Drugs
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Author : Tebogo E. Mabotha
language : en
Publisher:
Release Date : 2003
The Application Of Physicochemical Methods For The Analysis Of Small And Complex Pharmaceutical Drugs written by Tebogo E. Mabotha and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Fundamentals Of Drug Delivery
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Author : Heather A. E. Benson
language : en
Publisher: John Wiley & Sons
Release Date : 2021-10-12
Fundamentals Of Drug Delivery written by Heather A. E. Benson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-12 with Medical categories.
A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition Details the physiology and barriers to drug delivery for each administration route Presents a historical perspective and a look into the possible future of advanced drug delivery systems Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.