Polyamine Drug Discovery
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Polyamine Drug Discovery
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Author : Patrick M. Woster
language : en
Publisher: Royal Society of Chemistry
Release Date : 2012
Polyamine Drug Discovery written by Patrick M. Woster and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
This is the first comprehensive description of the discovery and therapeutic potential of polyamine drugs.
Rsc Drug Discovery 17
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Author : Patrick Woster
language : en
Publisher:
Release Date : 2011
Rsc Drug Discovery 17 written by Patrick Woster and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Polyamines are ubiquitous molecules that are involved in a number of important cellular processes. Aberrations in their function or metabolism play a role in diseases such as cancer and parasitic infection. A number of validated drug targets have been identified, including enzymes in the polyamine biosynthetic and catabolic pathways and the S-adenosylmethionine synthetic and salvage pathways. Polyamine Drug Discovery is the first comprehensive volume to cover all aspects of the design and development of potential therapeutics targeting polyamine metabolism. The book details research progress f.
Polyamines
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Author : Tomonobu Kusano
language : en
Publisher: Springer
Release Date : 2015-01-07
Polyamines written by Tomonobu Kusano and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-07 with Science categories.
This book covers key topics in polyamine research from a range of organisms, including plants, mammals, and prokaryotes such as bacteria and archaea. The book provides an introduction to general concepts in the field of polyamine research, as well as more detailed information. With the availability of genome sequence data from a broad range of organisms, the evolution of the genes involved in polyamine metabolism is discussed. The mode of action of polyamines has been shown to be dependent on cation channels, and this mechanism is described in the book. The origin of polyamine transporters (from bacteria, yeasts, and plants) is described. The various effects of polyamines on growth and survival are also documented. The book details the mechanisms of polyamine homeostasis and the role of polyamine molecules as precursors of secondary metabolites such as plant alkaloids and toxins derived from spiders and wasps. The role of polyamines in longevity and disease is discussed. A link between polyamine contents and cancer progression is reported, as is the use of polyamine metabolites as diagnostic markers in the initial stages of cancer. Moreover, a novel approach that utilizes the polyamine pathway of a parasite as a drug target in African sleeping sickness is described. Therefore, this book is a valuable resource, both as a textbook for undergraduate and graduate students and also as a reference book for front-line polyamine researchers.
Enzymes As Targets For Drug Design
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Author : Michael Palfreyman
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Enzymes As Targets For Drug Design written by Michael Palfreyman and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
Enzymes as Targets for Drug Design is a collection of scientific discussions related to enzyme inhibitors that show the many facets of the drug discovery process from the basic sciences through clinical applications. Topics include the biogenesis of phosphatidylinositol glycosyl membrane proteins, structure and catalytic function of ADP-ribose polymerase (ADPRT), and modulation of the dopaminergic system in cardiovascular therapeutics. The therapeutic utility of selected enzyme-activated irreversible inhibitors, the role of proteinases in the fibrosis of systemic sclerosis, and therapeutic opportunities in eicosanoid biosynthesis are also discussed. This book consists of 18 chapters and begins with examples of enzymes whose activities have recently been elucidated, or for which newer insights have been gleaned, but which do not yet have selective or potent inhibitors. The second part provides examples of enzymes where inhibitors have been identified but it is still not clear whether or not such an enzymatic blockade will be therapeutically beneficial. The final section describes clinical studies of newer, and not so new, enzyme inhibitors that are clearly of therapeutic importance. The therapeutic activity of monoamine oxidase inhibitors and the associated clinical issues are considered. This book is intended for clinicians as well as basic scientists in biochemistry, chemistry, pharmacology, and cell biology.
Discovery And Characterization Of Polyamine Analogues As Inhibitors Of The Plasmodium Falciparum Polyamine Pathway Using Cheminformatics
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Author : Jurgens Jacobus De Bruin
language : en
Publisher:
Release Date : 2013
Discovery And Characterization Of Polyamine Analogues As Inhibitors Of The Plasmodium Falciparum Polyamine Pathway Using Cheminformatics written by Jurgens Jacobus De Bruin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
It is well known that the costs associated with drug discovery are extremely high due the use of expensive in vitro methods as well as the high failure rate of drugs during clinical testing. In order to effectively fight the war against diseases such as malaria a far less expensive approach is required. Increasing the amount of in silico
Inhibition Of Polyamine Metabolism
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Author : Peter McCann
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Inhibition Of Polyamine Metabolism written by Peter McCann and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
Inhibition of Polyamine Metabolism: Biological Significance and Basis for New Therapies provides an overview of the field concerning polyamine biosynthesis inhibitors. The book is comprised of chapters which describe the compounds which are in use; the rationale for the design of such inhibitors; their synthesis and action; their biological effects on mammalian cells and tissues, plants, and microorganisms including protozoal parasites; and a review of the clinical experience with these inhibitors. The major beneficial effect which the wide availability of these inhibitors has had on the field of polyamine research in general is likewise demonstrated. Biochemists, pharmacologist, and cellular physiologists will find this text very useful.
Progress In Polyamine Research
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Author : V. Zappia
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Progress In Polyamine Research written by V. Zappia and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This book contains the scientific contributions presented at an International Symposium held in Sorrento, Italy, in June 1988 under the auspices of the University of Naples, the Italian Society of Biochemistry, and the National Research Council. The modern history of polyamines dates back to 1958 when the Tabors and Rosenthal first described the outlines of their biological synthesis. From then on, and particularly in the last ten years, a veri table explosion of Literature, characterized by thousands of papers, has witnessed the interest of the scientific community toward these molecules. Perhaps the old statement that "polyamines are molecules in search of a function" is no longer true today. A large number of effects exerted by these simple molecules are well known, and in many cases the mechanisms underlying these effects have been elucidated. The first section of the volume is entirely devoted to the enzymology and molecular biology of ornithine decarboxylase. Since its discovery by Gale more than forty years ago, this can be considered among the most widely studied enzymes in biology, and one of the most complex models in enzyme regulation. The mechanism of control of the enzyme activity at the transcriptional, post-transcriptional and post-translational levels, as well as the fine regulation by antizyme, are discussed in detail. The second group of contributions deals wi th AdoMet decarboxylase, propylamine transferase, polyamine oxidase and the other enzymes related to polyamine interconversion and regeneration.
Polyamines
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Author : Kazutomo Imahori
language : en
Publisher: VSP
Release Date : 1985-12
Polyamines written by Kazutomo Imahori and has been published by VSP this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985-12 with Science categories.
The significance of polyamines in cell proliferation and carcinogenesis has stimulated further research interest in their biochemistry and metabolism. These papers, which update the available literature on polyamines, are grouped into four main areas: the metabolism of polyamines; the effect of polyamines on cellular metabolism; inhibitors of polyamine metabolism and their clinical relevance; application to diagnosis and prognosis. The Proceedings include contributions from a wide range of research interests with special emphasis being placed on the clinical aspects of these compounds.
Polyamines
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Author : Anthony E. Pegg
language : en
Publisher: Humana Press
Release Date : 2016-08-23
Polyamines written by Anthony E. Pegg and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Science categories.
Recently, important new findings in the polyamine field and a variety of new experimental systems have revolutionized the study of these ubiquitous cellular components, essential for normal growth and development. In Polyamines: Methods and Protocols, leading researchers contribute an extensive collection of up-to-date laboratory techniques for the further pursuit of polyamine study. The volume delves into vital subjects such as neoplasia studies with animal models and human patients, therapeutic roles for polyamine inhibitors and analogs, polyamine metabolism and oxidative damage, polyamines as regulators of critical ion channels, as well as polyamine transport systems and polyamine-responsive genes. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Polyamines: Methods and Protocols provides a key resource for all scientists pursuing the study of this dynamic and significant aspect of cellular biology.
Polyamine Analogues In Anticancer Drug Design
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Author : Yanlong Li
language : en
Publisher:
Release Date : 1996
Polyamine Analogues In Anticancer Drug Design written by Yanlong Li and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.