Production Of Labyrinthopeptin A1 With Actinomadura Namibiensis
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Production Of Labyrinthopeptin A1 With Actinomadura Namibiensis
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Author : Sebastian Tesche
language : en
Publisher: Cuvillier Verlag
Release Date : 2020-12-21
Production Of Labyrinthopeptin A1 With Actinomadura Namibiensis written by Sebastian Tesche and has been published by Cuvillier Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-21 with Technology & Engineering categories.
The filamentous actinomycete Actinomadura namibiensis is the only known producer of labyrinthopeptins, a class of ribosomally synthesized and posttranslationally modified peptides (RiPPs) displaying highly attractive bioactive properties. In order to increase the labyrinthopeptin A1 productivity in shaking flask cultivations of A. namibiensis, a new cultivation method called salt-enhanced cultivation was used. Compared to the unsupplemented control, labyrinthopeptin A1 productivity was enhanced the most by addition of 50 mM (NH4)2SO4, reaching a 7-fold higher yield of 325 mg L-1 within 10 cultivation days. Salt-enhanced cultivation affected growth and product formation mechanisms, cell morphology characteristics and rheological characteristics of cultivation broth. An image analysis method was developed to quantify both the macro-morphology (pellet size and shape) and the micro-morphology (hyphal network structure) of the heterogeneous filamentous biomass in detail. Productivity-related morphological parameters were in particular the size and circularity of pellets and the degree of hyphal interweaving (hyphal network spacing). It was shown that the time-dependent change in morphology linked to the rheological properties of the cultivation broth. The results presented in this work provide new insights into the cultivation aspects of A. namibiensis and illustrate the challenges on the way to a comprehensive understanding of the complex relationship between productivity, morphology and rheology in filamentous cultivations.
Bioprocess Intensification
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Author : Dirk Holtmann
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2024-07-01
Bioprocess Intensification written by Dirk Holtmann and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-01 with Science categories.
Application of Process Intensification (PI) presents a set of radically innovative principles in process and equipment design, which can bring significant benefits in terms of process efficiency, capital and operating expenses, quality, process safety, and sustainability. Typical approaches in bioprocess intensification are the reduction of the number of production steps, continuous processing, integrated processes, and alternative energy inputs.
Micro And Macroparticle Enhanced Cultivation Of Filamentous Lentzea Aerocolonigenes For Increased Rebeccamycin Production
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Author : Kathrin Schrinner
language : en
Publisher: Cuvillier Verlag
Release Date : 2020-12-28
Micro And Macroparticle Enhanced Cultivation Of Filamentous Lentzea Aerocolonigenes For Increased Rebeccamycin Production written by Kathrin Schrinner and has been published by Cuvillier Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-28 with Science categories.
The filamentous actinomycete Lentzea aerocolonigenes produces the antitumor antibiotic rebeccamycin. However, the complex morphology of actinomycetes leads to challenges during the cultivation often accompanied by low product titers. In the recent past, the to date low rebeccamycin titers were increased by particle addition to cultivations of L. aerocolonigenes. In this thesis the addition of micro-, macro- and adsorbent particles to cultivations of L. aerocolonigenes were investigated in more detail. Furthermore, the scale-up to a bubble-free bioreactor was conducted. The addition of glass microparticles (x50 = 7.9 μm, 10 g L-1) to shake flask cultivations increased the rebeccamycin titer up to 3.6-fold compared to an unsupplemented approach. Pellet slices showed the incorporation of microparticles. With different surface modifications of the microparticles, specific incorporation patterns of the microparticles appeared. The incorporation of microparticles causes looser and smaller pellets allowing an increased nutrient and oxygen supply in the pellet core. With addition of larger (glass) macroparticles (ø = 0.2 – 2.1 mm, 100 g L-1) mechanical stress was induced on the biopellets. The additional supplementation of 5 g L-1 soy lecithin and glass beads (ø = 969 μm, 100 g L-1) resulted in a rebeccamycin titer of 388 mg L-1, one of the highest rebeccamycin titers ever achieved. For the scale-up of L. aerocolonigenes cultivations a bubble-free membrane aeration system was developed. The tubular membrane aeration system can additionally be pressurized to increase the oxygen transfer. First cultivations of L. aerocolonigenes successfully provided 18 mg L-1 rebeccamycin, a concentration similar to that of unsupplemented shake flask cultivations. XAD adsorbent particles were added to cultivations to facilitate rebeccamycin recovery. However, the XAD particles additionally increased the rebeccamycin titer which was likely to be caused by the adsorption of the rebeccamycin precursor tryptophan to the resins which in turn directly transferred the tryptophan to the microorganism.
Food Microbial Sustainability
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Author : Arun Karnwal
language : en
Publisher: Springer Nature
Release Date : 2023-09-23
Food Microbial Sustainability written by Arun Karnwal and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-23 with Science categories.
This book reviews all important aspects of Microbial sustainability in food production and food safety with the aim of shedding new light on these microbes through combined understanding of traditional and novel paradigms. The book is divided into three sections, the first of which reinterprets fundamentals of food microbiology, examining the beneficial aspects of microorganisms in food and microbial responses from food environments and preservation. The second section discusses recent advances in understanding of the sustainable food production, covering, for example, agriculturally important microbes, farming microbes, and fermentation. A wide range of bio-factory issues in food production are also addressed, before turning attention to contemporary food safety approaches in the context of novel assessment methods for microbiological food characterization, improving food safety and food quality, etc. The final section is devoted to public health and its importance of microorganisms in food processing as well as the economic importance of microorganisms as this is also an increasingly important area as we move toward microbial research advances.
Drug Discovery From Natural Products
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Author : Olga Genilloud
language : en
Publisher: Royal Society of Chemistry
Release Date : 2012
Drug Discovery From Natural Products written by Olga Genilloud and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
An integrated review of the most recent trends in natural products, drug discovery, and key lead candidates that are outstanding for their chemistry and biology in novel drug development.
Advances In Probiotics
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Author : Dharumaurai Dhansekaran
language : en
Publisher: Academic Press
Release Date : 2021-07-15
Advances In Probiotics written by Dharumaurai Dhansekaran and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-15 with Reference categories.
Advances in Probiotics: Microorganisms in Food and Health highlights recent advances in probiotic microorganisms, commercial probiotics, safety aspects of probiotics, preparation and commercialization, microbiome therapy for diseases and disorders, and next generation probiotics. This is a comprehensive resource of developments of new formulations and products for probiotic and prebiotic food with focus on the microorganisms to enable effective probiotic delivery. The book deliberates contemporary trends and challenges, risks, limitations in probiotic and prebiotic food to deliver an understanding not only for research development purposes but also to benefit further standardize industrial requirements and other techno-functional traits of probiotics. At present there is no solitary volume to describe the probiotics and prebiotics properties, Advances in Probiotics: Microorganisms in Food and Health provides novel information to fill the overall gap in the market. It presents the most current information on probiotic and prebiotics for the food industry. This book is a valuable resource for academicians, researchers, food industrialists, and entrepreneurs. Presents a simulated gastrointestinal system to analyze the probiotics effects on gut microbiome for learning purpose Includes research information on Next Generation Probiotics to foster new formulations Provides comprehensive information on probiotic microorganism behavior for more accurate analysis Discusses the potential of probiotic and prebiotic foods in preventing disease
Biology And Biotechnology Of Actinobacteria
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Author : Joachim Wink
language : en
Publisher: Springer
Release Date : 2017-10-19
Biology And Biotechnology Of Actinobacteria written by Joachim Wink and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-19 with Science categories.
This book provides in-depth insights into the biology, taxonomy, genetics, physiology and biotechnological applications of Actinobacteria. It especially focuses on the latter, reviewing the wide variety of actinobacterial bioactive molecules and their benefits for diverse industrial applications such as agriculture, aquaculture, biofuel production and food technology. Actinobacteria are one of the most promising sources of small bioactive molecules and it is estimated that only a small percentage of actinobacterial bioactive chemicals have been discovered to date. Identifying new diverse gene clusters of biotechnological relevance in the genome of Actinobacteria will be crucial to developing advanced applications for pharmaceutical, industrial and agricultural purposes. The book offers a unique resource for all graduate students, researchers and practitioners in the fields of microbiology, microbial biotechnology, and the genetic engineering of Actinobacteria.
Entwicklung Und Charakterisierung Von Tropfen Bioreaktoren Band 85
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Author : Lasse Jannis Frey
language : de
Publisher: Cuvillier Verlag
Release Date : 2021-10-22
Entwicklung Und Charakterisierung Von Tropfen Bioreaktoren Band 85 written by Lasse Jannis Frey and has been published by Cuvillier Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-22 with Science categories.
Miniaturisierte Kultivierungssysteme mit einem hohen Maß an integrierter Sensorik und Kontrollmöglichkeit haben sich als leistungsfähige Werkzeuge in der Entwicklung moderner Bioprozesse erwiesen. Besonders Tropfen-basierte Mikrobioreaktorsysteme (tMBR) eröffnen weitreichende Möglichkeiten zur parallelisierten Kultivierung von Zellen im Hochdurchsatzverfahren bei geringem Probeneinsatz. Das abgeschlossene Fluidelement eines Flüssigkeitstropfens wird dabei genutzt, um eine Kompartimentierung zu erzeugen und separate biologische Prozesse durchzuführen. Im Gegensatz zur Tropfen-basierten Mikrofluidik mit kontinuierlicher Fluidförderung, ermöglichen Kultivierungssysteme mit sessilen Tropfen eine erhöhte Flexibilität in der Fluidhandhabung sowie eine Integration von kontinuierlicher online-Analytik. Allerdings bergen das Aufrechterhalten einer optimalen Kultivierungsumgebung als auch die Förderung von Zellwachstum in einem Flüssigkeitstropfen inhärente Herausforderungen, besonders in Bezug auf Stofftransport und Verdunstung. Gegenstand dieser Arbeit ist die Entwicklung eines Tropfen-basierten Kultivierungssystems zur Kultivierung und Untersuchung von Zellen. Durch die Implementierung einer aktiven Mischtechnik und umfangreicher Sensorik wurde ein leistungsfähiges Kultivierungssystem entwickelt, das als analytisches Werkzeug für biopharmazeutische Applikationen eingesetzt werden kann. Aktive Durchmischung und Stofftransport wurden durch die Anregung von Kapillarwellen auf der Tropfenoberfläche mittels vertikaler Oszillation erzeugt. So kann der gesamte Reaktorinhalt innerhalb von 3 s homogenisiert und kLa-Werte von bis zu 345 h-1 erzeugt werden, ohne bewegte Mischelemente in den Reaktionsraum zu integrieren. Die Flüssigkeitstropfen sind dabei in einen Glas-Chip eingebettet, der für eine definierte Tropfenform und die Integration optischer Sensoren sorgt. Das hohe Potential des entwickelten Tropfen-basierten Mikrorektorsystems, das aufgrund der eingesetzten Mischtechnik als capillary wave microbioreactor (cwMBR) bezeichnet wird, wurde in einem proof-of-concept durch die Kultivierung von Escherichia coli und Chinese Hamster Ovary Zellen gezeigt.
Prokaryotic Antimicrobial Peptides
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Author : Djamel Drider
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-03-08
Prokaryotic Antimicrobial Peptides written by Djamel Drider and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-08 with Science categories.
The book will provide an overview of the advancement of fundamental knowledge and applications of antimicrobial peptides in biomedical, agricultural, veterinary, food, and cosmetic products. Antimicrobial peptides stand as potentially great alternatives to current antibiotics, and most research in this newly-created area has been published in journals and other periodicals. It is the editors’ opinion that it is timely to sum up the most important achievements in the field and provide the scientific community in a reference book. The goals of this project include illustrating the achievements made so far, debating the state of the art, and drawing new perspectives.
Computer Applications In Fermentation Technology Modelling And Control Of Biotechnological Processes
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Author : N. M. Fish
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Computer Applications In Fermentation Technology Modelling And Control Of Biotechnological Processes written by N. M. Fish and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Richard Fox Chairman, Scientific Programme Committee Between 25th and 29th September, 1988, 243 people who either apply or research the use of computers in fermentation gathered together at Robinson College, Cambridge, UK. They came from 30 countries. The conference brought together two traditions. Firstly, it continued the series on Computer Applications in Fermentation Technology (ICCAFT) inaugurated by Henri Blanchere in Dijon in 1973 and carried forward in Philadelphia and Manchester. Secondly, it brought the expertise of the many members of the International Federation of Automatic Control (IFAC), who focused their attention on biotechnology at Noordwijkerhout in the Netherlands in December, 1985. I am happy to say that the tradition carries on and a successor meeting will hopefully take place in the USA in 1991. If you find these proceedings useful or stimulating, then we hope to see you there. We set out to make ICCAFT4 a close-knit friendly conference. We housed all who cared to in Robinson College itself and organised no parallel sessions. Because we, the organisers, experience difficulty with the jargon of our colleagues from other disciplines, we asked Bruce Beck to present a breakfast tutorial on modern control and modelling techniques, and we set up informal panel discussions after dinner on two evenings. Neville Fish chaired a forum on the microbiological principles behind models, while Professors Derek Linkens and Ron Leigh led a discussion on expert systems in control.