Prognostic And Predictive Factors In Breast Cancer

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Prognostic And Predictive Factors In Breast Cancer

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Author : Rosemary A Walker
language : en
Publisher: CRC Press
Release Date : 2019-08-30

Prognostic And Predictive Factors In Breast Cancer written by Rosemary A Walker and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-30 with categories.

This title reviews the key prognostic factors in breast cancer, discussing the methodologies involved in measuring and reporting. It also examines the roles of major predictive markers such as the steroid receptors, p53 and HER-2. Given the wealth of information in the medical literature on breast cancer, this volume is useful in that it focuses strictly on these factors. That focus makes this text extremely useful for oncologists and researchers who want to learn more about best practices in prognoses.

Prognostic And Predictive Factors In Breast Cancer Second Edition

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Author : Rosemary A. Walker
language : en
Publisher: CRC Press
Release Date : 2003-06-12

Prognostic And Predictive Factors In Breast Cancer Second Edition written by Rosemary A. Walker and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-06-12 with Medical categories.

This title reviews the key prognostic factors in breast cancer, discussing the methodologies involved in measuring and reporting. It also examines the roles of major predictive markers such as the steroid receptors, p53 and HER-2. Given the wealth of information in the medical literature on breast cancer, this volume is useful in that it focuses strictly on these factors. That focus makes this text extremely useful for oncologists and researchers who want to learn more about best practices in prognoses.

Prognostic And Predictive Factors In Primary Breast Cancer

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Author : Pierre Stefanus Gerardus Johannes Hupperets
language : en
Publisher:
Release Date : 1995

Prognostic And Predictive Factors In Primary Breast Cancer written by Pierre Stefanus Gerardus Johannes Hupperets and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.

Diagnostic Prognostic And Predictive Factors Of Response In The Era Of Precision Oncology In Breast Cancer

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Author : Francesco Schettini
language : en
Publisher: Frontiers Media SA
Release Date : 2023-12-12

Diagnostic Prognostic And Predictive Factors Of Response In The Era Of Precision Oncology In Breast Cancer written by Francesco Schettini and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-12 with Medical categories.

In the last couple of decades, the study of the cancer genome and the progressive implementation of next-generation sequencing platforms have provided the Scientific and Oncology communities with a multitude of data, technologies, diagnostic, prognostic, and predictive tools that have been revolutionizing the way we can study, diagnose and treat cancer, including breast tumors. For example, genomic tests can now refine the prognosis of early-stage breast cancer patients beyond standard clinicopathological features and help guide escalated or de-escalated treatment choices. The identification of the molecular intrinsic subtypes might also be helpful in guiding treatment choices in advanced hormone receptor-positive disease. The identification of germline mutations in BRCA1 or BRCA2 has led to the development and introduction of PARP inhibitors for the treatment of advanced and early-stage breast cancer, along with personalized follow-up and prophylactic surgical procedures for patients with or without cancer, carrying such mutations.

Prognostic And Predictive Factors In Brca Associated Breast Cancer

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Author :
language : en
Publisher:
Release Date : 2018

Prognostic And Predictive Factors In Brca Associated Breast Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.

On Prognostic And Treatment Predictive Factors In Early Stage Breast Cancer

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Author : Ann-Marie Billgren
language : en
Publisher:
Release Date : 2002

On Prognostic And Treatment Predictive Factors In Early Stage Breast Cancer written by Ann-Marie Billgren and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.

Prognostic Variables In Node Negative And Node Positive Breast Cancer

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Author : Giampietro Gasparini
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Prognostic Variables In Node Negative And Node Positive Breast Cancer written by Giampietro Gasparini and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Long Term Prognostic And Predictive Factors In Hormone Receptor Positive Breast Cancer

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Author : Helena Fohlin
language : en
Publisher:
Release Date : 2018

Long Term Prognostic And Predictive Factors In Hormone Receptor Positive Breast Cancer written by Helena Fohlin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.

The breast cancer survival in Sweden is good (almost 90 % 5-year relative survival) and has increased over time. For women with hormone receptor negative tumors, most relapses occur within the first 5 years after diagnosis. Thereafter the recurrence risk decreases rapidly. For women with estrogen receptor positive (ER+) tumors the annual risk for late recurrences is 1 – 2 %, even after 5 years of endocrine therapy. This risk accumulates so that approximately 25 % of the patients that are recurrence-free after five years from diagnosis may experience a relapse within further 15 years of follow-up. The relatively high long-term risk calls for identification of prognostic and predictive markers with long-term effect. Though, the number of such markers with proven significance is limited. Of the clinical characteristics, only nodal status and to some extent tumor size and tumor grade have been shown to have long-term prognostic value. In this thesis, we propose long-term prognostic and predictive markers for breast cancer. In paper I , we suggest the protein v-akt murine thymoma viral oncogene homologue 2 (AKT2) as a long-term prognostic marker among patients with ER+ tumors. In our study, besides nodal status, AKT2 was the only factor with long-term prognostic value. This is in accordance with some other studies, though we also showed that the significance of AKT2 was limited to ER+ tumors and that the impact increased with higher ER expression. Approximately 75 – 85 % of the ER+ tumors are also progesterone receptor positive (PR+). ER+/progesterone receptor negative (PR-) tumors are considered to be more aggressive and patients with such tumors are often treated with chemotherapy. In this group, more specific subgroups for targeted therapy are needed. Whereas ER has long been established as a predictive factor regarding tamoxifen benefit, the role of PR has not been clarified to date. In paper II , we showed that PR status adds predictive value to ER considering the long-term benefit from tamoxifen. In paper III , we aimed to identify new prognostic markers among patients with ER+ tumors. Systemically untreated patients with ER+/PR- tumors and high expression of the Ras-related protein RAB6C (RAB6C) had reduced distant recurrence rate. Therefore, we suggest RAB6C as a candidate marker for subgroup division among patients with ER+/PR- tumors. According to the results from paper II, there might be subgroups of patients with ER+/PRtumors that do benefit from tamoxifen. The aim of paper IV was to identify such subgroups. Here, we suggest that patients with ER+/PR- tumors and low RAB6C expression do benefit from tamoxifen. The results from this thesis may encourage further studies for more specific subgroup divisions. Such studies may lead to changes in the management program, where some patients with ER+ tumors should receive prolonged or more intense treatment and others reduced treatment based on the pathological markers AKT2, PR and RAB6C.

Prognosis And Predictive Factors In Human Breast Cancer During Tumor Progression

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Author :
language : en
Publisher:
Release Date : 2014

Prognosis And Predictive Factors In Human Breast Cancer During Tumor Progression written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.

Prognostic And Predictive Factors In Primary High Risk Post Menopausal Breast Cancer

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Author : Ann Knoop
language : en
Publisher:
Release Date : 1998

Prognostic And Predictive Factors In Primary High Risk Post Menopausal Breast Cancer written by Ann Knoop and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.