Prostaglandins Leukotrienes And The Immune Response
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Prostaglandins Leukotrienes And The Immune Response
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Author : John L. Ninnemann
language : en
Publisher: Cambridge University Press
Release Date : 1988-09-30
Prostaglandins Leukotrienes And The Immune Response written by John L. Ninnemann and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-09-30 with Medical categories.
This study looks at the way the products of arachidonic acid metabolism are active both in normal and abnormal immune responses. While some of the fundamental issues such as whether lymphocytes are capable of producing prostaglandins and leukotrienes are still hotly debated, the evidence is overwhelming that many specific immunological problems and disease states are associated with alterations in the normal balance of arachidonic acid metabolism. This book provides a review of the history and chemistry of the arachidonic acid cascade as well as an exhaustive survey of the literature concerning the interaction of arachidonic acid metabolites with cells of the immune system. The author also presents and discusses the evidence demonstrating prostaglandin and leukotriene participation in response to injury and in malignancy, tissue and organ rejection, rheumatoid arthritis, autoimmunity and allergy.
Prostaglandins And Immunity
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Author : James S. Goodwin
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Prostaglandins And Immunity written by James S. Goodwin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E2 (PGE2), prostacyclin (PGI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di-and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.
Prostaglandins Leukotrienes And Other Eicosanoids
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Author : Friedrich Marks
language : en
Publisher: John Wiley & Sons
Release Date : 2008-11-21
Prostaglandins Leukotrienes And Other Eicosanoids written by Friedrich Marks and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-21 with Science categories.
Polyunsaturated fatty acids are essential for human cell metabolism. As precursors of a very large and extremely versatile family of signaling compounds they play a key role in intracellular communication. Eicosanoids constitute one of the most abundant and prominent subfamilies of these fatty acid derivatives which are formed primarily along oxidative pathways. Prostaglandins, leukotrienes, and related eicosanoids have a modulatory function in mammalian cells and are responsible for tissue responses such as inflammation or wound repair. Increasing activity in eicosanoid research sheds new light on today's most common diseases including atherosclerosis, cancer, Alzheimer's, allergies, and rheumatic diseases. The recent advances already have far-reaching implications in medicine. This detailed account, written by leading experts, covers the ground-breaking developments in recent eicosanoid research. The topics span eicosanoid biogenesis, new aspects of their pathophysiology, for example their influence on the cardiovascular system, as well as the clinical application of synthetic eicosanoids and their antagonists. Researchers and students working in biochemistry or in pharmaceutical, physiological, medicinal and neurochemistry will value this informative introduction to one of the most rapidly developing fields in cell biology.
Advances In Prostaglandin Leukotriene And Other Bioactive Lipid Research
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Author : Zeliha Yazici
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Advances In Prostaglandin Leukotriene And Other Bioactive Lipid Research written by Zeliha Yazici and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This volume, the Proceedings of the 12th International Conference on Advances in Prostaglandin, Leukotriene and Other Bioactive Lipid Research: Basic Science and Clinical Applications, held August 25-29, 2002, in Istanbul, Turkey, discusses advances in bioactive lipid research with special attention to cancer, cardiovascular diseases, gastrointestinal diseases and respiratory diseases. Specific topics covered include the role of leukotrienes and lipoxins in inflammation, the cytochrome P450 pathway, the genetics and genomics of bioactive lipids, lipid peroxidation, apoptosis, angiogenesis, isoprostanes, receptors and inhibitors, cyclooxygenase and lipoxygenase pathways and inhibitors, prostaglandin synthases and receptor signaling, phospholipases and inhibitors.
Prostaglandins And Leukotrienes Are Important Innate Immune Mediators In Vesicular Stomatitis Virus Encephalitis
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Author : Nannan Chen
language : en
Publisher:
Release Date : 2002
Prostaglandins And Leukotrienes Are Important Innate Immune Mediators In Vesicular Stomatitis Virus Encephalitis written by Nannan Chen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
Advances In Prostaglandin And Leukotriene Research
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Author : Bengt Samuelsson
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Advances In Prostaglandin And Leukotriene Research written by Bengt Samuelsson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.
This volume is the proceedings of the 11th International Conference on Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications, held in Florence, Italy, on June 4-8, 2000, which continues the tradition of covering both basic and clinical aspects of prostaglandin and leukotriene research. At this meeting particular emphasis was given to the potential application of the novel COX-2 inhibitors, the genetics of asthma relating to the production of leukotrienes, and novel cellular networks for the production of leukotrienes and lipoxins. Traditionally, as has been done in past meetings of this series, a considerable amount of new material was presented and discussed this year, with particular attention given to the newest clinical data.
Prostaglandin Regulation Of Immune Responses Against Coronavirus Infections
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Author : Rahul Vijay
language : en
Publisher:
Release Date : 2016
Prostaglandin Regulation Of Immune Responses Against Coronavirus Infections written by Rahul Vijay and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Alzheimer's disease categories.
Prostaglandins (PG) are ubiquitous lipid mediators that play key roles in pathophysiological responses to infections. They are considered to have both pro and anti-inflammatory roles depending upon the time of inflammation, the receptors that they bind to and the tissues that they act upon. Hence given their pleiotropic effects, a perfect balance between the pro and anti-inflammatory functions of PGs are required to ensure that a controlled timely immune response is elicited to mediate protection and to avoid immunopathology. PGD2 is one such PG that was reported to increase with age in the lungs of mice and to mediate an anti-inflammatory effect thereby blunting the immune response following Severe Acute Respiratory Syndrome - Coronavirus (SARS-CoV). Increase in PGD2 with age incapacitates respiratory dendritic cells (rDC) to migrate from lungs to the draining lymph node following SARS-CoV infection due to down regulation of CCR7 (a receptor for chemokines CCL19/21). Migration of rDCs to draining lymph nodes requires high expression of CCR7 and it's binding to CCL19/21, a chemokine that mediates migration of dendritic cells along its gradient. Although increase in levels of PGD2 might prove beneficial in high inflammatory conditions, it should be noted that high levels of such a potent anti-inflammatory mediator during the initiation of an immune response could prove detrimental. In chapter II of this thesis I show that age-related increases in oxidative stress result in the upregulation of a single phospholipase (PLA2) group II D (G2D) (PLA2G2D) with anti-inflammatory roles. PLA2G2D functions by releasing Arachidonic acid (AA) from the lipid membrane, which will be further metabolized to other pro-resolving/ anti-inflammatory lipid mediators including PGD2.
Prostaglandins Leukotrienes Lipoxins And Paf
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Author : J. Martyn Bailey
language : en
Publisher: Springer
Release Date : 1991
Prostaglandins Leukotrienes Lipoxins And Paf written by J. Martyn Bailey and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.
Proceedings of the XIth International Washington Spring Symposium at the George Washington University, held in Washington, D.C., May 13-17, 1991
Studies On The Immunoregulatory Roles Of Prostaglandins
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Author : Robert Paul Schleimer
language : en
Publisher:
Release Date : 1980
Studies On The Immunoregulatory Roles Of Prostaglandins written by Robert Paul Schleimer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with categories.
Regulation Of Immune Response By Prostaglandins
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Author : James S. Goodwin
language : en
Publisher:
Release Date : 1980
Regulation Of Immune Response By Prostaglandins written by James S. Goodwin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with categories.