Protein Degradation
DOWNLOAD
READ
Download Protein Degradation PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Protein Degradation book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Protein Degradation With New Chemical Modalities
DOWNLOAD
READ
Author : Craig Crews
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-10-08
Protein Degradation With New Chemical Modalities written by Craig Crews and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-08 with Medical categories.
Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally 'difficult to target' proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in this dynamically growing research area; an ideal reference work for researchers in drug discovery and chemical biology as well as advanced students.
The Proteasome Ubiquitin Protein Degradation Pathway
DOWNLOAD
READ
Author : Peter Zwickl
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Proteasome Ubiquitin Protein Degradation Pathway written by Peter Zwickl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This volume gives an overview of pro tea some-mediated protein degradation and the regulatory role of the ubiquitin system in cellular proteolysis. The first chapter describes the molecular evolution of the proteasome and its associated activators, i. e. , the 20S core, the base and the lid of the 19S cap, and the 11 S regulator. The ensuing chapter gives an overview of the structure and assembly of the 20S proteasome and the regulation of the archaeal proteasome by PAN. The third contribution summarizes our knowledge on the eukaryotic 26S proteasome and its regulation by the 19S regu lator, followed by a chapter devoted to the llS regulator, which elucidates the structural basis for the 11 S-mediated activation of the 20S proteasome. The fifth chapter reviews in detail the role of the proteasome in the immune response. The subsequent chapter of the natural substrates of the gives a comprehensive description proteasome and their recognition by the enzymes of the ubiqui tination machinery. The penultimate chapter rounds up the in formation on intracellular distribution of proteasomes in yeast and mammalian cells, while the last contribution highlights proteasome inhibitors, tools which proved to be very valuable for dissecting the cellular roles of the proteasome and which might turn out to be of pharmacological importance.
The Ubiquitin Proteasome System
DOWNLOAD
READ
Author : R. John Mayer
language : en
Publisher: John Wiley & Sons
Release Date : 2008-06-25
The Ubiquitin Proteasome System written by R. John Mayer and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-06-25 with Science categories.
The second volume in a new series dedicated to protein degradation, this book discusses the mechanism and cellular functions of targeted protein breakdown via the ubiquitin pathway. Drawing on the combined knowledge of the world's leading protein degradation experts, this handy reference compiles information on the proteasome-mediated degradation steps of the ubiquitin pathway. In addition to proteasomal function and regulation, it also presents the latest results on novel members of the ubiquitin superfamily and their role in cellular regulation. Further volumes in the series cover the function of ubiquitin-protein ligases, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.
Protein Degradation In Health And Disease
DOWNLOAD
READ
Author : Michele Reboud-Ravaux
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Protein Degradation In Health And Disease written by Michele Reboud-Ravaux and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Protein degradation has been identified as a major mechanism for the regulation of cellular functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated.
Protein Degradation
DOWNLOAD
READ
Author :
language : en
Publisher:
Release Date : 2005
Protein Degradation written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Proteins categories.
Targeted Protein Degradation
DOWNLOAD
READ
Author : Angela M. Cacace
language : en
Publisher: Humana
Release Date : 2022-09-09
Targeted Protein Degradation written by Angela M. Cacace and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-09 with Science categories.
This volume contains a collection of innovative techniques for studying targeted protein degradation. Chapters guide readers through heterobifunctional proteolysis-targeting chimeras (PROTACs) approaches, E3 ligase, E3 ligase-induced ubiquitylation, proteomic approaches, novel degrader molecules, molecular glue, and stabilize binding interaction between a target and E3 ubiquitin ligase. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Targeted Protein Degradation: Methods and Protocols aims to ensure successful results in this emerging field of drug discovery.
Inducing Targeted Protein Degradation
DOWNLOAD
READ
Author : Philipp Cromm
language : en
Publisher: John Wiley & Sons
Release Date : 2023-02-06
Inducing Targeted Protein Degradation written by Philipp Cromm and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-06 with Medical categories.
Enables drug developers in academia and industry to expand the range of accessible drug targets through induced protein degradation Since the introduction of the PROTAC technology in 2015, targeted protein degradation has greatly increased the range of druggable protein targets, enabling pharma companies to develop completely novel therapeutics. Inducing Targeted Protein Degradation is a timely guide to navigating the complexities of the subject and understanding its practical application, with an eye on expanding the range of druggable targets. In Inducing Targeted Protein Degradation, readers will find the most recent information on: Cellular mechanisms of targeted protein degradation and current approaches to retarget these mechanisms for therapeutic use A comparison of different induced degradation approaches, including PROTAC, light-activated degradation, and CHAMPS Drug development aspects such as DMPK optimization and selection of clinical candidates A discussion of the potential of targeted degradation for expanding the range of druggable protein targets Inducing Targeted Protein Degradation will serve as a practice-oriented reference on induced protein degradation for drug discovery professionals and for researchers employing chemical biology approaches.
Ubiquitin Dependent Protein Degradation
DOWNLOAD
READ
Author :
language : en
Publisher: Academic Press
Release Date : 2019-04-04
Ubiquitin Dependent Protein Degradation written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-04 with Science categories.
Ubiquitination and Protein Stability - Part B, Volume 619, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this updated volume presenting interesting chapters written by an international board of authors. Topics of note include chapters on Assays of SUMO protease function in mammalian cells, In vitro analysis of proteasome-associated USP14 activity for substrate degradation and deubiquitylation, Methods to study proteasome regulatory particle assembly, Native mass spectrometry approaches to study the proteasome, Single-molecule methods to study the ubiquitin-proteasome system, Assays for the function of ubiquitin in the mammalian endocytic pathway, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in this series on enzymology
Ubiquitin And The Chemistry Of Life
DOWNLOAD
READ
Author : R. John Mayer
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Ubiquitin And The Chemistry Of Life written by R. John Mayer and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
The first volume in a new series dedicated to protein degradation, this book lays the foundations of targeted protein breakdown via the ubiquitin pathway. The outstanding importance of the ubiquitin pathway has been recognized with the 2004 Nobel Prize in Chemistry for Aaaron Chiechanover, Avram Hershko, and Irwin Rose. Aaron Ciechanover is one of the editors of this series, and Avram Hershko has contributed to the opening chapter of the present volume. Drawing on the the expertise of two Nobel prize winners, this handy reference compiles information on the initial steps of the ubiquitin pathway. Starting out with a broad view of protein degradation and its functions in cellular regulation, it then goes on to examine the molecular mechanisms of ubiquitin conjugation and recycling in detail. All currently known classes of ubiquitin protein ligases are treated here, including latest structural data on these enzymes. Further volumes in the series cover the function of the proteasome, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.
Lysosomal Pathways Of Protein Degradation
DOWNLOAD
READ
Author : J Fred Dice
language : en
Publisher: CRC Press
Release Date : 2000-12-01
Lysosomal Pathways Of Protein Degradation written by J Fred Dice and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-12-01 with Science categories.
Lysosomal Pathways of Protein Degradation looks at cell biology from the view of a lysosome. It summarizes the composition and assembly of lysosomes in mammalian and yeast cells. It also reviews current knowledge about pathways of endocytosis and secretion and how both endocytosed and secreted proteins can be delivered to lysosomes for degradation.