Proton Pump Inhibitors And Acid Related Disorders
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Proton Pump Inhibitors And Acid Related Disorders
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Author : Richard H. Hunt
language : en
Publisher:
Release Date : 1994
Proton Pump Inhibitors And Acid Related Disorders written by Richard H. Hunt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Gastric acid categories.
Proton Pump Inhibitors A Balanced View
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Author : T. Chiba
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2013-09-23
Proton Pump Inhibitors A Balanced View written by T. Chiba and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-23 with Medical categories.
The discovery of proton pump inhibitors (PPIs) and their development over the years has dramatically changed the management of acid-related diseases. Today, the therapeutic domain of PPIs ranges from relief of symptoms to cure of mucosal lesions in the upper gastrointestinal tract. PPIs are among the most widely sold drugs in the world and are now even available as over-the-counter medication. This publication presents the experience of the last 25 years during which PPIs have become of enormous value in gastroenterology. The authors provide an update on a variety of subjects, starting with an introduction to the discovery and development of PPIs. This is followed by chapters on pharmacokinetics, pharmacodynamics and pharmacogenetics, gastroesophageal reflux disease, gastroprotection, Helicobacter pylori eradication treatment, peptic ulcer disease, functional dyspepsia, acid suppression in exocrine pancreatic insufficiency, and gastrointestinal and systemic side effects. Readers who are interested in a current overview of PPIs and their various applications will find this book of great value.
Proton Pump Inhibitors
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Author : Lars Olbe
language : en
Publisher: Birkhäuser
Release Date : 2012-12-06
Proton Pump Inhibitors written by Lars Olbe and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Inhibition of the proton pump in the parietal cells has been established as the main therapeutic principle in the treatment of acid-related diseases, such as peptic ulcer and gastro-oesophageal reflux. The proton pump inhi bitors are tailored for their purpose. They accumulate in the target cell, are activated by acid and bind strongly to the specific target - the proton pump. The clinical superiority of the proton pump inhibitors is due not only to their high efficacy but also to the long duration of the acid inhibition in comparison with other antisecretory drugs. At present when drug discovery mostly relies on identification and characterization of potential targets by genome research, molecular biology, combinatorial chemistry and automated screening, it seems worthwhile to present the development of the tITst proton pump inhibitor - omeprazol- starting from a chemical structure with an observed antisecretory effect but also severe toxic effects that had to be eliminated. As always, basic and applied research operate luind in hand to optimize the delicate balance be tween efficacy and safety of a new drug. This goal often involves time and many different specialists.
Acid Related Diseases
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Author : Irvin M. Modlin
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2004
Acid Related Diseases written by Irvin M. Modlin and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
This textbook explores the history, biology, and treatment of acid related diseases, including gastric and duodenal ulcer disease, gastroesophageal reflux disease (GERD), and the role of H. pylori. The text offers thorough coverage of the subject matter, with an in-depth historical and biological focus. Equal focus is given to the biology and pharmacology of acid secretion and to the specific disease states of ulcers and GERD. This edition is full of new full-color medical illustrations of all aspects of this topic.
Analytical Review Of Proton Pump Inhibitors
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Author : Anas Rasheed
language : en
Publisher: Createspace Independent Publishing Platform
Release Date : 2017-03-11
Analytical Review Of Proton Pump Inhibitors written by Anas Rasheed and has been published by Createspace Independent Publishing Platform this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-11 with categories.
Proton-pump inhibitors (PPIs) have emerged as the drug class of choice for treating patients with acid-related diseases, including gastro esophageal reflux disease (GERD), duodenal ulcer, and gastric ulcer. PPIs are also effective in treating patients with Barrett's esophagus and Zollinger-Ellison syndrome. These agents inhibit gastric acid secretion by targeting the gastric acid pump, H+ K+ adenosine triphosphatase (ATPase), in the canalicular membrane of the parietal cell. The regulation of acid secretion is a complex process involving many cell types, hormones, and mediators, but these processes converge in a final common step involving H+ K+ ATPase. As a result, PPIs effectively inhibit acid secretion in a manner independent of the processes that stimulate the parietal cell. Each member of the PPI class omeprazole, lansoprazole, pantoprazole and rabeprazole has been shown to be effective and well tolerated in randomized, controlled clinical trials.
Validation For The Determination Of Proton Pump Inhibitors
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Author : Anas Rasheed
language : en
Publisher: Createspace Independent Publishing Platform
Release Date : 2017-03-19
Validation For The Determination Of Proton Pump Inhibitors written by Anas Rasheed and has been published by Createspace Independent Publishing Platform this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-19 with categories.
Proton-pump inhibitors (PPIs) have emerged as the drug class of choice for treating patients with acid-related diseases, including gastro esophageal reflux disease (GERD), duodenal ulcer, and gastric ulcer. PPIs are also effective in treating patients with Barrett's esophagus and Zollinger-Ellison syndrome. These agents inhibit gastric acid secretion by targeting the gastric acid pump, H+ K+ adenosine triphosphatase (ATPase), in the canalicular membrane of the parietal cell. The regulation of acid secretion is a complex process involving many cell types, hormones, and mediators, but these processes converge in a final common step involving H+ K+ ATPase. As a result, PPIs effectively inhibit acid secretion in a manner independent of the processes that stimulate the parietal cell. Each member of the PPI class omeprazole, lansoprazole, pantoprazole and rabeprazole has been shown to be effective and well tolerated in randomized, controlled clinical trials.
Proton Pump Inhibitors Ppis
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Author : Barbara Parker
language : en
Publisher: Nova Science Publishers
Release Date : 2015
Proton Pump Inhibitors Ppis written by Barbara Parker and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Proton pump inhibitors categories.
Proton pump inhibitors (PPIs) have become a mainstay of therapy not only in the practice of gastroenterology, but also for general medicine and even for the general public. Recently, proton pump inhibitors have been associated with a number of potential complications including impaired vitamin and mineral absorption, altered drug metabolism and increased risk for infections. The outline for the basis for these reported risks are examined in this book, the current clinical evidence is discussed, and the authors offer insight into the likely clinical significance of each complication. Furthermore, the pathophysiology of acid secretion and inhibition, with a specific focus on the pharmacological principles surrounding the use of PPIs are reviewed. Relevant information on the management of acid-related disordered is provided for clinicians. Other chapters explore the current literature on potential complications associated with long-term PPI use, the benefits and risks of routine use of proton pump inhibitors in the intensive care unit (ICU), often associated with adverse events such as a significantly increased risk of infectious complications, and the use and misuse of proton pump inhibitors in the general population.
Acid Related Disorders
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Author : George Sachs
language : en
Publisher: Ingram
Release Date : 1995
Acid Related Disorders written by George Sachs and has been published by Ingram this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Medical categories.
Synthesis Of Best Seller Drugs
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Author : Ruben Vardanyan
language : en
Publisher: Academic Press
Release Date : 2016-01-07
Synthesis Of Best Seller Drugs written by Ruben Vardanyan and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-07 with Medical categories.
Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation
The Influence Of The Pharmaceutical Industry On Medicine As Exemplified By Proton Pump Inhibitors
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Author : Helge L. Waldum
language : en
Publisher: Cambridge Scholars Publishing
Release Date : 2020-09-23
The Influence Of The Pharmaceutical Industry On Medicine As Exemplified By Proton Pump Inhibitors written by Helge L. Waldum and has been published by Cambridge Scholars Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-23 with Biography & Autobiography categories.
This book is based upon 45 years of clinical and scientific experience with gastroenterology, especially the stomach. In clinical medicine, Marshall and Warren’s assertion that Helicobacter pylori is the main cause of gastritis, peptic ulcer disease, and gastric cancer made an immense impact. However, although peptic ulcers now can be treated with antibiotics, drugs that inhibit gastric acid secretion, including proton pump inhibitors (PPIs), are used in up to 10% of the adult population in Western countries in the treatment of gastro-oesophageal reflux disease and dyspepsia. For a long time, PPIs were the most frequently sold drugs, which made their economic impact huge. The reduction of gastric acidity induces the release of the gastric hormone gastrin, which stimulates its target, the ECL cell, to release histamine; this subsequently augments the acid secretion from the parietal cell. Gastrin also stimulates ECL cell proliferation, and long-term hyperstimulation leads to the development of tumors. The author of this book began his studies into the role of the ECL cell in human gastric carcinomas by demonstrating ECL cell markers in gastric cancer cells. This incriminated the ECL and its main regulator, gastrin, in gastric carcinogenesis. Every condition with reduced gastric acidity including treatment with drugs inhibiting acid secretion, leads to increased gastrin and thus to a predisposition to gastric cancer. This short book provides ample evidence of the pharmaceutical industry’s influence on medical science. It also highlights the lack of respect and attention that the medical world gives to a biological function like gastric acidity, which prevents microbes, including viruses and prions, from entering the body through the gut.