Psp94 What Is It Good For Third Edition
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Psp94 What Is It Good For Third Edition
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Author : Martin Laurence
language : en
Publisher: Shipshaw Labs
Release Date : 2013-04-21
Psp94 What Is It Good For Third Edition written by Martin Laurence and has been published by Shipshaw Labs this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-21 with Medical categories.
This monograph reviews the literature linking prostate secretory protein 94 (PSP94) to prostate cancer and benign prostatic hyperplasia (BPH). It reveals four important insights not previously reported in the scientific literature: PSP94 is fungicidal within epithelial cells that synthesize it, but it is not fungicidal extracellularly due to inhibition by calcium ions. Prostatic epithelial cells of BPH men secrete an incomplete version of PSP94 which is not fungicidal; non-BPH men only secrete the fungicidal version. Epidemiological data indicate that a yet-to-be-identified sexually transmissible infection is causing prostate cancer, BPH and non-bacterial prostatitis. The gene responsible for the synthesis of PSP94 is expressed in all late onset cancers sites, representing 75% of all cancer cases in developed countries; it is not expressed in any early onset cancer sites of unknown etiology. The etiologies of prostate cancer and BPH are not known. Prostatic inflammation can be observed in 80% of elderly men. Epidemiologists have been predicting for more than a decade that a yet-to-be-identified sexually transmissible infection is causing prostate cancer. The search for prostatic pathogens has resulted in dozens of studies, yet a disease causing agent still eludes researchers. Research has focused on known sexually transmissible infections and bacteria. Two 2008 genome wide association studies reported that a single-nucleotide polymorphism near the PSP94 gene was associated with a 1.6x increase in risk of prostate cancer: the risk allele causes reduced synthesis of PSP94 in the prostate. Taken together, these facts suggest that PSP94's primary purpose is to defend epithelial cells from an intracellular pathogen which is causing prostate cancer and BPH, and possibly other diseases. Though this hypothesis is fully consistent with the current scientific literature, additional studies are necessary. Might this hypothesis be correct or not, understanding the mechanisms behind PSP94's protective properties for prostate cancer and its role in other late onset cancers should be given high priority in cancer research.
Land Snakes Of Medical Significance In Malaysia
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Author : Ahmad Khaldun Ismail
language : en
Publisher: Malaysia Biodiversity Information System (MyBIS)
Release Date : 2017-07-03
Land Snakes Of Medical Significance In Malaysia written by Ahmad Khaldun Ismail and has been published by Malaysia Biodiversity Information System (MyBIS) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-03 with categories.
The purpose of this book is to highlight the potentially dangerous species to humans, with a list of the main potentially medically significant snakes. It is important to note that if a species is not listed below, it does not necessarily mean that it does not exist in Malaysia nor that its bite cannot cause harmful effects in humans. In particular, the list of colubrid (non-front-fanged) snakes has been selective, to include only a number known to be of potential medical significance. It is also important to note that a poor surveillance of the pet trade and irresponsible importation of exotic snakes may introduce a medically significant species, which is not indigenous to Malaysia. This may add to the complexity of managing envenomings in this country.
Hypercalcemia Of Malignancy
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Author : Friedhelm Raue
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Hypercalcemia Of Malignancy written by Friedhelm Raue and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Hypercalcemia is the most common life-threatening metabolic disorder associated with cancer. The pathophysiological, epidemiological and clinical aspects of hypercalcemia of malignancy are presented in this issue, with a focus on the recently discovered humoral factor responsible for the development of hypercalcemia. With a better understanding of the pathophysiology of this condition and the development of new potent drugs, capable of inhibiting bone resorption, especially bisphosphonates, the clinician will be more successful in correcting hypercalcemia in the great majority of patients.
Precision Medicine For Investigators Practitioners And Providers
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Author : Joel Faintuch
language : en
Publisher: Academic Press
Release Date : 2019-11-16
Precision Medicine For Investigators Practitioners And Providers written by Joel Faintuch and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-16 with Science categories.
Precision Medicine for Investigators, Practitioners and Providers addresses the needs of investigators by covering the topic as an umbrella concept, from new drug trials to wearable diagnostic devices, and from pediatrics to psychiatry in a manner that is up-to-date and authoritative. Sections include broad coverage of concerning disease groups and ancillary information about techniques, resources and consequences. Moreover, each chapter follows a structured blueprint, so that multiple, essential items are not overlooked. Instead of simply concentrating on a limited number of extensive and pedantic coverages, scholarly diagrams are also included. Provides a three-pronged approach to precision medicine that is focused on investigators, practitioners and healthcare providers Covers disease groups and ancillary information about techniques, resources and consequences Follows a structured blueprint, ensuring essential chapters items are not overlooked
Anatomy For Urologic Surgeons In The Digital Era
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Author : Emre Huri
language : en
Publisher: Springer Nature
Release Date : 2021-11-01
Anatomy For Urologic Surgeons In The Digital Era written by Emre Huri and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-01 with Medical categories.
This book provides a practical guide in the use of imaging and visualization technologies in urology. It details how output from diagnostic systems, can be represented through synthetic, virtual and augmented reality tools, such as holograms and three dimensional (3D) modelling and how they can improve everyday surgical procedures including laparoscopic, robotic-assisted, open, endoscopic along with the latest and most innovative approaches. Anatomy for Urologic Surgeons in the Digital Era: Scanning, Modelling and 3D Printing systematically reviews diagnostic imaging, visualization tools available in urology and is a valuable resource for all practicing and in-training urological surgeons.
Medical Toxicology
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Author : Pınar Erkekoglu
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-02-03
Medical Toxicology written by Pınar Erkekoglu and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-03 with Medical categories.
Medical toxicology is a sub-branch of toxicology concerned with the diagnosis, management, and prevention of poisoning and other adverse effects of drugs, cosmetics, personal care products, occupational and environmental toxicants, and biological agents. Poisoning with drugs, herbs, venoms, and toxins is a significant global public health problem. Medical toxicologists are involved in the assessment and treatment of acute or chronic poisoning, substance abuse, adverse drug reactions, drug overdoses, envenomation, industrial accidents, and other chemical exposures. As such, there is a pressing need for safe and specific antidotes, as many antidotes currently in use have a relatively low margin of safety or therapeutic index. This book focuses on poisonings with drugs, venoms, toxins, interaction in clinics, antidotes, and forensics. It provides qualified scientific knowledge on different aspects of medical toxicology, drug and substance abuse, clinical interactions between drugs and herbs, antidotes, antidote networks, and forensic toxicology.
Microfluidics
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Author : Yu Song
language : en
Publisher: John Wiley & Sons
Release Date : 2018-05-07
Microfluidics written by Yu Song and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-07 with Science categories.
The first book offering a global overview of fundamental microfluidics and the wide range of possible applications, for example, in chemistry, biology, and biomedical science. As such, it summarizes recent progress in microfluidics, including its origin and development, the theoretical fundamentals, and fabrication techniques for microfluidic devices. The book also comprehensively covers the fluid mechanics, physics and chemistry as well as applications in such different fields as detection and synthesis of inorganic and organic materials. A useful reference for non-specialists and a basic guideline for research scientists and technicians already active in this field or intending to work in microfluidics.
The Great Prostate Hoax
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Author : Richard J. Ablin
language : en
Publisher: St. Martin's Press
Release Date : 2014-03-04
The Great Prostate Hoax written by Richard J. Ablin and has been published by St. Martin's Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-04 with Medical categories.
Every year, more than a million men undergo painful needle biopsies for prostate cancer, and upward of 100,000 have radical prostatectomies, resulting in incontinence and impotence. But the shocking fact is that most of these men would never have died from this common form of cancer, which frequently grows so slowly that it never even leaves the prostate. How did we get to a point where so many unnecessary tests and surgeries are being done? In The Great Prostate Hoax, Richard J. Ablin exposes how a discovery he made in 1970, the prostate-specific antigen (PSA), was co-opted by the pharmaceutical industry into a multibillion-dollar business. He shows how his discovery of PSA was never meant to be used for screening prostate cancer, and yet nonetheless the test was patented and eventurally approved by the FDA in 1994. Now, doctors and victims are beginning to speak out about the harm of the test, and beginning to search for a true prostate cancer-specific marker.
Mouse Models Of Human Cancer
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Author : Eric C. Holland
language : en
Publisher: John Wiley & Sons
Release Date : 2004-08-27
Mouse Models Of Human Cancer written by Eric C. Holland and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-08-27 with Science categories.
Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments. Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. Offering a survey of the latest research and a description of future areas of interest, this text: Presents real experimental data Describes organ site-specific mouse models Clearly identifies suitable models for further drug testing Critically analyzes current methodologies and their limitations Features numerous recognizable expert contributors Lists key Web sites, reagents, and companies From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions. Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.
Cap Today
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Author :
language : en
Publisher:
Release Date : 1991-07
Cap Today written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-07 with Pathology categories.