Purine Metabolism In Man Ii
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Purine Metabolism In Man Ii
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Author : Mathias M. Muller
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Purine Metabolism In Man Ii written by Mathias M. Muller and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The study of gouty arthritis has provided a common meeting ground for the research interests of both the basic scientist and the clinician. The interest of the chemist in gout began 1776 with the isolation of uric acid from a concretion of the urinary tract by the Swedish chemist SCHEELE. The same substance was subsequently extracted from a gouty tophus by the British chemist WOLLASTONE in 1797 and a half century later the cause of the deposits of sodium urate In such tophi was traced to a hyperuricemia in the serum of gouty patients by the British physician Alfred Baring GARROD who had also received training in the chemical laboratory and was therefore a fore-runner of many of today's clinician-investigators. The recent surge of progress in understanding of some of the causes of gout in terms of specific enzyme defects marks the entrance of the biochemist into this field of investigation. The identification of the first primary defect of purine metabolism associated with over-production of uric acid, a severe or partial deficiency of the enzyme hypoxanthine-guanine phospho ribosyl transferase was achieved less than a decade ago. The knowledge of the mechanism of purine over-production that it generated led shortly to the identification of families carrying a dominantly (possibly X-linked) inherited increase in the activity of the enzyme phosphoribosylpyrophosphate synthetase as a cause of purine over-production. Yet this is only a start as these two types of enzyme defects account for less than five per cent of gouty patients.
Purine Metabolism In Man Ii
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Author : Mathias M. Muller
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Purine Metabolism In Man Ii written by Mathias M. Muller and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
The study of gouty arthritis has provided a common meeting ground for the research interests of both the basic scientist and the clinician. The interest of the chemist in gout began 1776 with the isolation of uric acid from a concretion of the urinary tract by the Swedish chemist SCHEELE. The same substance was subsequently extracted from a gouty tophus by the British chemist WOLLASTONE in 1797 and a half century later the cause of the deposits of sodium urate in such tophi was traced to a hyperuricemia in the serum of gouty patients by the British physician Alfred Baring GARROD who had also received training in the chemical laboratory and was therefore a fore-runner of many of today's clinician-investigators. The recent surge of progress in understanding of some of the causes of gout in terms of specific enzyme defects marks the entrance of the biochemist into this field of investigation. The identification of the first primary defect of purine metabolism associated with over-production of uric acid, a severe or partial deficiency of the enzyme hypoxanthine-guanine phospho ribosyltransferase was achieved less than a decade ago. The knowledge of the mechanism of purine over-production that it generated led shortly to the identification of families carrying a dominantly (possibly X-linked) inherited increase in the activity of the enzyme phosphoribosylpyrophosphate synthetase as a cause of purine over-production. Yet this is only a start as these two types of enzyme defects account for less than five per cent of gouty patients.
Purine Metabolism In Man Ii
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Author : Mathias M. Muller
language : en
Publisher:
Release Date : 1977
Purine Metabolism In Man Ii written by Mathias M. Muller and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with categories.
Purine Metabolism In Man Ii
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Author : Mathias M Muller
language : en
Publisher: Springer
Release Date : 2014-01-15
Purine Metabolism In Man Ii written by Mathias M Muller and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
Purine Metabolism In Man 2 Proceedings 2nd International Symposium On Purine Metabolism In Man 2 Parts
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Author :
language : en
Publisher:
Release Date :
Purine Metabolism In Man 2 Proceedings 2nd International Symposium On Purine Metabolism In Man 2 Parts written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Purine Metabolism In Man Ii
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Author : Mathias M. Muller
language : en
Publisher: Springer
Release Date : 1977-03-01
Purine Metabolism In Man Ii written by Mathias M. Muller and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977-03-01 with Science categories.
The study of gouty arthritis has provided a common meeting ground for the research interests of both the basic scientist and the clinician. The interest of the chemist in gout began 1776 with the isolation of uric acid from a concretion of the urinary tract by the Swedish chemist SCHEELE. The same substance was subsequently extracted from a gouty tophus by the British chemist WOLLASTONE in 1797 and a half century later the cause of the deposits of sodium urate In such tophi was traced to a hyperuricemia in the serum of gouty patients by the British physician Alfred Baring GARROD who had also received training in the chemical laboratory and was therefore a fore-runner of many of today's clinician-investigators. The recent surge of progress in understanding of some of the causes of gout in terms of specific enzyme defects marks the entrance of the biochemist into this field of investigation. The identification of the first primary defect of purine metabolism associated with over-production of uric acid, a severe or partial deficiency of the enzyme hypoxanthine-guanine phospho ribosyl transferase was achieved less than a decade ago. The knowledge of the mechanism of purine over-production that it generated led shortly to the identification of families carrying a dominantly (possibly X-linked) inherited increase in the activity of the enzyme phosphoribosylpyrophosphate synthetase as a cause of purine over-production. Yet this is only a start as these two types of enzyme defects account for less than five per cent of gouty patients.
Purine Metabolism In Man Ii
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Author :
language : en
Publisher:
Release Date : 1977
Purine Metabolism In Man Ii written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with categories.
Purine Metabolism In Man Ii
DOWNLOAD
Author : Mathias M. Müller
language : en
Publisher:
Release Date : 1977
Purine Metabolism In Man Ii written by Mathias M. Müller and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with categories.
Purine Metabolism In Man 2
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Author : Mathias M. Müller
language : en
Publisher:
Release Date : 1977
Purine Metabolism In Man 2 written by Mathias M. Müller and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with categories.
Purine Metabolism In Man 2
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Author : Mathias M. Müller
language : en
Publisher:
Release Date : 1977
Purine Metabolism In Man 2 written by Mathias M. Müller and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with categories.